Positive immunohistochemical staining of γH2AX is associated with tumor progression in gastric cancers from radiation-exposed patients

Oncology Reports

Volumn 20, Issue 5, 2008, Pages 1131-1136

  Sentani, Kazuhiro ^a   Oue, Naohide ^a   Sakamoto, Naoya ^a   Nishisaka, Takashi ^b   Fukuhara, Toshiyuki ^b   Matsuura, Hiroo ^c   Yasui, Wataru ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

^b HIROSHIMA PREFECTURAL HOSPITAL   (Japan)

^c HIROSHIMA CITY HOSPITAL   (Japan)

Author keywords

H2AX; Atomic bomb; DNA double strand break; Gastric cancer; Radiation

Indexed keywords

HISTONE H2AX; SERINE; H2AFX PROTEIN, HUMAN; HISTONE; UNCLASSIFIED DRUG;

ARTICLE; ATOMIC BOMB SURVIVOR; CANCER GROWTH; CANCER INVASION; CANCER STAGING; CANCER SURGERY; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MOLECULAR GENETICS; PRIORITY JOURNAL; RADIATION CARCINOGENESIS; RADIATION DOSE; RADIATION EXPOSURE; STOMACH CANCER; ATOMIC BOMB; DOUBLE STRANDED DNA BREAK; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; METABOLISM; PATHOLOGY; RADIATION INJURY; RADIOACTIVE WASTE; STOMACH TUMOR; SURVIVOR;

DNA BREAKS, DOUBLE-STRANDED; FLUORESCENT ANTIBODY TECHNIQUE; HISTONES; HUMANS; IMMUNOHISTOCHEMISTRY; NEOPLASMS, RADIATION-INDUCED; NUCLEAR WEAPONS; RADIOACTIVE FALLOUT; STOMACH NEOPLASMS; SURVIVORS;

EID: 58149352926     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or_00000120     Document Type: Article

References (26)

1. Preston DL, Ron E, Tokuoka S, et al: Solid cancer incidence in atomic bomb survivors: 1958-1998. Radiat Res 168: 1-64, 2007.
2. Yiin JH, Schubauer-Berigan MK, Silver SR, et al: Risk of lung cancer and leukemia from exposure to ionizing radiation and potential confounders among workers at the Portsmouth Naval Shipyard. Radiat Res 163: 603-613, 2005.
3. Ron E, Preston DL, Mabuchi K, Thompson DE and Soda M: Cancer incidence in atomic bomb survivors. Part IV: comparison of cancer incidence and mortality. Radiat Res 137: 98-112, 1994.
4. Yasui W, Oue N, Kitadai Y and Nakayama H: Recent advances in molecular pathobiology of gastric carcinoma. In: The Diversity of Gastric Carcinoma Pathogenesis: Diagnosis and Therapy. Kaminishi M, Takubo K and Mafune K (eds). Springer, Tokyo, pp51-71, 2005.
5. Ushijima T and Sasako M: Focus on gastric cancer. Cancer Cell 5: 121-125, 2004.
6. Takeshima Y, Seyama T, Bennett WP, et al: p53 mutations in lung cancers from non-smoking atomic-bomb survivors. Lancet 342: 1520-1521, 1993.
7. Takahashi K, Eguchi H, Arihiro K, et al: The presence of BRAF point mutation in adult papillary thyroid carcinomas from atomic bomb survivors correlates with radiation dose. Mol Carcinog 46: 242-248, 2007.
8. Iwamoto KS, Mizuno T, Tokuoka S, Mabuchi K and Seyama T: Frequency of p53 mutations in hepatocellular carcinomas from atomic bomb survivors. J Natl Cancer Inst 90: 1167-1168, 1998.
9. Hoeijmakers JH: Genome maintenance mechanisms for preventing cancer. Nature 411: 366-374, 2001.
10. Van Gent DC, Hoeijmakers JH and Kanaar R: Chromosomal stability and the DNA double-stranded break connection. Nat Rev Genet 2: 196-206, 2001.
11. Rogakou EP, Pilch DR, Orr AH, Ivanova VS and Bonner WM: DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J Biol Chem 273: 5858-5868, 1998.
12. Paull TT, Rogakou EP, Yamazaki V, Kirchgessner CU, Gellert M and Bonner WM: A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage. Curr Biol 10: 886-895, 2000.
13. Rothkamm K and Lobrich M: Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses. Proc Natl Acad Sci USA 100: 5057-5062, 2003.
14. Sedelnikova OA, Rogakou EP, Panyutin IG and Bonner WM: Quantitative detection of (125)IdU-induced DNA double-strand breaks with gamma-H2AX antibody. Radiat Res 158: 486-492, 2002.
15. Bartkova J, Horejsi Z, Koed K, et al: DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature 434: 864-870, 2005.
16. Gorgoulis VG, Vassiliou LV, Karakaidos P, et al: Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature 434: 907-913, 2005.
17. Fan C, Quan R, Feng X, et al: ATM activation is accompanied with earlier stages of prostate tumorigenesis. Biochim Biophys Acta 1763: 1090-1097, 2006.
18. Sobin LH, Wittekind CH (eds): TNM Classification of Malignant Tumors. 6th edition. John Wiley & Sons, New York, pp65-68, 2002.
19. Lauren P: The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma. An attempt at a histo-clinical classification. Acta Pathol Microbiol Scand 64: 31-49, 1965.
20. Yasui W and Oue N: Systematic collection of tissue specimens and molecular pathological analysis of newly diagnosed solid cancers among atomic bomb survivors. Int Congr Ser: 81-86, 2007.
21. Preston DL, Pierce DA, Shimizu Y, et al: Effect of recent changes in atomic bomb survivor dosimetry on cancer mortality risk estimates. Radiat Res 162: 377-389, 2004.
22. Rogakou EP, Boon C, Redon C and Bonner WM: Megabase chromatin domains involved in DNA double-strand breaks in vivo. J Cell Biol 146: 905-916, 1999.
23. Lu C, Zhu F, Cho YY, et al: Cell apoptosis: requirement of H2AX in DNA ladder formation, but not for the activation of caspase-3. Mol Cell 23: 121-132, 2006.
24. Pusapati RV, Rounbehler RJ, Hong S, et al: ATM promotes apoptosis and suppresses tumorigenesis in response to Myc. Proc Natl Acad Sci USA 103: 1446-1451, 2006.
25. Park JH, Park EJ, Lee HS, et al: Mammalian SWI/SNF complexes facilitate DNA double-strand break repair by promoting gamma-H2AX induction. EMBO J 25: 3986-3997, 2006.
26. Sentani K, Oue N, Kondo H, et al: Increased expression but not genetic alteration of BRG1, a component of the SWI/SNF complex, is associated with the advanced stage of human gastric carcinomas. Pathobiology 69: 315-320, 2001.