The influenza A virus spliced messenger RNA M mRNA3 is not required for viral replication in tissue culture

Journal of General Virology

Volumn 89, Issue 12, 2008, Pages 3097-3101

  Jackson, David ^a,b   Lamb, Robert A ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b UNIVERSITY OF ST ANDREWS   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

M2 MESSENGER RNA; MESSENGER RNA; UNCLASSIFIED DRUG; VIRUS M MESSENGER RNA 3; VIRUS MESSENGER RNA; M PROTEIN, INFLUENZA VIRUS; M-PROTEIN, INFLUENZA VIRUS; M2 PROTEIN, INFLUENZA A VIRUS; MATRIX PROTEIN; VIRUS RNA;

ALTERNATIVE RNA SPLICING; ANIMAL CELL; ARTICLE; CELL STRAIN; CONTROLLED STUDY; GENE MUTATION; INFLUENZA VIRUS A; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; TISSUE CULTURE; VIROGENESIS; VIRUS GENOME; VIRUS INFECTION; VIRUS RECOMBINANT; VIRUS REPLICATION; WILD TYPE; ANIMAL; CELL LINE; GENETICS; GROWTH, DEVELOPMENT AND AGING; HUMAN; METABOLISM; MUTATION; PHYSIOLOGY; RNA SPLICING;

INFLUENZA A VIRUS; ORTHOMYXOVIRIDAE;

ALTERNATIVE SPLICING; ANIMALS; CELL LINE; HUMANS; INFLUENZA A VIRUS; MUTATION; RNA SPLICE SITES; RNA, MESSENGER; RNA, VIRAL; VIRAL MATRIX PROTEINS; VIRUS REPLICATION;

EID: 58149382816     PISSN: 00221317     EISSN: None     Source Type: Journal    
DOI: 10.1099/vir.0.2008/004739-0     Document Type: Article

References (26)

1. Adams, M. D., Rudner, D. Z. & Rio, D. C. (1996). Biochemistry and regulation of pre-mRNA splicing. Curr Opin Cell Biol 8, 331-339.
2. Bohne, J., Schambach, A. & Zychlinski, D. (2007). New way of regulating alternative splicing in retroviruses: the promoter makes a difference. J Virol 81, 3652-3656.
3. Bourmakina, S. V. & Garcia-Sastre, A. (2005). The morphology and composition of influenza A virus particles are not affected by low levels of M1 and M2 proteins in infected cells. J Virol 79, 7926-7932.
4. Cheung, T. K., Guan, Y., Ng, S. S., Chen, H., Wong, C. H., Peiris, J. S. & Poon, L. L. (2005). Generation of recombinant influenza A virus without M2 ion-channel protein by introduction of a point mutation at the 5′ end of the viral intron. J Gen Virol 86, 1447-1454.
5. Filippova, M., Johnson, M. M., Bautista, M., Filippov, V., Fodor, N., Tungteakkhun, S. S., Williams, K. & Duerksen-Hughes, P. J. (2007). The large and small isoforms of human papillomavirus type 16 E6 bind to and differentially affect procaspase 8 stability and activity. J Virol 81, 4116-4129.
6. Fodor, E., Devenish, L., Engelhardt, O. G., Palese, P., Brownlee, G. G. & Garcia-Sastre, A. (1999). Rescue of influenza A virus from recombinant DNA. J Virol 73, 9679-9682.
7. Inglis, S. C. & Brown, C. M. (1981). Spliced and unspliced RNAs encoded by virion RNA segment 7 of influenza virus. Nucleic Acids Res 9, 2727-2740.
8. Inglis, S. C. & Brown, C. M. (1984). Differences in the control of virus mRNA splicing during permissive or abortive infection with influenza A (fowl plague) virus. J Gen Virol 65, 153-164.
9. Jurica, M. S. & Moore, M. J. (2003). Pre-mRNA splicing: awash in a sea of proteins. Mol Cell 12, 5-14.
10. Kammler, S., Otte, M., Hauber, I., Kjems, J., Hauber, J. & Schaal, H. (2006). The strength of the HIV-1 39 splice sites affects Rev function. Retrovirology 3, 89.
11. Kraunus, J., Zychlinski, D., Heise, T., Galla, M., Bohne, J. & Baum, C. (2006). Murine leukemia virus regulates alternative splicing through sequences upstream of the 5′ splice site. J Biol Chem 281, 37381-37390.
12. Lamb, R. A. & Choppin, P. W. (1981). Identification of a second protein (M2) encoded by RNA segment 7 of influenza virus. Virology 112, 729-737.
13. Lamb, R. A., Lai, C. J. & Choppin, P. W. (1981). Sequences of mRNAs derived from genome RNA segment 7 of influenza virus: colinear and interrupted mRNAs code for overlapping proteins. Proc Natl Acad Sci U S A 78, 4170-4174.
14. Lee, Y. S. & Seong, B. L. (1996). Mutational analysis of influenza B virus RNA transcription in vitro. J Virol 70, 1232-1236.
15. Lee, Y. S. & Seong, B. L. (1998). Nucleotides in the panhandle structure of the influenza B virus virion RNA are involved in the specificity between influenza A and B viruses. J Gen Virol 79, 673-681.
16. Lutzelberger, M., Reinert, L. S., Das, A. T., Berkhout, B. & Kjems, J. (2006). A novel splice donor site in the gag-pol gene is required for HIV-1 RNA stability. J Biol Chem 281, 18644-18651.
17. Neumann, G., Watanabe, T., Ito, H., Watanabe, S., Goto, H., Gao, P., Hughes, M., Perez, D. R., Donis, R. & other authors (1999). Generation of influenza A viruses entirely from cloned cDNAs. Proc Natl Acad Sci U S A 96, 9345-9350.
18. Schaub, M. C., Lopez, S. R. & Caputi, M. (2007). Members of the heterogeneous nuclear ribonucleoprotein H family activate splicing of an HIV-1 splicing substrate by promoting formation of ATP-dependent spliceosomal complexes. J Biol Chem 282, 13617-13626.
19. Shih, S. R. & Krug, R. M. (1996). Novel exploitation of a nuclear function by influenza virus: the cellular SF2/ASF splicing factor controls the amount of the essential viral M2 ion channel protein in infected cells. EMBO J 15, 5415-5427.
20. Shih, S. R., Nemeroff, M. E. & Krug, R. M. (1995). The choice of alternative 5′ splice sites in influenza virus M1 mRNA is regulated by the viral polymerase complex. Proc Natl Acad Sci U S A 92, 6324-6328.
21. Smith, C. W. & Valcarcel, J. (2000). Alternative pre-mRNA splicing: the logic of combinatorial control. Trends Biochem Sci 25, 381-388.
22. Tormanen, H., Backstrom, E., Carlsson, A. & Akusjarvi, G. (2006). L4-33K, an adenovirus-encoded alternative RNA splicing factor. J Biol Chem 281, 36510-36517.
23. Valcarcel, J., Portela, A. & Ortin, J. (1991). Regulated M1 mRNA splicing in influenza virus-infected cells. J Gen Virol 72, 1301-1308.
24. Xing, Y. & Lee, C. (2006). Alternative splicing and RNA selection pressure - evolutionary consequences for eukaryotic genomes. Nat Rev Genet 7, 499-509.
25. Zhirnov, O. P., Konakova, T. E., Wolff, T. & Klenk, H. D. (2002). NS1 protein of influenza A virus down-regulates apoptosis. J Virol 76, 1617-1625.
26. Zhou, Z., Licklider, L. J., Gygi, S. P. & Reed, R. (2002). Comprehensive proteomic analysis of the human spliceosome. Nature 419, 182-185.