Role of neoadjuvant treatment in cT3N0M0 rectal cancer

Anticancer Research

Volumn 28, Issue 6 B, 2008, Pages 4129-4135

  Pasetto, Lara Maria ^a   Friso, Maria Luisa ^b   Pucciarelli, Salvatore ^a   Basso, Umberto ^a   Rugge, Massimo ^a   Sinigaglia, Giulietta ^a   Rossi, Elena ^a   Compostella, Alessia ^a   Toppan, Paola ^a   Agostini, Marco ^a   Monfardini, Silvio ^a  

^a VENETO INSTITUTE OF ONCOLOGY IOV IRCCS   (Italy)

^b UNIVERSITY HOSPITAL OF PADOVA   (Italy)

Author keywords

cT3N0M0; Neoadjuvant chemotherapy; Rectal cancer

Indexed keywords

ANTINEOPLASTIC AGENT; CAPECITABINE; FLUOROURACIL; FOLINIC ACID; OXALIPLATIN;

ADJUVANT CHEMOTHERAPY; ADULT; AGED; ANEMIA; ARTICLE; ASTHENIA; CANCER GROWTH; CANCER RADIOTHERAPY; CANCER RELAPSE; CANCER STAGING; CANCER SURGERY; CANCER SURVIVAL; CLINICAL ARTICLE; COMBINATION CHEMOTHERAPY; CONTINUOUS INFUSION; CONTROLLED STUDY; DIARRHEA; DISEASE SEVERITY; DRUG DOSE REDUCTION; DYSURIA; FATIGUE; FEMALE; FOLLOW UP; GASTROINTESTINAL TOXICITY; HEMATOLOGIC DISEASE; HUMAN; HUMAN TISSUE; LEUKOPENIA; MALE; MONOTHERAPY; MORBIDITY; MORTALITY; MUCOSA INFLAMMATION; NAUSEA; PATIENT COMPLIANCE; PRIORITY JOURNAL; PROCTITIS; RADIATION DOSE; RECTUM CANCER; SKIN DISEASE; SPHINCTER; STOMATITIS; THROMBOCYTOPENIA; TREATMENT DURATION; TREATMENT RESPONSE; TUMOR LOCALIZATION; VOMITING;

ADULT; AGED; AGED, 80 AND OVER; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CHEMOTHERAPY, ADJUVANT; DEOXYCYTIDINE; DISEASE-FREE SURVIVAL; FEMALE; FLUOROURACIL; HUMANS; MALE; MIDDLE AGED; NEOADJUVANT THERAPY; NEOPLASM STAGING; ORGANOPLATINUM COMPOUNDS; RADIOTHERAPY, ADJUVANT; RECTAL NEOPLASMS; YOUNG ADULT;

EID: 58149151511     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. NIH Consensus Conference 'Adjuvant therapy for patients with colon and rectal cancer' JAMA 264: 1444-1450, 1990.
2. Minsky BD, Cohen AM, Kemeny N, Enker WE, Kelsen DP, Reichman B et al: Combined modality therapy of rectal cancer: decreased acute toxicity with the preoperative approach. J Clin Oncol 10: 1218-1224, 1992.
3. Minsky BD, Cohen AM, Enker WE, Saltz L, Guillem JG, Paty PB et al: Preoperative 5-FU, low-dose leucovorin, and radiation therapy for locally advanced and unresectable rectal cancer. Int J Radiat Oncol Biol Phys 37: 289-295, 1997.
4. Minsky BD, Cohen AM, Enker WE and Paty P: Sphincter preservation with preoperative radiation therapy and coloanal anastomosis. Int J Radiat Oncol Biol Phys 31: 553-559, 1995.
5. Janjan NA, Khoo VS, Abbruzzese J, Pazdur R, Dubrow R, Cleary KR et al: Tumour down-staging and sphincter preservation with preoperative chemoradiation in locally advanced rectal cancer: the M.D. Anderson Cancer Center Experience. Int J Radiat Oncol Biol Phys 44: 1027-1038, 1999.
6. Valentini V, Coco C, Picciocchi A, Morganti AG, Tradelia L, Ciabattoni A et al: Does down-staging predict improved outcome after preoperative chemoradiation for extraperitoneal locally advanced rectal cancer? A long-term analysis of 165 patients. Int J Radiat Oncol Biol Phys 53: 664-674, 2002.
7. Janjan NA, Crane CN, Feig BW, Cleary K, Dubrow R, Curley SA et al: Prospective trial of preoperative concomitant boost radiotherapy with continuous infusion 5-fluorouracil for locally advanced rectal cancer. Int J Radiat Oncol Biol Phys 47: 713-718, 2000.
8. Pucciarelli S, Friso ML, Toppan P, Fornasiero A, Carnio S, Marchiori E and Lise M: Preoperative combined radiotherapy and chemotherapy for middle and lower rectal cancer: preliminary results. Ann Surg Oncol 7: 38-44, 2000.
9. Chan AK, Wong AO, Langevin J, Jenken D, Heine J, Buie D and Johnson DR: Preoperative chemotherapy and pelvic radiation therapy for tethered or fixed rectal cancer: a phase II dose escalation study. Int J Radiat Oncol Biol Phys 48: 843-856, 2000.
10. Desch CE, Benson AB, Smith TJ, Flynn PJ, Krause C, Loprinzi CL et al: Recommended colorectal cancer surveillance guidelines by the American Society of Clinical Oncology. J Clin Oncol 17(4): 1312-1316, 1999.
11. Paty PB, Enker WE, Cohen AM, Minsky BD and Friedlander-Klar H: Long-term functional results of coloanal anastomosis for rectal cancer. Am J Surg 167: 90-95, 1994.
12. Minsky BD, Cohen AM, Kemeny N, Enker WE, Kelsen DP, Saltz L and Frankel J: The efficacy of preoperative 5-fluorouracil, high-dose leucovorin, and sequential radiation therapy for unresectable rectal cancer. Cancer 71(11): 3486-3492, 1993.
13. Merchant NB, Guillem JG, Paty PB, Enker WE, Minsky BD, Quan SH et al: T3N0 rectal cancer: results following sharp mesorectal excision and no adjuvant therapy. J Gastrointest Surg 3(6): 642-647, 1999.
14. Bosset JF, Pavy JJ, Hamers HP, Horiot JC, Fabri MC, Rougier P et al: Determination of the optimal dose of 5-fluorouracil when combined with low dose D,L-leucovorin and irradiation in rectal cancer: results of three consecutive phase II studies. EORTC Radiotherapy Group. Eur J Cancer 29(10): 1406-1410, 1993.
15. Marsh RD, Chu NM, Vauthey JN, Mendenhall WM, Lauwers GY, Bewsher C and Copeland EM: Preoperative treatment of patients with locally advanced unresectable rectal adenocarcinoma utilizing continuous chronobiologically shaped 5fluorouracil infusion and radiation therapy. Cancer 78(2): 217-225, 1996.
16. Mohiuddin M, Regine Wf, John WJ, Hagihara PF, McGrath PC, Kenady DE and Marks G: Preoperative chemoradiation in fixed distal rectal cancer: dose time factors for pathological complete response. Int Radiat Oncol Biol Phys 46(4): 883-888, 2000.
17. Streit M, Jaehde U, Stremetzne S, Ridwelski K, Kerz H, Strohbach F et al: Five days continuous infusion of 5-fluorouracil and pulsed folinic acid in patients with metastatic colorectal carcinoma: an effective second-line regimen. Ann Oncol 8(11): 163-165, 1997.
18. Hartmann JT, Kohne CH, Schmoll HJ, Daikeler T, Kanz L and Bokemeyer C: Is continuous 24-hour infusion of 5-fluorouracil plus high dose folinic-acid effective in patients with progressive or recurrent colorectal cancer? A phase II study. Oncology 55(4): 320-325, 1998.
19. Chiara S, Nobile MT, Vincenti M, Lionetto R, Gozza A. Barzacchi MC et al: Advanced colorectal cancer in the elderly: results of consecutive trials with 5-fluorouracil-based chemotherapy. Cancer Chemother Pharmacol 42(4): 336-340, 1998.
20. Stein BN, Petrelli NJ, Douglass HO, Driscoll DL, Arcangeli G and Meropol NJ: Age and sex are independent predictors of 5-FU toxicity. Analysis of a large scale phase III trial. Cancer 75: 11-17, 1995.
21. AJCC American Joint Committee on Cancer. Fleming DI, Cooper SJ, Henson ED, Hutter VR, Kennedy JB, Murphy PG, O'Sullivan B, Sobin HL and Yarbro WJ (eds.). AJCC Cancer Staging Manual, 5th ed. Philadelphia, Lippincott-Raven pp. 83-90, 1997.
22. Park JO, Lee Sl, Song SY, Kim K, Kim WS, Jung CW et al: Measuring response in solid tumours: comparison of RECIST and WHO response criteria. Jpn J Clin Oncol 33(10): 533-537, 2003.
23. Kaplan EL and Meier P: Non-parametric estimation for incomplete observation. J Am Stat Assoc 53: 457-481, 1958.
24. Pucciarelli S, Toppan P, Friso ML, Russo V, Pasetto L, Urso E, Marino F, Ambrosi A and Lise M: Complete pathologic response following preoperative chemoradiation therapy for middle to lower rectal cancer is not a prognostic factor for a better outcome. Dis Colon Rectum 47(11): 1798-1807, 2004.
25. Valentini V, Glimelius B, Minsky BD, Van Cutsem E, Bartelink H, Beets-Tan RG et al: The multidisciplinary rectal cancer treatment: main convergences, controversial aspects and investigational areas which support the need for an European Consensus. Radiother Oncol 76(3): 241-250, 2005.
26. Desch CE, Benson AB, Smith TJ, Flynn PJ, Krause C, Loprinzi CL et al: Recommended colorectal cancer surveillance guidelines by the American Society of Clinical Oncology. J Clin Oncol 17(4): 1312, 1999.
27. Roh M, Petrelli N, Wieand S et al: Phase III randomized trial of preoperative versus postoperative multimodality therapy in patients with carcinoma of the rectum. Proc Am Soc Clin Oncol 20: 123a (abs 490), 2001.
28. Sauer R, Fietkau R, Wittekind C, Rödel C, Martus P, Hohenberger W et al: Adjuvant versus neoadjuvant radiochemotherapy for locally advanced rectal cancer: the German trial CAO/ARO/AIO-94. Colorectal Dis 5(5): 406-415, 2003.