Analysis of the antiestrogenic activity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in human ovarian carcinoma BG-1 cells

Molecular Pharmacology

Volumn 61, Issue 6, 2002, Pages 1393-1403

  Rogers, Jane M ^a   Denison, Michael S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; ANTIESTROGEN; ESTRADIOL; ETICYCLIDINE;

ARTICLE; CONTROLLED STUDY; DNA BINDING; DRUG EFFECT; DRUG MECHANISM; ESTRADIOL BLOOD LEVEL; ESTROGEN RESPONSIVE ELEMENT; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; OVARY CARCINOMA; PRIORITY JOURNAL; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; TUMOR CELL LINE;

CARRIER PROTEINS; CELL DIVISION; DNA; DRUG INTERACTIONS; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGENS; FEMALE; GENE EXPRESSION; GENES, REPORTER; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LUCIFERASES; OVARIAN NEOPLASMS; PROTEIN BIOSYNTHESIS; PROTEIN SYNTHESIS INHIBITORS; PROTEINS; RECEPTORS, ARYL HYDROCARBON; RECEPTORS, ESTROGEN; RNA, MESSENGER; SIGNAL TRANSDUCTION; TERATOGENS; TETRACHLORODIBENZODIOXIN; TRANSFECTION; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEINS;

EID: 0036262435     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.61.6.1393     Document Type: Article

References (44)

1. Ligand-dependent interaction of the aryl hydro-carbon receptor with a novel immunophilin homolog in vivo
2. The Ah receptor signal transduction pathway
3. Inducible, receptor-dependent protein-DNA interactions at a dioxin-responsive transcriptional enhancer
4. The DNA recognition site for the dioxin-Ah receptor complex. Nucleotide sequence and functional analysis
5. Antiestrogenic action of 2,3,7,8-tetrachlorodibenzo-p-dioxin: Tissue-specific regulation of estrogen receptor in CD1 mice
6. Transcriptional activation of c-fos protooncogene by 17beta-estradiol: Mechanism of aryl hydrocarbon receptor-mediated inhibition
7. The steroid and thyroid hormone receptor superfamily
8. Species-specific recombinant cell lines as bioassay systems for the detection of 2,3,7,8-tetrachlorodibenzo-p-dioxin-like chemicals
9. Suppression of estrogen-regulated extracellular tissue plasminogen activator activity of MCF-7 cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin
10. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin, 12-O-tetradecanoylphorbol-13-acetate and 17 beta-estradiol on estrogen receptor regulation in MCF-7 human breast cancer cells
11. Identification of a motif within the 5′ regulatory region of pS2 which is responsible for AP-1 binding and TCDD-mediated suppression
12. Inhibition of 7,12-dimethylbenzanthracene-induced rat mammary tumor growth by 2,3,7,8-tetrachlorodibenzo-p-dioxin
13. Role of estradiol receptor-alpha in differential expression of 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible genes in the RL95-2 and KLE human endometrial cancer cell lines
14. Efficient analysis of cytochrome P4501A catalytic activity, porphyrins and total proteins in chicken embryo hepatocyte cultures with a fluorescence plate reader
15. Estrogen receptor interaction with co-activators and co-repressors
16. Molecular mechanism of inhibition of estrogen-induced cathepsin D gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in MCF-7 cells
17. Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta
18. Nuclear receptor coactivator SRC-1 interacts with the Q-rich subdomain of the AhR and modulates its transactivation potential
19. Differential recruitment of coactivator RIP140 by Ah and estrogen receptors. Absence of a role for LXXLL motifs
20. The interaction of human estrogen receptor with DNA is modulated by receptor-associated proteins
21. Development of a stably transfected estrogen receptor-mediated luciferase reporter gene assay in the human T47D breast cancer cell line
22. Indolo[3,2-b]carbazole: A dietary-derived factor that exhibits both antiestrogenic and estrogenic activity
23. Identification of 3′-methoxy-4′-nitroflavone as a pure aryl hydrocarbon (Ah) receptor antagonist and evidence for more than one form of the nuclear Ah receptor in MCF-7 human breast cancer cells
24. A novel cytoplasmic protein that interacts with the Ah receptor, contains tetratricopeptide repeat motifs and augments the transcriptional response to 2,3,7,8-tetrachlorodibenzo-p-dioxin
25. Hepatitis B virus X-associated protein 2 is a subunit of the unliganded aryl hydrocarbon receptor core complex and exhibits transcriptional enhancer activity
26. Steroid hormone receptors compete for factors that mediate their enhancer function
27. ER beta: Identification and characterization of a novel human estrogen receptor
28. Inhibition of estrogen-induced activity by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the MCF-7 human breast cancer and other cell lines transfected with vitellogenin A2 gene promoter constructs
29. Induction of the drug-metabolizing enzymes
30. 2,3,7,8-Tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons: Examination of the mechanism of toxicity
31. Application of a human ovarian cell bioassay for the detection and analysis of estrogen-toxicant interactions
32. Recombinant cell bioassays for endocrine disruptors: Development of a stably transfected human ovarian cell line for the detection of estrogenic and anti-estrogenic chemicals
33. Analysis of the anti-estrogenic effect of TCDD in human ovarian carcinoma (BG-1) cells
34. Molecular biology of the Ah receptor and its role in carcinogenesis
35. Comparative toxicology and mechanism of action of polychlorinated dibenzo-p-dioxins and dibenzofurans
36. Role of co-activators and co-repressors in the mechanism of steroid/thyroid receptor action
37. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on serum concentrations and the uterotrophic action of exogenous estrone in rats
38. Steroid receptor coactivator-1 is a histone acetyltransferase
39. 2,3,7,8-Tetrachlorodibenzo-p-dioxin causes an extensive alteration of 17 beta-estradiol metabolism in MCF-7 breast tumor cells
40. Regulation of estrogen receptor mRNA by 2,3,7,8-tetrachlorodibenzo-p-dioxin as measured by competitive RT-PCR
41. Reproductive toxicity in female mice of dioxin-contaminated soils from a 2,4,5-trichlorophenoxyacetic acid manufacturing site
42. Mechanism of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-mediated decrease of the nuclear estrogen receptor in MCF-7 human breast cancer cells
43. Induction of cytochrome P4501A1
44. Crosstalk between estrogen receptor alpha and the aryl hydrocarbon receptor in breast cancer cells involves unidirectional activation of proteasomes