Aberrant alternative splicing of human zinc finger gene ZNF268 in human hematological malignancy

Oncology Reports

Volumn 20, Issue 5, 2008, Pages 1243-1248

  Zhao, Zhouzhou ^a   Wang, Di ^a   Zhu, Chengang ^a   Shao, Huanjie ^a   Sun, Chong ^a   Qiu, Hongling ^a   Xue, Lu ^a   Xu, Junhua ^a   Guo, Mingxiong ^a   Li, Wenxin ^a  

^a WUHAN UNIVERSITY   (China)

Author keywords

Aberrant alternative splicing; Hematological malignancy; ZNF268

Indexed keywords

MESSENGER RNA; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN; ZINC FINGER PROTEIN 268; ZINC FINGER PROTEIN 268A; ZINC FINGER PROTEIN 268C; ZINC FINGER PROTEIN 268F; ZINC FINGER PROTEIN 268G; DNA BINDING PROTEIN; REPRESSOR PROTEIN; TUMOR MARKER; ZNF268 PROTEIN, HUMAN;

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ADULT; AGED; ALTERNATIVE RNA SPLICING; ARTICLE; CHILD; CHRONIC LYMPHATIC LEUKEMIA; CHRONIC MYELOID LEUKEMIA; CLINICAL ARTICLE; CONTROLLED STUDY; EMBRYO DEVELOPMENT; FEMALE; GENETIC ASSOCIATION; HEMATOLOGIC MALIGNANCY; HUMAN; LEUKEMOGENESIS; MALE; MALIGNANT HISTIOCYTOSIS; NONHODGKIN LYMPHOMA; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRESCHOOL CHILD; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCHOOL CHILD; BLOOD DISEASE; GENETICS;

ALTERNATIVE SPLICING; DNA-BINDING PROTEINS; HEMATOLOGIC NEOPLASMS; HUMANS; PROGNOSIS; REPRESSOR PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TUMOR MARKERS, BIOLOGICAL;

EID: 58149335455     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or_00000136     Document Type: Article

References (28)

1. Davis RL, Weintraub H and Lassar AB: Expression of a single transfected cDNA converts fibroblasts to myoblasts. Cell 51: 987-1000, 1987.
2. Blau HM and Baltimore D: Differentiation requires continuous regulation. J Cell Biol 112: 781-783, 1991.
3. Orkin SH: Transcription factors and hematopoietic development. J Biol Chem 270: 4955-4958, 1995.
4. Shivdasani RA and Orkin SH: The transcriptional control of hematopoiesis. Blood 87: 4025-4039, 1996.
5. Joslin JM, Fernald AA, Tennant TR, et al: Haploinsufficiency of EGR1, a candidate gene in the del(5q), leads to the development of myeloid disorders. Blood 110: 719-726, 2007.
6. Chen Z, Brand NJ, Chen A, et al: Fusion between a novel Kruppel-like zinc finger gene and the retinoic acid receptor-alpha locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia. EMBO J 12: 1161-1167, 1993.
7. Magalhaes IQ, Splendore A, Emerenciano M, Figueiredo A, Ferrari I and Pombo-de-Oliveira MS: GATA1 mutations in acute leukemia in children with Down syndrome. Cancer Genet Cytogenet 166: 112-116, 2006.
8. Miyagawa K, Hayashi Y, Fukuda T, Mitani K, Hirai H and Kamiya K: Mutations of the WT1 gene in childhood nonlymphoid hematological malignancies. Genes Chromosomes Cancer 25: 176-183, 1999.
9. Gou DM, Sun Y, Gao L, et al: Cloning and characterization of a novel Kruppel-like zinc finger gene, ZNF268, expressed in early human embryo. Biochim Biophys Acta 1518: 306-310, 2001.
10. Krackhardt AM, Witzens M, Harig S, et al: Identification of tumor-associated antigens in chronic lymphocytic leukemia by SEREX. Blood 100: 2123-2131, 2002.
11. Guo MX, Wang D, Shao HJ, et al: Transcription of human zinc finger ZNF268 gene requires an intragenic promoter element. J Biol Chem 281: 24623-24636, 2006.
12. Shankar DB, Cheng JC, Kinjo K, et al: The role of CREB as a proto-oncogene in hematopoiesis and in acute myeloid leukemia. Cancer Cell 7: 351-362, 2005.
13. Komor M, Guller S, Baldus CD, et al: Transcriptional profiling of human hematopoiesis during in vitro lineage-specific differentiation. Stem Cells 23: 1154-1169, 2005.
14. Shao H, Zhu C, Zhao Z, et al: KRAB-containing zinc finger gene ZNF268 encodes multiple alternatively spliced isoforms that contain transcription regulatory domains. Int J Mol Med 18: 457-463, 2006.
15. Sun C, Zhao ZZ, Gao L, Sun Y, Shao HJ and Li WX: Cloning and characterization of two novel alternatively spliced transcripts of ZNF268. Yi Chuan 28: 513-517, 2006.
16. Caceres JF and Kornblihtt AR: Alternative splicing: multiple control mechanisms and involvement in human disease. Trends Genet 18: 186-193, 2002.
17. Johnson JM, Castle J, Garrett-Engele P, et al: Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays. Science 302: 2141-2144, 2003.
18. Brinkman BM: Splice variants as cancer biomarkers. Clin Biochem 37: 584-594, 2004.
19. Pajares MJ, Ezponda T, Catena R, Calvo A, Pio R and Montuenga LM: Alternative splicing: an emerging topic in molecular and clinical oncology. Lancet Oncol 8: 349-357, 2007.
20. Black DL: Mechanisms of alternative pre-messenger RNA splicing. Annu Rev Biochem 72: 291-336, 2003.
21. Modrek B and Lee C: A genomic view of alternative splicing. Nat Genet 30: 13-19, 2002.
22. Black DL: Protein diversity from alternative splicing: a challenge for bioinformatics and post-genome biology. Cell 103: 367-370, 2000.
23. Graveley BR: Alternative splicing: increasing diversity in the proteomic world. Trends Genet 17: 100-107, 2001.
24. Pettigrew CA and Brown MA: Pre-mRNA splicing aberrations and cancer. Front Biosci 13: 1090-1105, 2008.
25. Baudry D, Hamelin M, Cabanis MO, et al: WT1 splicing alterations in Wilms' tumors. Clin Cancer Res 6: 3957-3965, 2000.
26. Zucchini C, Concu M, Martini F, et al: FHIT oncosuppressor gene expression profile in human anal cancers. Int J Biol Markers 22: 39-42, 2007.
27. Scaruffi P, Casciano I, Masiero L, Basso G, Romani M and Tonini GP: Lack of p73 expression in mature B-ALL and identification of three new splicing variants restricted to pre B and C-ALL indicate a role of p73 in B cell ALL differentiation. Leukemia 14: 518-519, 2000.
28. Maratheftis CI, Bolaraki PE, Giannouli S, Kapsogeorgou EK, Moutsopoulos HM and Voulgarelis M: Aberrant alternative splicing of interferon regulatory factor-1 (IRF-1) in myelodysplastic hematopoietic progenitor cells. Leukemia Res 30: 1177-1186, 2006.