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Volumn 12, Issue 5, 2008, Pages 877-883

The synthesis of (S)-5-fluoro-1-(2-fluorophenyl)-3-(piperidin-3-ylmethoxy)- 1H-indazole, a norepinephrine/serotonin reuptake inhibitor for the treatment of fibromyalgia

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EID: 58149116790     PISSN: 10836160     EISSN: 1520586X     Source Type: Journal    
DOI: 10.1021/op800113s     Document Type: Article
Times cited : (42)

References (33)
  • 2
    • 58149117441 scopus 로고    scopus 로고
    • PCT Int. Appl. WO 2006056873 A2
    • Schelkun, R. M.; Yuen, P.-W. PCT Int. Appl. WO 2006056873 A2, 2006.
    • (2006)
    • Schelkun, R.M.1    Yuen, P.-W.2
  • 28
    • 26244459297 scopus 로고    scopus 로고
    • The explosive properties of 1-hydroxybenzotriazoles have been recently reported. See Wehrstedt, K. D.; Wandrey, P. A.; Heitkamp, D. J. Hazard. Mater. 2005, 126, 1.
    • The explosive properties of 1-hydroxybenzotriazoles have been recently reported. See Wehrstedt, K. D.; Wandrey, P. A.; Heitkamp, D. J. Hazard. Mater. 2005, 126, 1.
  • 30
    • 58149120728 scopus 로고    scopus 로고
    • Even though at this point we do not have experimental evidence about the amount of diazonium salt present in the reaction medium, the fact that the precipitation of the desired product started during the NaNO2 addition seems to indicate that this is a short-lived intermediate that immediately cyclizes to provide the indazolone
    • 2 addition seems to indicate that this is a short-lived intermediate that immediately cyclizes to provide the indazolone.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.