Insight on the Molecular Envelope of Lipid-Bound Apolipoprotein E from Electron Paramagnetic Resonance Spectroscopy

Journal of Molecular Biology

Volumn 386, Issue 1, 2009, Pages 261-271

  Hatters, Danny M ^a,b,c   Voss, John C ^d   Budamagunta, Madhu S ^d   Newhouse, Yvonne N ^a   Weisgraber, Karl H ^a,b,c  

^a GLADSTONE INSTITUTES   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

lipoproteins; models; protein structure; spin labels

Indexed keywords

APOLIPOPROTEIN E; CYSTEINE; DIPALMITOYLPHOSPHATIDYLCHOLINE; LIPID;

ARTICLE; CELL NUCLEUS MEMBRANE; ELECTRON SPIN RESONANCE; MOLECULAR DYNAMICS; MUTAGENESIS; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PURIFICATION; PROTEIN STRUCTURE; STRUCTURE ACTIVITY RELATION; X RAY ANALYSIS;

EID: 58549107197     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2008.12.040     Document Type: Article

References (44)

1. Weisgraber K.H. Apolipoprotein E: structure-function relationships. Adv. Protein Chem. 45 (1994) 249-302
2. Mahley R.W. Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Science 240 (1988) 622-630
3. Nathan B.P., Bellosta S., Sanan D.A., Weisgraber K.H., Mahley R.W., and Pitas R.E. Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro. Science 264 (1994) 850-852
4. Weisgraber K.H., Pitas R.E., and Mahley R.W. Lipoproteins, neurobiology, and Alzheimer's disease: structure and function of apolipoprotein E. Curr. Opin. Struct. Biol. 4 (1994) 507-515
5. Mahley R.W., and Huang Y. Apolipoprotein E: from atherosclerosis to Alzheimer's disease and beyond. Curr. Opin. Lipidol. 10 (1999) 207-217
6. Strittmatter W.J., Saunders A.M., Schmechel D., Pericak-Vance M., Enghild J., Salvesen G.S., and Roses A.D. Apolipoprotein E: high-avidity binding to β-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proc. Natl Acad. Sci. USA 90 (1993) 1977-1981
7. Corder E.H., Saunders A.M., Strittmatter W.J., Schmechel D.E., Gaskell P.C., Small G.W., et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 261 (1993) 921-923
8. Saunders A.M., Strittmatter W.J., Schmechel D., St George-Hyslop P.H., Pericak-Vance M.A., Joo S.H., et al. Association of apolipoprotein E allele e{open}4 with late-onset familial and sporadic Alzheimer's disease. Neurology 43 (1993) 1467-1472
9. Innerarity T.L., Pitas R.E., and Mahley R.W. Binding of arginine-rich (E) apoprotein after recombination with phospholipid vesicles to the low density lipoprotein receptors of fibroblasts. J. Biol. Chem. 254 (1979) 4186-4190
10. Peters-Libeu C.A., Newhouse Y., Hatters D.M., and Weisgraber K.H. Model of biologically active apolipoprotein E bound to dipalmitoylphosphatidylcholine. J. Biol. Chem. 281 (2006) 1073-1079
11. Hatters D.M., Budamagunta M.S., Voss J.C., and Weisgraber K.H. Modulation of apolipoprotein E structure by domain interaction. Differences in lipid-bound and lipid-free forms. J. Biol. Chem. 280 (2005) 34288-34295
12. Narayanaswami V., Szeto S.S.W., and Ryan R.O. Lipid association-induced N- and C-terminal domain reorganization in human apolipoprotein E3. J. Biol. Chem. 276 (2001) 37853-37860
13. f 100-400 hypertriglyceridemic very low density lipoproteins by the low density lipoprotein receptor pathway in normal human fibroblasts. J. Biol. Chem. 258 (1983) 4526-4533
14. Weisgraber K.H., Mahley R.W., Kowal R.C., Herz J., Goldstein J.L., and Brown M.S. Apolipoprotein C-I modulates the interaction of apolipoprotein E with β-migrating very low density lipoproteins (β-VLDL) and inhibits binding of β-VLDL to low density lipoprotein receptor-related protein. J. Biol. Chem. 265 (1990) 22453-22459
15. Narayanaswami V., and Ryan R.O. Molecular basis of exchangeable apolipoprotein function. Biochim. Biophys. Acta 1483 (2000) 15-36
16. Peters-Libeu C.A., Newhouse Y., Hall S.C., Witkowska H.E., and Weisgraber K.H. Apolipoprotein E-dipalmitoylphosphatidylcholine particles are ellipsoidal in solution. J. Lipid Res. 48 (2007) 1035-1044
17. Hatters D.M., Zhong N., Rutenber E., and Weisgraber K.H. Amino-terminal domain stability mediates apolipoprotein E aggregation into neurotoxic fibrils. J. Mol. Biol. 361 (2006) 932-944
18. Aggerbeck L.P., Wetterau J.R., Weisgraber K.H., Wu C.-S.C., and Lindgren F.T. Human apolipoprotein E3 in aqueous solution: II. Properties of the amino- and carboxyl-terminal domains. J. Biol. Chem. 263 (1988) 6249-6258
19. Wetterau J.R., Aggerbeck L.P., Rall Jr. S.C., and Weisgraber K.H. Human apolipoprotein E3 in aqueous solution: I. Evidence for two structural domains. J. Biol. Chem. 263 (1988) 6240-6248
20. Wilson C., Wardell M.R., Weisgraber K.H., Mahley R.W., and Agard D.A. Three-dimensional structure of the LDL receptor-binding domain of human apolipoprotein E. Science 252 (1991) 1817-1822
21. Hatters D.M., Peters-Libeu C.A., and Weisgraber K.H. Apolipoprotein E structure: insights into function. Trends Biochem. Sci. 31 (2006) 445-454
22. Matz C.E., and Jonas A. Micellar complexes of human apolipoprotein A-I with phosphatidylcholines and cholesterol prepared from cholate-lipid dispersions. J. Biol. Chem. 257 (1982) 4535-4540
23. Newhouse Y., Peters-Libeu C., and Weisgraber K.H. Crystallization and preliminary x-ray diffraction analysis of apolipoprotein E-containing lipoprotein particles. Acta Crystallogr., Sect. F 61 (2005) 981-984
24. Langen R., Oh K.J., Cascio D., and Hubbell W.L. Crystal structures of spin labeled T4 lysozyme mutants: implications for the interpretation of EPR spectra in terms of structure. Biochemistry 39 (2000) 8396-8405
25. Guo Z., Cascio D., Hideg K., Kálái T., and Hubbell W.L. Structural determinant of nitroxide motion in spin-labeled proteins: tertiary contact and solvent-inaccessible sites in helix G of T4 lysozyme. Protein Sci. 16 (2007) 1069-1086
26. Fajer M.I., Li H., Yang W., and Fajer P.G. Mapping electron paramagnetic resonance spin label conformations by the simulated scaling method. J. Am. Chem. Soc. 129 (2007) 13840-13846
27. Mchaourab H.S., Oh K.J., Fang C.J., and Hubbell W.L. Conformation of T4 lysozyme in solution. Hinge-bending motion and the substrate-induced conformational transition studied by site-directed spin labeling. Biochemistry 36 (1997) 307-316
28. Segrest J.P., Jones M.K., Klon A.E., Sheldahl C.J., Hellinger M., Loof H.-D., and Harvey S.C. A detailed molecular belt model for apolipoprotein A-I in discoidal high density lipoprotein. J. Biol. Chem. 274 (1999) 31755-31758
29. Qin Z., and Cafiso D.S. Membrane structure of protein kinase C and calmodulin binding domain of myristoylated alanine rich C kinase substrate determined by site-directed spin labeling. Biochemistry 35 (1996) 2917-2925
30. Nielsen R.D., Che K., Gelb M.H., and Robinson B.H. A ruler for determining the position of proteins in membranes. J. Am. Chem. Soc. 127 (2005) 6430-6442
31. Oda M.N., Forte T.M., Ryan R.O., and Voss J.C. The C-terminal domain of apolipoprotein A-I contains a lipid-sensitive conformational trigger. Nat. Struct. Biol. 10 (2003) 455-460
32. Martin D.D., Budamagunta M.S., Ryan R.O., Voss J.C., and Oda M.N. Apolipoprotein A-I assumes a "looped belt" conformation on reconstituted high density lipoprotein. J. Biol. Chem. 281 (2006) 20418-20426
33. Lagerstedt J.O., Budamagunta M.S., Oda M.N., and Voss J.C. Electron paramagnetic resonance spectroscopy of site-directed spin labels reveals the structural heterogeneity in the N-terminal domain of apoA-I in solution. J. Biol. Chem. 282 (2007) 9143-9149
34. Glomset J.A. The plasma lecithin:cholesterol acyltransferase reaction. J. Lipid Res. 9 (1968) 155-167
35. Gordon V., Innerarity T.L., and Mahley R.W. Formation of cholesterol- and apoprotein E-enriched high density lipoproteins in vitro. J. Biol. Chem. 258 (1983) 6202-6212
36. Koo C., Innerarity T.L., and Mahley R.W. Obligatory role of cholesterol and apolipoprotein E in the formation of large cholesterol-enriched and receptor-active high density lipoproteins. J. Biol. Chem. 260 (1985) 11934-11943
37. Dong L.-M., Wilson C., Wardell M.R., Simmons T., Mahley R.W., Weisgraber K.H., and Agard D.A. Human apolipoprotein E. Role of arginine 61 in mediating the lipoprotein preferences of the E3 and E4 isoforms. J. Biol. Chem. 269 (1994) 22358-22365
38. Dong L.-M., and Weisgraber K.H. Human apolipoprotein E4 domain interaction. Arginine 61 and glutamic acid 255 interact to direct the preference for very low density lipoproteins. J. Biol. Chem. 271 (1996) 19053-19057
39. Zhong N., Scearce-Levie K., Ramaswamy G., and Weisgraber K.H. Apolipoprotein E4 domain interaction: synaptic and cognitive deficits in mice. Alzheimer's & Dementia 4 (2008) 179-192
40. Ramaswamy G., Xu Q., Huang Y., and Weisgraber K.H. Effect of domain interaction on apolipoprotein E levels in mouse brain. J. Neurosci. 25 (2005) 10658-10663
41. Raffaï R.L., Dong L.-M., Farese Jr. R.V., and Weisgraber K.H. Introduction of human apolipoprotein E4 "domain interaction" into mouse apolipoprotein E. Proc. Natl Acad. Sci. USA 98 (2001) 11587-11591
42. Lu B., Morrow J.A., and Weisgraber K.H. Conformational reorganization of the four-helix bundle of human apolipoprotein E in binding to phospholipid. J. Biol. Chem. 275 (2000) 20775-20781
43. Fisher C.A., Narayanaswami V., and Ryan R.O. The lipid-associated conformation of the low density lipoprotein receptor binding domain of human apolipoprotein E. J. Biol. Chem. 275 (2000) 33601-33606
44. Morrow J.A., Arnold K.S., and Weisgraber K.H. Functional characterization of apolipoprotein E isoforms overexpressed in Escherichia coli. Protein Expression Purif. 16 (1999) 224-230