A renewed look at laboratory rodent housing and management

ILAR Journal

Volumn 48, Issue 1, 2007, Pages 29-36

  Gonder, Janet C ^a,d   Laber, Kathy ^b,c  

^a Garber Consulting LLC   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d NONE   (United States)

Author keywords

Caging; Housing systems; Management; Rodent husbandry

Indexed keywords

AIR CONDITIONING; ANIMAL; ANIMAL DISEASE; ANIMAL HOUSING; ANIMAL WELFARE; BED; EXPERIMENTAL ANIMAL; FEMALE; MALE; METHODOLOGY; MOUSE; RAT; REVIEW; SOCIAL ENVIRONMENT; STANDARD; TEMPERATURE;

ANIMAL WELFARE; ANIMALS; ANIMALS, LABORATORY; BEDDING AND LINENS; FEMALE; HOUSING, ANIMAL; MALE; MICE; RATS; SOCIAL ENVIRONMENT; TEMPERATURE; VENTILATION;

EID: 39049180377     PISSN: 10842020     EISSN: None     Source Type: Journal    
DOI: 10.1093/ilar.48.1.29     Document Type: Review

References (51)

1. Andrade CS, Guimaraes FS. 2003. Anxiolytic-like effect of group housing on stress-induced behavior in rats. Depress Anxiety 18:149-152.
2. Arakawa H. 2005. Age dependent effects of space limitation and social tension on open-field behavior in male rats. Physiol Behav 84:429-436.
3. Bartolomucci A, Palanza P, Sacerdote P, Ceresini G, Chirieleison A, Panera AE, Parmigiani S. 2003. Individual housing induces altered immuno-endocrine responses to psychological stress in male mice. Psychoneuroendocrinology 28:540-558.
4. Baumans V, Schlingmann F, Vonck M, van Lith HA. 2002. Individually ventilated cages: Beneficial for mice and men? Contemp Top Lab Anim Sci 41:13-19.
5. Bazille PG, Walden SD, Koniar BL, Gunther R. 2001. Commercial cotton nesting material as a predisposing factor for conjunctivitis in athymic nude mice. Lab Anim 30:40-42.
6. Buddaraju AKV, Van Dyke RW. 2003. Effect of animal bedding on rat liver endosome acidification. Comp Med 53:616-621.
7. Compton SR, Homberger FR, MacArthur Clark J. 2004a. Microbiological monitoring in individually ventilated cage systems. Lab Anim 33:36-41.
8. Compton SR, Homberger FR, Paturzo FX, Clark JM. 2004b. Efficacy of three microbiological monitoring methods in a ventilated cage rack. Comp Med 54:382-392.
9. Eriksson E, Royo F, Lyberg K, Carlsson HE, Hau J. 2004. Effect of metabolic cage housing on immunoglobulin A and corticosterone excretion in faeces and urine of young male rats. Exp Physiol 89:427-433.
10. Fullwood S, Hicks TA, Brown JC, Norman RL, McGlone JJ. 1998. Floor space needs for laboratory mice: C57BL/6 males in solid-bottom cages with bedding. ILAR J 39:29-36.
11. Georgsson L, Barrett J, Gietzen D. 2001. The effects of group-housing and relative weight on feeding behaviour in rats. Scand J Lab Anim Sci 28:201-209.
12. Gordon CJ. 2004. Effect of cage bedding on temperature regulation and metabolism of group-housed female mice. Comp Med 54:63-68.
13. Gordon CJ, Becker P, Ali JS. 1998. Behavioral thermoregulatory responses of single- and group-housed mice. Physiol Behav 65:255-262.
14. Hasegawa M, Kagiyama S, Tajima M, Yoshida K, Minami Y, Kurosawa T. 2003. Evaluation of a forced-air-ventilated micro-isolation system for protection of mice against Pasteurella pneumotropica. Exp Anim 52:145-151.
15. Hoglund AU, Renstrom A. 2001. Evaluation of individually ventilated cage systems for laboratory rodents: Cage environment and animal health aspects. Lab Anim 35:51-57.
16. Karolewicz B, Paul IA. 2001. Group housing of mice increases immobility and antidepressant sensitivity in the forced swim and tail suspension tests. Eur J Pharmacol 415:197-201.
17. Kingston SG, Hoffman-Goetz L. 1996. Effect of environmental enrichment and housing density on immune system reactivity to acute exercise stress. Physiol Behav 60:145-150.
18. Krohn TC, Hansen AK, Dragsted N. 2003. The impact of cage ventilation on rats housed in IVC systems. Lab Anim 37:85-93.
19. McGlone JJ, Anderson DL, Norman RL. 2001. Floor space needs for laboratory mice: BALB/cJ males or females in solid-bottom cages with bedding. Contemp Top Lab Anim Sci 40:21-25.
20. Memarzadeh F. 1998. Ventilation Design Handbook on Animal Research Facilities Using Static Microisolators. Vol I and II. Bethesda MD: National Institutes of Health.
21. Memarzadeh F, Harrison PC, Riskowski GL, Henze T. 2004. Comparison of environment and mice in static and mechanically ventilated isolator cages with different air velocities and ventilation designs. Contemp Top Lab Anim Sci 43:14-20.
22. Myers DD, Smith E, Schweitzer I, Stockwell JD, Paigen BJ, Bates R, Palmer J, Smith AL. 2003. Assessing the risk of transmission of three infectious agents among mice housed in a negatively pressurized caging system. Contemp Top Lab Anim Sci 42:16-21.
23. Nevalainen T, Vartiainen T. 1996. Volatile organic compounds in commonly used beddings before and after autoclaving. Scand J Lab Anim Sci 23:101-104.
24. NRC [National Research Council]. 1996. Guide for the Care and Use of Laboratory Animals. 7th ed. Washington DC: National Academy Press.
25. Peace TA, Singer, Niemuth NA, Shaw ME. 2001. Effects of caging type and animal source on the development of foot lesions in Sprague-Dawley rats (Rattus norvegicus). Contem Top Lab Anim Sci 40:17-21.
26. Perez C, Canal JR, Dominguez E, Campillo JE, Guillen M, Torres MD. 1997. Individual housing influences certain biochemical parameters in the rat. Lab Anim 31:357-361.
27. Peters A, Festing M. 1990. Population density and growth rate in laboratory mice. Lab Anim 24:273-279.
28. Ras T, van de Ven M, Patterson Kane EG, Nelson K. 2002. Rats' preferences for corn versus wood-based bedding and nesting materials. Lab Anim 36:420-425.
29. Reeb C, Jones R, Bearg D, Bedigan H, Myers D, Paigen B. 1998. Microenvironment in ventilated animal cages with differing ventilation rates, mice populations, and frequency of bedding changes. Contemp Top Lab Anim Sci 37:43-49.
30. Reeb-Whitaker CK, Paigen B, Beamer WG, Bronson RT, Churchill GA, Schweitzer IB, Myers DD. 2001. The impact of reduced frequency of cage changes on the health of mice housed inventilated cages. Lab Anim 35:58-73.
31. Rock FM, Landi MS, Hughes HC, Gagnon RC. 1997. Effects of caging type and group size on selected physiologic variables in rats. Contemp Top Lab Anim Sci 36:69-72
32. Sanford AN, Clark SE, Talham G, Sidelsky MG, Coffin SE. 2002. Influence of bedding type on mucosal immune responses. Comp Med 52:429-432.
33. Sauer MB, Dulac H, Clark S, Moffitt KM, Price J, Dambach D, Mosher H, Bounous D, Keller L. 2006. Clinical pathology laboratory values of rats housed in wire-bottom cages compared with those of rats housed in solid-bottom cages. J Am Assoc Lab Anim Sci 45:30-35.
34. Sherwin CM. 1997. Observations on the prevalence of nest-building in non-breeding TO strain mice and their use of two nesting materials. Lab Anim 31:125-132.
35. Sherwin CM. 2004. The motivation of group-housed laboratory mice, Mus musculus, for additional space. Anim Behav 67:711-717.
36. Sherwin CM, Olsson IAS. 2004. Housing conditions affect self-administration of anxiolytic by laboratory mice. Anim Welfare 13:33-38.
37. Smith AL, Mabus SL, Muir C, Woo Y. 2005. Effect of housing density and cage floor space on three strains of young adult inbred mice. Comp Med 55:368-376.
38. Smith AL, Mabus SL, Stockwell JD, Muir C. 2004a. Effects of housing density and cage floor space on C57BL/6J mice. Comp Med 54:656-663.
39. Smith E, Stockwell JD, Schweitzer I, Langley SH, Smith AL. 2004b. Evaluation of cage micro-environment of mice housed on various types of bedding materials. Contemp Top Lab Anim Sci 43:12-17.
40. Swoap SJ, Overton JM, Garber G. 2004. Effect of ambient temperature on cardiovascular parameters in rats and mice: A comparative approach. Am J Physiol Reg Int Comp Physiol 287:R391-R396.
41. Thulin H, Bjorkdahl M, Karlsson A-S, Renstrom A. 2002. Reduction of exposure to laboratory animal allergens in a research laboratory. Ann Occup Hyg 46:61-68.
42. Tsai PP, Oppermann D, Stelzer HD, Mahler M, Hackbarth H. 2003. The effects of different rack systems on the breeding performance of DBA/2 mice. Lab Anim 37:44-53.
43. Tu H, Diberadinis LJ, Lipman NS. 1997. Determination of air distribution, exchange, velocity, and leakage in three individually ventilated rodent caging systems. Contemp Top Lab Anim Sci 36:69-73.
44. VandeWeerd HA, van Loo PL, van Zutphen LF, Koolhaas JM, Baumans V. 1997. Preferences for nesting material as environmental enrichment for laboratory mice. Lab Anim 31:133-143.
45. Van Loo PL, Baumans V. 2004. The importance of learning young: The use of nesting material in laboratory rats. Lab Anim 38:17-24.
46. Van Loo PL, Mol JA, Koolhaas JM, Van Zutphen BM, Baumans V. 2001. Modulation of aggression in male mice: Influence of group size and cage size. Physiol Behav 72:675-683.
47. Van Loo PL, Van de Weerd HA, Van Zutphen LF, Baumans V. 2004. Preference for social contact versus environmental enrichment in male laboratory mice. Lab Anim 38:178-188.
48. Van Praag H, Kempermann G, Gage FH. 2000. Neural consequences of environmental enrichment. Nature Rev Neurosci 1:191-198.
49. Wurbel, H. 2001. Ideal homes? Housing effects on rodent brain and behaviour. Trends Neurosci 24:207-211.
50. Zahorsky-Reeves JL, Schimmel AA, Suckow CE, Couto MA, Lawson PT. 2005. Paper-based bedding dramatically decreased the incidence of blepharitis in a nude rat population. Contemp Top Lab Anim Sci 44:62.
51. Zhu S, Yee BK, Nyffeler M, Winblad B, Feldon J, Mohammed AH. 2006. Influence of differential housing on emotional behaviour and neurotrophin levels in mice. Behav Brain Res 169:10-20.