Lys-110 is essential for targeting PCNA to replication and repair foci, and the K110A mutant activates apoptosis

Biology of the Cell

Volumn 100, Issue 12, 2008, Pages 675-686

  Kim, Byung Ju ^a,b   Lee, Hoyun ^a,b,c  

^a UNIVERSITY OF OTTAWA   (Canada)

^b Northeastern Ontario Regional Cancer Centre   (Canada)

^c NORTHERN ONTARIO SCHOOL OF MEDICINE   (Canada)

Author keywords

Apoptosis; Nuclear localization sequence (NLS); Proliferating cell nuclear antigen (PCNA); Repair foci; Replication foci; Targeting sequence

Indexed keywords

ALANINE; CASPASE 3; CYCLINE; GREEN FLUORESCENT PROTEIN; KARYOPHERIN BETA; LYSINE; LYSINE 110; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL FUNCTION; CHO CELL; CONTROLLED STUDY; DNA REPAIR; DNA REPLICATION; FRAGMENTATION REACTION; HETEROCHROMATIN; HUMAN; HUMAN CELL; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN TARGETING; SEQUENCE ALIGNMENT; AMINO ACID SEQUENCE; ANIMAL; CELL NUCLEUS; CHEMISTRY; CRICETULUS; DNA FRAGMENTATION; GENETICS; HAMSTER; HELA CELL; METABOLISM; MISSENSE MUTATION; MOLECULAR GENETICS; PROTEIN TRANSPORT;

AMINO ACID SEQUENCE; ANIMALS; APOPTOSIS; CASPASE 3; CELL NUCLEUS; CHO CELLS; CRICETINAE; CRICETULUS; DNA FRAGMENTATION; DNA REPAIR; DNA REPLICATION; HELA CELLS; HETEROCHROMATIN; HUMANS; LYSINE; MOLECULAR SEQUENCE DATA; MUTATION, MISSENSE; NUCLEAR LOCALIZATION SIGNALS; PROLIFERATING CELL NUCLEAR ANTIGEN; PROTEIN TRANSPORT;

EID: 58149352656     PISSN: 02484900     EISSN: 1768322X     Source Type: Journal    
DOI: 10.1042/BC20070158     Document Type: Article

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