Modified tumour antigen-encoding mRNA facilitates the analysis of naturally occurring and vaccine-induced CD4 and CD8 T cells in cancer patients

Cancer Immunology, Immunotherapy

Volumn 58, Issue 3, 2009, Pages 325-338

  Knights, Ashley J ^a   Nuber, Natko ^a   Thomson, Christopher W ^a   De La Rosa, Olga ^a   Jäger, Elke ^b   Tiercy, Jean Marie ^c   Van Den Broek, Maries ^a   Pascolo, Steve ^a   Knuth, Alexander ^a   Zippelius, Alfred ^a,d  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b KRANKENHAUS NORDWEST   (Germany)

^c UNIVERSITY HOSPITAL   (Switzerland)

^d UNIVERSITY HOSPITAL BASEL   (Switzerland)

Author keywords

Antigens peptides epitopes; T cells; Tumour immunity; Vaccination

Indexed keywords

CANCER VACCINE; EPITOPE; HLA B ANTIGEN; HLA B49 ANTIGEN; MESSENGER RNA; NY ESO 1 ANTIGEN; RECOMBINANT VACCINE; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG; VACCINIA VACCINE; VIRUS VACCINE;

ANTIGEN PRESENTING CELL; ANTIGEN RECOGNITION; ARTICLE; BLOOD ANALYSIS; CANCER IMMUNIZATION; CANCER PATIENT; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL CLONE; CELL KILLING; CONTROLLED STUDY; FOWLPOX VIRUS; HLA SYSTEM; HUMAN; HUMAN CELL; HUMORAL IMMUNITY; IN VITRO STUDY; MEMORY T LYMPHOCYTE; NEOPLASM; PRIORITY JOURNAL; TREATMENT RESPONSE; TUMOR IMMUNITY;

ANTIBODIES, MONOCLONAL; ANTIGENS, NEOPLASM; CANCER VACCINES; CARCINOMA, NON-SMALL-CELL LUNG; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL LINE, TUMOR; EPITOPES; HUMANS; INTERFERON-GAMMA; LUNG NEOPLASMS; MODELS, GENETIC; NEOPLASMS; PEPTIDES; RNA, MESSENGER;

EID: 58149308061     PISSN: 03407004     EISSN: 14320851     Source Type: Journal    
DOI: 10.1007/s00262-008-0556-8     Document Type: Article

References (41)

1. P van der Bruggen C Traversari P Chomez C Lurquin E De Plaen B Van den Eynde A Knuth T Boon 1991 A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma Science 254 1643 1647
2. MJ Scanlan AJ Simpson LJ Old 2004 The cancer/testis genes: review, standardization, and commentary Cancer Immun 4 1
3. MJ Scanlan AO Gure AA Jungbluth LJ Old YT Chen 2002 Cancer/testis antigens: an expanding family of targets for cancer immunotherapy Immunol Rev 188 22 32
4. J Vansteenkiste M Zielinski A Linder J Dahabre E Esteban W Malinowski J Jassem B Passlick F Lehmann VG Brichard 2007 Final results of a multi-center, double-blind, randomized, placebo-controlled phase II study to assess the efficacy of MAGE-A3 immunotherapeutic as adjuvant therapy in stage IB/II non-small cell lung cancer (NSCLC) J Clin Oncol 25 18S 7554
5. S Gnjatic H Nishikawa AA Jungbluth AO Gure G Ritter E Jager A Knuth YT Chen LJ Old 2006 NY-ESO-1: review of an immunogenic tumor antigen Adv Cancer Res 95 1 3077
6. T Nicholaou L Ebert ID Davis N Robson O Klein E Maraskovsky W Chen J Cebon 2006 Directions in the immune targeting of cancer: lessons learned from the cancer-testis Ag NY-ESO-1 Immunol Cell Biol 84 303 317
7. E Jager J Karbach S Gnjatic A Neumann A Bender D Valmori M Ayyoub E Ritter G Ritter D Jager D Panicali E Hoffman L Pan H Oettgen LJ Old A Knuth 2006 Recombinant vaccinia/fowlpox NY-ESO-1 vaccines induce both humoral and cellular NY-ESO-1-specific immune responses in cancer patients Proc Natl Acad Sci U S A 103 14453 14458
8. ID Davis W Chen H Jackson P Parente M Shackleton W Hopkins Q Chen N Dimopoulos T Luke R Murphy AM Scott E Maraskovsky G McArthur D MacGregor S Sturrock TY Tai S Green A Cuthbertson D Maher L Miloradovic SV Mitchell G Ritter AA Jungbluth YT Chen S Gnjatic EW Hoffman LJ Old JS Cebon 2004 Recombinant NY-ESO-1 protein with ISCOMATRIX adjuvant induces broad integrated antibody and CD4(+) and CD8(+) T cell responses in humans Proc Natl Acad Sci U S A 101 10697 10702
9. VH Engelhard M Altrich-Vanlith M Ostankovitch AL Zarling 2006 Post-translational modifications of naturally processed MHC-binding epitopes Curr Opin Immunol 18 92 97
10. LD Falo Jr LJ Colarusso B Benacerraf KL Rock 1992 Serum proteases alter the antigenicity of peptides presented by class I major histocompatibility complex molecules Proc Natl Acad Sci U S A 89 8347 8350
11. SK Nair D Boczkowski M Morse RI Cumming HK Lyerly E Gilboa 1998 Induction of primary carcinoembryonic antigen (CEA)-specific cytotoxic T lymphocytes in vitro using human dendritic cells transfected with RNA Nat Biotechnol 16 364 369
12. A Heiser D Coleman J Dannull D Yancey MA Maurice CD Lallas P Dahm D Niedzwiecki E Gilboa J Vieweg 2002 Autologous dendritic cells transfected with prostate-specific antigen RNA stimulate CTL responses against metastatic prostate tumors J Clin Invest 109 409 417
13. Grunebach F, Erndt S, Hantschel M, Heine A, Brossart P (2008) Generation of antigen-specific CTL responses using RGS1 mRNA transfected dendritic cells. Cancer Immunol Immunother Feb 27 [Epub ahead of print]. doi: 10.1007/s00262-008-0486-5
14. B Weide JP Carralot A Reese B Scheel TK Eigentler I Hoerr HF Rammensee C Garbe S Pascolo 2008 Results of the first phase I/II clinical vaccination trial with direct injection of mRNA J Immunother 31 180 188
15. R Teufel JP Carralot B Scheel J Probst S Walter G Jung I Hoerr HG Rammensee S Pascolo 2005 Human peripheral blood mononuclear cells transfected with messenger RNA stimulate antigen-specific cytotoxic T-lymphocytes in vitro Cell Mol Life Sci 62 1755 1762
16. S Kreiter T Konrad M Sester C Huber O Tureci U Sahin 2007 Simultaneous ex vivo quantification of antigen-specific CD4+ and CD8+ T cell responses using in vitro transcribed RNA Cancer Immunol Immunother 56 1577 1587
17. SM Walton M Gerlinger O de la Rosa N Nuber A Knights A Gati M Laumer L Strauss C Exner N Schafer M Urosevic R Dummer JM Tiercy A Mackensen E Jaeger F Levy A Knuth D Jager A Zippelius 2006 Spontaneous CD8 T cell responses against the melanocyte differentiation antigen RAB38/NY-MEL-1 in melanoma patients J Immunol 177 8212 8218
18. G Pawelec SG Marsh 2006 ESTDAB: a collection of immunologically characterised melanoma cell lines and searchable databank Cancer Immunol Immunother 55 623 627
19. MG Mathieu AJ Knights G Pawelec CL Riley D Wernet FA Lemonnier PT Straten L Mueller RC Rees SE McArdle 2007 HAGE, a cancer/testis antigen with potential for melanoma immunotherapy: identification of several MHC class I/II HAGE-derived immunogenic peptides Cancer Immunol Immunother 56 1885 1895
20. YT Chen MJ Scanlan U Sahin O Tureci AO Gure S Tsang B Williamson E Stockert M Pfreundschuh LJ Old 1997 A testicular antigen aberrantly expressed in human cancers detected by autologous antibody screening Proc Natl Acad Sci USA 94 1914 1918
21. JP Carralot J Probst I Hoerr B Scheel R Teufel G Jung HG Rammensee S Pascolo 2004 Polarization of immunity induced by direct injection of naked sequence-stabilized mRNA vaccines Cell Mol Life Sci 61 2418 2424
22. A Zippelius P Batard V Rubio-Godoy G Bioley D Lienard F Lejeune D Rimoldi P Guillaume N Meidenbauer A Mackensen N Rufer N Lubenow D Speiser JC Cerottini P Romero MJ Pittet 2004 Effector function of human tumor-specific CD8 T cells in melanoma lesions: a state of local functional tolerance Cancer Res 64 2865 2873
23. MJ Pittet A Zippelius DE Speiser M Assenmacher P Guillaume D Valmori D Lienard F Lejeune JC Cerottini P Romero 2001 Ex vivo IFN-gamma secretion by circulating CD8 T lymphocytes: implications of a novel approach for T cell monitoring in infectious and malignant diseases J Immunol 166 7634 7640
24. D Atanackovic M Matsuo E Ritter G Mazzara G Ritter E Jager A Knuth LJ Old S Gnjatic 2003 Monitoring CD4+ T cell responses against viral and tumor antigens using T cells as novel target APC J Immunol Methods 278 57 66
25. JW Yewdell CV Nicchitta 2006 The DRiP hypothesis decennial: support, controversy, refinement and extension Trends Immunol 27 368 373
26. E Jager YT Chen JW Drijfhout J Karbach M Ringhoffer D Jager M Arand H Wada Y Noguchi E Stockert LJ Old A Knuth 1998 Simultaneous humoral and cellular immune response against cancer-testis antigen NY-ESO-1: definition of human histocompatibility leukocyte antigen (HLA)-A2-binding peptide epitopes J Exp Med 187 265 270
27. S Gnjatic D Atanackovic E Jager M Matsuo A Selvakumar NK Altorki RG Maki B Dupont G Ritter YT Chen A Knuth LJ Old 2003 Survey of naturally occurring CD4+ T cell responses against NY-ESO-1 in cancer patients: correlation with antibody responses Proc Natl Acad Sci U S A 100 8862 8867
28. F Sallusto D Lenig R Forster M Lipp A Lanzavecchia 1999 Two subsets of memory T lymphocytes with distinct homing potentials and effector functions Nature 401 708 712
29. J Karbach C Pauligk A Bender S Gnjatic K Franzmann C Wahle D Jager A Knuth LJ Old E Jager 2006 Identification of new NY-ESO-1 epitopes recognized by CD4+ T cells and presented by HLA-DQ B1 03011 Int J Cancer 118 668 674
30. P Baumgaertner N Rufer E Devevre L Derre D Rimoldi C Geldhof V Voelter D Lienard P Romero DE Speiser 2006 Ex vivo detectable human CD8 T-cell responses to cancer-testis antigens Cancer Res 66 1912 1916
31. G Bioley C Jandus S Tuyaerts D Rimoldi WW Kwok DE Speiser JM Tiercy K Thielemans JC Cerottini P Romero 2006 Melan-A/MART-1-specific CD4 T cells in melanoma patients: identification of new epitopes and ex vivo visualization of specific T cells by MHC class II tetramers J Immunol 177 6769 6779
32. R Harrop N Drury W Shingler P Chikoti I Redchenko MW Carroll SM Kingsman S Naylor A Melcher J Nicholls H Wassan N Habib A Anthoney 2007 Vaccination of colorectal cancer patients with modified vaccinia ankara encoding the tumor antigen 5T4 (TroVax) given alongside chemotherapy induces potent immune responses Clin Cancer Res 13 4487 4494
33. PG Coulie T Connerotte 2005 Human tumor-specific T lymphocytes: does function matter more than number? Curr Opin Immunol 17 320 325
34. W Zou 2005 Immunosuppressive networks in the tumour environment and their therapeutic relevance Nat Rev Cancer 5 263 274
35. V Appay C Jandus V Voelter S Reynard SE Coupland D Rimoldi D Lienard P Guillaume AM Krieg JC Cerottini P Romero S Leyvraz N Rufer DE Speiser 2006 New generation vaccine induces effective melanoma-specific CD8+ T cells in the circulation but not in the tumor site J Immunol 177 1670 1678
36. A Michiels S Tuyaerts A Bonehill J Corthals K Breckpot C Heirman S Van Meirvenne M Dullaers S Allard F Brasseur P van der Bruggen K Thielemans 2005 Electroporation of immature and mature dendritic cells: implications for dendritic cell-based vaccines Gene Ther 12 772 782
37. H Naota Y Miyahara S Okumura K Kuzushima Y Akatsuka A Hiasa S Kitano T Takahashi A Yuta Y Majima H Shiku 2006 Generation of peptide-specific CD8+ T cells by phytohemagglutinin-stimulated antigen-mRNA-transduced CD4+ T cells J Immunol Methods 314 54 66
38. S Kreiter A Selmi M Diken M Sebastian P Osterloh H Schild C Huber O Tureci U Sahin 2008 Increased antigen presentation efficiency by coupling antigens to MHC class I trafficking signals J Immunol 180 309 318
39. A Bonehill C Heirman S Tuyaerts A Michiels Y Zhang P van der Bruggen K Thielemans 2003 Efficient presentation of known HLA class II-restricted MAGE-A3 epitopes by dendritic cells electroporated with messenger RNA encoding an invariant chain with genetic exchange of class II-associated invariant chain peptide Cancer Res 63 5587 5594
40. M Fassnacht J Lee C Milazzo D Boczkowski Z Su S Nair E Gilboa 2005 Induction of CD4(+) and CD8(+) T-cell responses to the human stromal antigen, fibroblast activation protein: implication for cancer immunotherapy Clin Cancer Res 11 5566 5571
41. DG Kavanagh DE Kaufmann S Sunderji N Frahm S Le Gall D Boczkowski ES Rosenberg DR Stone MN Johnston BS Wagner MT Zaman C Brander E Gilboa BD Walker N Bhardwaj 2006 Expansion of HIV-specific CD4+ and CD8+ T cells by dendritic cells transfected with mRNA encoding cytoplasm- or lysosome-targeted Nef Blood 107 1963 1969