Endothelial Monocyte Activating Polypeptide II inhibits lung neovascularization and airway epithelial morphogenesis

Mechanisms of Development

Volumn 95, Issue 1-2, 2000, Pages 123-132

  Schwarz, Margaret A ^a   Zhang, Fangrong ^a   Gebb, Sarah ^b   Starnes, Vaughn ^a   Warburton, David ^a  

^a CHILDREN S HOSPITAL LOS ANGELES   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

Angiogenesis; Anti angiogenesis; Endothelial Monocyte Activating Polypeptide II; Lung morphogenesis; Neovascularization; Pulmonary microvasculature

Indexed keywords

ANGIOGENESIS INHIBITOR; ANGIOGENIC FACTOR; ENDOTHELIAL MONOCYTE ACTIVATING POLYPEPTIDE II; MESSENGER RNA; NEUTRALIZING ANTIBODY; POLYPEPTIDE; RECOMBINANT PROTEIN; SURFACTANT PROTEIN C; UNCLASSIFIED DRUG;

ALLOGRAFT; ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; FETUS; HISTOLOGY; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; LUNG BLOOD VESSEL; LUNG DEVELOPMENT; LUNG TRANSPLANTATION; MICROVASCULATURE; MORPHOGENESIS; MOUSE; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RESPIRATORY EPITHELIUM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANGIOGENESIS INHIBITORS; ANIMALS; CELL DIFFERENTIATION; CYTOKINES; EPITHELIAL CELLS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; LUNG; MICE; MORPHOGENESIS; NEOPLASM PROTEINS; NEOVASCULARIZATION, PHYSIOLOGIC; RNA-BINDING PROTEINS;

ANIMALIA; MURINAE;

EID: 0034234724     PISSN: 09254773     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0925-4773(00)00361-0     Document Type: Article

References (22)

1. Burri P. Development and growth of the lung. McDonald J. Lung Growth and Development. 1997;1-35 Marcel Dekker, Inc, New York.
2. Coffin J.D., Harrison J., Schwartz S., Heimark R. Angioblast differentiation and morphogenesis of the vascular endothelium in the mouse embryo. Dev. Biol. 148:1991;51-62.
3. D'Amato R.J., Loughnan M.S., Flynn E., Folkman J. Thalidomide is an inhibitor of angiogenesis. Proc. Natl. Acad. Sci. USA. 91:1994;4082-4085.
4. Dickson M.C., Martin J.S., Cousins F.M., Kulkarni A.B., Karlsson S., Akhurst R.J. Defective haematopoiesis and vasculogenesis in transforming growth factor-beta 1 knock out mice. Development. 121:1995;1845-1854.
5. Drake C.J., Little C.D. Exogenous vascular endothelial growth factor induces malformed and hyperfused vessels during embryonic neovascularization. Proc. Natl. Acad. Sci. USA. 92:1995;7657-7661.
6. Drake C.J., Hungerford J.E., Little C.D. Morphogenesis of the first blood vessels. Ann. N.Y. Acad. Sci. 857:1998;155-179.
7. Flamme I., von Reutern M., Drexler H.C., Syed-Ali S., Risau W. Overexpression of vascular endothelial growth factor in the avian embryo induces hypervascularization and increased vascular permeability without alterations of embryonic pattern formation. Dev. Biol. 171:1995;399-414.
8. Gebb S., Shannon J. Tissue interactions mediate early events in pulmonary vasculogenesis. Am. J. Respir. Crit. Care Med. 157:1998;A208.
9. Gebb S.A., Shannon J.M. Tissue interactions mediate early events in pulmonary vasculogenesis [In Process Citation]. Dev. Dyn. 217:2000;159-169.
10. Kao J., Ryan J., Brett G., Chen J., Shen H., Fan Y.G., Godman G., Familletti P.C., Wang F., Pan Y.C., Stern D., Clauss M. Endothelial monocyte-activating polypeptide II. A novel tumor-derived polypeptide that activates host-response mechanisms. J. Biol. Chem. 267:1992;20239-20247.
11. Kao J., Fan Y.G., Haehnel I., Clauss M., Stern D. Endothelial-monocyte activating polypeptides (EMAPs): tumor derived mediators which activate the host inflammatory response. Behring. Inst. Mitt. 92:1993;92-106.
12. Kao J., Houck K., Fan Y., Haehnel I., Libutti S.K., Kayton M.L., Grikscheit T., Chabot J., Nowygrod R., Greenberg S., Kuang W., Leung D., Hayward J.R., Kisiel W., Heath M., Brett J., Stern D.M. Characterization of a novel tumor-derived cytokine. Endothelial monocyte-activating polypeptide II. J. Biol. Chem. 269:1994;25106-25119.
13. Masters J.R. Epithelial-mesenchymal interaction during lung development: the effect of mesenchymal mass. Dev. Biol. 51:1976;98-108.
14. Poole T.J., Coffin J.D. Vasculogenesis and angiogenesis: two distinct morphogenetic mechanisms establish embryonic vascular pattern. J. Exp. Zool. 251:1989;224-231.
15. Schwarz M., Lee M., Zhang F., Zhao J., Jin Y., Smith S., Bhuva J., Stern D., Warburton D., Starnes V. EMAP II: a modulator of neovascularization in the developing lung. Am. J. Physiol. 276:1999;L365-L375.
16. Schwarz M.A., Kandel J., Brett G., Li J., Hayward J., Schwarz R.E., Chappey O., Wautier J., Chabot J., Lo Gerfo P., Stern D. Endothelial-Monocyte Activating Polypeptide II, a novel antitumor cytokine that suppresses primary and metastatic tumor growth, and induces apoptosis in growing endothelial cells. J. Exp. Med. 190:1999;341-353.
17. Schwarz M.A., Zhang F., Lane J.E., Schachtner S., Jin Y., Deutsch G., Starnes V., Pitt B.R. Angiogenesis and morphogenesis of murine fetal distal lung in an allograft model. Am. J. Physiol.: Lung Cell. Mol. Physiol. 278:2000;L1000-L1007.
18. Vermeulen P.B., Gasparini G., Fox S.B., Toi M., Martin L., McCulloch P., Pezzella F., Viale G., Weidner N., Harris A.L., Dirix L.Y. Quantification of angiogenesis in solid human tumours: an international consensus on the methodology and criteria of evaluation. Eur. J. Cancer. 14:1996;2474-2484.
19. Wessells N. Tissue Interactions and Development. 1977;Benjamin, Meno Park, CA.
20. Yamaguchi T.P., Dumont D.J., Conlon R.A., Breitman M.L., Rossant J. flk-1, an flt-related receptor tyrosine kinase is an early marker for endothelial cell precursors. Development. 118:1993;489-498.
21. Zeng X., Wert S.E., Federici R., Peters K.G., Whitsett J.A. VEGF enhances pulmonary vasculogenesis and disrupts lung morphogenesis in vivo. Dev. Dyn. 211:1998;215-227.
22. Zhou L., Dey C.R., Wert S.E., Whitsett J.A. Arrested lung morphogenesis in transgenic mice bearing an SP-C-TGF-beta 1 chimeric gene. Dev. Biol. 175:1996;227-238.