Circulating progenitor cells decrease immediately after marathon race in advanced-age marathon runners

European Journal of Preventive Cardiology

Volumn 15, Issue 5, 2008, Pages 602-607

  Adams, Volker ^a   Linke, Axel ^a   Breuckmann, Frank ^b   Leineweber, Kirsten ^d   Erbs, Sandra ^a   Kränkel, Nicolle ^a   Bröcker Preuss, Martina ^c   Woitek, Felix ^a   Erbel, Raimun D ^b   Heusch, Gerd ^b   Hambrecht, Rai Ner ^e   Schuler, Gerhard ^a   Möhlenkamp, Stefan ^b  

^a UNIVERSITY OF LEIPZIG HEART CENTER   (Germany)

^b UNIVERSITY HOSPITAL ESSEN   (Germany)

^c UNIVERSITY OF DUISBURG ESSEN   (Germany)

^d BAYER PHARMA AG   (Germany)

^e Klinikum Links der Weser   (Germany)

Author keywords

marathon running; progenitor cells

Indexed keywords

EPIDERMAL GROWTH FACTOR; VASCULOTROPIN; CD133 ANTIGEN; CD34 ANTIGEN; GLYCOPROTEIN; LEUKOCYTE ANTIGEN; PEPTIDE; STEM CELL FACTOR RECEPTOR; UNCLASSIFIED DRUG; VASCULOTROPIN A; VEGFA PROTEIN, HUMAN;

ADULT; AGE DISTRIBUTION; ARTICLE; CELL COUNT; CELL LOSS; CELL SUBPOPULATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUORESCENCE ACTIVATED CELL SORTING; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; LEUKOCYTE COUNT; LYMPHOCYTE COUNT; MARATHON RUNNER; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DETERMINATION; AGE; BLOOD; ENDOTHELIUM CELL; ENDURANCE; IMMUNOLOGY; INFLAMMATION; METABOLISM; MIDDLE AGED; PATHOLOGY; RUNNING; STEM CELL;

AGE FACTORS; ANTIGENS, CD; ANTIGENS, CD34; DOWN-REGULATION; ENDOTHELIAL CELLS; EPIDERMAL GROWTH FACTOR; GLYCOPROTEINS; HEMATOPOIETIC STEM CELLS; HUMANS; INFLAMMATION; LEUKOCYTE COUNT; MIDDLE AGED; PEPTIDES; PHYSICAL ENDURANCE; PROTO-ONCOGENE PROTEINS C-KIT; RUNNING; STEM CELLS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 58149402339     PISSN: 20474873     EISSN: 20474881     Source Type: Journal    
DOI: 10.1097/HJR.0b013e328309c756     Document Type: Article

References (28)

1. Hambrecht R, Wolff A, Gielen S, Linke A, Hofer J, Erbs S et al. Effect of exercise on coronary endothelial function in patients with coronary artery disease. N Engl J Med 2000; 342: 454–460.
2. Walsh JH, Bilsborough W, Maiorana A, Best M, O'Driscoll GJ, Taylor RR et al. Exercise training improves conduit vessel function in patients with coronary artery disease. J Appl Physiol 2003; 95: 20–25.
3. Gokce N, Vita JA, Bader DS, Sherman DL, Hunter LM, Holbrook M et al. Effect of exercise on upper and lower extremity endothelial function in patients with coronary artery disease. Am J Cardiol 2002; 90: 124–127.
4. Hambrecht R, Gielen S, Linke A, Fiehn E, Yu J, Walther C et al. Effects of exercise training on left ventricular function and peripheral resistance in patients with chronic heart failure. A randomised trial. JAMA 2000; 283: 3095–3101.
5. Belardinelli R, Georgiou D, Cianci G, Purcaro A. Effects of exercise training on left ventricular filling at rest and during exercise in patients with ischemic cardiomyopathy and severe left ventricular systolic dysfunction. Am Heart J 1996; 132: 61–70.
6. Hambrecht R, Adams V, Erbs S, Linke A, Kränkel N, Shu Y et al. Regular physical activity improves endothelial function in patients with CAD by increasing phosphorylation of endothelial nitric oxide synthase. Circulation 2003; 107: 3152–3158.
7. Adams V, Linke A, Kränkel N, Erbs S, Gielen S, Möbius-Winkler S et al. Impact of regular physical activity on the NAD(P)H oxidase and angiotensin receptor system in patients with coronary artery disease. Circulation 2005; 111: 555–562.
8. Laufs U, Werner N, Link A, Endres M, Wassmann S, Jürgens K et al. Physical training increases endothelial progenitor cells, inhibition of neointima formation, and enhances angiogenesis. Circulation 2004; 109: 220–226.
9. Sandri M, Adams V, Gielen S, Linke A, Lenk K, Kränkel N et al. Effects of exercise and ischemia on mobilization and functional activation of blood-derived progenitor cells in patients with ischemic syndromes: results of 3 randomized studies. Circulation 2005; 111: 3391–3399.
10. Löllgen H, Dickhut HH, Dirschedl P. Vorbeugung durch körperliche Bewegung. Deutsches Ärtzeblatt 1998; 24: B1228–B1234.
11. Bonsignore MR, Morici G, Santoro A, Pagano M, Cascio L, Bonanno A et al. Circulating hematopoietic progenitor cells in runners. J Appl Physiol 2002; 93: 1691–1697.
12. Morici G, Zangla D, Santoro A, Pelosi E, Petrucci E, Gioia M et al. Supramaximal exercise mobilizes hematopoietic progenitors and reticulocytes in athletes. Am J Physiol Regul Integr Comp Physiol 2005; 289: R1496–R1503.
13. Möhlenkamp S, Schmermund A, Kroger K, Kerkhoff G, Bröcker-Preuss M, Adams V et al. Coronary atherosclerosis and cardiovascular risk in masters male marathon runners. Herz 2006; 31: 575–585.
14. Möhlenkamp S, Lehmann N, Breuckmann F, Bröcker-Preuss M, Nassenstein K, Halle M et al. Running: the risk of coronary events. Prevalence and prognostic relevance of coronary atherosclerosis in marathon runners. Eur Heart J (in press).
15. Suzuki K, Totsuka M, Nakaji S, Yamada M, Kudoh S, Liu Q et al. Endurance exercise causes interaction among stress hormones, cytokines, neutrophil dynamics, and muscle damage. J Appl Physiol 1999; 87: 1360–1367.
16. Ostrowski K, Rohde T, Asp S, Schjerling P, Pedersen BK. Pro- and antiinflammatory cytokine balance in strenuous exercise in humans. J Physiol 1999; 515: 287–291.
17. Dufaux B, Order U. Plasma elastase-alpha 1-antitrypsin, neopterin, tumor necrosis factor, and soluble interleukin-2 receptor after prolonged exercise. Int J Sports Med 1989; 10: 434–438.
18. Siegel AJ, Stec JJ, Lipinska I, Van Cott EM, Lewandrowski KB, Ridker PM et al. Effect of marathon running on inflammatory and hemostatic markers. Am J Cardiol 2001; 88: 918–920.
19. Nieman DC, Henson DA, Smith LL, Utter AC, Vinci DM, Davis JM et al. Cytokine changes after a marathon race. J Appl Physiol 2001; 91: 109–114.
20. Nehlsen-Cannarella SL, Fagoaga OR, Nieman DC, Henson DA, Butterworth DE, Schmitt RL et al. Carbohydrate and the cytokine response to 2.5 h of running. J Appl Physiol 1997; 82: 1662–1667.
21. Valgimigli M, Rigolin GM, Fucili A, Porta MD, Soukhomovskaia O, Malagutti P et al. CD34+ and endothelial progenitor cells in patients with various degrees of congestive heart failure. Circulation 2004; 110: 1209–1212.
22. Nonaka-Sarukawa M, Yamamoto K, Aoki H, Nishimura Y, Tomizawa H, Ichida M et al. Circulating endothelial progenitor cells in congestive heart failure. Int J Cardiol 2007; 119: 344–348.
23. Asahara T, Takahashi T, Masuda H, Kalka C, Chen D, Iwaguro H et al. VEGF contributes to postnatal neovascularization by mobilizing bone-marrow endothelial progenitor cells. EMBO J 1999; 18: 3964–3972.
24. Kalka C, Masuda H, Takahashi T, Gordon R, Tepper O, Gravereaux E et al. Vascular endothelial growth factor (165) gene transfer augments circulating endothelial progenitor cells in human subjects. Circ Res 2000; 86: 1198–1202.
25. Mauro E, Rigolin GM, Fraulini C, Sofritti O, Ciccone M, De Angeli C et al. Mobilization of endothelial progenitor cells in patients with hematological malignancies after treatment with filgrastim and chemotherapy for autologous transplantation. Eur J Haematol 2007; 78: 374–380.
26. Heeschen C, Aicher A, Lehmann R, Fichtlscherer S, Vasa M, Urbich C et al. Erythropoietin is a potent physiological stimulus for endothelial progenitor cell mobilization. Blood 2003; 102: 1340–1346.
27. Schobersberger W, Hobisch-Hagen P, Fries D, Wiedermann F, Rieder-Scharinger J, Villiger B et al. Increase in immune activation, vascular endothelial growth factor and erythropoietin after an ultramarathon run at moderate altitude. Immunobiology 2000; 201: 611–620.
28. Roecker L, Kowoll R, Fraszl W, Battal K, Brechtel L, Brachmann S et al. Observation of serum erythropoietin concentrations in female athletes for up to eight days after a marathon run. Clin Lab 2006; 52: 511–513.