Enhancement of diphtheria toxin potency by replacement of the receptor binding domain with tetanus toxin C-fragment: A potential vector for delivering heterologous proteins to neurons

Journal of Neurochemistry

Volumn 74, Issue 6, 2000, Pages 2528-2536

  Francis, Jonathan W ^d   Brown Jr , Robert H ^e   Figueiredo, Dayse ^b   Remington, Mary P ^c   Castillo, Orlando ^e   Schwarzschild, Michael A ^e   Fishman, Paul S ^b,c   Murphy, John R ^a   VanderSpek, Johanna C ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^c BALTIMORE VA MEDICAL CENTER   (United States)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

^e NONE

Author keywords

Diphtheria toxin:tetanus toxin fusion protein; Neurons; Vector delivery system

Indexed keywords

ADENOSINE DIPHOSPHATE; CELL PROTEIN; DIPHTHERIA TOXIN; HYBRID PROTEIN; TETANUS TOXIN;

ARTICLE; CATALYSIS; CYTOSOL; ENZYME ACTIVITY; FUSION GENE; NEUROTOXICITY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PURIFICATION; PROTEIN SYNTHESIS; RECEPTOR BINDING;

3T3 CELLS; ANIMALS; BINDING SITES; CARBON RADIOISOTOPES; CLONING, MOLECULAR; CORPUS STRIATUM; CYTOSOL; CYTOTOXINS; DIPHTHERIA TOXIN; ENDOCYTOSIS; GENE EXPRESSION; GENETIC VECTORS; HYBRID CELLS; LEUCINE; MICE; NEURONS; PEPTIDE FRAGMENTS; PLASMIDS; RATS; RECOMBINANT FUSION PROTEINS; TETANUS TOXIN;

EID: 0034073932     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2000.0742528.x     Document Type: Article

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