Lovastatin prevents steroid induced adipogenesis and osteonecrosis

Clinical Orthopaedics and Related Research

Volumn 344, Issue , 1997, Pages 8-19

  Cui, Quanjun ^a   Wang, Gwo Jaw ^a   Su, Chin Chien ^a   Balian, Gary ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; COLLAGEN TYPE 1; CORTICOSTEROID; DEXAMETHASONE; FAT; MESSENGER RNA; METHYLPREDNISOLONE; MEVINOLIN; OSTEOCALCIN; STEROID; TRIACYLGLYCEROL; GLUCOCORTICOID; HYPOCHOLESTEROLEMIC AGENT;

ADIPOCYTE; ADIPOSE TISSUE; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; BONE NECROSIS; CELL CULTURE; CELL PROLIFERATION; CHICKEN; CONFERENCE PAPER; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; INTRAMUSCULAR DRUG ADMINISTRATION; LIPID VESICLE; MORPHOMETRICS; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; OSSIFICATION; OSTEOLYSIS; PHASE CONTRAST MICROSCOPY; PRIORITY JOURNAL; ANIMAL; ARTICLE; AWARDS AND PRIZES; DRUG EFFECT; FEMUR HEAD; FEMUR HEAD NECROSIS; METABOLISM; ORTHOPEDICS; PATHOLOGY;

ADIPOSE TISSUE; ANIMALS; ANTICHOLESTEREMIC AGENTS; AWARDS AND PRIZES; CELLS, CULTURED; CHICKENS; FEMALE; FEMUR HEAD; FEMUR HEAD NECROSIS; GLUCOCORTICOIDS; LOVASTATIN; METHYLPREDNISOLONE; ORTHOPEDICS;

MLCS; MLOWN;

EID: 0031278834     PISSN: 0009921X     EISSN: 15281132     Source Type: Journal    
DOI: 10.1097/00003086-199711000-00003     Document Type: Conference Paper

References (33)

1. Anonymous: Lovastatin 5-year safety and efficacy study Lovastatin study groups I through IV. Arch Intern Med 153:1079-1087, 1993.
2. Arlet J: Nontraumatic avascular necrosis of the femoral head. Past, present and future. Clin Orthop 277:12-21, 1992.
3. Atsumi T, Kuroki Y, Yamamo K: A microangiographic study of idiopathic osteonecrosis of the femoral head. Clin Orthop 246:186-194, 1989.
4. Beresford JN, Bennett J, Devlin C, et al: Evidence for, and inverse relationship between, the differentiation of adipocytic and osteogenic cells in rat marrow stroma cell cultures. J Cell Sci 102:341-351, 1992.
5. Bernlohr DA, Angus CW, Lane MD, et al: Expression of specific mRNAs during adipose differentiation: identification of an mRNA encoding a homologue of myelin P2 protein. Proc Natl Acad Sci USA 81:5468-5472, 1984.
6. Boutellier G, Arlet J, Blasco A, et al: Is Osteonecrosis of the Femoral Head Avascular? Bone Blood Flow Measurements on Femoral Parts After Long-Term Treatment With Corticosteroids. In Arlet J (ed). Bone Circulation. Baltimore, Williams and Wilkins 53-58, 1984.
7. Boyle IT: Secondary osteoporosis. Baillieres Clin Rheumatol 7:515-534, 1993.
8. Burkhardt R, Ketter G, Bohm W, et al: Changes in trabecular bone, hematopoiesis and bone marrow vessels in aplastic anemia, primary osteoporosis, and old age: A comparative histomorphomeric study. Bone 8:157-164, 1987.
9. Cui Q, Wang GJ, Balian G: Steroid induced fat specific gene expression and adipogenesis in cells from bone marrow stroma. J Bone Joint Surg 79A: 1054-1063, 1997.
10. Delany AM, Dong Y, Canalis E: Mechanisms of glucocorticoid action in bone cells. J Cell Biochem 56:295-302, 1994.
11. Glimcher MH, Kenzora JE: The biology of osteonecrosis of the human femoral head and its clinical implications. III. Discussion of the etiology and genesis of the pathological sequelae; comments on treatment. Clin Orthop 140:273-312, 1979.
12. Gold EW, Fox OD, Weissfeld S, et al: Corticosteroid-induced avascular necrosis: An experimental study in rabbits. Clin Orthop 135:272-280, 1978.
13. Hungerford DS: Pathogenic considerations in ischemic necrosis of bone. Can J Surg 24:583-590, 1981.
14. Hungerford DS, Lennox DW: The importance of increased intraosseous pressure in the development of osteonecrosis of the femoral head: Implications for treatment. Orthop Clin North Am 16:635-654, 1985.
15. Hunt GR, Ro JHS. Dobson DE, et al: Adipocyte P2 gene: Developmental expression and homology of 5′-flanking sequences among fat cell-specific genes. Proc Natl Acad Sci USA 83:3786-3790, 1986.
16. Jones Jr JP: Etiology and pathogenesis of osteonecrosis. Semin Arthroplasty 2:160-168, 1991.
17. Jones Jr JP: Fat embolism, intravascular coagulation, and osteonecrosis. Clin Orthop 292:294-308, 1993.
18. Jones LC, Hungerford DS: Models of Ischemic Necrosis of Bone. In Arlet J, Ficat RP (eds). Bone Circulation. Baltimore, Williams and Wilkins 30-34, 1984.
19. Kawai K, Tamaki A, Hirohata K: Steroid-induced accumulation of lipid in the osteocytes of the rabbit femoral head: A histochemical and electron microscopic study. J Bone Joint Surg 67A:755-763, 1985.
20. Kenzoro JE, Steele RE, Yosipovitch ZH, et al: Experimental osteonecrosis of the femoral head in adult rabbits. Clin Orthop 130:8-46, 1978.
21. Locklin RM, Williamson MC, Beresford JN, et al: In vitro effects of growth factors and dexamethasone on rat marrow stromal cells. Clin Orthop 313:27-35, 1995.
22. Matsui M, Saito S, Ohzono K, et al: Experimental steroid-induced osteonecrosis in adult rabbits with hypersensitivity vasculitis. Clin Orthop 277:61-72, 1992.
23. Meunier PJ, Aaron J, Edouard C, et al: Osteoporosis and the replacement of cell populations of the marrow by adipose tissue: A quantitative study of 84 iliac bone biopsies. Clin Orthop 80:147-154, 1971.
24. Moran TG: Cortisone-induced alterations in lipid metabolism. Arch Pathol 73:300-312, 1962.
25. Nasseri D, Hungerford DS, White K, et al: Equine model of ischemic necrosis of bone. Trans Orthop Res Soc 7:234, 1982.
26. Paolaggi JB, Leparc JM, Barrees D, et al: Early Alterations of Bone and Marrow After High Doses of Steroids: Results in Two Animal Species. In Arlet J, Ficat RP (eds). Bone Circulation. Baltimore, Williams and Wilkins 44-47, 1984.
27. Parfitt AM, Drezner MK, Glorieux FH, et al: Bone histomorphometry: Standardization of nomenclature, symbols, and units. J Bone Miner Res 2:595-610, 1987.
28. Rubin CS, Hirsch A, Fung C, et al: Development of hormone receptors and normal responsiveness in vitro. Insulin receptors and insulin sensitivity in the preadipocyte and adipocyte forms of 3T3-L1 cells. J Biol Chem 253:7570-7578, 1978.
29. Saito S, Ohzono K, Ono K: Early arteriopathy and postulated pathogenesis of osteonecrosis of the femoral head. Clin Orthop 277:98-110, 1992.
30. Steinberg ME: Osteonecrosis of the hip: Summary and conclusions. Semin Arthroplasty 2:241-249, 1991.
31. Urbaniak JR, Coogan PG, Gunneson EB, et al: Treatment of osteonecrosis of the femoral head with free vascularized fibular grafting. A long-term follow-up study of one hundred and three hips. J Bone Joint Surg 77A:681-694, 1995.
32. Wang GJ: Pathogenesis of Steroid-Induced Avascular Necrosis and Its Response to Lipid Clearing Agent. In Hirohata K, Mizuno K, Matsubara T (eds). Trends in Research and Treatment of Joint Diseases. Tokyo, Springer-Verlag 59-71, 1992.
33. Wang GJ, Sweet DE, Reger SI, et al: Fat-cell changes as a mechanism of avascular necrosis of the femoral head in cortisone-treated rabbits. J Bone Joint Surg 59A:729-735, 1977.