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Volumn 1253, Issue , 2009, Pages 184-190

LAU-0901, a novel platelet-activating factor receptor antagonist, confers enduring neuroprotection in experimental focal cerebral ischemia in the rat

Author keywords

Behavioral; Histopathology; LAU 0901; Middle cerebral artery occlusion; Neuroprotection; PAF antagonist

Indexed keywords

2,4,6 TRIMETHYL 1, 4 DIHYDRO PYRIDINE 3, 5 DICARBOXYLIC ACID; 2,4,6 TRIMETHYL 1,4 DIHYDRO 3,5 PYRIDINEDICARBOXYLIC ACID 2 (3,4 DICHLOROPHENOXY)ETHYL BIS(MORPHOLINOMETHYL)METHYL ESTER; THROMBOCYTE ACTIVATING FACTOR ANTAGONIST; THROMBOCYTE ACTIVATING FACTOR RECEPTOR; UNCLASSIFIED DRUG;

EID: 58249144068     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2008.11.074     Document Type: Article
Times cited : (15)

References (24)
  • 1
    • 0030863206 scopus 로고    scopus 로고
    • Effects of combined glutamate and platelet-activating factor inhibition on the outcome of focal cerebral ischemia - an initial screening study
    • Aspey B.S., Alp M.S., Patel Y., and Harrison M.J. Effects of combined glutamate and platelet-activating factor inhibition on the outcome of focal cerebral ischemia - an initial screening study. Metab. Brain Dis. 12 (1997) 237-249
    • (1997) Metab. Brain Dis. , vol.12 , pp. 237-249
    • Aspey, B.S.1    Alp, M.S.2    Patel, Y.3    Harrison, M.J.4
  • 2
    • 0035053038 scopus 로고    scopus 로고
    • COX-2 as a multifunctional neuronal modulator
    • Bazan N.G. COX-2 as a multifunctional neuronal modulator. Nat. Med. 7 (2001) 414-415
    • (2001) Nat. Med. , vol.7 , pp. 414-415
    • Bazan, N.G.1
  • 3
    • 0345861750 scopus 로고    scopus 로고
    • Synaptic lipid signaling: significance of polyunsaturated fatty acids and platelet-activating factor
    • Bazan N.G. Synaptic lipid signaling: significance of polyunsaturated fatty acids and platelet-activating factor. J. Lipid Res. 44 (2003) 2221-2233
    • (2003) J. Lipid Res. , vol.44 , pp. 2221-2233
    • Bazan, N.G.1
  • 4
    • 23444444518 scopus 로고    scopus 로고
    • Lipid signaling in neural plasticity, brain repair, and neuroprotection
    • Bazan N.G. Lipid signaling in neural plasticity, brain repair, and neuroprotection. Mol. Neurobiol. 32 (2005) 89-103
    • (2005) Mol. Neurobiol. , vol.32 , pp. 89-103
    • Bazan, N.G.1
  • 5
    • 0003054522 scopus 로고    scopus 로고
    • Platelet-activating factor and other bioactive lipids
    • Ginsberg M.D., and Bogousslavsky J. (Eds), Blackwell Science Publishers, Malden, Massachusetts
    • Bazan N.G., and Allan G. Platelet-activating factor and other bioactive lipids. In: Ginsberg M.D., and Bogousslavsky J. (Eds). Cerebrovascular Disease, Pathophysiology, Diagnosis and Management (1998), Blackwell Science Publishers, Malden, Massachusetts 532-555
    • (1998) Cerebrovascular Disease, Pathophysiology, Diagnosis and Management , pp. 532-555
    • Bazan, N.G.1    Allan, G.2
  • 6
    • 58249134366 scopus 로고    scopus 로고
    • Assignee Louisiana State University, 2,4,6-trimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid esters as neuroprotective drugs
    • Bazan N.G., Sunkel C., Marcheselli V.L., and Builla G.J. Assignee Louisiana State University, 2,4,6-trimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid esters as neuroprotective drugs. US Patent 6,566,359 (2003) B1
    • (2003) US Patent 6,566,359
    • Bazan, N.G.1    Sunkel, C.2    Marcheselli, V.L.3    Builla, G.J.4
  • 7
    • 0029839695 scopus 로고    scopus 로고
    • Middle cerebral artery occlusion in the rat by intraluminal suture. neurological and pathological evaluation of an improved model
    • Belayev L., Alonso O.F., Busto R., Zhao W., and Ginsberg M.D. Middle cerebral artery occlusion in the rat by intraluminal suture. neurological and pathological evaluation of an improved model. Stroke 27 (1996) 1616-1622
    • (1996) Stroke , vol.27 , pp. 1616-1622
    • Belayev, L.1    Alonso, O.F.2    Busto, R.3    Zhao, W.4    Ginsberg, M.D.5
  • 8
    • 56349131188 scopus 로고    scopus 로고
    • LAU-0901, a novel platelet-activating factor antagonist, is highly neuroprotective in cerebral ischemia
    • Belayev L., Khoutorova L., Atkins K., Gordon W.C., Alvarez-Builla J., and Bazan N.G. LAU-0901, a novel platelet-activating factor antagonist, is highly neuroprotective in cerebral ischemia. Exp. Neurol. 214 (2008) 253-258
    • (2008) Exp. Neurol. , vol.214 , pp. 253-258
    • Belayev, L.1    Khoutorova, L.2    Atkins, K.3    Gordon, W.C.4    Alvarez-Builla, J.5    Bazan, N.G.6
  • 9
    • 34548862329 scopus 로고    scopus 로고
    • Synergism in the repression of COX-2- and TNFalpha-induction in platelet activating factor-stressed human neural cells
    • Boetkjaer A., Boedker M., Cui J.G., Zhao Y., and Lukiw W.J. Synergism in the repression of COX-2- and TNFalpha-induction in platelet activating factor-stressed human neural cells. Neurosci. Lett. 426 (2007) 59-63
    • (2007) Neurosci. Lett. , vol.426 , pp. 59-63
    • Boetkjaer, A.1    Boedker, M.2    Cui, J.G.3    Zhao, Y.4    Lukiw, W.J.5
  • 10
    • 33947323018 scopus 로고    scopus 로고
    • Platelet-activating factor antagonist (ABT-491) decreases neuronal apoptosis in neonatal rat model of hypoxic ischemic brain injury
    • Bozlu G., Atici A., Turhan A.H., Polat A., Nayci A., Okuyaz C., and Taskinlar H. Platelet-activating factor antagonist (ABT-491) decreases neuronal apoptosis in neonatal rat model of hypoxic ischemic brain injury. Brain Res. 1143 (2007) 193-198
    • (2007) Brain Res. , vol.1143 , pp. 193-198
    • Bozlu, G.1    Atici, A.2    Turhan, A.H.3    Polat, A.4    Nayci, A.5    Okuyaz, C.6    Taskinlar, H.7
  • 11
    • 0022620369 scopus 로고
    • Integration of data obtained at fixed intervals
    • Carnevale N.T. Integration of data obtained at fixed intervals. Brain Res. Bull. 16 (1986) 137-142
    • (1986) Brain Res. Bull. , vol.16 , pp. 137-142
    • Carnevale, N.T.1
  • 12
    • 0027081205 scopus 로고
    • Enhancement of hippocampal excitatory synaptic transmission by platelet-activating factor
    • Clark G.D., Happel L.T., Zorumski C.F., and Bazan N.G. Enhancement of hippocampal excitatory synaptic transmission by platelet-activating factor. Neuron 9 (1992) 1211-1216
    • (1992) Neuron , vol.9 , pp. 1211-1216
    • Clark, G.D.1    Happel, L.T.2    Zorumski, C.F.3    Bazan, N.G.4
  • 13
    • 29044445172 scopus 로고    scopus 로고
    • Oxidative stress-induced retinal damage up-regulates DNA polymerase gamma and 8-oxoguanine-DNA-glycosylase in photoreceptor synaptic mitochondria
    • Cortina M.S., Gordon W.C., Lukiw W.J., and Bazan N.G. Oxidative stress-induced retinal damage up-regulates DNA polymerase gamma and 8-oxoguanine-DNA-glycosylase in photoreceptor synaptic mitochondria. Exp. Eye Res. 81 (2005) 742-750
    • (2005) Exp. Eye Res. , vol.81 , pp. 742-750
    • Cortina, M.S.1    Gordon, W.C.2    Lukiw, W.J.3    Bazan, N.G.4
  • 14
    • 0027360449 scopus 로고
    • Transient platelet accumulation in the rat brain after common carotid artery thrombosis. An 111 In-labeled platelet study
    • Dietrich W.D., Dewanjee S., Prado R., Watson B.D., and Dewanjee M.K. Transient platelet accumulation in the rat brain after common carotid artery thrombosis. An 111 In-labeled platelet study. Stroke 24 (1993) 1534-1540
    • (1993) Stroke , vol.24 , pp. 1534-1540
    • Dietrich, W.D.1    Dewanjee, S.2    Prado, R.3    Watson, B.D.4    Dewanjee, M.K.5
  • 15
    • 0027314268 scopus 로고
    • Molecular profile of reactive astrocytes-implications for their role in neurologic disease
    • Eddleston M., and Mucke L. Molecular profile of reactive astrocytes-implications for their role in neurologic disease. Neuroscience 54 (1993) 15-36
    • (1993) Neuroscience , vol.54 , pp. 15-36
    • Eddleston, M.1    Mucke, L.2
  • 16
    • 0031885950 scopus 로고    scopus 로고
    • Combating hyperthermia in acute stroke: a significant clinical concern
    • Ginsberg M.D., and Busto R. Combating hyperthermia in acute stroke: a significant clinical concern. Stroke 29 (1998) 529-534
    • (1998) Stroke , vol.29 , pp. 529-534
    • Ginsberg, M.D.1    Busto, R.2
  • 17
    • 33645384039 scopus 로고    scopus 로고
    • Synergistic effect of platelet-activating factor and tumor necrosis factor-alpha on corneal myofibroblast apoptosis
    • He J., and Bazan H.E. Synergistic effect of platelet-activating factor and tumor necrosis factor-alpha on corneal myofibroblast apoptosis. Invest. Ophthalmol. Vis. Sci. 47 (2006) 883-891
    • (2006) Invest. Ophthalmol. Vis. Sci. , vol.47 , pp. 883-891
    • He, J.1    Bazan, H.E.2
  • 19
    • 0028009186 scopus 로고
    • Platelet-activating factor as a potential retrograde messenger in CA1 hippocampal long-term potentiation
    • Kato K., Clark G.D., Bazan N.G., and Zorumski C.F. Platelet-activating factor as a potential retrograde messenger in CA1 hippocampal long-term potentiation. Nature 367 (1994) 175-179
    • (1994) Nature , vol.367 , pp. 175-179
    • Kato, K.1    Clark, G.D.2    Bazan, N.G.3    Zorumski, C.F.4
  • 20
    • 0024655025 scopus 로고    scopus 로고
    • Kimelberg, H.K., Norenberg, M.D., 1989. Astrocytes. Sci. Am. 260, 66-72, 74, 76.
    • Kimelberg, H.K., Norenberg, M.D., 1989. Astrocytes. Sci. Am. 260, 66-72, 74, 76.
  • 21
    • 0036263330 scopus 로고    scopus 로고
    • Correlation between changes in apparent diffusion coefficient and induction of heat shock protein, cell-specific injury marker expression, and protein synthesis reduction on diffusion-weighted magnetic resonance images after temporary focal cerebral ischemia in rats
    • Kokubo Y., Matson G.B., Liu J., Mancuso A., Kayama T., Sharp F.R., and Weinstein P.R. Correlation between changes in apparent diffusion coefficient and induction of heat shock protein, cell-specific injury marker expression, and protein synthesis reduction on diffusion-weighted magnetic resonance images after temporary focal cerebral ischemia in rats. J. Neurosurg. 96 (2002) 1084-1093
    • (2002) J. Neurosurg. , vol.96 , pp. 1084-1093
    • Kokubo, Y.1    Matson, G.B.2    Liu, J.3    Mancuso, A.4    Kayama, T.5    Sharp, F.R.6    Weinstein, P.R.7
  • 23
    • 29744435061 scopus 로고    scopus 로고
    • Neuroprotection by platelet-activating factor antagonism
    • Tian X., and Bazan N.G. Neuroprotection by platelet-activating factor antagonism. Ann. N. Y. Acad. Sci. 1053 (2005) 455-456
    • (2005) Ann. N. Y. Acad. Sci. , vol.1053 , pp. 455-456
    • Tian, X.1    Bazan, N.G.2
  • 24
    • 0027048917 scopus 로고
    • A century of neuronal and neuroglial interactions, and their pathological implications: an overview
    • Tower D.B. A century of neuronal and neuroglial interactions, and their pathological implications: an overview. Prog. Brain Res. 94 (1992) 3-17
    • (1992) Prog. Brain Res. , vol.94 , pp. 3-17
    • Tower, D.B.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.