KRAB-containing zinc finger gene ZNF268 encodes multiple alternatively spliced isoforms that contain transcription regulatory domains

International Journal of Molecular Medicine

Volumn 18, Issue 3, 2006, Pages 457-463

  Shao, Huanjie ^a   Zhu, Chengang ^a   Zhao, Zhouzhou ^a   Guo, Mingxiong ^a   Qiu, Hongling ^a   Liu, Hui ^a   Wang, Di ^a   Xue, Lu ^a   Gao, Li ^a   Sun, Chong ^a   Li, Wenxin ^a  

^a WUHAN UNIVERSITY   (China)

Author keywords

Alternative splicing; KRAB; Subcellular localization; Transcriptional activator; ZNF268

Indexed keywords

DNA BINDING PROTEIN; ISOPROTEIN; REPRESSOR PROTEIN; ZNF268 PROTEIN, HUMAN;

ALTERNATIVE RNA SPLICING; ANIMAL; ANTIBODY SPECIFICITY; ARTICLE; CELL CULTURE; CELL STRAIN COS1; CELL STRAIN K 562; CERCOPITHECUS; FETUS DEVELOPMENT; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HELA CELL; HUMAN; ISOLATION AND PURIFICATION; LEUKEMIA CELL LINE; METABOLISM; PROTEIN TERTIARY STRUCTURE; TISSUE DISTRIBUTION;

ALTERNATIVE SPLICING; ANIMALS; CERCOPITHECUS AETHIOPS; COS CELLS; DNA-BINDING PROTEINS; FETAL DEVELOPMENT; HELA CELLS; HUMANS; JURKAT CELLS; K562 CELLS; ORGAN SPECIFICITY; PROTEIN ISOFORMS; PROTEIN STRUCTURE, TERTIARY; REPRESSOR PROTEINS; TISSUE DISTRIBUTION; TRANSCRIPTION, GENETIC; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 33750581080     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.18.3.457     Document Type: Article

References (23)

1. Johnson JM, Castle J, Garrett-Engele P, Kan Z, Loerch PM, et al: Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays. Science 302: 2141-2144, 2003.
2. Modrek B and Lee C: A genomic view of alternative splicing. Nat Genet 30: 13-19, 2002.
3. Modrek B, Resch A, Grasso C and Lee C: Genome-wide detection of alternative splicing in expressed sequences of human genes. Nucleic Acids Res 29: 2850-2859, 2001.
4. Kan Z, Rouchka EC, Gish WR and States DJ: Gene structure prediction and alternative splicing analysis using genomically aligned ESTs. Genome Res 11: 889-900, 2001.
5. Brett D, Brett D, Hanke J, Lehmann G, Haase S, et al: EST comparison indicates 38% of human mRNAs contain possible alternative splice forms. FEBS Lett 474: 83-86, 2000.
6. Stamm S, Ben-Ari S, Rafalska I, Tang YS, et al: Function of alternative splicing. Gene 344: 1-20, 2005.
7. Schmucker D, Clemens JC, Shu H, Worby CA, Xiao J, et al: Drosophila Dscam is an axon guidance receptor exhibiting extraordinary molecular diversity. Cell 101: 671-684, 2000.
8. Watson FL, Puttmann-Holgado R, Thomas F, Lamar DL, et al: Extensive diversity of Ig-superfamily proteins in the immune system of insects. Science 309: 1874-1878, 2005.
9. Gou DM, Sun Y, Gao L, Chow LMC, Huang J, et al: Cloning and characterization of a novel Kruppel-like zinc finger gene, ZNF268, expressed in early human embryo. BBA 1518: 306-310, 2001.
10. Gebelein B and Urrutia R: Sequence-specific transcriptional repression by KS1, a multiple-zinc-finger-Kruppel-associated box protein. Mol Cell Biol 21: 928-939, 2001.
11. Sun Y, Shao HJ, Li Z, Liu J, Gao L, et al: ZNF268, a novel Kruppel-like zinc finger protein, is implicated in early human liver development. Int J Mol Med 14: 971-975, 2004.
12. Sun C, Zhao ZZ, Gao L, Sun Y, Shao HJ and Li WX: Cloning and characterization of two novel transcripts of ZNF268 in human blood cells. Yichuan (In press).
13. Krackhardt AM, Witzens M, Harig S, Hodi FS, et al: Identification of tumor-associated antigens in chronic lymphocytic leukemia by SEREX. Blood 100: 2123-2131, 2002.
14. Sun Y, Gou DM, Liu H, Peng X and Li WX: The KRAB domain of zinc finger gene ZNF268: a potential transcriptional repressor. IUBMB Life 55: 127-131, 2003.
15. Dang DT, Pevsner J and Yang VW: The biology of the mammalian Kruppel-like family of transcription factors. Int J Biochem Cell Biol 32: 1103-1121, 2001.
16. Gao L, Sun C, Qiu HL, Liu H, Shao HJ, et al: Cloning and characterization of a novel human zinc finger gene, hKid3, from a C2H2-ZNF enriched human embryonic cDNA library. Biochem Biophy Res Commun 325: 1145-1152, 2004.
17. Black DL: Mechanisms of alternative pre-messenger RNA splicing. Annu Rev Biochem 72: 291-336, 2003.
18. Garcia-Blanco MA, Baraniak AP and Lasda EL: Alternative splicing in disease and therapy. Nat Biotechnol 22: 535-546, 2004.
19. Faustino NA and Cooper TA: Pre-mRNA splicing and human disease. Genes Dev 17: 419-437, 2003.
20. Urrutia R: KRAB-containing zinc-finger repressor proteins. Genome Biol 4: 231, 2003.
21. Li YQ, Wang YQ, Zhang CB, et al: ZNF322, a novel human C2H2 Krüppel-like zinc-finger protein, regulates transcriptional activation in MAPK signaling pathways. Biochem Biophy Res Commun 325: 1383-1392, 2004.
22. Luo K, Yuan J, Shan Y, Li J, Xu M, et al: Activation of transcriptional activities of AP1 and SRE by a novel zinc finger protein ZNF445. Gene 367: 89-100, 2006.
23. Wang S, Liu S, Wu MH, Geng Y and Wood C: Identification of a cellular protein that interacts and synergizes with the RTA (ORF50) protein of Kaposi's sarcoma-associated herpesvirus in transcriptional activation. J Virol 75: 11961-11973, 2001.