메뉴 건너뛰기




Volumn 89, Issue 1, 2009, Pages 38-46

Endothelial monocyte activating polypeptide II interferes with VEGF-induced proangiogenic signaling

Author keywords

Angiogenesis; EMAP II; Endothelial cells; Migration; Proliferation; VEGF inhibition

Indexed keywords

ENDOTHELIAL MONOCYTE ACTIVATING POLYPEPTIDE II; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN KINASE B; RAF PROTEIN; RECOMBINANT PROTEIN; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2;

EID: 58149112611     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.2008.106     Document Type: Article
Times cited : (55)

References (45)
  • 1
    • 0026781869 scopus 로고
    • Endothelial monocyte-activating polypeptide II. A novel tumor-derived polypeptide that activates host-response mechanisms
    • Kao J, Ryan J, Brett G, et al. Endothelial monocyte-activating polypeptide II. A novel tumor-derived polypeptide that activates host-response mechanisms. J Biol Chem 1992;267:20239-20247.
    • (1992) J Biol Chem , vol.267 , pp. 20239-20247
    • Kao, J.1    Ryan, J.2    Brett, G.3
  • 2
    • 0027959468 scopus 로고
    • Characterization of a novel tumor-derived cytokine. Endothelial-monocyte activating polypeptide II
    • Kao J, Houck K, Fan Y, et al. Characterization of a novel tumor-derived cytokine. Endothelial-monocyte activating polypeptide II. J Biol Chem 1994;269:25106-25119.
    • (1994) J Biol Chem , vol.269 , pp. 25106-25119
    • Kao, J.1    Houck, K.2    Fan, Y.3
  • 3
    • 33749995841 scopus 로고    scopus 로고
    • Endothelial monocyte-activating polypeptide-II and its functions in (patho)physiological processes
    • van Horssen R, Eggermont AM, ten Hagen TL. Endothelial monocyte-activating polypeptide-II and its functions in (patho)physiological processes. Cytokine Growth Factor Rev 2006;17:339-348.
    • (2006) Cytokine Growth Factor Rev , vol.17 , pp. 339-348
    • van Horssen, R.1    Eggermont, A.M.2    ten Hagen, T.L.3
  • 4
    • 0034214084 scopus 로고    scopus 로고
    • Prostate adenocarcinoma cells release the novel proinflammatory polypeptide EMAP-II in response to stress
    • Barnett G, Jakobsen AM, Tas M, et al. Prostate adenocarcinoma cells release the novel proinflammatory polypeptide EMAP-II in response to stress. Cancer Res 2000;60:2850-2857.
    • (2000) Cancer Res , vol.60 , pp. 2850-2857
    • Barnett, G.1    Jakobsen, A.M.2    Tas, M.3
  • 5
    • 33745262526 scopus 로고    scopus 로고
    • Identification of protease-sensitive sites in human endothelial-monocyte activating polypeptide II protein
    • Liu J, Schwarz MA. Identification of protease-sensitive sites in human endothelial-monocyte activating polypeptide II protein. Exp Cell Res 2006;312:2231-2237.
    • (2006) Exp Cell Res , vol.312 , pp. 2231-2237
    • Liu, J.1    Schwarz, M.A.2
  • 6
    • 20344377898 scopus 로고    scopus 로고
    • Endothelial monocyte activating polypeptide-II induced gene expression changes in endothelial cells
    • Tandle AT, Mazzanti C, Alexander HR, et al. Endothelial monocyte activating polypeptide-II induced gene expression changes in endothelial cells. Cytokine 2005;30:347-358.
    • (2005) Cytokine , vol.30 , pp. 347-358
    • Tandle, A.T.1    Mazzanti, C.2    Alexander, H.R.3
  • 7
    • 27744436481 scopus 로고    scopus 로고
    • Endothelial-monocyte activating polypeptide II alters fibronectin based endothelial cell adhesion and matrix assembly via alpha5 beta1 integrin
    • Schwarz MA, Zheng H, Liu J, et al. Endothelial-monocyte activating polypeptide II alters fibronectin based endothelial cell adhesion and matrix assembly via alpha5 beta1 integrin. Exp Cell Res 2005;311:229-239.
    • (2005) Exp Cell Res , vol.311 , pp. 229-239
    • Schwarz, M.A.1    Zheng, H.2    Liu, J.3
  • 8
    • 0032894132 scopus 로고    scopus 로고
    • In vivo sensitivity of human melanoma to tumor necrosis factor (TNF)-alpha is determined by tumor production of the novel cytokine endothelial-monocyte activating polypeptide II (EMAP II)
    • Wu PC, Alexander HR, Huang J, et al. In vivo sensitivity of human melanoma to tumor necrosis factor (TNF)-alpha is determined by tumor production of the novel cytokine endothelial-monocyte activating polypeptide II (EMAP II). Cancer Res 1999;59:205-212.
    • (1999) Cancer Res , vol.59 , pp. 205-212
    • Wu, P.C.1    Alexander, H.R.2    Huang, J.3
  • 9
    • 0033567895 scopus 로고    scopus 로고
    • Sensitization of tumor necrosis factor alpha-resistant human melanoma by tumor-specific in vivo transfer of the gene encoding endothelial monocyte-activating polypeptide II using recombinant vaccinia virus
    • Gnant MF, Berger AC, Huang J, et al. Sensitization of tumor necrosis factor alpha-resistant human melanoma by tumor-specific in vivo transfer of the gene encoding endothelial monocyte-activating polypeptide II using recombinant vaccinia virus. Cancer Res 1999;59:4668-4674.
    • (1999) Cancer Res , vol.59 , pp. 4668-4674
    • Gnant, M.F.1    Berger, A.C.2    Huang, J.3
  • 10
    • 0343962297 scopus 로고    scopus 로고
    • Tumour necrosis factor receptor I (p55) is upregulated on endothelial cells by exposure to the tumour-derived cytokine endothelial monocyte-activating polypeptide II (EMAP-II)
    • Berger AC, Alexander HR, Wu PC, et al. Tumour necrosis factor receptor I (p55) is upregulated on endothelial cells by exposure to the tumour-derived cytokine endothelial monocyte-activating polypeptide II (EMAP-II). Cytokine 2000;12:992-1000.
    • (2000) Cytokine , vol.12 , pp. 992-1000
    • Berger, A.C.1    Alexander, H.R.2    Wu, P.C.3
  • 11
    • 0033517112 scopus 로고    scopus 로고
    • Endothelial-monocyte activating polypeptide II, a novel antitumor cytokine that suppresses primary and metastatic tumor growth and induces apoptosis in growing endothelial cells
    • Schwarz MA, Kandel J, Brett J, et al. Endothelial-monocyte activating polypeptide II, a novel antitumor cytokine that suppresses primary and metastatic tumor growth and induces apoptosis in growing endothelial cells. J Exp Med 1999;190:341-354.
    • (1999) J Exp Med , vol.190 , pp. 341-354
    • Schwarz, M.A.1    Kandel, J.2    Brett, J.3
  • 12
    • 0033947124 scopus 로고    scopus 로고
    • Endothelial monocyte activating polypeptide II induces endothelial cell apoptosis and may inhibit tumor angiogenesis
    • Berger AC, Alexander HR, Tang G, et al. Endothelial monocyte activating polypeptide II induces endothelial cell apoptosis and may inhibit tumor angiogenesis. Microvasc Res 2000;60:70-80.
    • (2000) Microvasc Res , vol.60 , pp. 70-80
    • Berger, A.C.1    Alexander, H.R.2    Tang, G.3
  • 13
    • 2542467676 scopus 로고    scopus 로고
    • In vivo therapy of local tumor progression by targeting vascular endothelium with EMAP-II
    • Schwarz RE, Schwarz MA. In vivo therapy of local tumor progression by targeting vascular endothelium with EMAP-II. J Surg Res 2004;120:64-72.
    • (2004) J Surg Res , vol.120 , pp. 64-72
    • Schwarz, R.E.1    Schwarz, M.A.2
  • 14
    • 0030576517 scopus 로고    scopus 로고
    • Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
    • Hanahan D, Folkman J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 1996;86:353-364.
    • (1996) Cell , vol.86 , pp. 353-364
    • Hanahan, D.1    Folkman, J.2
  • 15
    • 0028929803 scopus 로고
    • Angiogenesis in cancer, vascular, rheumatoid and other disease
    • Folkman J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat Med 1995;1:27-31.
    • (1995) Nat Med , vol.1 , pp. 27-31
    • Folkman, J.1
  • 16
  • 17
    • 0026502754 scopus 로고
    • Binding sites for vascular endothelial growth factor are localized on endothelial cells in adult rat tissues
    • Jakeman LB, Winer J, Bennett GL, et al. Binding sites for vascular endothelial growth factor are localized on endothelial cells in adult rat tissues. J Clin Invest 1992;89:244-253.
    • (1992) J Clin Invest , vol.89 , pp. 244-253
    • Jakeman, L.B.1    Winer, J.2    Bennett, G.L.3
  • 18
    • 0023039225 scopus 로고
    • A highly conserved vascular permeability factor secreted by a variety of human and rodent tumor cell lines
    • Senger DR, Perruzzi CA, Feder J, et al. A highly conserved vascular permeability factor secreted by a variety of human and rodent tumor cell lines. Cancer Res 1986;46:5629-5632.
    • (1986) Cancer Res , vol.46 , pp. 5629-5632
    • Senger, D.R.1    Perruzzi, C.A.2    Feder, J.3
  • 19
    • 0030952289 scopus 로고    scopus 로고
    • Mechanisms of angiogenesis
    • Risau W. Mechanisms of angiogenesis. Nature 1997;386:671-674.
    • (1997) Nature , vol.386 , pp. 671-674
    • Risau, W.1
  • 20
    • 0027197245 scopus 로고
    • Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo
    • Kim KJ, Li B, Winer J, et al. Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo. Nature 1993;362:841-844.
    • (1993) Nature , vol.362 , pp. 841-844
    • Kim, K.J.1    Li, B.2    Winer, J.3
  • 21
    • 0032890051 scopus 로고    scopus 로고
    • Vascular endothelial growth factor: Molecular and biological aspects
    • Ferrara N. Vascular endothelial growth factor: molecular and biological aspects. Curr Top Microbiol Immunol 1999;237:1-30.
    • (1999) Curr Top Microbiol Immunol , vol.237 , pp. 1-30
    • Ferrara, N.1
  • 22
    • 0028803509 scopus 로고
    • Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity
    • Alon T, Hemo I, Itin A, et al. Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity. Nat Med 1995;1:1024-1028.
    • (1995) Nat Med , vol.1 , pp. 1024-1028
    • Alon, T.1    Hemo, I.2    Itin, A.3
  • 23
    • 0029863730 scopus 로고    scopus 로고
    • Dominant-negative inhibition of Flk-1 suppresses the growth of many tumor types in vivo
    • Millauer B, Longhi MP, Plate KH, et al. Dominant-negative inhibition of Flk-1 suppresses the growth of many tumor types in vivo. Cancer Res 1996;56:1615-1620.
    • (1996) Cancer Res , vol.56 , pp. 1615-1620
    • Millauer, B.1    Longhi, M.P.2    Plate, K.H.3
  • 24
    • 13144262858 scopus 로고    scopus 로고
    • Paracrine expression of a native soluble vascular endothelial growth factor receptor inhibits tumor growth, metastasis, and mortality rate
    • Goldman CK, Kendall RL, Cabrera G, et al. Paracrine expression of a native soluble vascular endothelial growth factor receptor inhibits tumor growth, metastasis, and mortality rate. Proc Natl Acad Sci USA 1998;95:8795-8800.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 8795-8800
    • Goldman, C.K.1    Kendall, R.L.2    Cabrera, G.3
  • 25
    • 0032698140 scopus 로고    scopus 로고
    • Antivascular endothelial growth factor receptor (fetal liver kinase 1) monoclonal antibody inhibits tumor angiogenesis and growth of several mouse and human tumors
    • Prewett M, Huber J, Li Y, et al. Antivascular endothelial growth factor receptor (fetal liver kinase 1) monoclonal antibody inhibits tumor angiogenesis and growth of several mouse and human tumors. Cancer Res 1999;59:5209-5218.
    • (1999) Cancer Res , vol.59 , pp. 5209-5218
    • Prewett, M.1    Huber, J.2    Li, Y.3
  • 26
    • 0032890052 scopus 로고    scopus 로고
    • Structure and function of vascular endothelial growth factor receptor-1 and -2
    • Shibuya M, Ito N, Claesson-Welsh L. Structure and function of vascular endothelial growth factor receptor-1 and -2. Curr Top Microbiol Immunol 1999;237:59-83.
    • (1999) Curr Top Microbiol Immunol , vol.237 , pp. 59-83
    • Shibuya, M.1    Ito, N.2    Claesson-Welsh, L.3
  • 27
    • 0348049834 scopus 로고    scopus 로고
    • VEGF signalling: Integration and multi-tasking in endothelial cell biology
    • Zachary I. VEGF signalling: integration and multi-tasking in endothelial cell biology. Biochem Soc Trans 2003;31:1171-1177.
    • (2003) Biochem Soc Trans , vol.31 , pp. 1171-1177
    • Zachary, I.1
  • 28
    • 0034234724 scopus 로고    scopus 로고
    • Endothelial monocyte activating polypeptide II inhibits lung neovascularization and airway epithelial morphogenesis
    • Schwarz MA, Zhang F, Gebb S, et al. Endothelial monocyte activating polypeptide II inhibits lung neovascularization and airway epithelial morphogenesis. Mech Dev 2000;95:123-132.
    • (2000) Mech Dev , vol.95 , pp. 123-132
    • Schwarz, M.A.1    Zhang, F.2    Gebb, S.3
  • 29
    • 0025688912 scopus 로고
    • Vascular permeability factor: A tumor-derived polypeptide that induces endothelial cell and monocyte procoagulant activity, and promotes monocyte migration
    • Clauss M, Gerlach M, Gerlach H, et al. Vascular permeability factor: a tumor-derived polypeptide that induces endothelial cell and monocyte procoagulant activity, and promotes monocyte migration. J Exp Med 1990;172:1535-1545.
    • (1990) J Exp Med , vol.172 , pp. 1535-1545
    • Clauss, M.1    Gerlach, M.2    Gerlach, H.3
  • 30
    • 0032101999 scopus 로고    scopus 로고
    • Antiangiogenic tumour therapy: Will it work?
    • Augustin HG. Antiangiogenic tumour therapy: will it work? Trends Pharmacol Sci 1998;19:216-222.
    • (1998) Trends Pharmacol Sci , vol.19 , pp. 216-222
    • Augustin, H.G.1
  • 31
    • 34547941252 scopus 로고    scopus 로고
    • Autocrine VEGF signaling is required for vascular homeostasis
    • Lee S, Chen TT, Barber CL, et al. Autocrine VEGF signaling is required for vascular homeostasis. Cell 2007;130:691-703.
    • (2007) Cell , vol.130 , pp. 691-703
    • Lee, S.1    Chen, T.T.2    Barber, C.L.3
  • 32
    • 0026702970 scopus 로고
    • Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor
    • Terman BI, Dougher-Vermazen M, Carrion ME, et al. Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor. Biochem Biophys Res Commun 1992;187:1579-1586.
    • (1992) Biochem Biophys Res Commun , vol.187 , pp. 1579-1586
    • Terman, B.I.1    Dougher-Vermazen, M.2    Carrion, M.E.3
  • 33
    • 33748683966 scopus 로고    scopus 로고
    • Vascular endothelial growth factor receptors: Molecular mechanisms of activation and therapeutic potentials
    • Rahimi N. Vascular endothelial growth factor receptors: molecular mechanisms of activation and therapeutic potentials. Exp Eye Res 2006;83:1005-1016.
    • (2006) Exp Eye Res , vol.83 , pp. 1005-1016
    • Rahimi, N.1
  • 34
    • 0037040963 scopus 로고    scopus 로고
    • Interaction of the C-terminal domain of p43 and the alpha subunit of ATP synthase. Its functional implication in endothelial cell proliferation
    • Chang SY, Park SG, Kim S, et al. Interaction of the C-terminal domain of p43 and the alpha subunit of ATP synthase. Its functional implication in endothelial cell proliferation. J Biol Chem 2002;277:8388-8394.
    • (2002) J Biol Chem , vol.277 , pp. 8388-8394
    • Chang, S.Y.1    Park, S.G.2    Kim, S.3
  • 35
    • 0037699954 scopus 로고    scopus 로고
    • The biology of VEGF and its receptors
    • Ferrara N, Gerber HP, LeCouter J. The biology of VEGF and its receptors. Nat Med 2003;9:669-676.
    • (2003) Nat Med , vol.9 , pp. 669-676
    • Ferrara, N.1    Gerber, H.P.2    LeCouter, J.3
  • 36
    • 35348952483 scopus 로고    scopus 로고
    • Gambogic acid inhibits angiogenesis through suppressing vascular endothelial growth factor-induced tyrosine phosphorylation of KDR/Flk-1
    • Lu N, Yang Y, You QD, et al. Gambogic acid inhibits angiogenesis through suppressing vascular endothelial growth factor-induced tyrosine phosphorylation of KDR/Flk-1. Cancer Lett 2007;258:80-89.
    • (2007) Cancer Lett , vol.258 , pp. 80-89
    • Lu, N.1    Yang, Y.2    You, Q.D.3
  • 37
    • 34548101663 scopus 로고    scopus 로고
    • Acute pharmacodynamic and antivascular effects of the vascular endothelial growth factor signaling inhibitor AZD2171 in Calu-6 human lung tumor xenografts
    • Smith NR, James NH, Oakley I, et al. Acute pharmacodynamic and antivascular effects of the vascular endothelial growth factor signaling inhibitor AZD2171 in Calu-6 human lung tumor xenografts. Mol Cancer Ther 2007;6:2198-2208.
    • (2007) Mol Cancer Ther , vol.6 , pp. 2198-2208
    • Smith, N.R.1    James, N.H.2    Oakley, I.3
  • 38
    • 0031466232 scopus 로고    scopus 로고
    • The vascular endothelial growth factor receptor KDR activates multiple signal transduction pathways in porcine aortic endothelial cells
    • Kroll J, Waltenberger J. The vascular endothelial growth factor receptor KDR activates multiple signal transduction pathways in porcine aortic endothelial cells. J Biol Chem 1997;272:32521-32527.
    • (1997) J Biol Chem , vol.272 , pp. 32521-32527
    • Kroll, J.1    Waltenberger, J.2
  • 39
    • 0028145688 scopus 로고
    • Basic fibroblast growth factor-stimulated endothelial cell movement is mediated by a pertussis toxin-sensitive pathway regulating phospholipase A2 activity
    • Sa G, Fox PL. Basic fibroblast growth factor-stimulated endothelial cell movement is mediated by a pertussis toxin-sensitive pathway regulating phospholipase A2 activity. J Biol Chem 1994;269:3219-3225.
    • (1994) J Biol Chem , vol.269 , pp. 3219-3225
    • Sa, G.1    Fox, P.L.2
  • 41
    • 0032515047 scopus 로고    scopus 로고
    • Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 30-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation
    • Gerber HP, McMurtrey A, Kowalski J, et al. Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 30-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation. J Biol Chem 1998;273:30336-30343.
    • (1998) J Biol Chem , vol.273 , pp. 30336-30343
    • Gerber, H.P.1    McMurtrey, A.2    Kowalski, J.3
  • 42
    • 30044448929 scopus 로고    scopus 로고
    • Aspirintriggered Lipoxin A4 inhibition of VEGF-induced endothelial cell migration involves actin polymerization and focal adhesion assembly
    • Cezar-de-Mello PF, Nascimento-Silva V, Villela CG, et al. Aspirintriggered Lipoxin A4 inhibition of VEGF-induced endothelial cell migration involves actin polymerization and focal adhesion assembly. Oncogene 2006;25:122-129.
    • (2006) Oncogene , vol.25 , pp. 122-129
    • Cezar-de-Mello, P.F.1    Nascimento-Silva, V.2    Villela, C.G.3
  • 43
    • 0034615992 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF)-driven actin-based motility is mediated by VEGFR2 and requires concerted activation of stress-activated protein kinase 2 (SAPK2/p38) and geldanamycin-sensitive phosphorylation of focal adhesion kinase
    • Rousseau S, Houle F, Kotanides H, et al. Vascular endothelial growth factor (VEGF)-driven actin-based motility is mediated by VEGFR2 and requires concerted activation of stress-activated protein kinase 2 (SAPK2/p38) and geldanamycin-sensitive phosphorylation of focal adhesion kinase. J Biol Chem 2000;275:10661-10672.
    • (2000) J Biol Chem , vol.275 , pp. 10661-10672
    • Rousseau, S.1    Houle, F.2    Kotanides, H.3
  • 44
    • 33646107369 scopus 로고    scopus 로고
    • VEGF receptor signaling - in control of vascular function
    • Olsson AK, Dimberg A, Kreuger J, et al. VEGF receptor signaling - in control of vascular function. Nat Rev Mol Cell Biol 2006;7:359-371.
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 359-371
    • Olsson, A.K.1    Dimberg, A.2    Kreuger, J.3
  • 45
    • 0343920277 scopus 로고    scopus 로고
    • Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele
    • Carmeliet P, Ferreira V, Breier G, et al. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature 1996;380:435-439.
    • (1996) Nature , vol.380 , pp. 435-439
    • Carmeliet, P.1    Ferreira, V.2    Breier, G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.