Effect of gadolinium chloride treatment on concanavalin A-induced cytokine mRNA expression in mouse liver

Japanese Journal of Pharmacology

Volumn 78, Issue 1, 1998, Pages 101-103

  Okamoto, Toshihiro ^a   Maeda, Osamu ^a   Tsuzuike, Naoki ^b   Hara, Kaoru ^a  

^a Nippon Chemiphar Co Ltd   (Japan)

^b ZERIA PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Concanavalin A; Cytokine; Gadolinium chloride

Indexed keywords

ALANINE AMINOTRANSFERASE; CONCANAVALIN A; CYTOKINE; GADOLINIUM CHLORIDE; INTERLEUKIN 2; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; FEMALE; INTRAPERITONEAL DRUG ADMINISTRATION; KUPFFER CELL; LIVER; LIVER TOXICITY; MOUSE; NONHUMAN;

EID: 0031659391     PISSN: 00215198     EISSN: None     Source Type: Journal    
DOI: 10.1254/jjp.78.101     Document Type: Article

References (12)

1. Tiegs G, Hentshel J and Wendel A: A T cell-dependent experimental liver injury in mice inducible by concanavalin A. J Clin Invest 90, 196-203 (1992)
2. Gantner F, Leist M, Lohse AW, Germann PG and Tiegs G: Concanavalin A-induced T cell-mediated hepatic injury in mice: The role of tumor necrosis factor. Hepatology 21, 190-198 (1995)
3. Okamoto T and Kobayashi T: Effects of concanavalin A on cytokine mRNA expression in mouse liver. Jpn J Pharmacol 75, 199-201 (1997)
4. Weiss A and Littman DR: Signal transduction by lymphocyte antigen receptors. Cell 76, 263-274 (1994)
5. Tocci MJ, Matkovich DA, Collier KA, Kwok P, Dumont F, Lin S, Degudicibus S, Siekierka JJ, Chin J and Hutchinson NI: The immunosuppressant FK506 selectively inhibits expression of early T cell activation genes. J Immunol 143, 718-726 (1989)
6. Andus T, Bauer J and Gerok W: Effects of cytokines on the liver. Hepatology 13, 364-375 (1991)
7. Hardonk MJ, Dijkhuis FWJ, Hulstaert CE and Koudstaal J: Heterogeneity of rat liver and spleen macrophages in gadolinium chloride-induced elimination and repopulation. J Leukoc Biol 52, 296-302 (1992)
8. Okamoto T, Mitsuhashi M, Fujita I, Sindhu RK and Kikkawa Y: Induction of cytochrome P450 1A1 and 1A2 by hyperoxia. Biochem Biophys Res Commun 197, 878-885 (1993)
9. Okamoto T, Furuya M, Yamakawa T, Yamamura K-I and Hino O: TNF-α gene expression in the liver of the IFN-γ transgenic mouse with chronic active hepatitis. Biochem Biophys Res Commun 226, 762-768 (1996)
10. Tiegs G, Wolter M and Wendel A: Tumor necrosis factor is a terminal mediator in D-galactosamine/endotoxin-induced hepatitis in mice. Biochem Pharmacol 38, 627-631 (1989)
11. Leist M, Gantner F, Bohlinger I, Tiegs G, Germann PG and Wendel A: Tumor necrosis factor-induced hepatocyte apoptosis precedes liver failure in experimental murine shock models. Am J Pathol 146, 120-1234 (1995)
12. Leist M, Gantner F, Bohlinger I, Germann PG, Tiegs G and Wendel A: Murine hepatocyte apoptosis induced in vitro and in vivo by TNF-α requires transcriptional arrest. J Immunol 153, 1778-1788 (1994)