메뉴 건너뛰기




Volumn 33, Issue 10, 2008, Pages 829-837

ABT-263. Bcl-2 inhibitor, apoptosis inducer, oncolytic

Author keywords

[No Author keywords available]

Indexed keywords

4 [4 (4' CHLORO 2 BIPHENYLYLMETHYL) 1 PIPERAZINYL] N [4 [3 DIMETHYLAMINO 1 (PHENYLTHIOMETHYL)PROPYLAMINO] 3 NITROBENZENESULFONYL]BENZAMIDE; ABT 263; ANTINEOPLASTIC AGENT; BORTEZOMIB; CARBOPLATIN; CISPLATIN; CYCLOPHOSPHAMIDE; DOCETAXEL; DOXORUBICIN; ETOPOSIDE; N [4 [4 [2 (4 CHLOROPHENYL) 5,5 DIMETHYL 1 CYCLOHEXENYLMETHYL]PIPERAZIN 1 YL]BENZOYL] 4 [3 (4 MORPHOLINYL) 1 (PHENYLSULFANYLMETHYL)PROPYLAMINO] 3 (TRIFLUOROMETHYLSULFONYL)BENZENESULFONAMIDE; PACLITAXEL; PREDNISOLONE; PROTEIN BCL 2; RITUXIMAB; UNCLASSIFIED DRUG; VINCRISTINE;

EID: 58349104582     PISSN: 03778282     EISSN: None     Source Type: Journal    
DOI: 10.1358/dof.2008.33.10.1265203     Document Type: Article
Times cited : (2)

References (43)
  • 1
    • 58349095416 scopus 로고    scopus 로고
    • Bruncko, M, Ding, H, Elmore, S.W. et al, Abbott Laboratories Inc, Apoptosis promoters. EP 1888550, US 2007027135, US 7390799, WO 2007040650
    • Bruncko, M., Ding, H., Elmore, S.W. et al. (Abbott Laboratories Inc.). Apoptosis promoters. EP 1888550, US 2007027135, US 7390799, WO 2007040650.
  • 2
    • 58349095814 scopus 로고    scopus 로고
    • ABT-263, an orally bioavailable inhibitor of Bcl-2 family proteins
    • April 6-10, New Orleans, Abst MEDI 110
    • Ding, H., Park, C.-M., Bruncko, M. et al. ABT-263, an orally bioavailable inhibitor of Bcl-2 family proteins. 235th ACS Natl Meet (April 6-10, New Orleans) 2008, Abst MEDI 110.
    • (2008) 235th ACS Natl Meet
    • Ding, H.1    Park, C.-M.2    Bruncko, M.3
  • 3
    • 49649106694 scopus 로고    scopus 로고
    • An efficient synthesis of ABT-263, a novel inhibitor of antiapoptotic Bcl-2 proteins
    • Zhang, H., Zhou, J., Ha, C., Pei, D., Ding, K. An efficient synthesis of ABT-263, a novel inhibitor of antiapoptotic Bcl-2 proteins. Synthesis 2008, (15): 2398-404.
    • (2008) Synthesis , vol.15 , pp. 2398-2404
    • Zhang, H.1    Zhou, J.2    Ha, C.3    Pei, D.4    Ding, K.5
  • 4
    • 58349086570 scopus 로고    scopus 로고
    • P2 site SAR development toward ABT-263, an orally bioavailable inhibitor of Bcl-2 family proteins
    • April 6-10, New Orleans, Abst MEDI 78
    • Song, X., Bruncko, M., Ding, H. et al. P2 site SAR development toward ABT-263, an orally bioavailable inhibitor of Bcl-2 family proteins. 235th ACS Natl Meet (April 6-10, New Orleans) 2008, Abst MEDI 78.
    • (2008) 235th ACS Natl Meet
    • Song, X.1    Bruncko, M.2    Ding, H.3
  • 5
    • 0036728834 scopus 로고    scopus 로고
    • Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics
    • Letai, A., Bassik, M.C., Walensky, L.D., Sorcinelli, M.D., Weiler, S., Korsmeyer, S.J. Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics. Cancer Cell 2002, 2(3): 183-92.
    • (2002) Cancer Cell , vol.2 , Issue.3 , pp. 183-192
    • Letai, A.1    Bassik, M.C.2    Walensky, L.D.3    Sorcinelli, M.D.4    Weiler, S.5    Korsmeyer, S.J.6
  • 6
    • 13944277343 scopus 로고    scopus 로고
    • BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly
    • Kuwana, T., Bouchier-Hayes, L., Chipuk, J.E., Bonzon, C., Sullivan, B.A., Green, D.R., Newmeyer, D.D. BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly. Mol Cell 2005, 17(4): 525-35.
    • (2005) Mol Cell , vol.17 , Issue.4 , pp. 525-535
    • Kuwana, T.1    Bouchier-Hayes, L.2    Chipuk, J.E.3    Bonzon, C.4    Sullivan, B.A.5    Green, D.R.6    Newmeyer, D.D.7
  • 7
    • 33646354381 scopus 로고    scopus 로고
    • Mitochondfia primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members
    • Certo, M., Del Gaizo, Moore, V., Nishino, M., Wei, G., Korsmeyer, S., Armstrong, S.A., Letai, A. Mitochondfia primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members. Cancer Cell 2006, 9(5): 351-65.
    • (2006) Cancer Cell , vol.9 , Issue.5 , pp. 351-365
    • Certo, M.1    Gaizo, D.2    Moore, V.3    Nishino, M.4    Wei, G.5    Korsmeyer, S.6    Armstrong, S.A.7    Letai, A.8
  • 8
    • 33846964621 scopus 로고    scopus 로고
    • Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak
    • Willis, S.N., Fletcher, J.I., Kaufmann, T. et al. Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak. Science 2007, 315(5813): 856-9.
    • (2007) Science , vol.315 , Issue.5813 , pp. 856-859
    • Willis, S.N.1    Fletcher, J.I.2    Kaufmann, T.3
  • 9
    • 33847328289 scopus 로고    scopus 로고
    • The Bcl-2 apoptotic switch in cancer development and therapy
    • Adams, J.M., Cory, S. The Bcl-2 apoptotic switch in cancer development and therapy. Oncogene 2007, 26: 1324-37.
    • (2007) Oncogene , vol.26 , pp. 1324-1337
    • Adams, J.M.1    Cory, S.2
  • 10
    • 0032418092 scopus 로고    scopus 로고
    • Role of Bcl-2 family proteins in apoptosis: Apoptosomes or mitochondria?
    • Tsujimoto, Y. Role of Bcl-2 family proteins in apoptosis: Apoptosomes or mitochondria? Genes Cells 1998, 3(11): 697-707.
    • (1998) Genes Cells , vol.3 , Issue.11 , pp. 697-707
    • Tsujimoto, Y.1
  • 11
    • 33847404358 scopus 로고    scopus 로고
    • Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL
    • Bruncko, M., Oost, T.K., Bell, B.A. et al. Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL. J Med Chem 2007, 50(4): 641-62.
    • (2007) J Med Chem , vol.50 , Issue.4 , pp. 641-662
    • Bruncko, M.1    Oost, T.K.2    Bell, B.A.3
  • 12
    • 33846674886 scopus 로고    scopus 로고
    • Mcl-1 downregulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocation
    • Chen, S., Dai, Y., Harada, H., Dent, P., Grant, S. Mcl-1 downregulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocation. Cancer Res 2007, 67(2): 782-91.
    • (2007) Cancer Res , vol.67 , Issue.2 , pp. 782-791
    • Chen, S.1    Dai, Y.2    Harada, H.3    Dent, P.4    Grant, S.5
  • 13
    • 34447642522 scopus 로고    scopus 로고
    • BH3 mimetic ABT-737 neutralizes resistance to FLT3 inhibitor treatment medated by FLT3-independent expression of BCL2 in primary AML blasts
    • Kohl, T.M., Hellinger, C., Ahmed, F., Buske, C., Hiddemann, W., Bohlander, S.K., Spiekermann, K. BH3 mimetic ABT-737 neutralizes resistance to FLT3 inhibitor treatment medated by FLT3-independent expression of BCL2 in primary AML blasts. Leukemia 2007, 21(8): 1763-72.
    • (2007) Leukemia , vol.21 , Issue.8 , pp. 1763-1772
    • Kohl, T.M.1    Hellinger, C.2    Ahmed, F.3    Buske, C.4    Hiddemann, W.5    Bohlander, S.K.6    Spiekermann, K.7
  • 14
    • 34548814971 scopus 로고    scopus 로고
    • Activity of vincristine, L-ASP, and dexamethasone against acute lymphoblastic leukemia is enhanced by the BH3-mimetic ABT-737 in vitro and in vivo
    • Kang, M.H., Kang, Y.H., Szymanska, B. et al. Activity of vincristine, L-ASP, and dexamethasone against acute lymphoblastic leukemia is enhanced by the BH3-mimetic ABT-737 in vitro and in vivo. Blood 2007, 110(6): 2057-66.
    • (2007) Blood , vol.110 , Issue.6 , pp. 2057-2066
    • Kang, M.H.1    Kang, Y.H.2    Szymanska, B.3
  • 15
    • 33847061737 scopus 로고    scopus 로고
    • Influence of Bcl-2 family members on the cellular response of small-cell lung cancer cell lines to ABT-737
    • Tahir, S.K., Yang, X., Anderson, M.G. et al. Influence of Bcl-2 family members on the cellular response of small-cell lung cancer cell lines to ABT-737. Cancer Res 2007, 67(3): 1176-83.
    • (2007) Cancer Res , vol.67 , Issue.3 , pp. 1176-1183
    • Tahir, S.K.1    Yang, X.2    Anderson, M.G.3
  • 16
    • 20444486559 scopus 로고    scopus 로고
    • An inhibitor of Bcl-2 family proteins induces regression of solid tumours
    • Oltersdorf, T., Elmore, S.W., Shoemaker, A.R. et al. An inhibitor of Bcl-2 family proteins induces regression of solid tumours. Nature 2005, 435(7042): 677-81.
    • (2005) Nature , vol.435 , Issue.7042 , pp. 677-681
    • Oltersdorf, T.1    Elmore, S.W.2    Shoemaker, A.R.3
  • 17
    • 33750834023 scopus 로고    scopus 로고
    • The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized
    • van Delft, M.F., Wei, A.H., Mason, K.D. et al. The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized. Cancer Cell 2005, 10(5): 389-99.
    • (2005) Cancer Cell , vol.10 , Issue.5 , pp. 389-399
    • van Delft, M.F.1    Wei, A.H.2    Mason, K.D.3
  • 18
    • 33846884216 scopus 로고    scopus 로고
    • The Bcl-2 family protein inhibitor, ABT-737, has substantial antimyeloma activity and shows synergistic effect with dexamethasone and melphalan
    • Trudel, S., Stewart, A. K., Li, Z. et al. The Bcl-2 family protein inhibitor, ABT-737, has substantial antimyeloma activity and shows synergistic effect with dexamethasone and melphalan. Clin Cancer Res 2007, 13(2, Pt. 1): 621-9.
    • (2007) Clin Cancer Res , vol.13 , Issue.2 and PART. 1 , pp. 621-629
    • Trudel, S.1    Stewart, A.K.2    Li, Z.3
  • 19
    • 34250770481 scopus 로고    scopus 로고
    • ABT-737, an inhibitor of Bcl-2 family proteins, is a potent inducer of apoptosis in multiple meyloma cells
    • Kline, M.P., Rajkumar, S.V., Timm, M.M. et al. ABT-737, an inhibitor of Bcl-2 family proteins, is a potent inducer of apoptosis in multiple meyloma cells. Leukemia 2007, 21(7): 1549-60.
    • (2007) Leukemia , vol.21 , Issue.7 , pp. 1549-1560
    • Kline, M.P.1    Rajkumar, S.V.2    Timm, M.M.3
  • 20
    • 33845994359 scopus 로고    scopus 로고
    • Del Gaizo Moore, V., Brown, J.R., Certo, M.., Love, T.M.., Novina, C.D., Letai, A. Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737. J Clin Invest 2007, 117(1): 112-21.
    • Del Gaizo Moore, V., Brown, J.R., Certo, M.., Love, T.M.., Novina, C.D., Letai, A. Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737. J Clin Invest 2007, 117(1): 112-21.
  • 21
    • 58349094568 scopus 로고    scopus 로고
    • ABT-263, an orally bioavailable and efficacious inhibitor of Bcl-2 family proteins
    • April 6-10, New Orleans, Abst MEDI 340
    • Bruncko, M. ABT-263, an orally bioavailable and efficacious inhibitor of Bcl-2 family proteins. 235th ACS Natl Meet (April 6-10, New Orleans) 2008, Abst MEDI 340.
    • (2008) 235th ACS Natl Meet
    • Bruncko, M.1
  • 22
    • 44849112219 scopus 로고    scopus 로고
    • ABT-263: A potent and orally bioavailable Bcl-2 family inhibitor
    • Tse, C., Shoemaker, A.R., Adickes, J. et al. ABT-263: A potent and orally bioavailable Bcl-2 family inhibitor. Cancer Res 2008, 68(9): 3421-8.
    • (2008) Cancer Res , vol.68 , Issue.9 , pp. 3421-3428
    • Tse, C.1    Shoemaker, A.R.2    Adickes, J.3
  • 28
    • 50349098706 scopus 로고    scopus 로고
    • Activity of the Bcl-2 family inhibitor ABT-263 in a panel of small cell lung cancer xenograft models
    • Shoemaker, A.R., Mitten, MJ, Adickes, J. et al. Activity of the Bcl-2 family inhibitor ABT-263 in a panel of small cell lung cancer xenograft models. Clin Cancer Res 2008, 14(11): 3268-77.
    • (2008) Clin Cancer Res , vol.14 , Issue.11 , pp. 3268-3277
    • Shoemaker, A.R.1    Mitten, M.J.2    Adickes, J.3
  • 29
    • 42349109916 scopus 로고    scopus 로고
    • Initial testing (stage 1) of the BH3 mimetic ABT-263 by the pediatric preclinical testing program
    • Lock, R., Carol, H., Houghton, P.J. et al. Initial testing (stage 1) of the BH3 mimetic ABT-263 by the pediatric preclinical testing program. Pediatr Blood Cancer 2008, 50(6): 1181-9.
    • (2008) Pediatr Blood Cancer , vol.50 , Issue.6 , pp. 1181-1189
    • Lock, R.1    Carol, H.2    Houghton, P.J.3
  • 30
    • 58349119841 scopus 로고    scopus 로고
    • An ongoing phase 1 study of ABT-263 in patients with relapsed small cell lung cancer and other solid tumors
    • Congr Sept 12-16, Stockholm, Abst 324P
    • Gandhi, L., Camidge, D.R., Khaira, D. et al. An ongoing phase 1 study of ABT-263 in patients with relapsed small cell lung cancer and other solid tumors. Ann Oncol [33rd Eur Soc Med Oncol (ESMO) Congr (Sept 12-16, Stockholm) 2008]2008, 19(Suppl. 8): Abst 324P.
    • (2008) Ann Oncol [33rd Eur Soc Med Oncol (ESMO) , vol.19 , Issue.SUPPL. 8
    • Gandhi, L.1    Camidge, D.R.2    Khaira, D.3
  • 31
    • 58349096937 scopus 로고    scopus 로고
    • ngoing phase 1 studies of ABT-263; pharmacokinetics, safety and anti-tumor activity in patients with relapsed chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL)
    • Congr Sept 12-16, Stockholm, Abst 729PD
    • Brown, J., Roberts, A., Seymour, J.F. et al. ngoing phase 1 studies of ABT-263; pharmacokinetics, safety and anti-tumor activity in patients with relapsed chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL). Ann Oncol [33rd Eur Soc Med Oncol (ESMO) Congr (Sept 12-16, Stockholm) 2008] 2008, 19(Suppl. 8): Abst 729PD.
    • (2008) Ann Oncol [33rd Eur Soc Med Oncol (ESMO) , vol.19 , Issue.SUPPL. 8
    • Brown, J.1    Roberts, A.2    Seymour, J.F.3
  • 32
    • 58349121903 scopus 로고    scopus 로고
    • The Bcl-2 family protein inhibitor, ABT-263, promotes apoptotic-like response in isolated platelets
    • Dec 9-12, Orlando, Abst 1122
    • Tse, C., Zhang, H., Chen, J. et al. The Bcl-2 family protein inhibitor, ABT-263, promotes apoptotic-like response in isolated platelets. Blood [48th Annu Meet Am Soc Hematol (Dec 9-12, Orlando) 2006] 2006, 108(11): Abst 1122.
    • (2006) Blood [48th Annu Meet Am Soc Hematol , vol.108 , Issue.11
    • Tse, C.1    Zhang, H.2    Chen, J.3
  • 33
    • 58349087249 scopus 로고    scopus 로고
    • The Bcl-2 family inhibitor ABT-263 shows significant but reversible thrombocytopenia in mice
    • Dec 9-12, Orlando, Abst 1107
    • Shoemaker, A.R., Mitten, M.J., Adickes, J. et al. The Bcl-2 family inhibitor ABT-263 shows significant but reversible thrombocytopenia in mice. Blood (48th Annu Meet Am Soc Hematol (Dec 9-12, Orlando) 2006] 2006, 108(11): Abst 1107.
    • (2006) Blood (48th Annu Meet Am Soc Hematol , vol.108 , Issue.11
    • Shoemaker, A.R.1    Mitten, M.J.2    Adickes, J.3
  • 34
    • 58349113893 scopus 로고    scopus 로고
    • Bcl-2 family protein inhibitors induce a unique thrombocytopenia in vivo
    • Dec 9-12, Orlando, Abst 4236
    • Elmore, S.W., Bauch, J., Fryer, R. M. et al. Bcl-2 family protein inhibitors induce a unique thrombocytopenia in vivo. Blood [48th Annu Meet Am Soc Hematol (Dec 9-12, Orlando) 2006] 2006, 108(11): Abst 4236.
    • (2006) Blood [48th Annu Meet Am Soc Hematol , vol.108 , Issue.11
    • Elmore, S.W.1    Bauch, J.2    Fryer, R.M.3
  • 35
    • 58349116485 scopus 로고    scopus 로고
    • A phase 1 study evaluating the safety, PK & efficacy of ABT-263 in subjects with refractory or relapsed lymphoid malignancies
    • Congr Sept 12-16, Stockholm, Abst 101
    • O'Connor, O., Czuczman, M.S., LaCasce, A. et al. A phase 1 study evaluating the safety, PK & efficacy of ABT-263 in subjects with refractory or relapsed lymphoid malignancies. Ann Oncol [33rd Eur Soc Med Oncol (ESMO) Congr (Sept 12-16, Stockholm) 2008] 2008, 19(Suppl. 8): Abst 101.
    • (2008) Ann Oncol [33rd Eur Soc Med Oncol (ESMO) , vol.19 , Issue.SUPPL. 8
    • O'Connor, O.1    Czuczman, M.S.2    LaCasce, A.3
  • 37
    • 40849129529 scopus 로고    scopus 로고
    • A phase 1/2a study evaluating the safety, pharmacokinetics, and efficacy of ABT-263 in subjects with refractory or relapsed lymphoid malignancies
    • Dec 8-11, Atlanta, Abst 1371
    • Wilson, W.H., Tulpule, A., Levine, A.M. et al. A phase 1/2a study evaluating the safety, pharmacokinetics, and efficacy of ABT-263 in subjects with refractory or relapsed lymphoid malignancies. Blood [49th Annu Meet Am Soc Hematol (Dec 8-11, Atlanta) 2007]2007, 110(11): Abst 1371.
    • (2007) Blood [49th Annu Meet Am Soc Hematol , vol.110 , Issue.11
    • Wilson, W.H.1    Tulpule, A.2    Levine, A.M.3
  • 38
    • 49749126692 scopus 로고    scopus 로고
    • Pediatric Preclinical Testing Program (PPTP) evaluation of the Bcl-2 inhibitor ABT-263
    • Abst 4951
    • Smith, M.A., Maris, J.M., Keir, S.T. et al. Pediatric Preclinical Testing Program (PPTP) evaluation of the Bcl-2 inhibitor ABT-263. Proc Am Assoc Cancer Res (AACR) 2007, 48: Abst 4951.
    • (2007) Proc Am Assoc Cancer Res (AACR) , vol.48
    • Smith, M.A.1    Maris, J.M.2    Keir, S.T.3
  • 39
    • 58349088544 scopus 로고    scopus 로고
    • The Bcl-2 family protein inhibitor, ABT-263, broadly potentiates the cytotoxicity of other therapeutic agents in vitro
    • Abst 726
    • Zhang, H., Chen, J., Chen, Z. et al. The Bcl-2 family protein inhibitor, ABT-263, broadly potentiates the cytotoxicity of other therapeutic agents in vitro. Proc Am Assoc Cancer Res (AACR) 2007, 48: Abst 726.
    • (2007) Proc Am Assoc Cancer Res (AACR) , vol.48
    • Zhang, H.1    Chen, J.2    Chen, Z.3
  • 43
    • 49749087529 scopus 로고    scopus 로고
    • Preclinical activity of the Bcl-2 family inhibitor ABT-263 in models of small cell lung cancer
    • Abst 4953
    • Shoemaker, A.R., Oleksijew, A., Mitten, M.J. et al. Preclinical activity of the Bcl-2 family inhibitor ABT-263 in models of small cell lung cancer. Proc Am Assoc Cancer Res (AACR) 2007, 48: Abst 4953.
    • (2007) Proc Am Assoc Cancer Res (AACR) , vol.48
    • Shoemaker, A.R.1    Oleksijew, A.2    Mitten, M.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.