The influence of old age and enzyme inducing comedication on the pharmacokinetics of valproic acid at steady-state: A case-matched evaluation based on therapeutic drug monitoring data

Epilepsy Research

Volumn 70, Issue 2-3, 2006, Pages 153-160

  Fattore, Cinzia ^a   Messina, Sara ^b   Battino, Dina ^b   Croci, Danilo ^b   Mamoli, Daniela ^b   Perucca, Emilio ^a,c  

^a UNIVERSITY OF PAVIA   (Italy)

^b DEPARTMENT OF NEUROSURGERY   (Italy)

^c C MONDINO NATIONAL NEUROLOGICAL INSTITUTE   (Italy)

Author keywords

Drug therapy; Elderly; Epilepsy; Pharmacokinetics; Therapeutic drug monitoring; Valproic acid

Indexed keywords

ANTICONVULSIVE AGENT; CARBAMAZEPINE; ETHOSUXIMIDE; ETIRACETAM; GABAPENTIN; LAMOTRIGINE; PHENOBARBITAL; PHENYTOIN; PLASMA PROTEIN; PRIMIDONE; TOPIRAMATE; VALPROIC ACID; VIGABATRIN;

ADULT; AGED; ANTICONVULSANT THERAPY; ARTICLE; BODY WEIGHT; CALCULATION; CONTROLLED STUDY; DATA BASE; DRUG BINDING; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG METABOLISM; DRUG MONITORING; ENZYME INDUCTION; EPILEPSY; FEMALE; GENDER; HOSPITAL; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SENESCENCE; STEADY STATE;

ADULT; AGED; AGING; ANTICONVULSANTS; CASE-CONTROL STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; DRUG MONITORING; DRUG THERAPY, COMBINATION; ENZYME INDUCTION; EPILEPSY; FEMALE; HUMANS; MALE; MIDDLE AGED; REGRESSION ANALYSIS; VALPROIC ACID;

EID: 33746918407     PISSN: 09201211     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.eplepsyres.2006.04.002     Document Type: Article

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