Dexamethasone-induced adipogenesis in primary marrow stromal cell cultures: Mechanism of steroid-induced osteonecrosis

Chinese Medical Journal

Volumn 119, Issue 7, 2006, Pages 581-588

  Yin, Li ^a   Li, Yue Bai ^a   Wang, Yi Sheng ^a  

^a ZHENGZHOU UNIVERSITY   (China)

Author keywords

Adipocytes; Bone marrow; Dexamethasone; Osteonecrosis

Indexed keywords

ALKALINE PHOSPHATASE; COLLAGEN TYPE 1; DEXAMETHASONE; MESSENGER RNA; OIL SCARLET; OSTEOCALCIN; TRIACYLGLYCEROL;

ADIPOCYTE; ADIPOGENESIS; ANALYSIS OF VARIANCE; ANIMAL CELL; ARTICLE; BONE MARROW CELL; BONE NECROSIS; CELL COUNT; CELL CULTURE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DOT HYBRIDIZATION; DRUG EXPOSURE; ENZYME ACTIVITY; FEMALE; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PROTEIN EXPRESSION; STATISTICAL SIGNIFICANCE; STROMA CELL; STUDENT T TEST; ANIMAL; CHEMICALLY INDUCED DISORDER; CYTOLOGY; DRUG EFFECT; GENETICS; METABOLISM; RADIOIMMUNOASSAY;

ADIPOGENESIS; ALKALINE PHOSPHATASE; ANIMALS; BONE MARROW CELLS; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; DEXAMETHASONE; FEMALE; MICE; OSTEOCALCIN; OSTEONECROSIS; RADIOIMMUNOASSAY; RNA, MESSENGER; STROMAL CELLS;

EID: 33646826837     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: 10.1097/00029330-200604010-00012     Document Type: Article

References (35)

1. Bradbury G, Benjamin J, Thompson J, Klees E, Copeland J. Avascular necrosis of bone after cardiac transplantation. J Bone J Surg 1994;76A:1385-1388.
2. Elmstedt W. Avascular bone necrosis in the renal transplant patient: a discriminant analysis of 144 cases. Clin Orthop 1981;158:149-157.
3. Gosling DC, Sampson WFD, Macleod M, Hanby AM, Slapak M. Susceptibility of the rabbit and the rat to steroid osteonecrosis: an experimental study. Transplantation 1987;43:751-759.
4. Matsui M, Saito S, Ohzono K, Sugano N, Saito M, Takaoka K, et al. Experimental steroid-induced osteonecrosis in adult rabbits with hypersensitivity vasculitis. Clin Orthop 1992;277:61-72.
5. Kawai K, Tamaki A, Hirohata K. Sreroid-induced accumulation of lipid in the osteocytes of the rabbit femoral head: a histochemical and electron microscopic study J. Bone Joint Surg 1985;67A:755-764.
6. Wang GJ, Dughman SS, Reger SI, Stamp WG. The effects of core decompression on femoral head blood flow in steroid-induced avascular necrosis of the femoral head. J Bone Joint Surg 1985;67A:121-124.
7. Cui Q, Wang GJ, Balian G. Steroid-induced adipogenesis in bone marrow and osteonecrosis. ARCO New 1994;6:117.
8. Kawai K, Maruno H, Watanabe Y, Hirohata K. Fat necrosis of osteocytes as a causative factor in idiopathic osteonecrosis in heritable hyperlipemic rabbits. Clin Orthop 1980;153:273-282.
9. Locklin RM, Williamson MC, Beresford JN, Triffitt JT, Owen ME. In vitro effects of growth factors and dexamethasone on rat marrow stromal cells. Clin Orthop 1995;313:27-35.
10. Kodama HA, Amagai Y, Koyama H, Kasai S. Hormonal responsiveness of a preadipose cell line derived from newborn mouse calvarias. J Cell physiol 1982;112: 83-88.
11. Liu XM, Wang SY, Li R, Song NL, Zhang YQ, Zhu XX, et al. Effect of the microelements on osteoblast-like cell proliferation and differentiation of rat calvaria in vitro. Chin J Orthop 1995;15:177-179.
12. Zhang WZ, Yu SF, Zheng LF. Experimental study on IL-1 regulating differentiation of osteoblast. Chin J Stomatol 1996;31:288-291.
13. Fang FD, Jou L, Ding L. Modern experimental techniques of medicine, 1st ed. Shanghai: Science & Technology Publishing Company; 1995:561-562.
14. Wu JL, Ding Y. Practical nonradioactive molecular biology experimental technology, 1st ed. Zhengzhou: Henan Medical University Publisher; 1997:60-61.
15. Pietrogrande V, Mastromarino R. Osteopatia da prolongato trattamento cortisono. Ortop Traumatol 1957; 25:791.
16. Arlet J. Nontraumatic avascular necrosis of the femoral head. Past, present, and future. Clin Orthop 1992; 277:12-21.
17. Jones Jr JP. Etiology and pathogenesis of osteonecrosis. Semin Arthroplasty 1991;2:160-168.
18. Mankin HJ. Nontraumatic necrosis of bone (osteonecrosis). New Eng J Med 1992; 326: 1473-1479.
19. Solomon L. Mechanism of idiopathic osteonecrosis. Orthop Clin North Am 1985;16:655-667.
20. Rickard DJ, Kazhdan I, Leboy PS. Importance of 1, 25-dihydroxyvitamin D3 and the nonadherent cells of marrow for osteoblast differentiation from rat marrow stromal cells. Bone 1995;16:671-678.
21. Friedenstein AJ, Latznik NV, Gorskaya YF, Luria EA, Moskvina IL. Bone marrow stromal colony formation requires stimulation by haemopoietic cells. Bone Miner 1992;18:199-213.
22. Bianco P, Robey PG. Marrow stromal stem cells. J Clin Invest 2000;105:1663-1668.
23. Prockop DJ. Marrow stromal cells as stem cells for nonhematopoietic tissues. Science 1997;276:71-74.
24. Wolf NS, Penn PE, Rao D, McKee MD. Intraclonal plasticity for bone, smooth muscle, and adipocyte lineages in bone marrow stromal fibroblastoid cells. Exp Cell Res 2003;290:346-357.
25. Herzog EL, Chai L, Krause DS. Plasticity of marrow-derived stem cells. Blood 2003; 102: 483-493.
26. Kha HT, Basseri B, Shouhed D, Richardson J, Tetradis S, Hahn TJ, et al. Oxysterols regulate differentiation of mesenchymal stem cells: pro-bone and anti-fat. J Bone Miner Res 2004;19:830-840.
27. Zhou S, Eid K, Glowacki J. Cooperation between TFG-beta and Wnt pathways during chondrocyte and adipocyte differentiation of human marrow stromal cells. J Bone Miner Res 2004;19:463-470.
28. Garcia Palacios V, Morita I, Murota S. Expression of adipogenesis markers in a murine stromal cell line treated with 15-deoxy Delta(12,14)-prostaglandin J2, interleukin-11, 9-cis retinoic acid and vitamin K2. Prostaglandins Leukot Essent Fatty Acids 2001;65: 215-221.
29. Kadner A, Hoerstrup SP, Zund G, Eid K, Maurus C, Melnitchouk S, et al. A new source for cardiovascular tissue engineering: human bone marrow stromal cells. Eur J Cardiothorac Surg 2002;21:1055-1060.
30. Chapman AB, Knight DM, Dieckmann BS, Ringold GM. Analysis of gene expression during differentiation of adipogenic cells in culture and hormonal control of the development program. J Biol Chem 1984;259: 15548-15555.
31. Cook JS, Lucas JJ, Sibley E, Bolanowski MA, Christy RJ, Kelly TJ, et al. Expression of the differentiation-induced gene for fatty acid-bind protein is activated by glucocorticoid and camp. Proc Natl Acad Sci 1988;85: 2949-2953.
32. Sakano S, Murata Y, Miura T, Iwata H, Sato K, Matsui N, et al. Collagen and alkaline phosphatase gene expression during bone morphogenetic protein (BMP)-induced cartilage and bone differentiation. Clin Orthop 1993;292:337-344.
33. Kawai K, Maruno H, Watanabe Y, Hirohata K. Fat necrosis of osteocytes as a causative factor in idiopathic osteonecrosis in heritable hyperlipemic rabbits. Clin Orthop 1980;153:273-282.
34. Wang YS, Li YB, Mao KY, Li J, Cui QJ, Wang GJ. Alcohol-induced adipogenesis in bone and marrow: a possible mechanism for osteonecrosis. Clin Orthop 2003;410:213-224.
35. Suh KT, Kim SW, Roh HL, Youn MS, Jung JS. Decreased osteogenic differentiation of mesenchymal stem cells in alcohol-induced osteonecrosis. Clin Orthop 2005;431:220-225