Novel human topoisomerase I inhibitors, topopyrones A, B, C and D. II. Structure elucidation

Journal of Antibiotics

Volumn 53, Issue 9, 2000, Pages 873-878

  Ishiyama, D ^a   Kanai, Y ^a   Senda, H ^a   Iwatani, W ^a   Takahashi, H ^a   Konno, H ^a   Kanazawa, S ^a  

^a KAKEN PHARMACEUTICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRAQUINONE DERIVATIVE; AROMATIC COMPOUND; CARBONYL DERIVATIVE; CHLORINE; DIAZOMETHANE; DNA TOPOISOMERASE; DNA TOPOISOMERASE INHIBITOR; EPOXIDE; KETONE DERIVATIVE; METHANOL; PHENOL DERIVATIVE; PYRONE DERIVATIVE; QUINONE DERIVATIVE; SODIUM HYDROXIDE; TOPOPYRONE A; TOPOPYRONE B; TOPOPYRONE C; TOPOPYRONE D; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL COMPOSITION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DRUG CONFORMATION; DRUG STRUCTURE; ENZYME INHIBITION; FUNGUS; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; REACTION ANALYSIS; SPECTROSCOPY; STRUCTURE ANALYSIS;

EID: 0033770559     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.53.873     Document Type: Article

References (7)

1. Novel human topoispmerase I inhibitors, topopyrone A, B, C and D from Phoma sp. I. Producing strain, fermentation, isolation, physico-chemical properties and biological activity
2. Synthese and Konstitution des Skutellareins
3. Ring isomerization of flavones. New synthesis of oroxylin-A and 7-methyl-oroxylin-A
4. Action of alkali on substituted chromones
5. A study of basecatalysed Wessely-moser rearrangement of 5-hydroxy-3,6″,6″-trimethylpyrano [2″,3″:7,8] flavone
6. A novel irreversible Wessely-Moser Rearrangement of a 5-mercaptochromone
7. Isomerisation of tetrahydroartocarpin to thermodynamically more stable tetrahydromulberrin