Relation between human papillomavirus positivity and p16 expression in head and neck carcinomas - A tissue microarray study

Anticancer Research

Volumn 27, Issue 1 A, 2007, Pages 283-288

  König, Frank ^a   Krekeler, Gisbert ^b   Hönig, Johannes F ^c   Cordon Cardo, Carlos ^d   Fischer, Gösta ^e   Korabiowska, Monika ^e,f  

^a DANUBE UNIVERSITY KREMS   (Austria)

^b UNIVERSITY OF FREIBURG   (Germany)

^c UNIVERSITY OF GÖTTINGEN   (Germany)

^d MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^e UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

^f Reinhard Nieter Krankenhaus Stadtische Kliniken gGmbH   (Germany)

Author keywords

Head and neck cancer; HPV16,18; HPV6,11; p16; Tissue microarrays

Indexed keywords

PROTEIN P16;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; HEAD AND NECK CARCINOMA; HUMAN; HUMAN PAPILLOMAVIRUS TYPE 16; HUMAN PAPILLOMAVIRUS TYPE 18; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; IN SITU HYBRIDIZATION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SQUAMOUS CELL CARCINOMA; TISSUE MICROARRAY; VIRUS STRAIN; WART VIRUS;

ADULT; AGED; AGED, 80 AND OVER; ALPHAPAPILLOMAVIRUS; CARCINOMA, SQUAMOUS CELL; CYCLIN-DEPENDENT KINASE INHIBITOR P16; FEMALE; HUMAN PAPILLOMAVIRUS 11; HUMAN PAPILLOMAVIRUS 16; HUMAN PAPILLOMAVIRUS 18; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; LARYNGEAL NEOPLASMS; MALE; MIDDLE AGED; MOUTH NEOPLASMS; PAPILLOMAVIRUS INFECTIONS; TISSUE ARRAY ANALYSIS;

EID: 33847643791     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Von Knebel Doeberitz M: New molecular tools for efficient screening of cervical cancer. Dis Markers 17: 123-128, 2001.
2. Unger ER, Vernon SD, Thoms WW et al: Human papillomavirus and disease free survival in FIGO stage Ib cervical cancer. J Infect Dis 127: 1184-1190, 1995.
3. Wright TC, Denny L, Kuhn L et al: HPV-DNA testing of self collected vaginal samples compared with cytologic screening to detect cervical cancer. JAMA 283: 81-86, 2000.
4. Bleul C, Müller M, Frank R et al: Human papillomavirus type 18 e6 and e7 antibodies in human sera; increased anti e7 prevalence in cervical cancer patients. J Clin Microbiol 29: 1579-1588, 1991.
5. Köchel HG, Monazachian M, Sievert K et al: Occurrence of antibodies to 11, 12, e4 and e7 gene products of hpv types 6b, 16 and 18 among cervical cancer patients and controls. Int J Cancer 48: 682-688, 1991.
6. Klaes R, Friedrich T, Spitkovsky D et al: Overexpression of p16(INK4a)as a specific marker for dysplastic and neoplastic epithelial cells of the cervix uteri. Int J Cancer 92: 276-284, 2001.
7. Klaes R, Benner A, Friedrich T et al: P16INK4a immunohistochemistry improves interobserver agreement in the diagnosis of cervical intraepithelial neoplasia. Am J Surg Pathol 26: 1389-1399, 2002.
8. Arap W, Nishikawa R, Furnari FB et al: Replacement of the p16/CDKN2 gene suppresses glioma cell growth. Cancer Res 55: 1351-1354, 1995.
9. Kamb A, Shattuck-Eidens D, Eeles R et al: Analysis of the p16 gene (CDKN2) as a candidate for the chromosome 9p melanoma susceptibility locus. Nat Genet 8: 22-26, 1994.
10. Dreyling MH, Bohlander SK, Adeyanju MO et al: Detection of CDKN2 deletions in tumor cell lines and primary glioma by interphase fluorescence in situ hybridisation. Cancer Res 55: 984-988, 1995.
11. Murphy N, Ring M, Killalea AG et al: P16 INKa4 as a marker of cervical dyskaryosis: CIN and cGIN in cervical biopsies and thinprep smears. J Clin Pathol 56: 56-63, 2003.
12. Saqi A, Pasha TL, McGrath CM et al: Overexpression of p16INK4a in liquid based specimens (surepath) as marker of cervical dysplasia and neoplasia. Diagn Cytopathol 27: 365-370, 2002.
13. Caldas C, Hahn SA, daCosta LT et al: Frequent somatic mutations and homozygous deletions of the p16 MTS1 gene in pancreatic adenocarcinoma. Nat Genet 8: 27-32, 1994.
14. Hussusian CJ, Struewing JP, Goldstein AM et al: Germline p16 mutations in familial melanoma. Nat Genet 8: 15-21, 1994.
15. Duensing S and Munger K: The human papillomavirus type 16 e6 and e7 oncoproteins independently induce numerical and structural chromosome instability. Cancer Res 62: 7075-7082, 2002.
16. Spiessl B: Clinical classification of mouth neoplasms according to their anatomical aspects. Strahlentherapie [Sonderb] 68: 31-37, 1969.
17. Spiessl B and Fries R: The TNM system as basis for the classification of mouth cavity carcinomas. Dtsch Zahn Mund Kieferheilkd Zentralbl Gesamte 54: 179-192, 1970.
18. Breitschopf H, Suchanek G, Gould RM et al: In situ hybridization with digoxigenin labeled probes sensitive and reliable detection method applied to myelinating rat brain. Acta Neuropathol Berl 84: 581-587, 1992.
19. Hernando E, Nahle Z, Juan G et al: Rb inactivation promotes genomic instability by uncoupling cell cycle progression from mitotic control. Nature 430: 797-802, 2004.
20. Missaoui N, Hmissa S, Frappart L et al: P16(INK4a) overexpression and HPV infection in uterine cervix adenocarcinoma. Virchows Arch, in press 2006.
21. O'Neill CJ and McCluggage WG: P16 expression in the female genital tract and its value in diagnosis. Adv Anat Pathol 13: 8-15, 2006.
22. Ishikawa M, Fujii T, Saito M et al: Overexpression of p16INK4a as an indicator for human papillomavirus oncogenic activity in cervical squamous neoplasia. Int J Gynecol Cancer 16: 347-353, 2006.
23. Benevolo M, Mottolese M, Marandino F et al: Immunohistochemical expression of p16(INK4a) is predictive of HR-HPV infection in cervical low-grade lesions. Mod Pathol 19: 384-391, 2006
24. Carozzi F, Cecchini S, Confortini M et al: Role of p16(INK4a) expression in identifying CIN2 or more severe lesions among HPV-positive patients referred for colcoscopy after abnormal cytology. Cancer 108(2): 119-123, 2006.
25. Hoos A, Urist MJ, Stojadinovic A et al: Validation of tissue microarrays for immunohistochemical profiling of cancer specimens using the example of human fibroblastic tumors. Am J Pathol 158: 1245-1251, 2001.
26. Kononen J, Bubendorf L, Kallioniemi A et al: Tissue microarrays for high throughput molecular profiling of tumour specimens. Nat Med 4: 844-847, 1998.
27. El-Mofty SK and Patil S: Human papillomavirus (HPV)-related oropharyngeal nonkeratinizing squamous cell carcinoma: characterisation of a distinct type. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 101: 339-345, 2006
28. Slebos RJ, Yi Y, Ely K et al: Gene expression differences associated with human papillomavirus status in head and neck squamous cell carcinoma. Clin Cancer Res 12: 701-709, 2006.
29. Weinberger PM, Yu Z, Haffty BG et al: Molecular classification identifies a subset of human papillomavirus-associated oropharyngeal cancers with favorable prognosis. J Clin Oncol 24: 736-747, 2006.
30. Mellin-Dahlstrand H, Lindquist D, Bjornestal L et al: P16(INK4A) correlates to human papillomavirus presence response to radiotherapy and clinical outcome in tonsilliar carcinomas. Anticancer Res 25: 4375-4384, 2005.