Effects of cage size and enrichment on reproductive performance and behavior in C57BL/6Tac mice

Lab Animal

Volumn 38, Issue 1, 2009, Pages 24-34

  Whitaker, Julia ^a   Moy, Sheryl S ^b   Godfrey, Virginia ^a   Nielsen, Judith ^a   Bellinger, Dwight ^a   Bradfield, John ^a  

^a Department of Pathology and Laboratory Medicine ^*

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANALYSIS OF VARIANCE; ANIMAL; ANIMAL HOUSING; ANXIETY; ARTICLE; BODY WEIGHT; C57BL MOUSE; EXPLORATORY BEHAVIOR; FEMALE; FERTILITY; LITTER SIZE; MALE; MAZE TEST; MOUSE; PATHOLOGY; PHYSIOLOGY; ROTAROD TEST; SEXUAL BEHAVIOR;

ANALYSIS OF VARIANCE; ANIMALS; ANXIETY; BODY WEIGHT; EXPLORATORY BEHAVIOR; FEMALE; FERTILITY; HOUSING, ANIMAL; LITTER SIZE; MALE; MAZE LEARNING; MICE; MICE, INBRED C57BL; ROTAROD PERFORMANCE TEST; SEXUAL BEHAVIOR, ANIMAL;

MUS;

EID: 58149125375     PISSN: 00937355     EISSN: 15484475     Source Type: Journal    
DOI: 10.1038/laban0109-24     Document Type: Article

References (34)

1. Gonder, J.C. & Laber, K. A renewed look at laboratory rodent housing and management. ILAR J. 48, 29-36 (2007).
2. Fultwood, S., Hicks, T.A., Brown, J.C, Norman, R.L. & McGlone, J.J. Floor space needs for laboratory mice: C57BL/6 males in solid-bottom cages with bedding. ILAR J. 39, 29-36 (1998).
3. McGlone, J.J., Anderson, D.L & Norman, R.L. Floor space needs for laboratory mice: BALB/cJ males or females in solid-bottom cages with bedding. Contemp. Top. Lab. Anim. Sci 40, 21-25 (2001).
4. Ortiz, R., Armario, A., Castellanas, J.M. & Balasch, J. Pastweaning crowding induces corticoadrenal hyperreactivity in male mice. Physiol. Behav. 34, 857-860 (1985).
5. Smith, A.L., Mabus, S.L., Stockwell, J.D. & Muir, C. Effects of housing density and cage floor space on C57BL/6J mice. Camp. Med. 54, 656-663 (2004).
6. Smith, A.L., Mabus, S.L., Muir, C. & Woo, Y. Effects of housing density and cage floor space on three strains of young adult inbred mice. Comp. Med. 55, 368-376 (2005).
7. van Loo, P.L.P., Mol, J.A., Koolhaas, J.M., van Zutphen, B.F.M. & Baumans, V. & Modulation of aggression in male mice: influence of group size and cage size. Physiol. Behav. 72, 675-683 (2001).
8. Whitaker, J. et al. The effect of cage size on reproductive performance and behavior of C57BL/6 mice. Lab Anim. (NY) 36, 32-39 (2007).
9. Forsyth, N., Young, G. & Mench, J. Effects of cage size and enrichment on aggression and stereotypic behavior in three strains of laboratory mice American Association for Laboratory Animal Science National Meeting. Charlotte, NC; 14-18 October 2007.
10. van Loo, P.L.P et al. Influence of cage enrichment on aggressive behaviour and physiological parameters in male mice. Appl. Anim. Behav. Sci. 76, 65-81 (2002).
11. Hunt, C. & Hambly, C. Faecal corticosterone concentrations indicate that separately housed male mice are not more stressed than group housed males. Physiol. Behav. 87, 519-526 (2006).
12. Olsson, I.A.S. & Sherwin, CM. Behaviour of laboratory mice in different housing conditions when allowed to selfadminister an anxiolytic. Lab. Anim. 40, 392-399 (2006).
13. Tsai, P.P., Pachowsky, U., Stelzer, H.D. S Hackbarth, H. Impact of environmental enrichment in mice. 1: effect of housing conditions on body weight, organ weights and haematology in different strains. Lab. Anim. 36, 411-419 (2002).
14. van de Weerd, H.A., Baumans, V., Koolhaas, J.M. & van Zutphen, L.F.M. Strain specific behavioural response to environmental enrichment in the mouse. J. Exp. Anim. Sci. 36, 117-127 (1994).
15. Wolfer, D.P. et al. Laboratory animal welfare: cage enrichment and mouse behaviour. Nature 432, 821-822 (2004).
16. Baumans, V. Environmental enrichment for laboratory rodents and rabbits: requirements of rodents, rabbits, and research. ILAR J. 46, 162-170 (2005).
17. Hutchinson, E., Avery, A. & Vandewoude, S. Environmental enrichment for laboratory rodents. ILAR J. 46, 148-161 (2005).
18. Olsson, I.A.S. & Dahlborn, K. Improving housing conditions for laboratory mice: a review of "environmental enrichment". Lab. Anim. 36, 243-270 (2001).
19. Smith, A.L. & Corrow, D.J. Modifications to husbandry and housing conditions of laboratory rodents for improved wellbeing. ILAR J. 46, 140-147 (2005).
20. Peters, A.G., Bywater, P.M. & Festing, M.F.W. The effect of daily disturbance on the breeding performance of mice. Lab. Anim. 36, 188-192 (2002).
21. Reeb-Whitaker, C.K. et al. The impact of reduced frequency of cage changes on the health of mice housed in ventilated cages. Lab. Anim. 35, 58-73 (2001).
22. Kristan, D.M. Effects of intestinal nematodes during lactation: consequences for host morphology, physiology, and offspring mass. J. Exp. Biol. 205, 3955-3965 (2002).
23. Martin, B. et al. Caloric restriction: impact upon pituitary function and reproduction. Ageing Res. Rev. 7, 209-224 (2008).
24. Tsai, P.P., Opperman, D., Stelzer, H.D., Mähler, M. & Hackbarth, H. The effects of different rack systems on the breeding performance of DBA/2 mice. Lab. Anim. 37, 44-53 (2003).
25. Fox, R.R., Witham, B.A. & Neleski, LA. Handbook on Genetically Standardized JAX Mice 5th edn. 44 (The Jackson Laboratory, Bar Harbor, 1997).
26. Paylor, R. & Crawley, J.N. Inbred strain differences in prepulse inhibition of the mouse startle response. Psychopharmacology (Berl). 132, 169-180 (1997).
27. Wahlsten, D., Cooper, S.F. & Crabbe, J.C. Different rankings of inbred mouse strains on the Morris maze and a refined 4-arm water escape task. Behav. Brain Res. 165, 36-51 (2005).
28. Wahlsten, D., Rustay, N.R., Metten, P. & Crabbe, J.C. In search of a better mouse test. Trends Neurosd. 26, 132-136 (2003).
29. Zhu, S.W. et al. Influence of differential housing on emotional behaviour and neurotrophin levels in mice. Behav. Brain Res. 169, 10-20 (2006).
30. Branchi, I. & Alleva, E. Communal nesting, an early social enrichment, increases the adult anxiety-like response and shapes the role of social context in modulating the emotional behavior. Behav. Brain Res. 172, 299-306 (2006).
31. Chapillon, P., Manneche, C, Belzung, C. S Caston, J. Rearing environment enrichment in two inbred strains of mice: 1. Effects on emotional reactivity. Behav. Genet. 29, 41-46 (1999).
32. Marques, J.M. & Olsson, I.A.S. The effect of preweaning and postweaning housing on the behaviour of the laboratory mouse (Mus musculus). Lab. Anim. 41, 92-102 (2005).
33. Davidson, L.P., Chedester, A.L. & Cole, M.N. Effects of cage density on behavior in young adult mice. Comp. Med. 57, 355-359 (2007).
34. Trullas, R. & Skolnick, P. Differences in fear motivated behaviors among inbred mouse strains. Psychopharmacology (Berl). 111, 323-331 (1993).