A cysteine-rich metal-binding domain from rubella virus non-structural protein is essential for viral protease activity and virus replication

Biochemical Journal

Volumn 417, Issue 2, 2009, Pages 477-483

  Zhou, Yubin ^a   Tzeng, Wen Pin ^a   Ye, Yiming ^b   Huang, Yun ^a   Li, Shunyi ^a   Chen, Yanyi ^a   Frey, Teryl K ^a   Yang, Jenny J ^a  

^a GEORGIA STATE UNIVERSITY   (United States)

^b CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

Author keywords

Conformational change; Fluorescence; Protease; Rubella virus (RUBV); Zinc binding protein

Indexed keywords

BINDING LIGANDS; BINDING MOTIF; CALCIUM IONS; CONFORMATIONAL CHANGE; DISSOCIATION CONSTANT; FLUORESCENCE METHOD; FLUORESCENCE QUENCHING; HYDROPHOBIC REGIONS; MATURE PROTEINS; METAL BINDING DOMAIN; MUTATIONAL ANALYSIS; OPTIMAL ACTIVITY; PROTEASE; PROTEOLYTIC ACTIVITIES; RUBELLA VIRUS (RUBV); SELF-CLEAVAGE; STRUCTURAL PROTEINS; SULFONIC ACID; VIRAL PROTEASE; VIRUS REPLICATION;

CALCIUM; DISSOCIATION; FLUORESCENCE; METAL REFINING; PROTEINS; QUENCHING; STOICHIOMETRY;

ZINC;

8 ANILINO 1 NAPHTHALENESULFONIC ACID; COMPLEMENTARY DNA; CYSTEINE; PROTEINASE; PROTEINASE RUBCA; UNCLASSIFIED DRUG; VIRUS DNA; VIRUS ENZYME; VIRUS PROTEIN; ZINC BINDING PROTEIN; CALCIUM; SERINE; ZINC;

ARTICLE; CONFORMATIONAL TRANSITION; DISSOCIATION CONSTANT; ENZYME ACTIVITY; FLUORESCENCE; FLUORESCENCE SPECTROSCOPY; HUMAN; HUMAN CELL; HYDROPHOBICITY; METAL BINDING; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN MOTIF; REPLICON; RUBELLA VIRUS; SITE DIRECTED MUTAGENESIS; STOICHIOMETRY; VIRUS REPLICATION; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; ENZYMOLOGY; GENETICS; METABOLISM; PHYSIOLOGY; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE;

RUBELLA VIRUS;

AMINO ACID MOTIFS; BINDING SITES; CALCIUM; CYSTEINE; ENDOPEPTIDASES; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RUBELLA VIRUS; SERINE; VIRAL NONSTRUCTURAL PROTEINS; VIRUS REPLICATION; ZINC;

EID: 58249083483     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20081468     Document Type: Article

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