In vitro lead-induced cell toxicity and cytoprotective activity of fetal calf serum in human fibroblasts

Molecular and Cellular Biochemistry

Volumn 237, Issue 1-2, 2002, Pages 47-53

  Domínguez, Carmen ^a   Solé, Eduard ^a   Fortuny, Anna ^a  

^a HOSPITAL MATERNO INFANTIL VALL D HEBRON   (Spain)

Author keywords

ATP; Cytotoxicity; DNA; Fetal calf serum; In vitro; Lead

Indexed keywords

ADENOSINE TRIPHOSPHATE; BETA N ACETYLHEXOSAMINIDASE; DNA; LEAD; NEUTRAL RED;

ARTICLE; CELL ADHESION; CELL DEATH; CELL ENERGY; CELL GROWTH; CELL LINE; CELL PROLIFERATION; CELL PROTECTION; CONTROLLED STUDY; CULTURE VESSEL; CYTOTOXICITY; DNA SYNTHESIS; DNA SYNTHESIS INHIBITION; ENDOCYTOSIS; ENZYME ACTIVITY; FETAL CALF SERUM; FIBROBLAST CULTURE; GROWTH INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; LEAD POISONING; LYSOSOME; LYSOSOME MEMBRANE; SKIN FIBROBLAST;

ADENOSINE TRIPHOSPHATE; ANIMALS; BETA-N-ACETYLHEXOSAMINIDASE; BLOOD; CATTLE; CELL ADHESION; CELL DEATH; CELLS, CULTURED; CULTURE MEDIA; FIBROBLASTS; HUMANS; LEAD; MYCOPLASMA; POLYMERASE CHAIN REACTION; TIME FACTORS;

EID: 0036686841     PISSN: 03008177     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1016547519763     Document Type: Article

References (35)

1. Unraveling the chronic toxicity of lead: An essential priority for environmental health
2. Preventing childhood lead poisoning
3. Low-level lead-induced neurotoxicity in children: An update on central nervous system effects
4. Lead toxicity: Current concerns
5. The long-term effects of exposure to low levels of lead childhood. An 11 year follow-up report
6. Mechanisms of lead cytotoxicity
7. Molecular mechanisms of lead neurotoxicity
8. The biological chemistry of lead
9. Lead inhibits growth and induces apoptosis in normal rat fibroblasts
10. Lead-related effects on fibroblasts
11. Effect of aluminum and lead salts on lipid peroxidation and cell survival in human skin fibroblasts
12. Neutral red uptake, cellular growth and lysosomal function: In vitro effects of 24 metals
13. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
14. A semi-automated protein assay for cell cultures
15. Growth-altering effects of sodium hypochlorite in cultured human dermal fibroblasts
16. Toxicity determined in vitro by morphological alterations and neutral red absorption
17. Applications of the neutral red cytotoxicity assay to in vitro toxicology
18. Study of cytotoxicity mechanisms of silver nitrate in human dermal fibroblasts
19. Use of an in vitro system to study the effects of lead on astrocyte-endothelial cell interactions: A model for studying toxic injury to the blood-brain barrier
20. Immunotoxicity of particulate lead: In vitro exposure alters pulmonary macrophage tumor necrosis factor production and activity
21. Effects of trace metals on mouse B16 melanoma cells in culture
22. Effects of inorganic lead on the differentiation and growth of cortical neurons in culture
23. Cytotoxicity and accumulation of Hg, Ag, Cd, Cu, Pb and Zn in human peripheral T and B lymphocytes and monocytes in vitro
24. The effect of lead exposure and serum deprivation on mesencephalic primary cultures
25. An in vitro study of the effects of lead on an epithelioid cell line
26. Effect of inorganic lead on some functions of the cerebral microvessel endothelium
27. Cell culture models for lead toxicity in neuronal and glial cells
28. Glucocorticoid potentiation of lead neurotoxicity in the mouse HN 9 hippocampal cell line
29. Lead causes human fibroblasts to mis-sort arylsulfatase A
30. Lead inhibition of DNA-binding mechanism of Cys(2)His(2)zinc finger proteins
31. Photo-oxidative disruption of lysosomal membranes causes apoptosis of cultured human fibroblasts
32. Defence mechanisms protecting glial cell cultures against the toxicity of lead
33. The interaction of lead exposure and arylsulfatase A genotype affects sulfatide catabolism in human fibroblasts
34. Lead exposure affects levels of galactolipid metabolic enzymes in the developing rat brain
35. Intracellular ATP concentration: A switch in the decision between apoptosis and necrosis