Cloning and characterisation of a 1.1kb Fragment of the carcinoma-associated epithelial cell adhesion molecule promoter

Anticancer Research

Volumn 23, Issue 4, 2003, Pages 3255-3261

  Gires, Olivier ^a   Eskofier, Sylvia ^a   Lang, Stephan ^a   Zeidler, Reinhard ^b   Münz, Markus ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b Vaecgene Biotech Inc   (Germany)

Author keywords

Carcinoma; EpCAM; Promoter

Indexed keywords

CELL ADHESION MOLECULE; DNA FRAGMENT; GAMMA INTERFERON; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CONTROLLED STUDY; EPITHELIUM CELL; GENE SEQUENCE; HUMAN; HUMAN CELL; MOLECULAR CLONING; MOLECULAR MECHANICS; PRIORITY JOURNAL; PROMOTER REGION; SILENCER GENE; TRANSCRIPTION INITIATION;

ANTIGENS, NEOPLASM; CARCINOMA; CELL ADHESION MOLECULES; CLONING, MOLECULAR; FLOW CYTOMETRY; HUMANS; INTERFERON-ALPHA; INTERLEUKIN-4; POLYMERASE CHAIN REACTION; PROMOTER REGIONS (GENETICS); TRANS-ACTIVATION (GENETICS); TRANSFECTION; TUMOR CELLS, CULTURED; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0042029375     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Balzar M, Winter M J, de Boer CJ and Litvinov SV: The biology of the 17-1A antigen (Ep-CAM). J Mol Med 77: 699-712, 1999.
2. Quak J J, Van Dongen G, Brakkee J G, Hayashida D J, Balm AJ, Snow GB and Meijer CJ: Production of a monoclonal antibody (K 931) to a squamous cell carcinoma associated antigen identified as the 17-1A antigen. Hybridoma 9: 377-87, 1990.
3. Litvinov SV, van Driel W, van Rhijn CM, Bakker HA, van Krieken H, Fleuren GJ and Warnaar SO: Expression of EpCAM in cervical squamous epithelia correlates with an increased proliferation and the disappearance of markers for terminal differentiation. Am J Pathol 148: 865-75, 1996.
4. Zaloudik J, Li W, Jacob L, Kieny MP, Somasundaram R, Acres B, Song H, Zhang T, Li J and Herlyn D: Inhibition of tumor growth by recombinant vaccinia virus expressing GA733/CO171A/EpCAM/KSA/KS1-4 antigen in mice. Cancer Gene Ther 9: 382-9, 2002.
5. Riethmüller G, Schneider Gadicke E, Schlimok G, Schmiegel W, Raab R, Hoffken K, Gruber R, Pichlmaier H, Hirche H, Pichlmayr R et al: Randomised trial of monoclonal antibody for adjuvant therapy of resected Dukes' C colorectal carcinoma. Lancet 343: 1177-83, 1994.
6. Zeidler R, Reisbach G, Wollenberg B, Lang S, Chaubal S, Schmitt B and Lindhofer H: Simultaneous activation of T cells and accessory cells by a new class of intact bispecific antibody results in efficient tumor cell killing. J Immunol 163: 1246-52, 1999.
7. Zeidler R, Mysliwietz J, Csanady M, Walz A, Ziegler I, Schmitt B, Wollenberg B and Lindhofer H: The Fc-region of a new class of intact bispecific antibody mediates activation of accessory cells and NK cells and induces direct phagocytosis of tumour cells. Br J Cancer 83: 261-6, 2000.
8. Naundorf S, Preithner S, Mayer P, Lippold S, Wolf A, Hanakam F, Fichtner I, Kufer P, Raum T, Riethmuller G, Baeuerle PA and Dreier T: In vitro and in vivo activity of MT201, a fully human monoclonal antibody for pancarcinoma treatment. Int J Cancer 100: 101-10, 2002.
9. Litvinov SV, Velders MP, Bakker HA, Fleuren GJ and Warnaar SO: Ep-CAM: a human epithelial antigen is a homophilic cell-cell adhesion molecule. J Cell Biol 125: 437-46, 1994.
10. Balzar M, Prins FA, Bakker HA, Fleuren GJ, Warnaar SO and Litvinov SV: The structural analysis of adhesions mediated by Ep-CAM. Exp Cell Res 246:108-21, 1999.
11. Meyaard L, van der Vuurst de Vries AR, de Ruiter T, Lanier LL, Phillips JH and Clevers H: The epithelial cellular adhesion molecule (Ep-CAM) is a ligand for the leukocyte-associated immunoglobulin-like receptor (LAIR). J Exp Med 194: 107-12, 2001.
12. Linnenbach A J, Seng B A, Wu S, Robbins S, Scollon M, Pyrc JJ, Druck T and Huebner K: Retroposition in a family of carcinoma-associated antigen genes. Mol Cell Biol 13: 1507-15, 1993.
13. Gires O, Kieu C, Fix P, Schmitt B, Munz M, Wollenberg B, Zeidler R: Tumor necrosis factor alpha negatively regulates the expression of the carcinoma-associated antigen epithelial cell adhesion molecule. Cancer 92: 620-8., 2001.
14. Yang CH, Murti A, Pfeffer SR, Basu L, Kim J G and Pfeffer LM: IFNalpha/beta promotes cell survival by activating NF-kappa B. Proc Natl Acad Sci USA 97: 13631-6, 2000.
15. Yang CH, Murti A, Pfeffer SR, Kim JG, Donner DB and Pfeffer LM: Interferon alpha /beta promotes cell survival by activating nuclear factor kappa B through phosphatidylinositol 3-kinase and Akt. J Biol Chem 276: 13756-61, 2001.