Methanolic extract of cuminum cyminum inhibits ovariectomy-induced bone loss in rats

Experimental Biology and Medicine

Volumn 233, Issue 11, 2008, Pages 1403-1410

  Shirke, Sarika S ^a   Jadhav, Sanket R ^a   Jagtap, Aarti G ^a  

^a BOMBAY COLLEGE OF PHARMACY   (India)

Author keywords

Apigenin; Cuminum cyminum; Luteolin; Phytoestrogen; Postmenopausal osteoporosis

Indexed keywords

ALKALINE PHOSPHATASE; CALCIUM; CUMINUM CYMINUM EXTRACT; ESTRADIOL BENZOATE; METHANOL; PHOSPHATASE; PHOSPHORUS; PLANT EXTRACT; TARTARATE RESISTANT ACID PHOSPHATASE; UNCLASSIFIED DRUG; ESTRADIOL; ESTROGEN;

ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATROPHY; BLOOD ANALYSIS; BLOOD SAMPLING; BONE; BONE DENSITY; BONE MINERAL; BONE STRENGTH; BONE STRUCTURE; CALCIUM BLOOD LEVEL; CALCIUM EXCRETION; CALCIUM URINE LEVEL; CONTROLLED STUDY; CUMIN; ENZYME BLOOD LEVEL; FEMALE; NONHUMAN; OVARIECTOMY; PHOSPHATE BLOOD LEVEL; POSTMENOPAUSE OSTEOPOROSIS; RAT; SCANNING ELECTRON MICROSCOPY; SHAM PROCEDURE; SPRAGUE DAWLEY RAT; TIBIA; TREATMENT DURATION; UTERUS; UTERUS WEIGHT; WEIGHT GAIN; ANIMAL; BLOOD; BODY SIZE; CHEMISTRY; ORGAN SIZE; OSTEOPOROSIS; PATHOLOGY; PHYTOTHERAPY; ULTRASTRUCTURE;

ANIMALIA; CUMINUM CYMINUM; RATTUS;

ANIMALS; BODY SIZE; BONE DENSITY; CUMINUM; ESTRADIOL; ESTROGENS; FEMALE; ORGAN SIZE; OSTEOPOROSIS; OVARIECTOMY; PHYTOTHERAPY; PLANT EXTRACTS; RATS; TIBIA;

EID: 58249084395     PISSN: 15353702     EISSN: 15353699     Source Type: Journal    
DOI: 10.3181/0803-RM-93     Document Type: Article

References (41)

1. World Health Organization. Guidelines for Preclinical Evaluation and Clinical Trials in Osteoporosis. Geneva, Switzerland, 1998.
2. Setchell KDR, Lydeking-Olsen E. Dietary phytoestrogens and their effects on bone: evidence from in vitro and in vivo, human observational and dietary intervention studies. Am J Clin Nutr 78 (suppl):593S-609S, 2003.
3. Cos P, Bruyne TD, Apers S, Berghe DV, Pieters L, Vlietinck AJ. Phytoestrogens: recent developments. Planta Medica 69:589-599, 2003.
4. Rishi RK. Phytoestrogens in health and illness. Ind J Pharmacol 34: 311-320, 2002.
5. Tham DM, Gardener CD, Haskell WL. Potential health benefits of dietary phytoestrogens: a review of the clinical, epidemiological and mechanistic evidence. J Clin Endocrinol Metab 83:2223-2235, 1998.
6. Brynin R. Soy and its isoflavones: a review of their effects on bone density. Altern Med Rev 7:317-327, 2002.
7. Dr. Dukes Phytochemical and ethnobotanical databases. Available at: http://www.drdukes.com. Accessed January 24, 2005.
8. Cuminum linn. In: Batnagar SS, Chopra RN, Prashad B, Ghosh JC, Saha MN, Lala S, Santapau H, Sastri BN, Eds. The Wealth of India-A dictionary of Indian raw materials and industrial products-Raw materials. Delhi, India: Director Council of Scientific and Industrial Research, Vol. II:pp396-398, 1950.
9. Berger TBM, Erler F, Dagh F. Ovicidal activity of essential oils from five plants against two stored-product insects. J Sto Prod Res 36:161168, 2000.
10. Malini T, Vanithakumari G. Estrogenic activity of Cuminum cyminum in rats. Ind J Exp Biol 25:442-444, 1987.
11. Khandelwal KR. Phytochemical evaluation. In: Practical Pharmacog-nosy Techniques and Experiments (12th ed.). Pune, India: Nirali Prakashan, pp149-156, 2004.
12. Malencic D, Popovic M, Miladinovic J. Phenolic content and antioxidant properties of soybean (Glycine max (L.) Merr.) seeds. Molecules 12:576-581, 2007.
13. Wanforth HB, Flecknell PA. Specific surgical operations. In: Experimental and Surgical Technique in the Rat (2nd ed.). New York: Academic Press, pp203-312, 1992.
14. Yin J, Tezuka Y, Subehan, Shi L, Nobukawa M, Kadota S. In vivo anti-osteoporotic activity of isotaxiresinol, a lignan from wood of Taxuz yunnanesis. Phytomedicine 13:37-42, 2006.
15. Ke HZ, Simmons HA, Pirie CM, Crawford DT. Droloxifene, a new estrogen antagonist/agonist, prevents bone loss in ovariectomized rats. Endocrinology 136: 2435-2441, 1995.
16. Weiss J, Taylor GR, Zimmermann F, Nebendahl K. Collection of body fluids. In: Laboratory Rat Book. New York: Academic Press, pp485-510, 2000.
17. Bessy OA, Lowry OH, Brock MJ. A method for the rapid determination of alkaline phosphatase with five cubic millimetres of serum. J Biol Chem 164:321-329, 1946.
18. Godkar P. Enzymes. In: Textbook of Medical Laboratory Techniques, Ed. Mumbai, India: Bhalani Publishing House, pp149-167, 1994.
19. Connerty HV, Briggs AR. Determination of serum calcium by means of o-cresophthalein complexon. Am J Clin Pathol 45:290-296, 1966.
20. Godkar P. Water and mineral metabolism. In: Textbook of Medical Laboratory Techniques, Ed. Mumbai, India: Bhalani Publishing House, pp233-251, 1994.
21. Lowry O, Rosebrough N, Farr AL, Randall R. Protein measurement with the folin Phenol reagent. J Biol Chem 193:265-275, 1951.
22. Changrani NR, Chonkar A, Adeghate E. Effects of streptozotocin-induced type 1 diabetes mellitus on total protein concentrations and cation contents in the isolated pancreas, parotid, submandibular, and lacrimal glands of rats. Ann N Y Acad Sci 1084:503-519, 2006.
23. Kalu DN. Evaluation of the pathogenesis of skeletal changes in ovariectomized rats. Endocrinology 115:507-512, 1984.
24. Lee YB, Lee HJ, Kim KS, Lee JY, Nam SY, Cheon SH, Sohn HS. Evaluation of preventive effect of isoflavone extract on bone loss in ovariectomized rats. Biosci Biotech Biochem 68:1040-1045, 2004.
25. Peng Z, Tuukkanen J, Zhang H. The mechanical strength of bone in different rat models of experimental osteoporosis. Bone 15:523-532, 1994.
26. Pytlik M, Janiec W, Cegiela U, Silwinski L. Influence of α-Eschin on the femoral bone strength in ovariectomized rats. Pol J Pharmacol 51: 511-515, 1999.
27. Kalu DN, Liu CC, Hardin R, Hollis BW. The aged rat model of ovarian hormone deficiency bone loss. Endocrinology 124:7-16, 1989.
28. Cai D J, Zhao Y, Glasier J, Cullen D, Barnes S, Turner CH, Wastney M, Weaver CM. Comparative effect of soy protein, soy isoflavones and 17βestradiol on bone metabolism in adult ovariectomized rats. J Bone Miner Res 20:828-839, 2005.
29. Horcajada-Molteni MN, Crespy V, Coxam V, Davicco MJ, Remesy C, Barlet JP. Rutin inhibits ovariectomy-induced osteopenia in rats. J Bone Min Res 15:2251-2258, 2000.
30. hang Y, Lai WP, Leung PC, Wu CF, Wong MS. Short-to mid term effects of ovariectomy on bone turnover, bone mass and bone strength in rats. Biol Pharm Bull 30:898-903, 2007.
31. Keenan MJ, Hegsted M, Jones KL, Delany JP, Kime JC, Melancon LE, Tulley RT, Hong KD. Comparison of bone density measurement techniques: DXA and Archimedes principal. J Bone Miner Res 12: 1903-1907, 1997.
32. Arjmandi BH, Hollis BW, Kalu DN. In vivo effect of 17βestradiol on intestinal calcium absorption in rats. Bone Miner 26:181-189, 1994.
33. Reddy PN, Lakshmana M. Prevention of bone loss in calcium deficient ovariectomized rats by OST-6, a herbal preparation. J Ethnopharmacol 84:259-264, 2003.
34. Fanti P, Monier-Faugere MC, Geng Z, Schmid J, Morris PE, Cohen D, Malluche HH. The phytoestrogen genistein reduces bone loss in short-term ovariectomized rats. Osteoporos Int 8:274-281, 1998.
35. Turner RT, Riggs BL, Spelsberg TC. Skeletal effects of estrogen. Endocrin Rev 15:275-300, 1994.
36. Recker RR. Low bone mass may not be the only cause of skeletal fragility in osteoporosis. Proc Soc Exp Biol Med 191:272-274, 1989.
37. Choi EM. Modulatory effects of luteolin on osteoblastic function and inflammatory mediators in osteoblastic MC3T3-E1 cells. Cell Biol Int 31:870-877, 2007.
38. Lean JM, Davis JT, Fuller K, Jagger CJ, Kirstein B, Partington GA, Zoe LU, Chambers TJ. A crucial role for thiol anti-oxidants in estrogen-deficiency induced bone loss. J Clin Invest 112:915-923, 2003.
39. Moffett SP, Zmuda JM, Oakley JI, Beck TJ, Cauley JA, Stone KL, Lui LY, Ensrud KE, Hillier TA, Hochberg MC, Morin P, Peltz G, Greene D, Cummings SR. Tumor necrosis factor-a polymorphism, bone strength phenotypes and the risk of fracture in older women. J Clin Endocrinol Metab 90:3491-3497, 2006.
40. Kuiper GGJM, Carlsson B, Grandien K, Enmark E, Haggblad J, Nilsson S and Gustafsson JA. Comparison of ligand binding specificity and transcription tissue distribution of estrogen receptors α and β. Endocrinology 138:863-870, 1997.
41. Young RL, Kumar NS, Goldzieher JW. Management of menopause when estrogen can not be used. Drugs 40:220-230, 1990.