Induction of micronuclei in rat bone marrow after chronic exposure to lead acetate trihydrate

Toxicology and Industrial Health

Volumn 24, Issue 9, 2008, Pages 587-593

  Alghazal, Ma ^a   Sutiakova I ^b   Kovalkovicova N ^a   Legath J ^a   Falis, M ^a   Pistl, J ^a   Sabo, R ^a   Benova K ^a   Sabova L ^a   Vaczi P ^a  

^a UNIVERSITY OF VETERINARY MEDICINE   (Slovakia)

^b UNIVERSITY OF PRE OV   (Slovakia)

Author keywords

erythrocyte bone marrow test; genotoxicity; lead acetate trihydrate; micronucleus; rat

Indexed keywords

LEAD ACETATE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE MARROW; CONTROLLED STUDY; CYTOTOXICITY; ERYTHROCYTE; FEMALE; GENOTOXICITY; LONG TERM EXPOSURE; MALE; MICRONUCLEUS; NONHUMAN; RAT; WISTAR RAT;

ANALYSIS OF VARIANCE; ANIMALS; CELL NUCLEUS; ERYTHROBLASTS; FEMALE; MALE; MICRONUCLEI, CHROMOSOME-DEFECTIVE; MICRONUCLEUS TESTS; ORGANOMETALLIC COMPOUNDS; RATS; RATS, WISTAR;

ANIMALIA; RATTUS; RATTUS NORVEGICUS;

EID: 58149144758     PISSN: 07482337     EISSN: None     Source Type: Journal    
DOI: 10.1177/0748233708100089     Document Type: Article

References (45)

1. Aboul-Ela EI (2002) The protective effect of calcium against genotoxicity of lead acetate administration on bone marrow and spermatocyte cells of mice in vivo. Mutat Res 516: 1–9.
2. Adonaylo VN, Oteiza PI (1999) Lead intoxication: antioxidant defences and oxidative damage in rat brain. Toxicology 134: 77–85.
3. Agency for Toxic Substances and Disease Registry (ATSDR) (2005) Toxicological Profile for Lead (Draft for Public Comment). Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service.
4. Bauchinger M, Schmid E (1972) Chromosomen analyse in Zellkulturen des chinesischen Hamsters nach Applikation von Bleiacetat. Mutat Res 14: 95–100.
5. Bonacker D, Stoiber T, Bohm KJ, Prots I, Wang M, Unger E (2005) Genotoxicity of inorganic lead salts and disturbance of microtubule function. Environ Mol Mutagen 45: 346–353.
6. Bouton CMLS, Pevsner J (2000) Effects of lead on gene expression. Neurotoxicology 21: 1045–1056.
7. Cavaş T (2008) In vivo genotoxicity of mercury chloride and lead acetate: Micronucleus test on acridine orange stained fish cells. Food Chem Toxicol 46: 352–358.
8. Celik A, Ögenler O, Cömelekoglu Ü (2005) The evaluation of micronucleus frequency by acridine orange fluorescent staining in peripheral blood of rats treated with lead acetate. Mutagenesis 20: 411–415.
9. DiPaolo JA, Nelson RL, Casto BC (1978) In vitro neoplastic transformation of Syrian hamster cells by lead acetate and its relevance to environmental carcinogenesis. Br J Cancer 38: 452–455.
10. Domingrez CF, Sole F, Tumy A (2002) In vitro lead-induced cell toxicity and cytoprotective activity of fetal calf serum in human fibroblasts. Mol Cell Biochem 237: 47–53.
11. El-Ashmawy IM, El-Nahas AF, Salama OM (2005) Protective effect of volatile oil, alcoholic and aqueous extracts of Origanum majorana on lead acetate toxicity in mice. Basic Clin Pharmacol Toxicol 97: 238–243.
12. El-Ashmawy IM, Khalid MA, El-Nahas AF, Salama OM (2006) Protection by turmeric and myrrh against liver oxidative damage and genotoxicity induced by lead acetate in mice. Basic Clin Pharmacol Toxicol 98: 32–37.
13. Fowler BA, Kahng MW, Smith DR (1994) Role of lead-binding proteins in renal cancer. Environ Health Perspect 102: 115–116.
14. Hartwig A, Schlepegrell R, Beyersmann D (1990) Indirect mechanism of lead-induced genotoxicity in cultured mammalian cells. Mutat Res 241: 75–82.
15. Hengstler JG, Bolm-Auorff U, Faldum A, Janssen K, Reifenrath M, Götte W (2003) Occupational exposure to heavy metals: DNA damage induction and DNA repair inhibition prove co-exposures to cadmium, cobalt and lead as more dangerous than hitherto expected. Carcinogenesis 24: 63–73.
16. Hwua Y-S, Yang J-L (1998) Effects of 3-aminotriazole on anchorage independence and mutagenicity in cadmium and lead-treated diploid human fibroblasts. Carcinogenesis 19: 881–888.
17. International Agency for Research and Cancer (IARC) (1987) Lead (7439-92-1) and Lead Compounds, inorganic. IARC Monographs 23 (Suppl. 7): Lyon. International Programme on Chemical Safety (IPCS), Inchem.
18. Jamieson JA, Taylor CG, Weiler HA (2006) Marginal zinc deficiency exacerbates bone lead accumulation and high dietary zinc attenuates lead accumulation at the expense of bone density in growing rats. Toxicol Sci 92: 286–294.
19. Johnson FM (1998) The genetic effects of environmental lead. Mutat Res 410: 123–140.
20. Kapka L, Baumgartner A, Siwińska E, Knudsen LE, Anderson D, Mielzyńska D (2007) Environmental lead exposure increases micronuclei in children. Mutagenesis 22: 201–207.
21. Kašuba V, Rozgaj R Fuči'c, A, Varnai, VM, Piasek, M (2004) Lead acetate genotoxicity in suckling rats. Biologia Bratislava 59: 779–785.
22. Koréneková B, Skalická M, Naď P (2006) Zinc in cattle from area polluted by long-term emissions. Bull Environ Contam Toxicol 76: 684–688.
23. Kramárová M, Massányi P, Slamecka J, Tataruch F, Jancová A, Gasparik J (2005) Distribution of cadmium and lead in liver and kidney of some wild animals in Slovakia. J Environ Sci Health 40: 593–600.
24. Ma HY, Li H, Wang JC, Liu XQ, Xu FS, Tan JS (2006) Effects of lead exposure to rat placenta and pups during different gestation periods. Zhonghua Yu Fang Yi Xue Za Zhi 40: 101–104.
25. Mac Gregor JT, Heddle JA, Hite M, Margolin BH, Ramel C, Salamone MF (1987) Guidelines for the conduct of micronucleus assays in mammalian bone marrow erythocytes. Mutat Res 189: 103–112.
26. Mishra M, Acharya UR (2004) Protective action of vitamins on the spermatogenesis in lead-treated Swiss mice. J Trace Elem Med Biol 18: 173–178.
27. Muro LA, Goyer RA (1969) Chromosome damage in experimental lead poisoning. Arch Pathol 87: 660–663.
28. Nehéz M, Lorencz R, Desi I (2000) Simultaneous action of cypermethrin and two environmental pollutant metals, cadmium and lead, on bone marrow cell chromosomes of rats in chronic administration. Ecotoxicol Environ Saf 45: 55–60.
29. Obe G, Beek B, Dudin G (1975) Some experiments on the action of lead acetate on human leucocytes in vitro. Mutat Res 29: 283.
30. OECD (Organization for Economic Cooperation and Development) (1997) Guidelines for Testing of Chemicals. Guideline 474. Genetic Toxicology: Micronucleus Test, OECD Publication Service, Paris, France.
31. Piao F, Cheng F, Chen H, Li G, Sun X, Liu S (2007) Effects of zinc coadministration on lead toxicities in rats. Ind Health 45: 546–551.
32. Poma A, Pittaluga E, Tucci A (2003) Lead acetate genotoxicity on human melanoma cells in vitro. Melanoma Res 13: 563–566.
33. Razani-Boroujerdi S, Edwards B, Sopori ML (1999) Lead stimulates lymphocyte proliferation through enhanced T-cell – B-cell interaction. J Pharmacol Exp Ther 288: 714–719.
34. Rusov C, Živković R, Popović S, Joji Ćmaličević L (1995) Study of lead acetate genotoxicity using the micronucleus test in mice. Acta Vet 45: 317–322.
35. Tachi K, Nishimae S, Saito K (1985) Cytogenetic effects of lead acetate on rat bone marrow cells. Arch Environ Health 40: 144–147.
36. Thier R, Bonacker D, Stoiber T, Böhm KJ, Wang M, Unger E (2003) Interaction of metal salts with cytoskeletal motor protein systems. Toxicol Lett 140–141: 75–81.
37. Valverde M, Trejo C, Rojas E (2001) Is the capacity of lead acetate and cadmium chloride to induce genotoxic damage due to direct DNA-metal interaction. Mutagenesis 16: 265–270.
38. Valverde M, Fortoul TI, Diaz-Barriga F, Mejía J, del Castillo ER (2002) Genotoxicity induced in CD-1 mice by inhaled lead: differential organ response. Mutagenesis 17: 55–61.
39. Vladimtseva TM, Pashkevich IA, Salmina AB (2006) The morphofunctional state of the bone marrow in lead and zinc intoxication. Gig Sanit 2: 71–72.
40. Willems MI, de Schepper GG, Wibowo AA, Immel HR, Dietrich AJ, Zielhuis RL (1982) Absence of an effect of lead acetate on sperm morphology, sister chromatid exchanges or on micronuclei formation in rabbits. Arch Toxicol 50: 149–157.
41. Winder C, Bonin T (1993) The genotoxicity of lead. Mutat Res 285: 117–124.
42. Wozniak K, Blasiak J (2003) In vitro genotoxicity of lead acetate: induction of single and double DNA strand breaks and DNA-protein cross-links. Mutat Res 535: 127–139.
43. Xu J, Lian LJ, Wu C, Wang XF, Fu WY, Xu LH (2008) Lead induces oxidative stress, DNA damage and alteration of p53, Bax and Bcl-2 expressions in mice. Food Chem Toxicol 46: 1488–1494.
44. Zelikoff J, Li JH, Hartwig A, Wang XW, Costa M, Rossman TG (1988) Genetic toxicology of lead compounds. Carcinogenesis 9: 1727–1732.
45. Zhou JH, Xue L, Shi XJ (2006) Lead acetate induced DNA damage in blood lymphocytes of rats. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 24: 290–292.