Early morphological and functional alterations in canine hepatocytes due to α-amanitin, a major toxin of Amanita phalloides

Archives of Toxicology

Volumn 83, Issue 1, 2009, Pages 55-60

  Magdalan, Jan ^a   Ostrowska, Alina ^b   Podhorska Okołów, Marzena ^a   Piotrowska, Aleksandra ^a   Iżykowska, Ilona ^a   Nowak, Marcin ^c   Dolińska Krajewska, Barbara ^a   Zabel, MacIej ^a,d   Szeląg, Adam ^a   Dzięgiel, Piotr ^a  

^a WROCLAW MEDICAL UNIVERSITY   (Poland)

^b XENOBIOTIC LABORATORIES INC   (United States)

^c WROC AW UNIVERSITY OF ENVIRONMENTAL AND LIFE SCIENCES   (Poland)

^d POZNAN UNIVERSITY OF MEDICAL SCIENCES   (Poland)

Author keywords

Amanita phalloides; Amanitin; Canine hepatocytes; Intoxication

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ALPHA AMANITIN; LACTATE DEHYDROGENASE;

AMANITA PHALLOIDES; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL CULTURE; CELL STRUCTURE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; INTOXICATION; LIVER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; UREA CYCLE;

AMANITA PHALLOIDES; BASIDIOMYCOTA; CANIS FAMILIARIS;

EID: 58149458646     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-008-0376-9     Document Type: Article

References (21)

1. Y Arima M Nitta S Kuninaka D Zhang T Fujiwara Y Taya M Nakao H Saya 2005 Transcriptional blockade induces p53-dependent apoptosis associated with translocation of p53 to mitochondria J Biol Chem 280 19166 19176
2. K Brasch GD Sinclair 2002 The organization, composition and matrix of hepatocyte nuclei exposed to alpha-amanitin Virchows Arch B Cell Pathol 27 193 204
3. JR Burton C Ryan TA Shaw-Stiffel 2002 Liver transplantation in mushroom poisoning J Clin Gastroenterol 35 276 280
4. T Decker ML Lohmann-Matthes 1998 A quick and simple method for the quantitation of lactate dehydrogenase release in measurements of cellular cytotoxicity and tumor necrosis factor (TNF) activity J Immunol Methods 15 61 69
5. Ellenhorn M (1997) Ellenhorn's medical toxicology. Diagnosis and treatment of human poisoning. Williams & Wilkins, Baltimore
6. A Enjalbert S Rapior J Nouguier-Soule S Guillon N Amoroux C Cabot 2002 Treatment of Amatoxin Poisoning: 20-Year retrospective analysis J Toxicol Clin Toxicol 40 715 757
7. V Fineschi M Di Paolo F Centini 1996 Histological criteria for diagnosis of amanita phalloides poisoning J Forensic Sci 41 429 432
8. Fiume L (1972) Pathogenesis of the cellular lesions produced by alpha-amanitin. In: Farber E (ed) The biochemistry of disease. Dekker, New York, pp 105-122
9. S Gundala LD Wells MT Milliano V Talkad BA Luxon BA Neuschwander-Tetri 2004 The hepatocellular bile acid transporter Ntcp facilitates uptake of the lethal mushroom toxin α-amanitin Arch Toxicol 78 68 73
10. A Jaeger F Jehl F Flesch P Sauder J Kopferschmitt 1993 Kinetics of amatoxins in human poisoning: therapeutic implications J Toxicol Clin Toxicol 31 63 80
11. AM Leathem RA Pursell VR Chan PD Kroeger 1997 Renal failure caused by mushroom poisoning J Toxicol Clin Toxicol 35 67 75
12. K Letschert H Faulstich D Keller D Keppler 2006 Molecular characterization and inhibition of amanitin uptake into human hepatocytes Toxicol Sci 91 140 149
13. AD Liggett R Weiss 1989 Liver necrosis caused by mushroom poisoning in dogs J Vet Diagn Invest 1 267 269
14. A Łaba A Ostrowska D Patrzałek L Paradowski A Lange 2005 Characterization of human hepatocytes isolated from non-transplantable livers Arch Immunol Ther Exp 53 442 453
15. T Mossman 1983 Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays J Immunol Methods 65 55 63
16. VT Nguyen F Giannoni MF Dubois SJ Seo M Vigneron C Kedinger O Bensaude 1996 In vivo degradation of RNA polymerase II largest subunit triggered by alpha-amanitin Nucleic Acids Res 24 2924 2929
17. A Ostrowska DC Bode J Pruss B Bilir GD Smith S Zeisloft 2000 Investigation of functional and morphological integrity of freshly isolated and cryopreserved human hepatocytes Cell Tissue Bank 1 55 68
18. B Puschner HH Rose MS Filigenzi 2007 Diagnosis of amanita toxicosis in a dog with acute hepatic necrosis J Vet Diagn Invest 19 312 317
19. M Rudd D Luse 1996 Amanitin greatly reduces the rate of transcription by RNA polymerase II ternary complexes but fails to inhibit some transcript cleavage modes J Biol Chem 271 21549 21558
20. Schneider SM (2001) Mushrooms. In: Ford MD, Delaney KA, Ling LJ, Erickson WB (eds) Clinical Toxicology. Saunders Company, Philadelphia London New York St. Louis Sydney Toronto, pp 899-909
21. G Vogel B Tuchweber W Trost U Mengs 1984 Protection by Silibinin against Amanita phalloides intoxication in beagles Toxicol Appl Pharmacol 73 355 362