Local effects of retrovirally transduced endostatin-expressing human umbilical cord blood CD34+ cells on transplanted malignancy in a mouse model of hepatic cancer

Cell Transplantation

Volumn 17, Issue 8, 2008, Pages 969-975

  Jiang, Zao ^a   Teng, Gao Jun ^a   Chen, Bao An ^a   Xu, Zheng Feng ^b   Hu, Jie ^a   Shao, Ze Ye ^a  

^a SOUTHEAST UNIVERSITY   (China)

^b NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Angiogenesis; CD34+ cells; Endostatin; Gene therapy; Tumor

Indexed keywords

CELL NUCLEUS ANTIGEN; ENDOSTATIN; RETROVIRUS VECTOR; ANGIOGENESIS INHIBITOR; CD34 ANTIGEN;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CD34 SELECTION; CELL ASSAY; CELL BASED GENE THERAPY; CELL CULTURE; CELL PROLIFERATION; CELL STRAIN 3T3; CELL TRANSFER; CONTROLLED STUDY; ENDOTHELIUM CELL; FEMALE; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; LIVER CANCER; MALE; MICROVASCULATURE; MOUSE; NEOVASCULARIZATION (PATHOLOGY); NEWBORN; NICK END LABELING; NONHUMAN; NONVIRAL GENE THERAPY; PLASMID; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STABLE EXPRESSION; SUPERNATANT; THERAPY EFFECT; TREATMENT OUTCOME; TUMOR MODEL; TUMOR REGRESSION; TUMOR VOLUME; TUMOR XENOGRAFT; UMBILICAL CORD BLOOD; VASCULAR ENDOTHELIUM; WESTERN BLOTTING; ANIMAL; CELL LINE; CORD BLOOD STEM CELL TRANSPLANTATION; DISEASE MODEL; GENE VECTOR; GENETIC TRANSDUCTION; GENETICS; IMMUNOLOGY; LIVER TUMOR; METABOLISM; METHODOLOGY; PATHOPHYSIOLOGY; RETROVIRUS; SECRETION; STEM CELL; TUMOR CELL LINE; VASCULARIZATION; XENOGRAFT;

ANIMALIA; MUS;

ANGIOGENESIS INHIBITORS; ANIMALS; ANTIGENS, CD34; CELL LINE; CELL LINE, TUMOR; CELL PROLIFERATION; CELLS, CULTURED; CORD BLOOD STEM CELL TRANSPLANTATION; DISEASE MODELS, ANIMAL; ENDOSTATINS; FEMALE; GENETIC VECTORS; HUMANS; LIVER NEOPLASMS, EXPERIMENTAL; MALE; MICE; NEOVASCULARIZATION, PATHOLOGIC; RETROVIRIDAE; STEM CELLS; TRANSDUCTION, GENETIC; TRANSPLANTATION, HETEROLOGOUS; TREATMENT OUTCOME;

EID: 58149383473     PISSN: 09636897     EISSN: None     Source Type: Journal    
DOI: 10.3727/096368908786576525     Document Type: Article

References (35)

1. Belessi, C. J.; Parasi, A. S.; Manioudaki, H. S.; Laoutaris, N. P.; Legakis, N. C.; Peros, G. T.; Androulakis, G. A. Prognostic impact of DNA ploidy pattern, S-phase fraction (SPF), and proliferating cell nuclear antigen (PCNA) in patients with primary gastric lymphoma. J. Surg. Oncol. 82:247-255; 2003.
2. Capillo, M.; Mancuso, P.; Gobbi, A.; Monestiroli, S.; Pruneri, G.; Dell'Agnola, C.; Martinelli, G.; Shultz, L.; Bertolini, F. Continuous infusion of endostatin inhibits differentiation, mobilization, and clonogenic potential of endothelial cell progenitors. Clin. Cancer Res. 9:377-382; 2003.
3. Chodon, D.; Banu, S. M.; Padmavathi, R.; Sakthisekaran, D. Inhibition of cell proliferation and induction of apoptosis by genistein in experimental hepatocellular carcinoma. Mol. Cell. Biochem. 297:73-80; 2007.
4. Dales, J. P.; Garcia, S.; Andrac, L.; Carpentier, S.; Ramuz, O.; Lavaut, M. N.; Allasia, C.; Bonnier, P.; Charpin, C. Prognostic significance of angiogenesis evaluated by CD105 expression compared to CD31 in 905 breast carcinomas: Correlation with long-term patient outcome. Int. J. Oncol. 24:1197-1204; 2004.
5. Folkman, J. Fundamental concepts of the angiogenic process. Curr. Mol. Med. 3:643-651; 2003.
6. Frau, E.; Magnon, C.; Opolon, P.; Connault, E.; Opolon, D.; Beerman, F.; Abitbol, M.; Perricaudet, M.; Bouquet, C. A gene transfer comparative study of HSA-conjugated antiangiogenic factors in a transgenic mouse model of metastatic ocular cancer. Cancer Gene Ther. 14:251-261; 2007.
7. Guo, J.; Zhu, J.; Sheng, X.; Wang, X.; Qu, L.; Han, Y.; Liu, Y.; Zhang, H.; Huo, L.; Zhang, S.; Lin, B.; Yang, Z. Intratumoral injection of dendritic cells in combination with local hyperthermia induces systemic antitumor effect in patients with advanced melanoma. Int. J. Cancer 120: 2418-2425; 2007.
8. Halberstadt, C. R.; Williams, D.; Emerich, D.; Goddard, M.; Vasconcellos, A. V.; Curry, W.; Bhatia, A.; Gores, P. F. Subcutaneous transplantation of islets into streptozocin-induced diabetic rats. Cell Transplant. 14:595-605; 2005.
9. Hamilton, M. J.; Huang, Q. X.; Li, C. L.; Ellem, K. A. Characterization of an HEK293-derived cell line for use in an intratumoral cytokine delivery system. Cell Transplant. 15:43-50; 2006.
10. Hansma, A. H. G.; Broxterman, H. J.; Van der Horst, I.; Yuana, Y.; Boven, E.; Giaccone, G.; Pinedo, H. M.; Hoekman, K. Recombinant human endostatin administered as a 28-day continuous intravenous infusion, followed by daily subcutaneous injections: A phase I and pharmacokinetic study in patients with advanced cancer. Ann. Oncol. 16:1695-1701; 2005.
11. Kirsch, M.; Schackert, G.; Black, P. M. Metastasis and angiogenesis. Cancer Treat. Res. 117:285-304; 2004.
12. Kumar, P.; Wang, J. M.; Bernabeu, C. CD105 and angiogenesis. J. Pathol. 178:363-366; 1996.
13. Li, G. C.; Yang, J. M.; Nie, M. M.; Su, C. G.; Sun, L. C.; Qian, Y. Z.; Fang, G. E.; Jonathan, S.; Wu, M. C.; Qian, Q. J. Potent antitumoral effects of a novel gene-viral therapeutic system CNHK300-m endostatin in hepatocellular carcinoma. Chin. Med. J. 118:179-185; 2005.
14. Liang, Z. H.; Wu, P. H.; Li, L.; Xue, G.; Zeng, Y. X.; Huang, W. L. Inhibition of tumor growth in xenografted nude mice with adenovirus-mediated endostatin gene comparison with recombinant endostatin protein. Chin. Med. J. 117(12):1809-1814; 2004.
15. Martinico, S. C. M.; Jezzard, S.; Start, N.; Julian, H.; Michils, G.; Tejpar, S.; Phillips, R. K.; Vassaux, G. Assessment of endostatin gene therapy for familial adenomatous polyposis-related desmoid tumors. Cancer Res. 66: 8233-8240; 2006.
16. Okada, N.; Sasaki, A.; Niwa, M.; Okada, Y.; Hatanaka, Y.; Tani, Y.; Mizuguchi, H.; Nakagawa, S.; Fujita, T.; Yamamoto, A. Tumor suppressive efficacy through augmentation of tumor-infiltrating immune cells by intratumoral injection of chemokine-expressing adenoviral vector. Cancer Gene Ther. 13:393-405; 2006.
17. O'Reilly, M. S.; Boehm, T.; Shing, Y.; Fukai, N.; Vasios, G.; Lane, W. S.; Flynn, E.; Birkhead, J. R.; Olsen, B. R.; Folkman, J. Endostatin: An endogenous inhibitor of angiogenesis and tumor growth. Cell 88:277-285; 1997.
18. Paunesku, T.; Mittal, S.; Protić, M.; Oryhon, J.; Korolev, S. V.; Joachimiak, A.; Woloschak, G. E. Proliferating cell nuclear antigen (PCNA): Ringmaster of the genome. Int. J. Radiat. Biol. 77:1007-1021; 2001.
19. Quan, S.; Seiter, K.; Feldman, E.; Yang, L.; Argani, I.; Farley, T. J.; Abraham, N. G.; Ahmed, T. Experimental Hematology Human CD34+ hematopoietic cells transduced by retrovirus-mediated interferon alpha gene maintains regeneration capacity and engraftment in NOD/SCID mice. Exp. Hematol. 27:1511-1518; 1999.
20. Quesnel, B.; Preudhomme, C.; Lepelley, P.; Hetuin, D.; Vanrumbeke, M.; Bauters, F.; Velu, T.; Fenaux, P. Transfer of p 16inka/CDKN2 gene in leukaemic cell lines inhibits cell proliferation. Br. J. Haematol. 95(2):291-298; 1996.
21. Robert, P.; Thomas, B.; Omar, Z.; Anna, E.; Yihai, C.; Philippe, L. Continuous intravascular secretion of endostatin in mice from transduced hematopoietic stem cells. Mol. Ther. 5:345-351; 2002.
22. Shang, S.; Takai, N.; Nishida, M.; Miyazaki, T.; Nasu, K.; Miyakawa, I. CaMKIV expression is associated with clinical stage and PCNA-labeling index in endometrial carcinoma. Int. J. Mol. Med. 11:181-186; 2003.
23. Shibata, M. A.; Morimoto, J.; Doi, H.; Morishima, S.; Naka, M.; Otsuki, Y. Electrogene therapy using endostatin, with or without suicide gene therapy, suppresses murine mammary tumor growth and metastasis. Cancer Gene Ther. 14(3):268-278; 2007.
24. Skovseth, D. K.; Kuchler, A. M.; Haraldsen, G. The HUVEC/Matrigel assay: An in vivo assay of human angiogenesis suitable for drag validation. Methods Mol. Biol. 360:253-268: 2007.
25. Stamm, C.; Westphal, B.; Kleine, H. D.; Petzsch, M.; Kittner, C.; Klinge, H.; Schtimichen, C.; Nienaber, C. A.; Freund, M.; Steinhof, G. Autologous bone-marrow stem-cell transplantation for myocardial regeneration. Lancet 361:45-46; 2003.
26. Subramanian, I. V.; Bui Nguyen, T. M.; Truskinovsky, A. M.; Tolar, J.; Blazar, B. R.; Ramakrishnan, S. Adenoassociated virus-mediated delivery of a mutant endostatin in combination with carboplatin treatment inhibits orthotopic growth of ovarian cancer and improves long-term survival. Cancer Res. 66:4319-4328; 2006.
27. Tanaka, F.; Otake, Y.; Yanagihara, K.; Kawano, Y.; Miyahara, R.; Li, M.; Yamada, T.; Hanaoka, N.; Inui, K.; Wada, H. Evaluation of angiogenesis in non-small cell lung cancer: Comparison between anti-CD34 antibody andanti-CD105 antibody. Clin. Cancer Res. 7:3410-3415; 2001.
28. Vermeulen, P. B.; Gasparini, G.; Fox, S. B.; Toi, M.; Martin, L.; McCulloch, P.; Pezzella, F.; Viale, G.; Weidner, N.; Harris, A. L.; Dirix, L. Y. Quantification of angiogenesis in solid human tumours: An international consensus on the methodology and criteria of evaluation. Eur. J. Cancer 32A:2474-2484; 1996.
29. Wang, J. S.; Chen, Z. X.; Xia, X. M.; Lu, D. R.; Ruan, C. G. Improvement of combination chemotherapy tolerance by introduction of polycistronic retroviral vector drug resistance genes MGMT and MDR1 into human umbilical cord blood CD34+ cells. Leuk. Res. 26:281-288; 2002.
30. Wang, J. W.; Sun, Y.; Liu, Y. Y.; Yu, Q. T.; Zhang, Y. P.; Li, K.; Zhu, Y. Z.; Zhou, Q. H.; Hou, M.; Guan, Z. Z.; Li, W. L.; Zhuang, W.; Wang, D. L.; Liang, H. J.; Qin, F. Z.; Lu, H. S.; Liu, X. Q.; Sun, H.; Zhang, Y. J.; Wang, J. J.; Luo, S. X.; Yang, R. H.; Tu, Y. R.; Wang, X. W.; Song, S. P.; Zhou, J. M.; You, L. F.; Wang, J.; Yao, C. Results of randomized, multicenter, double-blind phase III trial of rh-endostatin (YH-16) in treatment of advanced non-small cell lung cancer patients. Chin. J. Lung Cancer 8:283-290; 2005.
31. Wei, L.; Li, C. B. Effect of oral Lactococcus lactis containing endostatin on 1,2-dimethylhydrazine-induced colon tumor in rats. World J. Gastroenterol. 11:7242-7247; 2005.
32. Wikström, P.; Lissbrant, I. F.; Stattin, P.; Egevad, L.; Bergh, A. Endoglin (CD105) is expressed on immature blood vessels and is a marker for survival in prostate cancer. Prostate 51(4):268-275; 2002.
33. Yang, L. Y.; Lu, W. Q.; Huang, G. W.; Wang, W. Correlation between CD105 expression and postoperative recurrence and metastasis of hepatocellular carcinoma. BMC Cancer 6:110; 2006.
34. Zhang, H. L.; Wen, Z. Q.; Lan, S. M.; Li, C. Z.; Li, J. F.; Zhang, X. J. The AFT024 stromal cell line improves MDR1 gene transfer to CD34+ cells derived from human umbilical cord blood. Neoplasma 54:21-28; 2007.
35. Ziche, M.; Donnini, S.; Morbidelli, L. Development of new drugs in angiogenesis. Curr. Drug Targets 5:485-493; 2004.