Qat and its health effects

British Dental Journal

Volumn 206, Issue 1, 2009, Pages 17-21

  El Wajeh, Y A M ^a   Thornhill, M H ^b  

^a Barnsley Vocational Training Scheme   (United Kingdom)

^b UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL; ARTICLE; CATHA EDULIS; HUMAN; LEUKOPLAKIA; MICRONUCLEUS; MOUTH TUMOR; PERIODONTITIS; SQUAMOUS CELL CARCINOMA; UNITED KINGDOM;

ANIMALS; CARCINOMA, SQUAMOUS CELL; CATHA; GREAT BRITAIN; HUMANS; LEUKOPLAKIA, ORAL; MICRONUCLEI, CHROMOSOME-DEFECTIVE; MOUTH NEOPLASMS; PERIODONTITIS;

EID: 58149490928     PISSN: 00070610     EISSN: 17417503     Source Type: Journal    
DOI: 10.1038/sj.bdj.2008.1122     Document Type: Article

References (55)

1. IARC. GLOBOCAN 2002. Cancer incidence, mortality and prevalence worldwide (2002 estimates). 2004.
2. Rodriguez T, Altieri A, Chatenoud L, Gallus S et al. Risk factors for oral and pharyngeal cancer in young adults. Oral Oncol 2004; 40: 207-213.
3. Goldenberg D, Lee J, Koch W et al. Habitual risk factors for head and neck cancer. Otolaryngol Head Neck Surg 2004; 131: 986-993.
4. Kalix P. Cathinone: a natural amphetamine. J Pharmacol Toxicol 192; 70: 77-86.
5. Patel N B. Mechanism of action of cathinone: the active ingredient of qat (Catha edulis). East Afr Med J 2000; 77: 329-332.
6. WHO Expert Committee on Drug Dependence. World Health Organ Tech Rep Ser 2006; 942: 1-21, 23-24 passim.
7. Nabuzoka D, Badhade FA. Use and perceptions of qat among young Somalis in a UK city. Addiction Res 2000, 8: 5-26.
8. Goudi A J. Importing qat, legal but dangerous (letter). Lancet 1987; ii: 1340-1341.
9. Ali A A. Qat habit in Yemeni society.A causative factor for oral periodontal diseases. Int J Environ Res Public Health 2007; 4: 243-247.
10. Al-Sharabi A. Oral and para-oral lesions caused by takhzeen (chewing) al-qat. Doctoral thesis. Al-Qattoum, Sudan: Univ Khartoum, 2002.
11. Mengel R, Eigenbrodt M, Schunemann T, Floresde-Jacoby L. Periodontal status of a subject sample of Yemen. J Clin Periodontal 1996; 23: 437-443.
12. Al-Hebshi N N,Skaug N. Effect of qat chewing on 14 selected periodontal bacteria in sub- and supragingival plaque of a young male population. Oral Microbiol Immunol 2005; 20: 141-146.
13. Jorgensen E, Kaimenyi J T. The status of periodontal health and oral hygiene of Miraa (Catha edulis) chewers. East Afr Med J 1990; 67: 585-590.
14. Hattab F N, Angmar-Mansson B. Fluoride content in qat (Catha edulis) chewing leaves. Arch Oral Biol 2000; 45: 253-255.
15. Marker P, Krogdahl A. Plasma cell gingivitis apparently related to the use of Khat: report of a case. Br Dent J 2002; 192: 311-313.
16. Fasanmade A, Kwok E, Newman L. Oral squamous cell carcinoma associated with khat chewing. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007; 104: e53-e55.
17. Soufi H E, Kameswaran M, Malatani T. Qat and oral cancer, J Laryngol Otol 1991; 105: 643-645.
18. Nasr A, Qatri M. Head and neck squamous cell carcinoma in Hajjah, Yemen. Saudi Med J 2000; 21: 565-568.
19. Sawair F A, Al-Mutwakel A, Al-Eryani K, Al-Surhy A et al. High relative frequency of oral squamous cell carcinoma in Yemen: qat and tobacco chewing as its aetiological background. Int J Environ Health Res 2007; 17: 185-195.
20. Macfarlane GJ et al. Alcohol, tobacco, diet and the risk of oral cancer: a pooled analysis of three case-controlled studies. Eur J Cancer B Oral Oncol 1995; 31B: 181-187.
21. Hill C M, Gibson A. The oral and dental effects of qat chewing. Oral Surg Oral Med Oral Pathol 1987; 63: 433-436.
22. Sankaranarayanan R. Oral cancer in India: an epidemiologic and clinical review. Oral Surg Oral Med Oral Pathol 1990; 69: 325-330.
23. Sankaranarayanan R, Duffy S W, Padmakumary G et al. Risk factors for cancer of the buccal and labial mucosa in Kerala, Southern India. J Epidemiol Community Heaith 1990; 44: 286-292.
24. Macigo F G, Mwaniki D L, Guthua S W. The association between oral leukoplakia and use of tobacco, alcohol and qat based on relative risks association in Kenya. Eur J Oral Sci 1995; 103: 268-273.
25. Ali A A, Al-Sharab A K, Aguirre J M, Nahas R. A study of 342 oral keratotic white lesions induced by qat chewing among 2500 Yemeni. J Oral Pathol Med 2004; 33: 368-372.
26. Scheifele C, Nassar A, Reichart P A. Prevalence of oral cancer and potentially malignant lesions among shammah users in Yemen. Oral Oncol 2007; 1: 42-50.
27. Ali A A, Al-Sharabi A K, Aguire J M. Histopatho-logical changes in oral mucosa due to takhzeen al-qat: a study of 70 biopsies. J Oral Pathol Med 2006;35: 81-85.
28. Ali A A. Histopathologic changes in oral mucosa of Yemenis addicted to water-pipe and cigarette smoking in addition to takhzeen al-qat. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007; 103: e55-9.
29. Ali A A, Al-Sharab A K, Aguirre J M, Nahas R. A study of 342 oral keratotic white lesions induced by qat chewing among 2500 Yemeni. J Oral Pathol Med 2004; 33: 368-372.
30. Hassan N A, Gunaid A A, Murray-Lyon I M. Qat (Catha edulis): health aspects of qat chewing. East Mediterr Health J 2007; 13: 706-718.
31. Hassan N A, Gunaid A A, El Khally F M, Murray-Lyon I M. The subjective effects of chewing qat leaves in human volunteers. Ann Saudi Med 2002; 22: 34-37.
32. Nencini P, Ahmed A M, Elmi A. Subjective effects of qat chewing in humans. Drug Alcohol Depend 1986;18: 97-105.
33. Al-Habori M. The potential adverse effects of habitual use of Catha edulis (qat). Expert Opin
34. Drug Saf 2005; 4: 1145-1154.
35. Warfa N, Klein A, Bhui K et al. Qat use and mental illness: a critical review. SocSci Med July; 65: 309-318.
36. Hassan N A, Gunaid A A, Abdo-Rabbo A A, Abdel-Kader Z Y et al. The effect of qat chewing on blood pressure and heart rate in healthy volunteers. Trop Doct 2000; 30: 107-108.
37. Al-Motarreb A, Briancon S, Al-Jaber N, Al-Adhi B et al. Khat chewing is a risk factor for acute myocardial infarction: a case-control study. Br J Clin Pharmacol 2005; 59: 574-581.
38. Saif-Ali R, Al-Qirbi A, Al-Geiry A, Al-Habori M. Effect of Catha edulis on plasma glucose and C-peptide in both type 2 diabetics and non-diabetics, J Ethnopharmacol 2003; 86: 45-49.
39. Atef O A, Ali A A, Ali H M. Effect of qat chewing on the availability of ampicillin and amoxicillin. J Antimicrob Chemother 1997; 39: 523-525.
40. Al-Hebshi N, Al-Haroni M, Skaug N. In vitro antimicrobial and resistance-modifying activities of aqueous crude qat extracts against oral microorganisms. Arch Oral Biol 2006; 51: 183-188.
41. Al-Hebshi N N, Nielsen O, Skaug N. In vitro effects of crude qat extracts on the growth, colonization, and glucosyltransferases of Streptococcus mutans. Acta Odontol Scand 2005; 63: 136-142.
42. Warfa N, Klein A, Bhui K, Leavey G et al. Qat use and mental illness: a critical review. Soc Sci Med 2007; 65: 309-318.
43. Date J, Tanida N, Hobara T. Qat chewing and pesticides: a study of adverse health effects in people of the mountainous areas of Yemen. Int J Environ Health Res 2004; 14: 405-414.
44. Tariq M, Parmar N S, Qureshi S et al. Clastogenic evaluation of cathinone and amphetamine in somatic cells of mice. Mutat Res 1987; 190: 153-157.
45. Li J H, Lin L F. Genetic toxicology of abused drugs: a brief review. Mutagenesis 1998; 13: 557-565.
46. Al-Zubairi A, Ismail P, Pei C P, Rahmat A. Genotoxic effect of Catha edulis (khat) crude extract after sub-chronic administration in rats. Environ Toxicol Pharmacol 2007; in press.
47. Kassie F, Darroudi F, Kundi M et al. Qat (Cathaedulis) consumption causes genotoxic effects in humans, Int J Cancer 2001; 92: 329-332.
48. Dimba E A, Giertsen BT, Bredholt T et al. Qat (Catha edulis)-induced apoptosis is inhibited by antagonists of caspase-1 and -8 in human leukaemia cells. Br J Cancer 2004; 91: 1726-1734.
49. Dimba E, Giertsen BT, Francis G W et al.Cathaedulis (qat) induced cell death by apoptosis in leukaemia cell lines. Ann N Y Acad Sci 2003; 1010: 384-388.
50. Lukandu O M, Costea D E, Dimba E A et al. Khat induces G-1 phase arrest and increased expression of stress-sensitive p53 and p16 proteins in normal human oral keratinocytes and fibroblasts. Eur J Oral Sci 2008; 116: 23-30.
51. Sawair F A, Al-Mutawakel A, Al-Eryani K, AlSurhy A et al. High relative frequency of oral squamous cell carcinoma in Yemen: qat and tobacco chewing as its aetiological background. Int J Environ Health Res 2007; 17: 185-195.
52. Ralhan R, Agarwal S, Nath N, Mathur M et al. Correlation between p53 gene mutations and circulating antibodies in betel- and tobacco-consuming North Indian population. Oral Oncol 2001; 37: 243-250.
53. Warnakulasuriya KA, Tavassoli M, Johnson N W. Relationship of p53 overexpression to other cell cycle regulatory proteins in oral squamous cell carcinoma. J Oral Pathol Med 1998; 27: 376-381.
54. Kassim S, Croucher R. Qat chewing amongst UK resident male Yemeni adults: an exploratory study. Int Dent J 2005; 56: 97-101.
55. Devlin N, Parkin D. 'Does NICE have a cost-effectiveness threshold and what other factors influence its decisions? A binary choice analysis." Health Econ 2004; 13: 437-452.