Design and synthesis of stereochemically defined novel spirocyclic p2-ligands for hiv-1 protease inhibitors

Organic Letters

Volumn 10, Issue 22, 2008, Pages 5135-5138

  Ghosh, Arun K ^a   Chapsal, Bruno D ^a   Baldridge, Abigail ^a   Ide, Kazuhiko ^b   Koh, Yashiro ^c   Mitsuya, Hiroaki ^b,c  

^a PURDUE UNIVERSITY   (United States)

^b KUMAMOTO UNIVERSITY   (Japan)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LIGAND; P16 PROTEASE, HUMAN IMMUNODEFICIENCY VIRUS 1; PROTEINASE; PROTEINASE INHIBITOR; SPIRO COMPOUND; UNCLASSIFIED DRUG;

ARTICLE; CHEMISTRY; DRUG DESIGN; DRUG EFFECT; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; METABOLISM; STEREOISOMERISM; SYNTHESIS;

DRUG DESIGN; HIV PROTEASE; HIV PROTEASE INHIBITORS; HIV-1; HUMANS; LIGANDS; SPIRO COMPOUNDS; STEREOISOMERISM;

EID: 58149186764     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol8020308     Document Type: Article

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