The role of helper and regulatory T cells in the pathogenesis of vitiligo

Journal of the American Academy of Dermatology

Volumn 60, Issue 2, 2009, Pages 256-260

  Basak, Pinar Y ^a   Adiloglu, Ali K ^a   Ceyhan, Ali Murat ^a   Tas, Tekin ^a   Akkaya, Vahide B ^a  

^a SULEYMAN DEMIREL UNIVERSITY SCHOOL OF MEDICINE   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 4; INTERLEUKIN 6; LYMPHOTOXIN; TRANSFORMING GROWTH FACTOR BETA;

ADULT; ARTICLE; AUTOIMMUNE DISEASE; BODY SURFACE; CELLULAR IMMUNITY; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE DURATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FAMILY HISTORY; FEMALE; HELPER CELL; HUMAN; IMMUNOPATHOGENESIS; LYMPHOCYTE FUNCTION; MALE; ONSET AGE; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; TH1 CELL; TH17 CELL; TH2 CELL; VITILIGO;

ADULT; FEMALE; HUMANS; INTERFERON-GAMMA; INTERLEUKIN-10; INTERLEUKIN-17; INTERLEUKIN-4; INTERLEUKIN-6; LYMPHOTOXIN-ALPHA; MALE; T-LYMPHOCYTES, REGULATORY; TH1 CELLS; TH2 CELLS; TRANSFORMING GROWTH FACTOR BETA1; VITILIGO;

EID: 58149345045     PISSN: 01909622     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaad.2008.09.048     Document Type: Article

References (18)

1. Ortonne J.-P. Vitiligo and other disorders of hypopigmentation. In: Bolognia J.L., Jorizzo J.L., Rapini R.P., Horn T.D., Mascaro J.M., Mancini A.J., et al. (Eds). Dermatology (2003), Mosby, Edinburg 947-973
2. Afzali B., Lombardi G., Lechler R.I., and Lord G.M. The role of T helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune disease. Clin Exp Immunol 148 (2007) 32-46
3. Furuzawa-Carballeda J., Vargas-Rojas M.I., and Cabral A.R. Autoimmune inflammation from the Th17 perspective. Autoimmun Rev 6 (2007) 169-175
4. Weaver C.T., Harrington L.E., Mangan P.R., Gavrieli M., and Murphy K.M. Th17: an effector CD4 T cell lineage with regulatory T cell ties. Immunity 24 (2006) 677-688
5. Moretti S., Spallanzani A., Amato L., Hautmann G., Gallerani I., Fabiani M., et al. New insights into the pathogenesis of vitiligo: imbalance of epidermal cytokines at sites of lesions. Pigment Cell Res 15 (2002) 87-92
6. Feldmann M., Brennan F.M., and Maini R. Cytokines in autoimmune disorders. Int Rev Immunol 17 (1998) 217-228
7. Swope V.B., Abdel-Malek Z., Kassem L.M., and Nordlund J.J. Interleukins 1 alpha and 6 and tumor necrosis factor-alpha are paracrine inhibitors of human melanocyte proliferation and melanogenesis. J Invest Dermatol 96 (1991) 180-185
8. Yu H.S., Chang K.L., Yu C.L., Li H.F., Wu M.T., Wu C.S., et al. Alterations in IL-6, IL-8, GM-CSF, TNF-alpha, and IFN-gamma release by peripheral mononuclear cells in patients with active vitiligo. J Invest Dermatol 108 (1997) 527-529
9. Tu C.X., Gu J.S., and Lin X.R. Increased interleukin-6 and granulocyte macrophage colony stimulating factor levels in the sera of patients with non-segmental vitiligo. J Dermatol Sci 31 (2003) 73-78
10. Grimes P.E., Morris R., Avaniss-Aghajani E., Soriano T., Meraz M., and Metzger A. Topical tacrolimus therapy for vitiligo: therapeutic responses and skin messenger RNA expression of proinflammatory cytokines. J Am Acad Dermatol 51 (2004) 52-61
11. Franczuk A., Szepietowski J.C., and Noworolska A. Serum concentrations of interleukin-2 soluble receptor (IL-2 sR) in patients with vitiligo: relationship with type and extent of the disease. Acta Dermatovenerol Croat 12 (2004) 71-76
12. Tu C.X., Fu H.W., and Lin X.R. Levels of soluble interleukin-2 receptor in the sera and skin tissue fluids of patients with vitiligo. J Dermatol Sci 21 (1999) 59-62
13. Zailaie M.Z. Decreased proinflammatory cytokine production by peripheral blood mononuclear cells from vitiligo patients following aspirin treatment. Saudi Med J 26 (2005) 799-805
14. Birol A., Kisa U., Kurtipek G.S., Kara F., Kocak M., Erkek E., et al. Increased tumor necrosis factor alpha (TNF-α) and interleukin 1 alpha (IL1-α) levels in the lesional skin of patients with nonsegmental vitiligo. Int J Dermatol 45 (2006) 992-993
15. Rodeck U., Hossler A., Graeven U., Fox F.E., Nowell P.C., Knabbe C., et al. Transforming growth factor beta production and responsiveness in normal human melanocytes and melanoma cells. Cancer Res 54 (1994) 575-581
16. Jandus C., Bioley G., Rivals J.P., Dudler J., Speiser D., and Romero P. Increased numbers of circulating polyfunctional Th17 memory cells in patients with seronegative spondylarthritides. Arthritis Rheum 58 (2008) 2307-2317
17. Veldhoen M., Hocking R.J., Atkins C.J., Locksley R.M., and Stockinger B. TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 24 (2006) 179-189
18. Dejaco C., Duftner C., Grubeck-Loebenstein B., and Schirmer M. Imbalance of regulatory T cells in human autoimmune diseases. Immunology 117 (2006) 289-300