Substitutions of proline 42 to alanine and methionine 46 to asparagine around the RGD domain of the neurotoxin dendroaspin alter its preferential antagonism to that resembling the disintegrin elegantin

Journal of Biological Chemistry

Volumn 271, Issue 1, 1996, Pages 289-294

  Lu, Xinjie ^a   Rahman, Salman ^a,b   Kakkar, Vijay V ^a   Authi, Kalwant S ^a  

^a THROMBOSIS RESEARCH INSTITUTE   (United Kingdom)

^b ST THOMAS HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; ASPARAGINE; CELL SURFACE RECEPTOR; DISINTEGRIN; GLUTATHIONE TRANSFERASE; INTEGRIN; METHIONINE; NEUROTOXIN; PROLINE; SNAKE VENOM;

AMINO ACID SUBSTITUTION; ARTICLE; ESCHERICHIA COLI; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN PURIFICATION; SEQUENCE HOMOLOGY; THROMBOCYTE ADHESION; THROMBOCYTE AGGREGATION;

ALANINE; AMINO ACID SEQUENCE; ASPARAGINE; CHROMATOGRAPHY, AFFINITY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ELAPID VENOMS; ESCHERICHIA COLI; METHIONINE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; OLIGOPEPTIDES; PEPTIDES; PLATELET AGGREGATION INHIBITORS; PROLINE; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID;

ESCHERICHIA COLI; SERPENTES;

EID: 0030042941     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.271.1.289     Document Type: Article

References (40)

1. Kieffer, N., and Phillips, D. R (1990) Annu. Rev. Cell Biol. 6, 329-357
2. Hynes, R. O. (1992) Cell 69, 11-25
3. McEver, R P (1992) Curr. Opin. Cell Biol. 4, 840-849
4. Smyth, S. S., Joneckis, C. C., and Parise, L. V. (1993) Blood 81, 2827-2843
5. Giancotti, F. G., and Maimero, F. (1994) Biochim. Biophys Acta 1198, 47-64
6. Pierschbacher, M. D , and Ruoslahti, E. (1994) Nature 309, 30-33
7. Plow, E. F , Pierschbacher, M. D., Ruoslahti, E., Marguerie, G , and Ginsberg. M H (1987) Blood 70, 110-115
8. Pytela, R., Pierschbacher, M. D., Ginsberg, M. H., Plow, E. F., and Ruoslahti, E. (1986) Science 231, 1559-1562
9. Nachman, R. L., and Nachman, L. L. K. (1992) J. Clin. Invest. 69, 263-269
10. Gardner, J. M., and Hynes, R. O. (1985) Cell 42, 439-448
11. Ruggeri, Z. M., De Mario, L., Gath, L., Bader, R., and Montgomery, R. R. (1983) J Clin. Invest. 72, 1-12
12. Pytela, R. M , Pierschbacher, M. D., and Ruoslahti, E. (1985) Proc. Natl. Acad. Sci. U. S. A. 82, 5766-5770
13. Karczewski, J., Knudsen, A., Smith, L , Murphy, A , Rothman, V. L , and Tuszynski, G. P. (1989) J. Biol. Chem. 264, 21322-21326
14. Sims, P J., Ginsberg, M. H., Plow, E. F., and Shattil, S. J (1991) J. Biol. Chem. 266, 7345-7352
15. Ugarova, T , Agbanyo, F. R., and Plow, E. F. (1995) Thromb. Haemostasis 74, 253-257
16. Gould, R. J., Polokoff, M A., Friedman, P. A., Huang, T. F., Holt J. C., Cook, J. J., and Niewiarowski, S. (1990) Proc. Soc Exp. Biol. Med. 195, 168-171
17. Scarborough, R. M., Rose, J W., Hsu, M. A., Phillips, D. R., Fried, V. A , Campbell, A. M., Nannizzi, L., and Charo, I F. (1991) J. Biol. Chem. 266, 9359-9362
18. McDowell, R S., Dennis, M. S., Louie, A., Shuster, M., Mulkerrin, M. G., and Lasarus, R. A. (1992) Biochemistry 31, 4766-4772
19. Williams, J A , Lu, X., Rahman, S., Keating, C., and Kakkar, V. V. (1992) Biochem. Soc. Trans. 21, 73S
20. Knapp, A., Degenhardt, T., and Dodt, J. (1992) J. Biol. Chem 267, 24230-24234
21. Adler, M., Lazarus, R. A., Dennis, M. S., and Wagner, G. (1991) Science 253, 445-448
22. Adler, M., and Wagner, G. (1992) Biochemistry 31, 1031-1039
23. Adler, M., Carter, P., Lazarus, R. A., and Wagner, G. (1993) Biochemistry 32, 282-289
24. Senn, H., and Klaus, W. (1993) J. Mol. Biol. 234, 907-925
25. Saudek, V., Atkinson, R. A , and Pelton, J. T. (1991) Biochemistry 30, 7369-7372
26. Saudek, V., Atkinson, R. A., Lepage, P., and Pelton, J. T. (1991) Eur. J. Biochem. 202, 329-338
27. Cooke, R. M., Carter. B. G., Martin, D. M. A., Murray-Rust, P., and Weir, M. P (1991) Sur J. Biochem. 202, 323-328
28. Cooke, R. M., Carter, B. G., Murray-Rust, P., Hartshorn, M. J., Herzyk, P., and Hubbard, R. E. (1992) Protein Eng. 5, 473-477
29. Jaseja, M., Smith, K. J., Lu, X , Williams, J. A., Trayer, H., Trayer, I. P., and Hyde, E. I. (1993) Eur. J Biochem. 218, 853-860
30. Krezel, A. M., Wagner, G., Seymour-Ulmer, J., and Lazarus, R. A. (1994) Science 264, 1944-1947
31. Jaseja, M., Lu, X. Williams, J. A., Sutcliffe, M. J., Kakkar, V. V., Parslow, R. A., and Hyde, E. I. (1994) Eur. J. Biochem. 226, 861-868
32. Sutcliffe, M. J , Jaseja, M., Hyde, E L, Lu, X., and Williams, J. A. (1994) Nature Struct. Biol. 1, 802-807
33. Scarborough, R. M., Rose, J. W., Naughton, M. A., Phillips, D. R., Nannizzi, L., Arfsten, A., Campbell, A. M., and Charo, I. F. (1993) J. Biol. Chem. 268, 1058-1065
34. Lu, X., Williams, J. A., Deadman, J. J., Salmon, G. P., Kakkar, V. V., Wilkinson, J. M., Baruch, D., Authi, K. S , and Rahman, S (1994) Biochem. J 304, 929-936
35. Wright, P S., Saudek, V., Owen, T. J., Harbeson, S L , and Bitonti, A J (1993) Biochem. J. 293, 263-267
36. Hornby, E J., Brown, S., Wilkinson, J. M., Mattock, C., and Authi, K. S. (1991) Br J. Haematol. 79, 277-285
37. Grosjean, F., and Fiers, W. (1982) Gene (Amst.) 18, 199-209
38. Sanger, F., Nicklen, S., and Coulson, A R (1977) Proc Natl. Acad. Sci U. S. A. 74, 5463-5467
39. Sambrook, J., Fntsch. E. F., and Maniatis, T. (1989) Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
40. Lu, X., Deadman, J. J., Williams, J. A., Kakkar, V V , and Rahman, S (1993) Biochem. J. 296, 21-24