-
1
-
-
58349095416
-
-
Bruncko, M, Ding, H, Elmore, S.W. et al, Abbott Laboratories Inc, Apoptosis promoters. EP 1888550, US 2007027135, US 7390799, WO 2007040650
-
Bruncko, M., Ding, H., Elmore, S.W. et al. (Abbott Laboratories Inc.). Apoptosis promoters. EP 1888550, US 2007027135, US 7390799, WO 2007040650.
-
-
-
-
2
-
-
58349095814
-
ABT-263, an orally bioavailable inhibitor of Bcl-2 family proteins
-
April 6-10, New Orleans, Abst MEDI 110
-
Ding, H., Park, C.-M., Bruncko, M. et al. ABT-263, an orally bioavailable inhibitor of Bcl-2 family proteins. 235th ACS Natl Meet (April 6-10, New Orleans) 2008, Abst MEDI 110.
-
(2008)
235th ACS Natl Meet
-
-
Ding, H.1
Park, C.-M.2
Bruncko, M.3
-
3
-
-
49649106694
-
An efficient synthesis of ABT-263, a novel inhibitor of antiapoptotic Bcl-2 proteins
-
Zhang, H., Zhou, J., Ha, C., Pei, D., Ding, K. An efficient synthesis of ABT-263, a novel inhibitor of antiapoptotic Bcl-2 proteins. Synthesis 2008, (15): 2398-404.
-
(2008)
Synthesis
, vol.15
, pp. 2398-2404
-
-
Zhang, H.1
Zhou, J.2
Ha, C.3
Pei, D.4
Ding, K.5
-
4
-
-
58349086570
-
P2 site SAR development toward ABT-263, an orally bioavailable inhibitor of Bcl-2 family proteins
-
April 6-10, New Orleans, Abst MEDI 78
-
Song, X., Bruncko, M., Ding, H. et al. P2 site SAR development toward ABT-263, an orally bioavailable inhibitor of Bcl-2 family proteins. 235th ACS Natl Meet (April 6-10, New Orleans) 2008, Abst MEDI 78.
-
(2008)
235th ACS Natl Meet
-
-
Song, X.1
Bruncko, M.2
Ding, H.3
-
5
-
-
0036728834
-
Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics
-
Letai, A., Bassik, M.C., Walensky, L.D., Sorcinelli, M.D., Weiler, S., Korsmeyer, S.J. Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics. Cancer Cell 2002, 2(3): 183-92.
-
(2002)
Cancer Cell
, vol.2
, Issue.3
, pp. 183-192
-
-
Letai, A.1
Bassik, M.C.2
Walensky, L.D.3
Sorcinelli, M.D.4
Weiler, S.5
Korsmeyer, S.J.6
-
6
-
-
13944277343
-
BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly
-
Kuwana, T., Bouchier-Hayes, L., Chipuk, J.E., Bonzon, C., Sullivan, B.A., Green, D.R., Newmeyer, D.D. BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly. Mol Cell 2005, 17(4): 525-35.
-
(2005)
Mol Cell
, vol.17
, Issue.4
, pp. 525-535
-
-
Kuwana, T.1
Bouchier-Hayes, L.2
Chipuk, J.E.3
Bonzon, C.4
Sullivan, B.A.5
Green, D.R.6
Newmeyer, D.D.7
-
7
-
-
33646354381
-
Mitochondfia primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members
-
Certo, M., Del Gaizo, Moore, V., Nishino, M., Wei, G., Korsmeyer, S., Armstrong, S.A., Letai, A. Mitochondfia primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members. Cancer Cell 2006, 9(5): 351-65.
-
(2006)
Cancer Cell
, vol.9
, Issue.5
, pp. 351-365
-
-
Certo, M.1
Gaizo, D.2
Moore, V.3
Nishino, M.4
Wei, G.5
Korsmeyer, S.6
Armstrong, S.A.7
Letai, A.8
-
8
-
-
33846964621
-
Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak
-
Willis, S.N., Fletcher, J.I., Kaufmann, T. et al. Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak. Science 2007, 315(5813): 856-9.
-
(2007)
Science
, vol.315
, Issue.5813
, pp. 856-859
-
-
Willis, S.N.1
Fletcher, J.I.2
Kaufmann, T.3
-
9
-
-
33847328289
-
The Bcl-2 apoptotic switch in cancer development and therapy
-
Adams, J.M., Cory, S. The Bcl-2 apoptotic switch in cancer development and therapy. Oncogene 2007, 26: 1324-37.
-
(2007)
Oncogene
, vol.26
, pp. 1324-1337
-
-
Adams, J.M.1
Cory, S.2
-
10
-
-
0032418092
-
Role of Bcl-2 family proteins in apoptosis: Apoptosomes or mitochondria?
-
Tsujimoto, Y. Role of Bcl-2 family proteins in apoptosis: Apoptosomes or mitochondria? Genes Cells 1998, 3(11): 697-707.
-
(1998)
Genes Cells
, vol.3
, Issue.11
, pp. 697-707
-
-
Tsujimoto, Y.1
-
11
-
-
33847404358
-
Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL
-
Bruncko, M., Oost, T.K., Bell, B.A. et al. Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL. J Med Chem 2007, 50(4): 641-62.
-
(2007)
J Med Chem
, vol.50
, Issue.4
, pp. 641-662
-
-
Bruncko, M.1
Oost, T.K.2
Bell, B.A.3
-
12
-
-
33846674886
-
Mcl-1 downregulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocation
-
Chen, S., Dai, Y., Harada, H., Dent, P., Grant, S. Mcl-1 downregulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocation. Cancer Res 2007, 67(2): 782-91.
-
(2007)
Cancer Res
, vol.67
, Issue.2
, pp. 782-791
-
-
Chen, S.1
Dai, Y.2
Harada, H.3
Dent, P.4
Grant, S.5
-
13
-
-
34447642522
-
BH3 mimetic ABT-737 neutralizes resistance to FLT3 inhibitor treatment medated by FLT3-independent expression of BCL2 in primary AML blasts
-
Kohl, T.M., Hellinger, C., Ahmed, F., Buske, C., Hiddemann, W., Bohlander, S.K., Spiekermann, K. BH3 mimetic ABT-737 neutralizes resistance to FLT3 inhibitor treatment medated by FLT3-independent expression of BCL2 in primary AML blasts. Leukemia 2007, 21(8): 1763-72.
-
(2007)
Leukemia
, vol.21
, Issue.8
, pp. 1763-1772
-
-
Kohl, T.M.1
Hellinger, C.2
Ahmed, F.3
Buske, C.4
Hiddemann, W.5
Bohlander, S.K.6
Spiekermann, K.7
-
14
-
-
34548814971
-
Activity of vincristine, L-ASP, and dexamethasone against acute lymphoblastic leukemia is enhanced by the BH3-mimetic ABT-737 in vitro and in vivo
-
Kang, M.H., Kang, Y.H., Szymanska, B. et al. Activity of vincristine, L-ASP, and dexamethasone against acute lymphoblastic leukemia is enhanced by the BH3-mimetic ABT-737 in vitro and in vivo. Blood 2007, 110(6): 2057-66.
-
(2007)
Blood
, vol.110
, Issue.6
, pp. 2057-2066
-
-
Kang, M.H.1
Kang, Y.H.2
Szymanska, B.3
-
15
-
-
33847061737
-
Influence of Bcl-2 family members on the cellular response of small-cell lung cancer cell lines to ABT-737
-
Tahir, S.K., Yang, X., Anderson, M.G. et al. Influence of Bcl-2 family members on the cellular response of small-cell lung cancer cell lines to ABT-737. Cancer Res 2007, 67(3): 1176-83.
-
(2007)
Cancer Res
, vol.67
, Issue.3
, pp. 1176-1183
-
-
Tahir, S.K.1
Yang, X.2
Anderson, M.G.3
-
16
-
-
20444486559
-
An inhibitor of Bcl-2 family proteins induces regression of solid tumours
-
Oltersdorf, T., Elmore, S.W., Shoemaker, A.R. et al. An inhibitor of Bcl-2 family proteins induces regression of solid tumours. Nature 2005, 435(7042): 677-81.
-
(2005)
Nature
, vol.435
, Issue.7042
, pp. 677-681
-
-
Oltersdorf, T.1
Elmore, S.W.2
Shoemaker, A.R.3
-
17
-
-
33750834023
-
The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized
-
van Delft, M.F., Wei, A.H., Mason, K.D. et al. The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized. Cancer Cell 2005, 10(5): 389-99.
-
(2005)
Cancer Cell
, vol.10
, Issue.5
, pp. 389-399
-
-
van Delft, M.F.1
Wei, A.H.2
Mason, K.D.3
-
18
-
-
33846884216
-
The Bcl-2 family protein inhibitor, ABT-737, has substantial antimyeloma activity and shows synergistic effect with dexamethasone and melphalan
-
Trudel, S., Stewart, A. K., Li, Z. et al. The Bcl-2 family protein inhibitor, ABT-737, has substantial antimyeloma activity and shows synergistic effect with dexamethasone and melphalan. Clin Cancer Res 2007, 13(2, Pt. 1): 621-9.
-
(2007)
Clin Cancer Res
, vol.13
, Issue.2 and PART. 1
, pp. 621-629
-
-
Trudel, S.1
Stewart, A.K.2
Li, Z.3
-
19
-
-
34250770481
-
ABT-737, an inhibitor of Bcl-2 family proteins, is a potent inducer of apoptosis in multiple meyloma cells
-
Kline, M.P., Rajkumar, S.V., Timm, M.M. et al. ABT-737, an inhibitor of Bcl-2 family proteins, is a potent inducer of apoptosis in multiple meyloma cells. Leukemia 2007, 21(7): 1549-60.
-
(2007)
Leukemia
, vol.21
, Issue.7
, pp. 1549-1560
-
-
Kline, M.P.1
Rajkumar, S.V.2
Timm, M.M.3
-
20
-
-
33845994359
-
-
Del Gaizo Moore, V., Brown, J.R., Certo, M.., Love, T.M.., Novina, C.D., Letai, A. Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737. J Clin Invest 2007, 117(1): 112-21.
-
Del Gaizo Moore, V., Brown, J.R., Certo, M.., Love, T.M.., Novina, C.D., Letai, A. Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737. J Clin Invest 2007, 117(1): 112-21.
-
-
-
-
21
-
-
58349094568
-
ABT-263, an orally bioavailable and efficacious inhibitor of Bcl-2 family proteins
-
April 6-10, New Orleans, Abst MEDI 340
-
Bruncko, M. ABT-263, an orally bioavailable and efficacious inhibitor of Bcl-2 family proteins. 235th ACS Natl Meet (April 6-10, New Orleans) 2008, Abst MEDI 340.
-
(2008)
235th ACS Natl Meet
-
-
Bruncko, M.1
-
22
-
-
44849112219
-
ABT-263: A potent and orally bioavailable Bcl-2 family inhibitor
-
Tse, C., Shoemaker, A.R., Adickes, J. et al. ABT-263: A potent and orally bioavailable Bcl-2 family inhibitor. Cancer Res 2008, 68(9): 3421-8.
-
(2008)
Cancer Res
, vol.68
, Issue.9
, pp. 3421-3428
-
-
Tse, C.1
Shoemaker, A.R.2
Adickes, J.3
-
28
-
-
50349098706
-
Activity of the Bcl-2 family inhibitor ABT-263 in a panel of small cell lung cancer xenograft models
-
Shoemaker, A.R., Mitten, MJ, Adickes, J. et al. Activity of the Bcl-2 family inhibitor ABT-263 in a panel of small cell lung cancer xenograft models. Clin Cancer Res 2008, 14(11): 3268-77.
-
(2008)
Clin Cancer Res
, vol.14
, Issue.11
, pp. 3268-3277
-
-
Shoemaker, A.R.1
Mitten, M.J.2
Adickes, J.3
-
29
-
-
42349109916
-
Initial testing (stage 1) of the BH3 mimetic ABT-263 by the pediatric preclinical testing program
-
Lock, R., Carol, H., Houghton, P.J. et al. Initial testing (stage 1) of the BH3 mimetic ABT-263 by the pediatric preclinical testing program. Pediatr Blood Cancer 2008, 50(6): 1181-9.
-
(2008)
Pediatr Blood Cancer
, vol.50
, Issue.6
, pp. 1181-1189
-
-
Lock, R.1
Carol, H.2
Houghton, P.J.3
-
30
-
-
58349119841
-
An ongoing phase 1 study of ABT-263 in patients with relapsed small cell lung cancer and other solid tumors
-
Congr Sept 12-16, Stockholm, Abst 324P
-
Gandhi, L., Camidge, D.R., Khaira, D. et al. An ongoing phase 1 study of ABT-263 in patients with relapsed small cell lung cancer and other solid tumors. Ann Oncol [33rd Eur Soc Med Oncol (ESMO) Congr (Sept 12-16, Stockholm) 2008]2008, 19(Suppl. 8): Abst 324P.
-
(2008)
Ann Oncol [33rd Eur Soc Med Oncol (ESMO)
, vol.19
, Issue.SUPPL. 8
-
-
Gandhi, L.1
Camidge, D.R.2
Khaira, D.3
-
31
-
-
58349096937
-
ngoing phase 1 studies of ABT-263; pharmacokinetics, safety and anti-tumor activity in patients with relapsed chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL)
-
Congr Sept 12-16, Stockholm, Abst 729PD
-
Brown, J., Roberts, A., Seymour, J.F. et al. ngoing phase 1 studies of ABT-263; pharmacokinetics, safety and anti-tumor activity in patients with relapsed chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL). Ann Oncol [33rd Eur Soc Med Oncol (ESMO) Congr (Sept 12-16, Stockholm) 2008] 2008, 19(Suppl. 8): Abst 729PD.
-
(2008)
Ann Oncol [33rd Eur Soc Med Oncol (ESMO)
, vol.19
, Issue.SUPPL. 8
-
-
Brown, J.1
Roberts, A.2
Seymour, J.F.3
-
32
-
-
58349121903
-
The Bcl-2 family protein inhibitor, ABT-263, promotes apoptotic-like response in isolated platelets
-
Dec 9-12, Orlando, Abst 1122
-
Tse, C., Zhang, H., Chen, J. et al. The Bcl-2 family protein inhibitor, ABT-263, promotes apoptotic-like response in isolated platelets. Blood [48th Annu Meet Am Soc Hematol (Dec 9-12, Orlando) 2006] 2006, 108(11): Abst 1122.
-
(2006)
Blood [48th Annu Meet Am Soc Hematol
, vol.108
, Issue.11
-
-
Tse, C.1
Zhang, H.2
Chen, J.3
-
33
-
-
58349087249
-
The Bcl-2 family inhibitor ABT-263 shows significant but reversible thrombocytopenia in mice
-
Dec 9-12, Orlando, Abst 1107
-
Shoemaker, A.R., Mitten, M.J., Adickes, J. et al. The Bcl-2 family inhibitor ABT-263 shows significant but reversible thrombocytopenia in mice. Blood (48th Annu Meet Am Soc Hematol (Dec 9-12, Orlando) 2006] 2006, 108(11): Abst 1107.
-
(2006)
Blood (48th Annu Meet Am Soc Hematol
, vol.108
, Issue.11
-
-
Shoemaker, A.R.1
Mitten, M.J.2
Adickes, J.3
-
34
-
-
58349113893
-
Bcl-2 family protein inhibitors induce a unique thrombocytopenia in vivo
-
Dec 9-12, Orlando, Abst 4236
-
Elmore, S.W., Bauch, J., Fryer, R. M. et al. Bcl-2 family protein inhibitors induce a unique thrombocytopenia in vivo. Blood [48th Annu Meet Am Soc Hematol (Dec 9-12, Orlando) 2006] 2006, 108(11): Abst 4236.
-
(2006)
Blood [48th Annu Meet Am Soc Hematol
, vol.108
, Issue.11
-
-
Elmore, S.W.1
Bauch, J.2
Fryer, R.M.3
-
35
-
-
58349116485
-
A phase 1 study evaluating the safety, PK & efficacy of ABT-263 in subjects with refractory or relapsed lymphoid malignancies
-
Congr Sept 12-16, Stockholm, Abst 101
-
O'Connor, O., Czuczman, M.S., LaCasce, A. et al. A phase 1 study evaluating the safety, PK & efficacy of ABT-263 in subjects with refractory or relapsed lymphoid malignancies. Ann Oncol [33rd Eur Soc Med Oncol (ESMO) Congr (Sept 12-16, Stockholm) 2008] 2008, 19(Suppl. 8): Abst 101.
-
(2008)
Ann Oncol [33rd Eur Soc Med Oncol (ESMO)
, vol.19
, Issue.SUPPL. 8
-
-
O'Connor, O.1
Czuczman, M.S.2
LaCasce, A.3
-
36
-
-
58349105822
-
A phase 1 study evaluating the safety, pharmacokinetics, and efficacy of ABT-263 in subjects with refractory or relapsed lymphoid malignancies
-
Abst 8511
-
Wilson, W.H., Czuczman, M.S., LaCasce, A.S. et al. A phase 1 study evaluating the safety, pharmacokinetics, and efficacy of ABT-263 in subjects with refractory or relapsed lymphoid malignancies. J Clin Oncol [44th Annu Meet Am Soc Clin Oncol (ASCO) (May 30-June 3, Chicago) 2008] 2008, 26(15, Suppl.): Abst 8511.
-
J Clin Oncol [44th Annu Meet Am Soc Clin Oncol (ASCO) (May 30-June 3, Chicago) 2008] 2008, 26(15, Suppl.)
-
-
Wilson, W.H.1
Czuczman, M.S.2
LaCasce, A.S.3
-
37
-
-
40849129529
-
A phase 1/2a study evaluating the safety, pharmacokinetics, and efficacy of ABT-263 in subjects with refractory or relapsed lymphoid malignancies
-
Dec 8-11, Atlanta, Abst 1371
-
Wilson, W.H., Tulpule, A., Levine, A.M. et al. A phase 1/2a study evaluating the safety, pharmacokinetics, and efficacy of ABT-263 in subjects with refractory or relapsed lymphoid malignancies. Blood [49th Annu Meet Am Soc Hematol (Dec 8-11, Atlanta) 2007]2007, 110(11): Abst 1371.
-
(2007)
Blood [49th Annu Meet Am Soc Hematol
, vol.110
, Issue.11
-
-
Wilson, W.H.1
Tulpule, A.2
Levine, A.M.3
-
38
-
-
49749126692
-
Pediatric Preclinical Testing Program (PPTP) evaluation of the Bcl-2 inhibitor ABT-263
-
Abst 4951
-
Smith, M.A., Maris, J.M., Keir, S.T. et al. Pediatric Preclinical Testing Program (PPTP) evaluation of the Bcl-2 inhibitor ABT-263. Proc Am Assoc Cancer Res (AACR) 2007, 48: Abst 4951.
-
(2007)
Proc Am Assoc Cancer Res (AACR)
, vol.48
-
-
Smith, M.A.1
Maris, J.M.2
Keir, S.T.3
-
39
-
-
58349088544
-
The Bcl-2 family protein inhibitor, ABT-263, broadly potentiates the cytotoxicity of other therapeutic agents in vitro
-
Abst 726
-
Zhang, H., Chen, J., Chen, Z. et al. The Bcl-2 family protein inhibitor, ABT-263, broadly potentiates the cytotoxicity of other therapeutic agents in vitro. Proc Am Assoc Cancer Res (AACR) 2007, 48: Abst 726.
-
(2007)
Proc Am Assoc Cancer Res (AACR)
, vol.48
-
-
Zhang, H.1
Chen, J.2
Chen, Z.3
-
41
-
-
58349119406
-
Reduction in platelet counts as a mechanistic bibmarker and guide for adaptive dose-escalation in phase/studies of the Bcl-2 family inhibitor ABT-263
-
Abst 3542
-
Roberts, A., Gandhi, L., O'Connor, O.A. et al. Reduction in platelet counts as a mechanistic bibmarker and guide for adaptive dose-escalation in phase/studies of the Bcl-2 family inhibitor ABT-263. J Clin Oncol [44th Annu Meet Am Soc Clin Oncol (ASCO) (May 30-June 3, Chicago) 2008] 2008, 26(15, Suppl.): Abst 3542.
-
J Clin Oncol [44th Annu Meet Am Soc Clin Oncol (ASCO) (May 30-June 3, Chicago) 2008] 2008, 26(15, Suppl.)
-
-
Roberts, A.1
Gandhi, L.2
O'Connor, O.A.3
-
42
-
-
58349110997
-
The Bcl-2 family inhibitor ABT-263 shows significant anti-tumor efficacy in models of B cell non-Hodgkin's lymphoma
-
Abst 825
-
Shoemaker, A.R., Mitten, M.J., Oleksijew, A. et al. The Bcl-2 family inhibitor ABT-263 shows significant anti-tumor efficacy in models of B cell non-Hodgkin's lymphoma. Blood [48th Annu Meet Am Soc Hematol (Dec 9-12, Orlando) 2006] 2006,108(l 1): Abst 825.
-
Blood [48th Annu Meet Am Soc Hematol (Dec 9-12, Orlando) 2006] 2006,108(l
, vol.1
-
-
Shoemaker, A.R.1
Mitten, M.J.2
Oleksijew, A.3
-
43
-
-
49749087529
-
Preclinical activity of the Bcl-2 family inhibitor ABT-263 in models of small cell lung cancer
-
Abst 4953
-
Shoemaker, A.R., Oleksijew, A., Mitten, M.J. et al. Preclinical activity of the Bcl-2 family inhibitor ABT-263 in models of small cell lung cancer. Proc Am Assoc Cancer Res (AACR) 2007, 48: Abst 4953.
-
(2007)
Proc Am Assoc Cancer Res (AACR)
, vol.48
-
-
Shoemaker, A.R.1
Oleksijew, A.2
Mitten, M.J.3
|