PCLO Variants Are Nominally Associated with Early-Onset Type 2 Diabetes and Insulin Resistance in Pima Indians

Diabetes

Volumn 57, Issue 11, 2008, Pages 3156-3160

  Lijun, Ma ^a   Hanson, Robert L ^a   Que, Lorem N ^a   Guo, Yan ^a   Kobes, Sayuko ^a   Bogardus, Clifton ^a   Baier, Leslie J ^a  

^a National Institute of Diabetes   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; CONTROLLED STUDY; FEMALE; GENE; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOME ANALYSIS; GENOTYPE; HUMAN; HUMAN TISSUE; INDIAN; INSULIN RESISTANCE; INSULIN SENSITIVITY; JUVENILE DIABETES MELLITUS; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NUCLEOTIDE SEQUENCE; PCLO GENE; PRIORITY JOURNAL; AMERICAN INDIAN; GENE EXPRESSION PROFILING; GENE FREQUENCY; GENETIC PREDISPOSITION; GENETICS; MIDDLE AGED; PATHOPHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SINGLE NUCLEOTIDE POLYMORPHISM; UNITED STATES;

CYTOSKELETON PROTEIN; NEUROPEPTIDE; PCLO PROTEIN, HUMAN; UNCLASSIFIED DRUG;

ADULT; ARIZONA; CYTOSKELETAL PROTEINS; DIABETES MELLITUS, TYPE 2; FEMALE; GENE EXPRESSION PROFILING; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; INDIANS, NORTH AMERICAN; INSULIN RESISTANCE; MALE; MIDDLE AGED; NEUROPEPTIDES; POLYMORPHISM, SINGLE NUCLEOTIDE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; YOUNG ADULT;

EID: 58149333719     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db07-1800     Document Type: Article

References (22)

1. Knowler WC, Bennett PH, Hamman RF, Miller M: Diabetes incidence and prevalence in Pima Indians: a 19-fold greater incidence than in Rochester, Minnesota. Am J Epidemiol 108:497-505, 1978
2. Bogardus C: Metabolic abnormalities in the development of non-insulin dependent diabetes mellitus. In Diabetes Mellitus: A Fundamental and Clinical Text. LeRoith D, Taylor SI, Olefsky JM, Eds. Philadelphia PA, Lippincott-Raven, p. 459 -467, 1996
3. Baier LJ, Hanson RL: Genetic studies of the etiology of type 2 diabetes in Pima Indians: hunting for pieces to a complicated puzzle. Diabetes 53:1181-1186, 2004
4. Ravussin E, Bogardus C: Energy expenditure in the obese: is there a thrifty gene? Infusionstherapie 17:108-112, 1990
5. Sakul H, Pratley R, Cardon L, Ravussin E, Mott D, Bogardus C: Familiality of physical and metabolic characteristics that predict the development of non-insulin-dependent diabetes mellitus in Pima Indians. Am J Hum Genet 60:651-656, 1997
6. Hanson RL, Bogardus C, Duggan D, Kobes S, Knowlton M, Infante AM, Marovich L, Benitez D, Baier LJ, Knowler WC: A search for variants associated with Young-onset type 2 diabetes in American Indians in a 100K genotyping array. Diabetes 56:3045-3052, 2007
7. Fujimoto K, Shibasaki T, Yokoi N, Kashima Y, Matsumoto M, Sasaki T, Tajima N, Iwanaga T, Seino S: Piccolo, a Ca2+ sensor in pancreatic beta-cells: involvement of cAMP-GEFII.Rim2.Piccolo complex in cAMP-dependent exocytosis. J Biol Chem 277:50497-50502, 2002
8. Shibasaki T, Sunaga Y, Fujimoto K, Kashima Y, Seino S: Interaction of ATP sensor, cAMP sensor, Ca2+ sensor, and voltage-dependent Ca2+ channel in insulin granule exocytosis. J Biol Chem 279:7956-7961, 2004
9. Shibasaki T, Sunaga Y, Seino S: Integration of ATP, cAMP, and Ca2+ signals in insulin granule exocytosis. Diabetes 53 (Suppl. 3):S59-S62, 2004
10. Lanner JT, Katz A, Tavi P, Sandström ME, Zhang SJ, Wretman C, James S, Fauconnier J, Lännergren J, Bruton JD, Westerblad H: The role of Ca2 + influx for insulin-mediated glucose uptake in skeletal muscle. Diabetes 55:2077-2083, 2006
11. World Health Organization: Diabetes Mellitus: Report of a WHO Study Group. Geneva, World Health Org., 1985 (Tech. Rep. Ser., no. 727)
12. Lillioja S, Mott DM, Spraul M, Ferraro R, Foley JE, Ravussin E, Knowler WC, Bennett PH, Bogardus C: Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus:prospective studies of Pima Indians. N Engl J Med 329:1988-1992, 1993
13. Abecasis GR, Cardon LR, Cookson WO: A general test of association for quantitative traits in nuclear families. Am, J Hum, Genet 66:279-292, 2000
14. Sladek R, Rocheleau G, Rung J, Dina C, Shen L, Serre D, Boutin P, Vincent D, Belisle A, Hadjadj S, Balkau B, Heude B, Charpentier G, Hudson TJ, Montpetit A, Pshezhetsky AV, Prentki M, Posner BI, Balding DJ, Meyre D, Polychronakos C, Froguel P: A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature 445:881-885, 2007
15. Steinthorsdottir V, Thorleifsson G, Reynisdottir I, Benediktsson R, Jonsdottir T, Walters GB, Styrkarsdottir U, Gretarsdottir S, Emilsson V, Ghosh S, Baker A, Snorradottir S, Bjarnason H, Ng MC, Hansen T, Bagger Y, Wilensky RL, Reilly MP, Adeyemo A, Chen Y, Zhou J, Gudnason V, Chen G, Huang H, Lashley K, Doumatey A, So WY, Ma RC, Andersen G, Borch-Johnsen K, Jorgensen T, van Vliet-Ostaptchouk JV, Hofker MH, Wijmenga C, Christiansen C, Rader DJ, Rotimi C, Gurney M, Chan JC, Pedersen O, Sigurdsson G, Gulcher JR, Thorsteinsdottir U, Kong A, Stefansson K: A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. Nat Genet 39:770-775, 2007
16. Diabetes Genetics Initiative of Broad Institute of Harvard and MIT, Lund University, and Novartis Institutes of BioMedical Research, Saxena R, Voight BF, Lyssenko V, Burtt NP, de Bakker PI, Chen H, Roix JJ, Kathiresan S, Hirschhorn JN, Daly MJ, Hughes TE, Groop L, Altshuler D, Almgren P, Florez JC, Meyer J, Ardlie K, Bengtsson Böstrom K, Isomaa B, Lettre G, Lindblad U, Lyon HN, Melander O, Newton-Cheh C, Nilsson P, Orho-Melander M, Rastam L, Speliotes EK, Taskinen MR, Tuomi T, Guiducci C, Berglund A, Carlson J, Gianniny L, Hackett R, Hall L, Holmkvist J, Laurila E, Sjögren M, Sterner M, Surti A, Svensson M, Svensson M, Tewhey R, Blumenstiel B, Parkin M, Defelice M, Barry R, Brodeur W, Camarata J, Chia N, Fava M, Gibbons J, Handsaker B, Healy C, Nguyen K, Gates C, Sougnez C, Gage D, Nizzari M, Gabriel SB, Chirn GW, Ma Q, Parikh H, Richardson D, Ricke D, Purcell S: Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science 316:1331-1336, 2007
17. Scott LJ, Mohlke KL, Bonnycastle LL, Willer CJ, Li Y, Duren WL, Erdos MR, Stringham HM, Chines PS, Jackson AU, Prokunina-Olsson L, Ding CJ, Swift AJ, Narisu N, Hu T, Pruim R, Xiao R, Li XY, Conneely KN, Riebow NL, Sprau AG, Tong M, White PP, Hetrick KN, Barnhart MW, Bark CW, Goldstein JL, Watkins L, Xiang F, Saramies J, Buchanan TA, Watanabe RM, Valle TT, Kinnunen L, Abecasis GR, Pugh EW, Doheny KF, Bergman RN, Tuomilehto J, Collins FS, Boehnke M: A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science 316:1341-1345, 2007
18. Zeggini E, Weedon MN, Lindgren CM, Frayling TM, Elliott KS, Lango H, Timpson NJ, Perry JR, Rayner NW, Freathy RM, Barrett JC, Shields B, Morris AP, Ellard S, Groves CJ, Harries LW, Marchini JL, Owen KR, Knight B, Cardon LR, Walker M, Hitman GA, Morris AD, Doney AS; Wellcome Trust Case Control Consortium (WTCCC), McCarthy MI, Hattersley AT: Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science 316:1336-1341, 2007
19. The Wellcome Trust Case Control Consortium: Genome-wide association study of 14,000 cases of seven common disease and 3,000 shared controls. Nature 447:661-678, 2007
20. Zeggini E, Scott LJ, Saxena R, Voight BF, for the Diabetes Genetics Replication and Meta-analysis (DIAGRAM) Consortium: Meta-analysis of genome-Wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet 40:638-645, 2008
21. Matsuda Y, Saegusa H, Zong S, Noda T, Tanabe T: Mice lacking Ca(v) 2.3 (alpha1E) calcium channel exhibit hyperglycemia. Biochem Biophys Res Commun 289:791-795, 2001
22. Li Muller Y, Hanson RL, Zimmerman C, Harper I, Sutherland J, Kobes S, The International Type 2 diabetes 1q Consortium, Knowler WC, Bogardus C, Baier LJ: Variants in the Cav2.3 (a1E) subunit of voltage-activated Ca2 + channels are associated with insulin resistance and type 2 diabetes in Pima Indians. Diabetes 56:3089-3094, 2007