Conjugated linoleic acid (CLA) inhibits expression of the spot 14 (THRSP) and fatty acid synthase genes and impairs the growth of human breast cancer and liposarcoma cells

Nutrition and Cancer

Volumn 61, Issue 1, 2009, Pages 114-122

  Donnelly, Christina ^a   Olsen, Arne M ^a   Lewis, Lionel D ^a   Eisenberg, Burton L ^a   Eastman, Alan ^a   Kinlaw, William B ^a,b  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

^b 606 RubinBuilding ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONJUGATED LINOLEIC ACID; FAS ANTIGEN; FATTY ACID SYNTHASE; MESSENGER RNA; NUCLEAR PROTEIN; PALMITIC ACID; SPOT 14 PROTEIN; UNCLASSIFIED DRUG;

ADIPOSE TISSUE CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL; CANCER CELL CULTURE; CANCER GROWTH; CARCINOGENESIS; CELL GROWTH; CELL STRAIN MDA MB 231; CELL STRAIN T47D; DRUG EFFICACY; EXPOSURE; FATTY ACID SYNTHESIS; FEMALE; FIBROBLAST; GENE EXPRESSION; GROWTH INHIBITION; HELA CELL; HUMAN; HUMAN CELL; ISOMER; LIPOGENESIS; LIPOSARCOMA; MILK; REGULATORY MECHANISM; SARCOMA CELL;

BREAST NEOPLASMS; CELL DIVISION; CELL PROLIFERATION; FATTY ACID SYNTHETASE COMPLEX; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; GROWTH INHIBITORS; HUMANS; LINOLEIC ACIDS, CONJUGATED; LIPOSARCOMA; NUCLEAR PROTEINS; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED;

BOVINAE;

EID: 58149147006     PISSN: 01635581     EISSN: None     Source Type: Journal    
DOI: 10.1080/01635580802348666     Document Type: Article

References (41)

1. Harvatine K and Bauman D: SREBP1 and thyroid hormone responsive spot 14 (S14) are involved in the regulation of bovine mammary lipid synthesis during diet-induced milk fat depression and treatment with CLA. J Nutrition 136, 2468-2474, 2006.
2. Bauman D and Grinari J: Nutritional regulation of milk fat synthesis. Ann Rev Nutr 23, 203-207, 2003.
3. House R, Cassady J, Eisen E, Eling T, Collins J, et al.: Functional genomic characterization of delipidation elicited by trans-10, cis-12-conjugated linoleic acid (t10,c12-CLA) in a polygenic obese line of mice. Physiol Genomics 21, 351-361, 2005.
4. Belury M: Inhibition of carcinogenesis by conjugated linoleic acid: potential mechanisms of action. J Nutr 132, 2995-2998, 2002.
5. Durgam V and Fernandes G: The growth inhibitory effect of conjugated linoleic acid on MCF-7 cells is related to estrogen response system. Cancer Lett 116, 121-130, 1997.
6. Ip C, Singh M, Thompson H, and Scimeca J: Conjugated linoleic acid suppresses mammary carcinogenesis and proliferative activity of the mammary gland in the rat. Cancer Res 54, 1212-1215, 1994.
7. Hubbard N, Lim D, Summers L, and Erikson K: Reduction of murine mammary tumor metastasis by conjugated linoleic acid. Cancer Lett 150, 93-100, 2000.
8. Ip C, Dong Y, Ip M, Banni S, Carta G, et al.: Conjugated linoleic acid isomers and mammary cancer prevention. Nutr Cancer 43, 52-58, 2002.
9. Ip M, Masso-Welch P, and Ip C: Prevention of mammary cancer with conjugated linoleic acid: role of the stroma and epithelium. J Mammary Gland Biol Neoplasia 8, 103-118, 2003.
10. Kinlaw W, Church J, Harmon J, and Mariash C: Direct evidence for a role of the "spot 14" protein in the regulation of lipid synthesis. J Biol Chem 270, 16615-16618, 1995.
11. Brown SB, Maloney M, and Kinlaw WB: "Spot 14" protein functions at the pretranslational level in the regulation of hepatic metabolism by thyroid hormone and glucose. J Biol Chem 272, 2163-2166, 1997.
12. Lepar G and Jump D: Hormonal regulation of the S14 gene in 3T3-F442A cells. Mol Endocrinol 3, 1207-1214, 1989.
13. Cunningham B, Moncur J, Huntington J, and Kinlaw WB: "Spot 14" protein: a metabolic integrator in normal and neoplastic cells. Thyroid 8, 815-825, 1998.
14. Kinlaw W, Quinn J, Wells W, Roser-Jones C, and Moncur J: S14 in breast cancer: a marker of aggressive disease and a potential therapeutic target. Endocrinology 147, 4048-4055, 2006.
15. Martel P, Bingham C, McGraw C, Baker C, Morganelli P, et al.: S14 protein in breast cancer cells: direct evidence for regulation by SREBP-1c, superinduction with progestin, and implication in cell growth. Exp Cell Res 312, 278-288, 2005.
16. Wells W, Schwartz G, Morganelli P, Cole B, Chambers J, et al.: Expression of "Spot 14" (THRSP) predicts disease free survival in invasive breast cancer: immunohistochemical analysis of a new molecular marker. Breast Cancer Res Treat 98, 231-240, 2006.
17. Ip M, Masso-Welch P, Shoemaker S, Shea-Elton W, and Ip C: Conjugated linoleic acid inhibits proliferation and induces apoptosis of normal rat mammary epithelial cells in primary culture. Exp Cell Res 250, 22-34, 1999.
18. Mosmann T: Rapid colorometric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65, 55-63, 1983.
19. Swinnen J, Ulrix W, Heyns W, and Verhoven G: Coordinate regulation of lipogenic gene expression by androgens: evidence for a cascade mechanism involving sterol regulatory element binding proteins. Proc Natl Acad Sci USA 94, 12975-12980, 1997.
20. Cross R, Ostrowska E, Muralitharan M, and Dunshea F: Mixed mode retention and the use of competing acid for the Ag+-HPLC analysis of underivatized conjugated linoleic acids. J High Resolute Cromatogr 23, 317-323, 2000.
21. Heemers H, Vanderhoydonc F, Heyns W, Verhoeven G, and Swinnen J: Progestins and androgens increase expression of spot 14 in T47-D breast tumor cells. Biochem Biophys Res Commun 269, 209-212, 2000.
22. Cailleau R, Olive M, and Crueiger Q: Long term human breast cancer cell lines of metastatic origin: preliminary characterization. In Vitro 14, 911-915, 1978.
23. Hollywood D and Hurst H: A novel transcription factor, OB2-1, is required for overexpression of the proto-oncogene c-eb-2 in mammary tumor lines. EMBO J 12, 2369-2375, 1993.
24. Hughes D, Martel P, Kinlaw W, and Eisenberg B: The synthetic triterpenoid CDDO-Im inhibits fatty acid synthase expression and has antiproliferative and proapoptotic effects in human liposarcoma cells. Cancer Invest 26, 118-127, 2008.
25. Swinnen J, Brusselmans K, and Verhoeven G: Increased lipogenesis in cancer cells: new players, novel targets. Curr Opin Clin Nutr Metab Care 9, 358-365, 2006.
26. Menendez J and Lupu R: Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis. Nat Rev Cancer 7, 763-777, 2007.
27. Moncur J, Park J, Mohandes TK, Memoli V, and Kinlaw W: The "spot 14" gene resides on the telomeric end of the 11q13 amplicon and is expressed in lipogenic breast cancers. Proc Natl Acad Sci USA 95, 6989-6994, 1998.
28. Kuhajda F: Fatty acid synthase and cancer: new application of an old pathway. Cancer Res 66, 5977-5980, 2006.
29. Kridel S, Axelrod F, Rozenkrantz N, and Smith J: Orlistat is a novel inhibitor of fatty acid synthase with antitumor activity. Cancer Res 64, 2070-2075, 2004.
30. Menendez J, Vellon L, and Lupu R: Antitumoral actions of the anti-obesity drug orlistat (Xenical) in breast cancer cells: blockade of cell cycle progression, promotion of apoptotic cell death and PEA3-mediated transcriptional repression of Her2/neu (erb B-2) oncogene. Ann Oncol 16, 1253-1267, 2005.
31. Pizer E, Thupari J, Han W, Pinn M, Chrest F, et al.: Malonyl-coenzyme-A is a potential mediator of cytotoxicity induced by fatty-acid synthase inhibition in human breast cancer cells and xenografts. Cancer Res 60, 213-218, 2000.
32. Thupari J, Pinn M, and Kuhajda F: Fatty acid synthase inhibition in human breast cancer cells leads to malonyl-CoA-induced inhibition of fatty acid oxidation and cytotoxicity. Biochem Biophys Res Commun 285, 217-223, 2001.
33. Hatsivassiliou G, Zhao F, Bauer D, Andreadis C, Shaw A, et al.: ATP citrate lyase inhibition can suppress tumor cell growth. Cancer Cell 8, 311-321, 2005.
34. Brusselmans K, De Schrijver E, Verhoeven G, and Swinnen J: RNA interference-mediated silencing of the acetyl-CoA-carboxylase-a gene induces growth inhibition and apoptosis of prostate cancer cells. Cancer Res 65, 6719-6725, 2005.
35. Chajes V, Cambot M, Moreau K, Lenoir G, and Joulin V: Acetyl-CoA carboxylase-a is essential to breast cancer cell survival. Cancer Res 66, 5287-5294, 2006.
36. Yang H, Crawford N, Lukes L, Finney R, Lancaster M, et al.: Metastasis predictive signature profiles pre-exist in normal tissues. Clin Exp Metastasis 22, 593-603, 2005.
37. Bhattacharya A, Banu J, Rahman M, Causey J, and Fernandes G: Biological effects of conjugated linoleic acids in health and disease. J Nutr Biochem 17, 789-810, 2006.
38. Pariza M, Park Y, and Cook M: The biologically active isomers of conjugated linoleic acid. Prog Lipid Res 40, 283-298, 2001.
39. Ip M, Sibel O, Masso-Welch A, Ip C, Meng X, et al.: The t10,c12 isomer of conjugated linoleic acid stimulates mammary tumorigenesis in transgenic mice over-expressing erbB2 in the mammary epithelium. Carcinogenesis 28, 1269-1276, 2007.
40. Oskouian B: Overexpression of fatty acid synthase in SKBR3 breast cancer cell line is mediated via a transcriptional mechanism. Cancer Lett 149, 43-51, 2000.
41. Gaullier J, Halse J, Hoye K, Kristiansen K, Fagertun H, et al.: Supplementation with conjugated linoleic acid for 24 months is well tolerated by and reduces body fat mass in healthy, overweight humans. J Nutr 135, 778-784, 2005.