Increased IL-2 production in T cells by xanthohumol through enhanced NF-AT and AP-1 activity

International Immunopharmacology

Volumn 9, Issue 1, 2009, Pages 103-107

  Choi, Jin Myung ^a   Kim, Hyun Jung ^a   Lee, Kwang Youl ^a   Choi, Hyun Jin ^a   Lee, Ik Soo ^a   Kang, Bok Yun ^a  

^a Chonnam National University   (South Korea)

Author keywords

AP 1; IL 2; NF AT; T cells; Xanthohumol

Indexed keywords

CHALCONE; GROWTH FACTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 2; IONOMYCIN; PHORBOL 13 ACETATE 12 MYRISTATE; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR NFAT; XANTHOHUMOL;

ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFECT; GENE EXPRESSION; IMMUNOMODULATION; LYMPHOCYTE ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE; UPREGULATION;

ANIMALS; CELL NUCLEUS; CELLS, CULTURED; ELECTROPHORETIC MOBILITY SHIFT ASSAY; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION; INDICATORS AND REAGENTS; INTERLEUKIN-2; L-LACTATE DEHYDROGENASE; LUCIFERASES; MICE; MICE, INBRED C57BL; NF-KAPPA B; NFATC TRANSCRIPTION FACTORS; PROPIOPHENONES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; T-LYMPHOCYTES; TRANSCRIPTION FACTOR AP-1; TRANSFECTION;

EID: 58149465897     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.intimp.2008.10.011     Document Type: Article

References (32)

1. Minami Y., Kono T., Miyazaki T., and Taniguchi T. The IL-2 receptor complex: its structure, function, and target genes. Annu Rev Immunol 11 (1993) 245-268
2. Nelson B.H., and Willerford D.M. Biology of the interleukin-2 receptor. Adv Immunol 70 (1998) 1-81
3. Crabtree G.R. Contingent genetic regulatory events in T lymphocyte activation. Science 243 (1989) 355-361
4. Nel A.E. T-cell activation through the antigen receptor. J Allergy Clin Immunol 109 (2002) 758-770
5. Morgan D.A., Ruscetti F.W., and Gallo R. Selective in vitro growth of T lymphocytes from normal human bone marrows. Science 193 (1976) 1007-1008
6. Garffen SL, Lie KD. Overview of interleukin-2 function, production and clinical applications. Cytokine 2004;28:109-123.
7. Smith K.A. Interleukin-2. Curr Opin Immunol 4 (1992) 271-276
8. Stevens J.F., Ivancic M., Hsu V.L., and Deinzer M.L. Prenylflavonoids from Humulus lupulus. Phytochemistry 44 (1997) 1575-1585
9. Stevens J.F., and Page J.E. Xanthohumol and related prenylflavonoids from hops and beer: to your good health!. Phytochemistry 65 (2004) 1317-1330
10. Gerhauser C., Alt A., Heiss E., Gamal-Eldeen A., Klimo K., Knauft J., et al. Cancer chemopreventive activity of Xanthohumol, a natural product derived from hop. Mol Cancer Ther 1 (2002) 959-969
11. Henderson M.C., Miranda C.L., Stevens J.F., Deinzer M.L., and Buhler D.R. In vitro inhibition of human P450 enzymes by prenylated flavonoids from hops, Humulus lupulus. Xenobiotica 30 (2000) 235-251
12. Dietz B.M., Kang Y.H., Liu G., Eggler A.L., Yao P., Chadwick L.R., et al. Xanthohumol isolated from Humulus lupulus inhibits menadione-induced DNA damage through induction of quinone reductase. Chem Res Toxicol 18 (2005) 1296-1305
13. Miranda C.L., Aponso G.L.M., Stevens J.F., Deinzer M.L., and Buhler D.R. Prenylated chalcones and flavanones as inducers of quinine reductase in mouse Hepa 1c1c7 cells. Cancer Lett 149 (2000) 21-29
14. Zhao F., Nozawa H., Daikonnya A., Kondo K., and Kitanaka S. Inhibitors of nitric oxide production from hops (Humulus lupulus L.). Biol Pharm Bull 26 (2003) 61-65
15. Miranda C.L., Stevens J.F., Helmrich A., Henderson M.C., Rodriguez R.J., and Yang Y.H. Antiproliferative and cytotoxic effects of prenylated flavonoids from hops (Humulus lupulus) in human cancer cell lines. Food Chem Toxicol 37 (1999) 271-285
16. Albini A., Dell'Eva R., Vené R., Ferrari N., Buhler D.R., and Noonan D.M. Mechanisms of the antiangiogenic activity by the hop flavonoid xanthohumol: NF-kappaB and Akt as targets. FASEB J 20 (2006) 527-529
17. Wang Q., Ding Z.H., Liu J.K., and Zheng Y.T. Xanthohumol, a novel anti-HIV-1 agent purified from hops Humulus lupulus. Antivir. Res 64 (2004) 189-194
18. Tobe H., Muraki Y., Kitamura K., Komiyama O., Sato Y., and Sugioka T. Bone resorption inhibitors from hop extract. Biosci Biotechnol Biochem 61 (1997) 158-159
19. Tabata N., Ito M., Tomoda H., and Omura S. Xanthohumols, diacylglycerol acyltransferase inhibitors, from Humulus lupulus. Phytochemistry 46 (1997) 683-687
20. Cho Y.C., Kim H.J., Kim Y.J., Lee K.Y., Choi H.J., Lee I.S., et al. Differential anti-inflammatory pathway by xanthohumol in IFN-gamma and LPS-activated macrophages. Int Immunopharmacol 8 (2008) 567-573
21. Rao A., Luo C., and Hogan P.G. Transcription factors of the NFAT family: regulation and function. Annu Rev Immunol 15 (1997) 707-747
22. Rooney J.W., Sun Y.L., Glimcher L.H., and Hoey T. Novel NFAT sites that mediate activation of the interleukin-2 promoter in response to T-cell receptor stimulation. Mol Cell Biol 15 (1995) 6299-6310
23. Shapiro V.S., Truitt K.E., Imboden J.B., and Weiss A. CD28 mediates transcriptional upregulation of the interleukin-2 (IL-2) promoter through a composite element containing the CD28RE and NF-IL-2B AP-1 sites. Mol Cell Biol 17 (1997) 4051-4058
24. Maggirwar S.B., Harhaj E.W., and Sun S.C. Regulation of the interleukin-2 CD28-responsive element by NF-ATp and various NF-κB/Rel transcription factors. Mol Cell Biol 17 (1997) 2605-2614
25. Hoyos B., Ballard D.W., Bohnlein E., Siekevitz M., and Greene W.C. Kappa B-specific DNA binding proteins: role in the regulation of human interleukin-2 gene expression. Science 244 (1989) 457-460
26. Ghosh P., Tan T.H., Rice N.R., Sica A., and Young H.A. The interleukin 2 CD28-responsive complex contains at least three members of the NF kappa B family: c-Rel, p50, and p65. Proc Natl Acad Sci USA 90 (1993) 1696-1700
27. Rothenberg E.V., and Ward S.B. A dynamic assembly of diverse transcription factors integrates activation and cell-type information for interleukin 2 gene regulation. Proc Natl Acad Sci USA 93 (1996) 9358-9365
28. Truneh A., Albert F., Golstein P., and Schmitt-Verhulst A.M. Early steps of lymphocyte activation bypassed by synergy between calcium ionophores and phorbol ester. Nature 313 (1985) 318-320
29. Jeon M.S., and Esser C. The murine IL-2 promoter contains distal regulatory elements responsive to the Ah receptor, a member of the evolutionarily conserved bHLH-PAS transcription factor family. J Immunol 165 (2000) 6975-6983
30. Doi H., Baba T., Tohyama C., and Nohara K. Functional activation of arylhydrocarbon receptor (AhR) in primary T cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Chemosphere 52 (2003) 655-662
31. Kerkvliet N.I. Recent advances in understanding the mechanisms of TCDD immunotoxicity. Int Immunopharmacol 2 (2002) 277-291
32. Jain J., Loh C., and Rao A. Transcriptional regulation of the IL-2 gene. Curr Opin Immunol 7 (1995) 333-342