A proton-activated, outwardly rectifying chloride channel in human umbilical vein endothelial cells

Biochemical and Biophysical Research Communications

Volumn 371, Issue 3, 2008, Pages 437-440

  Ma, Zhi yong ^a   Zhang, Wei ^a   Chen, Liang ^a   Wang, Rong ^a   Kan, Xiao hong ^a   Sun, Gui zhen ^a   Liu, Chun xi ^a   Li, Li ^a   Zhang, Yun ^a  

^a Qilu Hospital of Shandong University   (China)

Author keywords

Chloride channel; Human umbilical vein endothelial cells; pH

Indexed keywords

4,4' DIISOTHIOCYANATOSTILBENE 2,2' DISULFONIC ACID; CHLORIDE CHANNEL; CHLORIDE ION;

ACIDITY; ARTICLE; CHANNEL GATING; CHLORIDE CURRENT; CHLORIDE TRANSPORT; ENDOTHELIUM CELL; HEART MUSCLE; HEART MUSCLE ISCHEMIA; HUMAN; HUMAN CELL; MEMBRANE POTENTIAL; PH MEASUREMENT; PRIORITY JOURNAL; PROTON TRANSPORT; UMBILICAL VEIN;

4,4'-DIISOTHIOCYANOSTILBENE-2,2'-DISULFONIC ACID; ACIDS; CELL LINE; CELLS, CULTURED; CHLORIDE CHANNELS; ENDOTHELIAL CELLS; HUMANS; HYDROGEN-ION CONCENTRATION; UMBILICAL VEINS;

MAMMALIA;

EID: 43549100850     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2008.04.090     Document Type: Article

References (21)

1. Nilius B., and Droogmans G. Ion channels and their functional role in vascular endothelium. Physiol. Rev. 81 (2001) 1415-1459
2. Bragulat E., de la Sierra A., Antonio M.T., and Coca A. Endothelial dysfunction in salt-sensitive essential hypertension. Hypertension 37 (2001) 444-448
3. Libby P. Current concepts of the pathogenesis of the acute coronary syndromes. Circulation 104 (2001) 365-372
4. Deanfield J.E., Halcox J.P., and Rabelink T.J. Endothelial function and dysfunction: testing and clinical relevance. Circulation 115 (2007) 1285-1295
5. Stenmark K.R., Fagan K.A., and Frid M.G. Hypoxia-induced pulmonary vascular remodeling: cellular and molecular mechanisms. Circ. Res. 99 (2006) 675-691
6. Agulló L., Garcia-Dorado D., Escalona N., Inserte J., Ruiz-Meana M., Barrabés J.A., Mirabet M., Pina P., and Soler-Soler J. Hypoxia and acidosis impair cGMP synthesis in microvascular coronary endothelial cells. Am. J. Physiol. Heart Circ. Physiol. 283 (2002) H917-H925
7. Kumar S., Kasseckert S., Kostin S., Abdallah Y., Schafer C., Kaminski A., Reusch H.P., Piper H.M., Steinhoff G., and Ladilov Y. Ischemic acidosis causes apoptosis in coronary endothelial cells through activation of caspase-12. Cardiovasc. Res. 73 (2007) 172-180
8. Kumar S., Reusch H.P., and Ladilov Y. Acidic preconditioning suppresses apoptosis and increases expression of Bcl-xL in coronary endothelial cells under simulated ischemia. J. Cell. Mol. Med. (2007) [Epub ahead of print]
9. Nobles M., Higgins C.F., and Sardini A. Extracellular acidification elicits a chloride current that shares characteristics with ICl(swell). Am. J. Physiol. Cell Physiol. 287 (2004) C1426-C1435
10. Lambert S., and Oberwinkler J. Characterization of a proton-activated, outwardly rectifying anion channel. J. Physiol. 567 (2005) 191-213
11. Auzanneau C., Thoreau V., Kitzis A., and Becq F. A Novel voltage-dependent chloride current activated by extracellular acidic pH in cultured rat Sertoli cells. J. Biol. Chem. 278 (2003) 19230-19236
12. Bompadre S.G., Hu S., and Hwang T. Characterization of a proton activated chloride channel (Abstract). Biophys. J. 80 (2001) 468a
13. Yamamoto S., and Ehara T. Acidic extracellular pH-activated outwardly rectifying chloride current in mammalian cardiac myocytes. Am. J. Physiol. Heart Circ. Physiol. 290 (2006) H1905-H1914
14. Jordt S.E., and Jentsch T.J. Molecular dissection of gating in the ClC-2 chloride channel. EMBO J. 16 (1997) 1582-1592
15. Friedrich T., Breiderhoff T., and Jentsch T.J. Mutational analysis demonstrates that ClC-4 and ClC-5 directly mediate plasma membrane currents. J. Biol. Chem. 274 (1999) 896-902
16. Mo L., Hellmich H.L., Fong P., Wood T., Embesi J., and Wills N.K. Comparison of amphibian and human ClC-5: similarity of functional properties and inhibition by external Ph. J. Membr. Biol. 168 (1999) 253-264
17. Vanoye C.G., and George Jr. A.L. Functional characterization of recombinant human ClC-4 chloride channels in cultured mammalian cells. J. Physiol. 539 (2002) 373-383
18. Steinmeyer K., Schwappach B., Bens M., Vandewalle A., and Jentsch T.J. Cloning and functional expression of rat CLC-5, a chloride channel related to kidney disease. J. Biol. Chem. 270 (1995) 31172-31177
19. Evans M.G., and Marty A. Calcium-dependent chloride currents in isolated cells from rat lacrimal glands. J. Physiol. 378 (1986) 437-460
20. Jentsch T.J., Stein V., Weinreich F., and Zdebik A.A. Molecular structure and physiological function of chloride channels. Physiol. Rev. 82 (2002) 503-568
21. Nagel G., Hwang T.C., Nastiuk K.L., Nairn A.C., and Gadsby D.C. The protein kinase A-regulated cardiac Cl-channel resembles the cystic fibrosis transmembrane conductance regulator. Nature 360 (1992) 81-84