Simvastatin inhibits acidic extracellular pH-activated, outward rectifying chloride currents in RAW264.7 monocytic-macrophage and human peripheral monocytes

International Immunopharmacology

Volumn 9, Issue 2, 2009, Pages 247-252

  Shi, Cheng yao ^a   Wang, Rong ^a,b   Liu, Chun xi ^a,b   Jiang, Hao ^a,b   Ma, Zhi yong ^a,b   Li, Li ^a,b   Zhang, Wei ^a,b  

^a SHANDONG UNIVERSITY   (China)

^b Shandong University   (China)

Author keywords

Acidosis; Chloride channel; Macrophages; Monocytes; Simvastatin

Indexed keywords

CHLORIDE CHANNEL; SIMVASTATIN;

ACIDITY; ARTICLE; CELL PH; CHLORIDE CURRENT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG INHIBITION; DRUG MECHANISM; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IC 50; IMMUNOMODULATION; MACROPHAGE; MONOCYTE; PHARMACODYNAMICS; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; CELL LINE; CHLORIDE CHANNELS; HUMANS; HYDROGEN-ION CONCENTRATION; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MACROPHAGES; MICE; MONOCYTES; SIMVASTATIN;

EID: 58249129342     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.intimp.2008.11.011     Document Type: Article

References (25)

1. Sluimer J.C., Gasc J.M., Wanroij J.L., Kisters N., Groeneweg M., Sollewijn Gelpke M.D., et al. Hypoxia, hypoxia-inducible transcription factor, and macrophages in human atherosclerotic plaques are correlated with intraplaque angiogenesis. J Am Coll Cardiol 51 (2008) 1258-1265
2. Libby P. Current concepts of the pathogenesis of the acute coronary syndromes. Circulation 104 (2001) 365-372
3. Tovar A.M., Pecly I.M., Rangel E.P., Melo-Filho N.M., Mourão P.A., and Leite M.J. Experimentally induced metabolic acidosis in rabbits modulates the interaction of aortic glycosaminoglycan with plasma low-density lipoprotein-an interesting observation about the association of acidosis and atherosclerosis. Atherosclerosis 192 (2007) 33-39
4. Lardner A. The effects of extracellular pH on immune function. J Leukoc Biol 69 (2001) 522-530
5. Kellum J.A., Song M., and Li J. Science review: extracellular acidosis and the immune response: clinical and physiologic implications. Crit Care 8 (2001) 331-336
6. Bellocq A., Suberville S., Philippe C., Bertrand F., Perez J., Fouqueray B., et al. Low environmental pH is responsible for the induction of nitric-oxide synthase in macrophages. Evidence for involvement of nuclear factor kappa B activation. J Biol Chem 273 (1998) 5086-5092
7. Heming T.A., Tuazon D.M., Dave S.K., Chopra A.K., Peterson J.W., and Bidani A. Post-transcriptional effects of extracellular pH on tumour necrosis factor-alpha production in RAW 2467 and J774 A1 cells. Clin Sci 100 (2001) 259-266
8. Kos M., Kuebler J.F., Jesch N.K., Vieten G., Bax N.M., van der Zee D.C., et al. Carbon dioxide differentially affects the cytokine release of macrophage subpopulations exclusively via alteration of extracellular pH. Surg Endosc 20 (2006) 570-576
9. Gallin E.K. Ion channels in leukocytes. Physiol Rev 71 (2001) 775-811
10. Lambert S., and Oberwinkler J. Characterization of a proton-activated, outward rectifying anion channel. J Physiol 567 (2005) 191-213
11. Yamamoto S., and Ehara T. Acidic extracellular pH-activated outward rectifying chloride current in mammalian cardiac myocytes. Am J Physiol Heart Circ Physiol 290 (2006) H1905-H1914
12. Davignon J. Beneficial cardiovascular pleiotropic effects of statins. Circulation 109 (2004) III39-III43
13. Palinski W., and Tsimikas S. Immunomodulatory effects of statins: mechanisms and potential impact on arteriosclerosis. J Am Soc Nephrol 13 (2002) 1673-1681
14. Palinski W. Immunomodulation: a new role for statins. Nat Med 6 (2000) 1311-1312
15. Kwak B., Mulhaupt F., Myit S., and Mach F. Statins as a newly recognized type of immunomodulator. Nat Med 6 (2000) 1399-1402
16. Matsumoto M., Einhaus D., Gold E.S., and Aderem A. Simvastatin augments lipopolysaccharide-induced proinflammatory responses in macrophages by differential regulation of the c-Fos and c-Jun transcription factors. J Immunol 172 (2004) 7377-7384
17. Vicente R., Escalada A., Coma M., Fuster G., Sánchez-Tilló E., López-Iglesias C., et al. Differential voltage-dependent K+ channel responses during proliferation and activation in macrophages. J Biol Chem 278 (2003) 46307-46320
18. Ma Z.Y., Zhang W., Chen L., Wang R., Kan X.H., Sun G.Z., et al. A proton-activated, outward rectifying chloride channel in human umbilical vein endothelial cells. Biochem Biophys Res Commun 371 (2008) 437-440
19. Auzanneau C., Thoreau V., Kitzis A., and Becq F. A novel voltage-dependent chloride current activated by extracellular acidic pH in cultured rat Sertoli cells. J Biol Chem 278 (2003) 19230-19236
20. Nobles M., Higgins C.F., and Sardini A. Extracellular acidification elicits a chloride current that shares characteristics with ICl(swell). Am J Physiol Cell Physiol. 287 (2004) C1426-1435
21. 2+ current in the rat basilar artery. Pharmacol Toxicol 93 (2003) 128-134
22. 2+-activated K+ channels of porcine coronary artery smooth muscle cells. Br J Pharmacol 151 (2007) 987-997
23. Vaquero M., Caballero R., Gómez R., Núñez L., Tamargo J., and Delpón E. Effects of atorvastatin and simvastatin on atrial plateau currents. J Mol Cell Cardiol 42 (2007) 931-945
24. Lohn M., Fürstenau M., Sagach V., Elger M., Schulze W., Luft F.C., et al. Ignition of calcium sparks in arterial and cardiac muscle through caveolae. Circ Res 87 (2000) 1034-1039
25. Sen L., Bialecki R.A., Smith E., Smith T.W., and Colucci W.S. Cholesterol increases the L-type voltage-sensitive calcium channel current in arterial smooth muscle cells. Circ Res 71 (1992) 1008-1014