Mouse breast cancer model-dependent changes in metabolic syndrome-associated phenotypes caused by maternal dioxin exposure and dietary fat

American Journal of Physiology - Endocrinology and Metabolism

Volumn 296, Issue 1, 2009, Pages

  Merrill, Michele La ^a,b,d   Baston, David S ^f   Denison, Michael S ^f   Birnbaum, Linda S ^e   Pomp, Daniel ^a,c,d   Threadgill, David W ^a,b,d  

^a Curriculum in Toxicology   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c University of North Carolina

^d University of North Carolina at Chapel Hill

^e U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

2,3,7,8 tetrachlorodibenzo p dioxin; Dimethyl benz a anthracene; Metabolic syndrome; Tg(MMTV Neu)202mul j; TgN(MMTV PyMT)634Mul J

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; DIMETHYLBENZ[A]ANTHRACENE; DIOXIN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; GLUCOSE; TRIACYLGLYCEROL;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIRTH; BODY FAT; BODY WEIGHT; BREAST CANCER; CANCER RISK; CONTROLLED STUDY; ESTROGEN ACTIVITY; FAT INTAKE; FEMALE; GLUCOSE BLOOD LEVEL; MALE; METABOLIC SYNDROME X; MOUSE; NONHUMAN; PHENOTYPE; PREGNANCY; PRIORITY JOURNAL; PUBERTY; TRIACYLGLYCEROL BLOOD LEVEL;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ANIMALS; BODY COMPOSITION; BODY WEIGHT; CARCINOGENS; DIETARY FATS; DISEASE MODELS, ANIMAL; FEMALE; LONGITUDINAL STUDIES; MALE; MAMMARY NEOPLASMS, EXPERIMENTAL; MATERNAL EXPOSURE; METABOLIC SYNDROME X; MICE; MICE, TRANSGENIC; PHENOTYPE; PREGNANCY; RANDOM ALLOCATION; RECEPTORS, CYTOPLASMIC AND NUCLEAR; TETRACHLORODIBENZODIOXIN;

EID: 58249105969     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.90368.2008     Document Type: Article

References (50)

1. Birnbaum LS, McDonald MM, Blair PC, Clark AM, Harris MW. Differential toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in C57BL/6J mice congenic at the Ah Locus. Fundam Appl Toxicol 15:186-200, 1990.
2. Bunt JC. Metabolic actions of estradiol: significance for acute and chronic exercise responses. Med Sci Sports Exerc 22: 286-290, 1990.
3. Cardiff RD, Gumerlock PH, Soong MM, Dandekar S, Barry PA, Young LJ, Meyers FJ. c-H-ras-1 expression in 7,12-dimethyl benzan-thracene-induced Balb/c mouse mammary hyperplasias and their tumors. Oncogene 3: 205-213, 1988.
4. Chapman DE, Schiller CM. Dose-related effects of 2,3,7,8-tetrachlorod-ibenzo-p-dioxin (TCDD) in C57BL/6J and DBA/2J mice. Toxicol Appl Pharmacol 78: 147-157, 1985.
5. Cleary MP, Grande JP, Juneja SC, Maihle NJ. Diet-induced obesity and mammary tumor development in MMTV-neu female mice. Nutr Cancer 50: 174-180, 2004.
6. Consonni D, Pesatori AC, Zocchetti C, Sindaco R, D'Oro LC, Ruba-gotti M, Bertazzi PA. Mortality in a population exposed to dioxin after the Seveso, Italy, accident in 1976: 25 years of follow-Up. Am J Epidemiol 167: 847-858, 2008.
7. Cranmer M, Louie S, Kennedy RH, Kern PA, Fonseca VA. Exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is associated with hyper-insulinemia and insulin resistance. Toxicol Sci 56: 431-436, 2000.
8. Eberhardt MS, Ogden CL, Engelgau M, Cadwell B, Hedley AA, Saydah SH. Prevalence of overweight and obesity among adults with diagnosed diabetes-United States, 1988-1994 and 1999-2002, edited by NCHS and CDC. MMWR Weekly 53: 1066-1068, 2004.
9. Emond C, Birnbaum LS, DeVito MJ. Use of a physiologically based pharmacokinetic model for rats to study the influence of body fat mass and induction of CYP1A2 on the pharmacokinetics of TCDD. Environ Health Perspect 114: 1394-1400, 2006.
10. 10a.Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP). J Am Med Assoc 285: 2486-2497, 2001.
11. Ford ES, Giles WH, Dietz WH. Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. J Am Med Assoc 287: 356-359, 2002.
12. Gordon RR, Hunter KW, La Merrill M, Sorensen P, Threadgill DW, Pomp D. Genotype X diet interactions in mice predisposed to mammary cancer. II. Tumors and metastasis. Mamm Genome 19: 179 -189, 2008.
13. Guy CT, Cardiff RD, Muller WJ. Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease. Mol Cell Biol 12: 954-961, 1992.
14. Hakkak R, MacLeod S, Shaaf S, Holley AW, Simpson P, Fuchs G, Jo CH, Kieber-Emmons T, Korourian S. Obesity increases the incidence of 7,12-dimethylbenz(a)anthracene-induced mammary tumors in an ovariec-tomized Zucker rat model. Int J Oncol 30: 557-563, 2007.
15. Han D, Nagy SR, Denison MS. Comparison of recombinant cell bioas-says for the detection of Ah receptor agonists. Biofactors 20: 11-22, 2004.
16. Harrad S, Wang Y, Sandaradura S, Leeds A. Human dietary intake and excretion of dioxin-like compounds. J Environ Monit 5: 224-228, 2003.
17. Harrington M, Pond-Tor S, Boney CM. Role of epidermal growth factor and ErbB2 receptors in 3T3-L1 adipogenesis. Obesity (Silver Spring) 15:563-571, 2007.
18. Hayward DG, Hooper K, Andrzejewski D. Tandem-in-time mass spec-trometry method for the sub-parts-per-trillion determination of 2,3,7,8-chlorine-substituted dibenzo-p-dioxins and -furans in high-fat foods. Anal Chem 71: 212-220, 1999.
19. Henriksen GL, Ketchum NS, Michalek JE, Swaby JA. Serum dioxin and diabetes mellitus in veterans of Operation Ranch Hand. Epidemiology 8: 252-258, 1997.
20. Herschkowitz JI, Simin K, Weigman VJ, Mikaelian I, Usary J, Hu Z, Rasmussen KE, Jones LP, Assefnia S, Chandrasekharan S, Backlund MG, Yin Y, Khramtsov AI, Bastein R, Quackenbush J, Glazer RI, Brown PH, Green JE, Kopelovich L, Furth PA, Palazzo JP, Olopade OI, Bernard PS, Churchill GA, Van Dyke T, Perou CM. Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors (Abstract). Genome Biol 8: R76, 2007.
21. Hooper K, Petreas MX, Chuvakova T, Kazbekova G, Druz N, Semi-nova G, Sharmanov T, Hayward D, She J, Visita P, Winkler J, McKinney M, Wade TJ, Grassman J, Stephens RD. Analysis of breast milk to assess exposure to chlorinated contaminants in Kazakstan: high levels of 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD) in agricultural villages of southern Kazakstan. Environ Health Perspect 106: 797-806, 1998.
22. Huang Y, Kim SO, Jiang J, Frank SJ. Growth hormone-induced phosphorylation of epidermal growth factor (EGF) receptor in 3T3-F442A cells. Modulation of EGF-induced trafficking and signaling. J Biol Chem 278: 18902-18913, 2003.
23. Jackson Laboratories. JAX Mice Database. Bar Harbor, ME: Jackson Laboratories, 2008.
24. Jones LW, Haykowsky M, Peddle CJ, Joy AA, Pituskin EN, Tkachuk LM, Courneya KS, Slamon DJ, Mackey JR. Cardiovascular risk profile of patients with HER2/neu-positive breast cancer treated with anthracy-cline-taxane- containing adjuvant chemotherapy and/or trastuzumab. Cancer Epidemiol Biomarkers Prev 16: 1026 -1031, 2007.
25. Jones SN, Jones PG, Ibarguen H, Caskey CT, Craigen WJ. Induction of the Cyp1a-1 dioxin-responsive enhancer in transgenic mice. Nucleic Acids Res 19: 6547-6551, 1991.
26. Koops WJ. Multiphasic growth curve analysis. Growth 50: 169 -177, 1986.
27. Koops WJ, Grossman M. Multiphasic analysis of growth curves for progeny of a somatotropin transgenic male mouse. Growth Dev Aging 55:193-202, 1991.
28. Koops WJ, Grossman M, Michalska E. Multiphasic growth curve analysis in mice. Growth 51: 372-382, 1987.
29. Luijten M, Thomsen AR, van den Berg JA, Wester PW, Verhoef A, Nagelkerke NJ, Adlercreutz H, van Kranen HJ, Piersma AH, So-rensen IK, Rao GN, van Kreijl CF. Effects of soy-derived isoflavones and a high-fat diet on spontaneous mammary tumor development in Tg.NK (MMTV/c-neu) mice. Nutr Cancer 50: 46-54, 2004.
30. Martin TL, Alquier T, Asakura K, Furukawa N, Preitner F, Kahn BB. Diet-induced obesity alters AMP kinase activity in hypothalamus and skeletal muscle. J Biol Chem 281: 18933-18941, 2006.
31. Mayes JS, Watson GH. Direct effects of sex steroid hormones on adipose tissues and obesity. Obes Rev 5: 197-216, 2004.
32. Michalek JE, Tripathi RC. Pharmacokinetics of TCDD in veterans of Operation Ranch Hand: 15-year follow-up. J Toxicol Environ Health A 57: 369-378, 1999.
33. Moon A. Differential functions of Ras for malignant phenotypic conversion. Arch Pharm Res 29: 113-122, 2006.
34. Muntean N, Jermini M, Small I, Falzon D, Furst P, Migliorati G, Scortichini G, Forti A, Elke A, von Holst C, Niyazmatov B, Bahkridi-nov S, Aertgeerts R, Bertollini R, Tirado C, Kolb A. Assessment of dietary exposure to some persistent organic pollutants in the Republic of Karakalpakstan of Uzbekistan. Environ Health Perspect 111: 1306-1311, 2003.
35. Pelclova D, Fenclova Z, Dlaskova Z, Urban P, Lukas E, Prochazka B, Rappe C, Preiss J, Kocan A, Vejlupkova J. Biochemical, neuropsycho-logical, and neurological abnormalities following 2,3,7,8-tetrachlorod-ibenzo-p-dioxin (TCDD) exposure. Arch Environ Health 56: 493-500, 2001.
36. Pohjanvirta R, Tuomisto J. Short-term toxicity of 2,3,7,8-tetrachlorod-ibenzo-p-dioxin in laboratory animals: effects, mechanisms, and animal models. Pharmacol Rev 46: 483-549, 1994.
37. Qiu TH, Chandramouli GV, Hunter KW, Alkharouf NW, Green JE, Liu ET. Global expression profiling identifies signatures of tumor virulence in MMTV-PyMT-transgenic mice: correlation to human disease. Cancer Res 64: 5973-5981, 2004.
38. Roche HM, Phillips C, Gibney MJ. The metabolic syndrome: the crossroads of diet and genetics. Proc Nutr Soc 64: 371-377, 2005.
39. Rogers JM, Denison MS. Analysis of the antiestrogenic activity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in human ovarian carcinoma BG-1 cells. Mol Pharmacol 61: 1393-1403, 2002.
40. Savino W. Neuroendocrine control of T cell development in mammals: role of growth hormone in modulating thymocyte migration. Exp Physiol 92: 813-817, 2007.
41. Simpson ER. Sources of estrogen and their importance. J Steroid Biochem Mol Biol 86: 225-230, 2003.
42. Sorlie T, Perou CM, Tibshirani R, Aas T, Geisler S, Johnsen H, Hastie T, Eisen MB, van de Rijn M, Jeffrey SS, Thorsen T, Quist H, Matese JC, Brown PO, Botstein D, Eystein Lonning P, Borresen-Dale AL. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci USA 98: 10869-10874, 2001.
43. Sorlie T, Tibshirani R, Parker J, Hastie T, Marron JS, Nobel A, Deng S, Johnsen H, Pesich R, Geisler S, Demeter J, Perou CM, Lonning PE, Brown PO, Borresen-Dale AL, Botstein D. Repeated observation of breast tumor subtypes in independent gene expression data sets. Proc Natl Acad Sci USA 100: 8418-8423, 2003.
44. Sweeney MH, Mocarelli P. Human health effects after exposure to 2,3,7,8-TCDD. Food Addit Contam 17: 303-316, 2000.
45. Thigpen JE, Setchell KD, Saunders HE, Haseman JK, Grant MG, Forsythe DB. Selecting the appropriate rodent diet for endocrine disruptor research and testing studies. Ilar J 45: 401-416, 2004.
46. Trayhurn P, Wood IS. Adipokines: inflammation and the pleiotropic role of white adipose tissue. Br J Nutr 92: 347-355, 2004.
47. Vidal O, Lindberg M, Savendahl L, Lubahn DB, Ritzen EM, Gustafs-son JA, Ohlsson C. Disproportional body growth in female estrogen receptor-alpha-inactivated mice. Biochem Biophys Res Commun 265: 569-571, 1999.
48. Weinstein EJ, Kitsberg DI, Leder P. A mouse model for breast cancer induced by amplification and overexpression of the neu promoter and transgene. Mol Med 6: 4-16, 2000.
49. Witton CJ, Reeves JR, Going JJ, Cooke TG, Bartlett JM. Expression of the HER1-4 family of receptor tyrosine kinases in breast cancer. J Pathol 200: 290-297, 2003.
50. Ziccardi MH, Gardner IA, Denison MS. Development and modification of a recombinant cell bioassay to directly detect halogenated and polycy-clic aromatic hydrocarbons in serum. Toxicol Sci 54: 183-193, 2000.