The James Blundell Award Lecture 2007: Do we really understand immune red cell destruction?

Transfusion Medicine

Volumn 18, Issue 6, 2008, Pages 321-334

  Garratty, G ^a  

^a AMERICAN RED CROSS BLOOD SERVICES   (United States)

Author keywords

Immunoglobulins; Phagocytosis; RBC destruction

Indexed keywords

CD47 ANTIGEN; IMMUNOGLOBULIN; IMMUNOGLOBULIN G;

CELL DEATH; CELL SURVIVAL; COOMBS TEST; CYTOLYSIS; CYTOTOXICITY; ERYTHROCYTE; GLYCOSYLATION; HEMOLYTIC ANEMIA; HUMAN; MACROPHAGE; NATURAL KILLER CELL; NONHUMAN; PHAGOCYTOSIS; REVIEW;

ALLERGY AND IMMUNOLOGY; ANEMIA, HEMOLYTIC; ANEMIA, HEMOLYTIC, AUTOIMMUNE; ANTIGENS, CD47; AUTOANTIBODIES; AWARDS AND PRIZES; BLOOD TRANSFUSION; COMPLEMENT ACTIVATION; ERYTHROCYTE AGING; ERYTHROCYTES; GLYCOSYLATION; HUMANS; IMMUNOGLOBULIN FC FRAGMENTS; ISOANTIBODIES; LEUKOCYTES; MODELS, IMMUNOLOGICAL; MONONUCLEAR PHAGOCYTE SYSTEM; PHAGOCYTOSIS; REACTIVE OXYGEN SPECIES;

EID: 58149091726     PISSN: 09587578     EISSN: 13653148     Source Type: Journal    
DOI: 10.1111/j.1365-3148.2008.00891.x     Document Type: Review

References (98)

1. AABB 2008) Standards for Blood Banks and Transfusion Services (25th edn). AABB, Bethesda, MD.
2. Ahrens, N., Pagenkopf, C., Kiesewetter, H. Salama, A. (2006) CD47 is expressed at normal levels in patients with autoimmune haemolytic anaemia and/or immune thrombocytopenia. Transfusion Medicine, 16, 397 402.
3. Arese, P., Turrini, F. Schwarzer, E. (2005) Band 3/complement-mediated recognition and removal of normally senescent and pathological human erythrocytes. Cellular Physiology and Biochemistry, 16, 133 146.
4. null red blood cells with reduced CD47 do not show increased interactions with peripheral blood monocytes. British Journal of Haematology, 125, 405 417.
5. Barker, R.N., Leader, K.A. Elson, C.J. (1999) Serial changes in the galactosylation of autoantibodies and serum IgG in autoimmune haemolytic anaemia. Autoimmunity, 31, 103 108.
6. Baudino, L., Fossati-Jimack, L., Chevalley, C., Martinez-Soria, E., Shulman, M.J. Izui, S. (2007) IgM and IgA anti-erythrocyte autoantibodies induce anaemia in a mouse model through multivalency-dependent hemagglutination but not through complement activation. Blood, 109, 5355 5362.
7. Benson, K., Agosti, S.J., Latoni-Benedetti, G.E. Leparc, G.F. (2003) Acute and delayed hemolytic transfusion reactions secondary to HLA alloimmunization. Transfusion, 43, 753 757.
8. Boccardi, V., Girelli, G., Perricone, R., Ciccone, F., Romoli, P. Isacchi, G. (1978) Coombs-negative autoimmune hemolytic anemia: report of 11 cases. Haematologica, 63, 301 310.
9. Bocci, V. (1981) Determinants of erythrocyte ageing: a reappraisal. British Journal of Haematology, 48, 515 522.
10. Bosman, G.J.C.G.M., Willekens, F.L.A. Were, J.M. (2005) Erythrocyte aging: a more than superficial resemblance to apoptosis? Cellular Physiology and Biochemistry, 16, 1 8.
11. Brain, M.C., Prevost, J.M., Pihl, C.E. Brown, C.B. (2002) Glycophorin A-mediated haemolysis of normal human erythrocytes: evidence of antigen aggregation in the pathogenesis of immune haemolysis. British Journal of Haematology, 118, 899 908.
12. Bratosin, D., Mazurier, J., Tissier, J.P., Estaquier, J., Huart, J.J., Ameisen, J.C., Aminoff, D. Montreuil, J. (1998) Cellular and molecular mechanisms of senescent erythrocyte phagocytosis by macrophages. A review. Biochimie, 80, 173 195.
13. Chaplin, H. (1973) Clinical usefulness of specific antiglobulin reagents in autoimmune hemolytic anemias. Progress in Hematology, 8, 25 49.
14. Chapman, J.F., Elliott, C., Knowles, S.M., Milkins, C.E., Poole, G.D. Working Party of the British Committee for Standards in Haematology Blood Transfusion Task Force 2004) Guidelines for compatibility procedures in blood transfusion laboratories. Transfusion Medicine, 14, 59 73.
15. Coopamah, M.D., Freedman, J. Semple, J.W. (2003) Anti-D initially stimulates an Fc-dependent leukocyte oxidative burst and subsequently suppresses erythrophagocytosis via interleukin-1 receptor antagonist. Blood, 102, 2862 2867.
16. Dameshek, W. (1965) Autoimmunity: theoretical aspects. Annals of the New York Academy of Sciences, 124, 6 28.
17. Darabi, K. Dzik, S. (2005) Hyperhemolysis syndrome in anemia of chronic disease. Transfusion, 45, 1930 1933.
18. Dooren, M.C., Kuijpers, R.W., Joekes, E.C., Huiskes, E., Goldschmeding, R., Overbeeke, M.A., von dem Borne, A.E., Engelfriet, C.P. Ouwehand, W.H 1992) Protection against immune haemolytic disease of newborn infants by maternal monocyte-reactive IgG alloantibodies (anti-HLA-DR). Lancet, 339, 1067 1070.
19. Fossati-Jimack, L., Reininger, L., Chicheportiche, Y., Clynes, R., Ravetch, J.V., Honjo, T. Izui, S. (1999) High pathogenic potential of low-affinity autoantibodies in experimental autoimmune hemolytic anemia. Journal of Experimental Medicine, 190, 1689 1696.
20. Frank, M.M., Hamburger, M.I., Lawley, T.J., Kimberly, R.P. Plotz, P.H. (1979) Defective reticuloendothelial system Fc-receptor function in systemic lupus erythematosus. New England Journal of Medicine, 300, 518 523.
21. Friedman, D.F., Lukas, M.B., Jawad, A., Larson, P.J., Ohene-Frempong, K. Manno, C.S. (1996) Alloimmunization to platelets in heavily transfused patients with sickle cell disease. Blood, 88, 3216 3222.
22. Gaines, A.R. (2000) Acute onset hemoglobinemia and/or hemoglobinuria and sequelae following Rh(o)(D) immune globulin intravenous administration in immune thrombocytopenic purpura patients. Blood, 95, 2523 2539.
23. o(D) immune globulin intravenous administration for immune thrombocytopenia purpura. Blood, 106, 1532 1537.
24. Garcia-Suarez, J., Prieto, A., Reyes, E., Manzano, L., Merino, J.L. Alvarez-Mon, M. (1993) Severe chronic autoimmune thrombocytopenic purpura is associated with an expansion of CD56+ CD3- natural killer cells subset. Blood, 82, 1538 1545.
25. Garratty, G. (1981) Basic mechanisms of in vivo cell destruction. In : A Seminar on Immune-Mediated Cell Destruction (eds Bell, C.A. Engelfriet, C.P. 1 28. American Association of Blood Banks, Washington, DC.
26. Garratty, G. (1989) Factors affecting the pathogenicity of red cell auto- and alloantibodies. In : Immune Destruction of Red Blood Cells (ed. Nance, S.T. 109 169. American Association of Blood Banks, Arlington, Virginia.
27. Garratty, G. (1991) Effect of cell-bound proteins on the in vivo survival of circulating blood cells. Gerontology, 37, 68 94.
28. Garratty, G. (1997) Severe reactions associated with transfusion of patients with sickle cell disease. Transfusion, 47, 357 361.
29. Garratty, G. (2004) Autoantibodies induced by blood transfusion. Transfusion, 44, 5 9.
30. Garratty, G. (2005) Immune hemolytic anemia associated with negative routine serology. Seminars in Hematology, 42, 156 164.
31. Garratty, G. (2007) Sir John Dacie, MD, FRCP, FRCPath, FRS (1912-2005). Transfusion Medicine Reviews, 21, 72 74.
32. Garratty, G. Nance, S.J. (1990) Correlation between in vivo hemolysis and the amount of red cell-bound IgG measured by flow cytometry. Transfusion, 30, 617 621.
33. Garratty, G., Arndt, P., Postoway, N. Nance, S. (1996) Severe hemolytic transfusion reactions associated with antibodies not detectable by routine methods. Transfusion, 36, 23S (abstract).
34. Garratty, G., Leger, R.M., Hunt, P. Co, A. (2004) Serological investigation of a large series of direct antiglobulin test-negative hemolytic anemia. Transfusion, 44, 121A (abstract).
35. Gilsanz, F., De La Serna, J., Moltó, L. Alvarez-Mon, M. (1996) Hemolytic anemia in chronic large granular lymphocytic leukemia of natural killer cells: cytotoxicity of natural killer cells against autologous red cells is associated with hemolysis. Transfusion, 36, 463 466.
36. Götze, O. Müeller-Eberhard, H.J. (1970) Lysis of erythrocytes by complement in the absence of antibody. The Journal of Experimental Medicine, 132, 898 915.
37. Griffiths, H.L., Kumpel, B.M., Elson, C.J. Hadley, A.G. (1994) The functional activity of human monocytes passively sensitized with monoclonal anti-D suggests a novel role for FcγRI in the immune destruction of blood cells. Immunology, 83, 370 377.
38. Hadley, A.G., Zupanska, B., Kumpel, B.M. et al 1995) The glycosylation of red cell autoantibodies affects their functional activity in vitro. British Journal of Haematology, 91, 587 594.
39. Head, D.J., Lee, Z.E., Poole, J. Avent, N.D. (2005) Expression of phosphatidylserine (PS) on wild-type Gerbich variant erythrocytes following glycophorin-C (GPC) ligation. British Journal of Haematology, 129, 130 137.
40. Heal, J.M., Cowles, D., Masel, D., Rowe, J.M. Blumberg, N. (1992) Antibodies to plasma proteins: an association with platelet transfusion refractoriness. British Journal of Haematology, 80, 83 90.
41. Heddle, N.M., Soutar, R.L., O'Hoski, P.L., Singer, J., McBride, J.A., Ali, M.A.M. Kelton, J.G. (1995) A prospective study to determine the frequency and clinical significance of alloimmunization post-transfusion. British Journal of Haematology, 91, 1000 1005.
42. Hymes, K.B., Schuck, M.P. Karpatkin, S. (1990) Regulation of autoimmune anti-platelet antibody-mediated adhesion of monocytes to platelet GPIIb/GPIIIa: effect of armed monocytes and the Mac-1 receptor. Blood, 75, 1813 1819.
43. Kelton, J.G. (1985) Impaired reticuloendothelial function in patients treated with methyldopa. New England Journal of Medicine, 313, 596 600.
44. King, K.E., Shirey, R.S., Lankiewicz, M.W., Young-Ramsaran, J. Ness, P.M. (1997) Delayed hemolytic transfusion reactions in sickle cell disease: simultaneous destruction of recipients' red cells. Transfusion, 37, 376 381.
45. Kumpel, B.M., Rademacher, T.W., Rook, G.A.W., Williams, P.J. Wilson, I.B.H. (1994) Galactosylation of human IgG monoclonal anti-D produced by EBV-transformed B-lymphoblastoid cell lines is dependent on culture method and affects Fc receptor-mediated functional activity. Human Antibodies and Hybridomas, 5, 143 151.
46. Lachmann, P.J. Thompson, R.A. (1970) Reactive lysis: the complement-mediated lysis of unsensitized cells. Journal of Experimental Medicine, 131, 643 657.
47. Lang, K.S., Lang, P.A., Bauer, C., Duranton, C., Wieder, T., Huber, S.M. Lang, F. (2005) Mechanisms of suicidal erythrocyte death. Cellular Physiology and Biochemistry, 15, 192 202.
48. Lee, J.-M., Chan, K., Kan, Y.W. Johnson, J.A. (2004) Targeted disruption of Nrf2 causes regenerative immune-mediated hemolytic anemia. Proceedings of the National Academy of Sciences, 101, 9751 9756.
49. Linden, J.V. Dressler, K.P. (1992) A report of 104 transfusion errors in New York State. Transfusion, 32, 601 608.
50. Malaise, M.G., Franchimont, P. Mahieu, P.R. (1989) The ability of normal human monocytes to phagocytose IgG-coated red blood cells is related to the number of accessible galactosyl and mannosyl residues in the Fc domain of the anti-red blood cell IgG antibody molecule. Journal of Immunological Methods, 119, 231 239.
51. Malaise, M.G., Hoyoux, C., Franchimont, P. Mahieu, P.R. (1990) Evidence for a role of accessible galactosyl or mannosyl residues of Fc domain in the in vivo clearance of IgG antibody-coated autologous erythrocytes in the rat. Clinical Immunology and Immunopathology, 54, 469 483.
52. Malasit, P., Mahasorn, W., Mongkolsapaya, J., Singhathong, B., Fucharoen, S., Wasi, P. Bhakdi, S. (1997) Presence of immunoglobulins, C3 and cytolytic C5b-9 complement components on the surface of erythrocytes from patients with β-thalassaemia/HbE disease. British Journal of Haematology, 96, 507 513.
53. Malhotra, R., Wormald, M.R., Rudd, P.M., Fischer, P.B., Dwek, R.A. Sim, R.B. (1995) Glycosylation changes of IgG associated with rheumatoid arthritis can activate complement via the mannose-binding protein. Nature Medicine, 1, 237 243.
54. Masouredis, S.P., Branks, M.J., Garratty, G. Victoria, E.J. (1987a) Immunospecific red cell binding of iodine 125-labeled immunoglobulin G erythrocyte autoantibodies. The Journal of Laboratory and Clinical Medicine, 110, 308 317.
55. Masouredis, S.P., Branks, M.J. Victoria, E.J. (1987b) Antiidiotype IgG crossreactive with Rh alloantibodies in red cell autoimmunity. Blood, 70, 710 715.
56. Masouredis, S.P., Branks, M.J., Pierce, S.W. Victoria, E.J. (1989) Nonhemolytic red cell autoantibodies consist of multiple immunoglobulin G populations directed against complex membrane epitopes. The Journal of Laboratory and Clinical Medicine, 113, 569 576.
57. Mollison, P.L., Engelfriet, C.P. Contreras, M. (1997) Blood Transfusion in Clinical Medicine (10th edn). Blackwell Scientific Publications, Oxford.
58. Mouro-Chanteloup, I., Delaunay, J., Gane, P., Nicolas, V., Johansen, M., Brown, E.J., Peters, L.L., Kim, C.L.V., Cartron, J.P. Colin, Y 2003) Evidence that the red cell skeleton protein 4.2 interacts with the Rh membrane complex member CD47. Blood, 101, 338 344.
59. Nardi, M., Tomlinson, S., Greco, M.A. Karpatkin, S. (2001) Complement-independent, peroxide-induced antibody lysis of platelets in HIV-1-related immune thrombocytopenia. Cell, 106, 551 561.
60. Nardi, M., Feinmark, S.J., Hu, L., Li, Z. Karpatkin S. (2004) Complement-independent Ab-induced peroxide lysis of platelets requires 12-lipoxygenase and a platelet NADPH oxidate pathway. The Journal of Clinical Investigation, 113, 973 980.
61. Ness, P.M., Shirey, R.S., Thoman, S.K. Buck, S.A. (1990) The differentiation of delayed serologic and delayed hemolytic transfusion reactions: incidence, long-term serologic findings, and clinical significance. Transfusion, 30, 688 693.
62. Nordhagen, R. Aas, M. (1978) Association between HLA and red cell antigens. VII. Survival studies of incompatible red blood cells in a patient with HLA-associated haemagglutinins. Vox Sanguinis, 35, 319 323.
63. Oldenborg, P.A. (2004) Role of CD47 in erythroid cells and in autoimmunity. Leukemia & Lymphoma, 45, 1319 1327.
64. Oldenborg, P.A., Zheleznyak, A., Fang, Y.F., Lagenaur, C.F., Gresham, H.D. Lindberg, F.P. (2000) Role of CD47 as a marker of self on red blood cells. Science, 288, 2051 2054.
65. Oldenborg, P.A., Gresham, H.D. Lindberg, F.P. (2001) CD47-signal regulatory protein α (SIRPα) regulates Fcγ and complement receptor-mediated phagocytosis. Journal of Experimental Medicine, 193, 855 861.
66. Oldenborg, P.A., Gresham, H.D., Chen, Y., Izui, S. Lindberg, F.P. (2002) Lethal autoimmune hemolytic anemia in CD47-deficient nonobese diabetic (NOD) mice. Blood, 99, 3500 3504.
67. Olsson, B., Andersson, P.O., Jernås, M., Jacobsson, S., Carlsson, B., Carlsson, L.M. Wadenvik, H. (2003) T-cell-mediated cytotoxicity toward platelets in chronic idiopathic thrombocytopenic purpura. Nature Medicine, 9, 1123 1124.
68. Panzer, S., Mueller-Eckhardt, G., Salama, A., Strauss, B.E., Kiefel, V. Mueller-Eckhardt, C. (1984) The clinical significance of HLA antigens on red cells. Transfusion, 24, 486 489.
69. Panzer, S., Mayr, W.R., Graninger, W., Hocker, P., Graninger, W. Lechner, K. (1987) Haemolytic transfusion reactions due to HLA antibodies. Lancet, 1, 474 478.
70. Petz, L.D. (2006) Bystander immune cytolysis. Transfusion Medicine Reviews, 20, 110 140.
71. Petz, L.D. Garratty, G. (1980) Acquired Immune Hemolytic Anemias. Churchill Livingstone, New York, New York.
72. Petz, L.D., Garratty G. (2004). Immune Hemolytic Anemias. Churchill Livingstone, Philadelphia, Pennsylvania.
73. Petz, L.D., Calhoun, L., Shulman, I.A., Johnson, C. Herron, R.M. (1997) The sickle cell hemolytic transfusion reaction syndrome. Transfusion, 37, 382 392.
74. Pineda, A.A., Vamvakas, E.C., Gorden, L.D., Winters, J.L. Moore, S.B. (1999) Trends in the incidence of delayed hemolytic and delayed serologic transfusion reactions. Transfusion, 39, 1097 1103.
75. Pinkerton, P.H., Coovadia, A.S. Goldstein, J. (1992) Frequency of delayed hemolytic transfusion reactions following antibody screening and immediate-spin crossmatching. Transfusion, 32, 814 817.
76. Robillard, P., Nawej, K.I. Garneau, N. (2004) Trends in red cell-associated ABO mistransfusions. Acute and delayed serologic transfusion reactions in the Quebec Hemovigilance System: 2000-2003. Transfusion, 44, 17A (abstract).
77. Ruiz-Argüelles, A. Llorente, L. (2007) The role of complement regulatory proteins (CD55 and CD59) in the pathogenesis of autoimmune hemocytopenias. Autoimmunity Reviews, 6, 155 161.
78. Salama, M.A.S., Sadek, N.A., Hassab, H.M.A., Abadeer, A.F. Mikhael, I.L. (2004) Erythrocyte autoantibodies and expression of CD59 on the surface of red blood cells of polytransfused patients with β-thalassaemia major. British Journal of Biomedical Science, 61, 88 92.
79. Shibata, T., Berney, T., Reininger, L., Chicheportiche, Y., Ozaki, S., Shiral, T. Izui, S. (1990) Monoclonal anti-erythrocyte autoantibodies derived from NZB mice cause autoimmune hemolytic anemia by two distinct pathogenic mechanisms. International Immunology, 2, 1133 1141.
80. Sirchia, G., Ferrone, S. Mercuriali, F. (1970) Leukocyte antigen-antibody reaction and lysis of paroxysmal nocturnal hemoglobinuria erythrocytes. Blood, 36, 334 336.
81. Sirchia, G., Morelati, F. Rebulla, P. (1997) The sickle cell hemolytic transfusion reaction syndrome. Transfusion, 37, 1098 1099.
82. Subramanian, S., Parthasarathy, R., Sen, S., Boder, E.T. Discher, D.E. (2006) Species- and cell type-specific interactions between CD47 and human SIRPα. Blood, 107, 2548 2556.
83. Sunada, M., Suzuki, S. Ota, Z. (1985) Reticuloendothelial cell function in autoimmune hemolytic anemia (AIHA): studies on the mechanism of peripheral monocyte activation. Acta Medica Okayama, 39, 375 384.
84. Test, S.T. Woolworth, V.A. (1994) Defective regulation of complement by the sickle erythrocyte: evidence for a defect in control of membrane attack complex formation. Blood, 83, 842 852.
85. Thompson, R.A. Lachmann, P.J. (1970) Reactive lysis: the complement-mediated lysis of unsensitized cells. Journal of Experimental Medicine, 131, 629 641.
86. Thompson, R.A. Rowe, D.S. (1968) Reactive hemolysis - a distinctive form of red cell lysis. Immunology, 14, 745 762.
87. Treleaven, J.G. Win, N. (2004) Hyperhaemolysis syndrome in a patient with myelofibrosis. Hematology, 9, 147 149.
88. Vamvakas, E.C., Pineda, A.A. Moore, S.B. (1995a) Incidence of delayed hemolytic transfusion reactions. Vox Sanguinis, 69, 86.
89. Vamvakas, E.C., Pineda, A.A., Reisner, R., Santrach, P.J. Moore, S.B. (1995b) The differentiation of delayed hemolytic and delayed serologic transfusion reactions: incidence and predictors of hemolysis. Transfusion, 35, 26 32.
90. Van der Hart, M., Szaloky, A., Van den Berg-Loonen, E.M., Engelfriet, C.P. Van Loghem, J.J. (1974) Presence of HL-A antigens on the erythrocytes of a normal donor. Nouvelle Revue Francaise d'Hematologie, 14, 555 563.
91. Van der Meulen, F.W., De Bruin, H.G., Goosen, P.C.M., Bruynes, E.C.E., Joustra-Maas, C.J., Telkamp, H.G., Von Dem Borne, A.E.G. Kr. Engelfriet, C.P 1980) Quantitative aspects of the destruction of red cells sensitized with IgG1 autoantibodies: an application of flow cytofluorometry. British Journal of Haematology, 46, 47 56.
92. Walker, M.R., Lund, J., Thompson, K.M. Jefferis, R. (1989) Aglycosylation of human IgG1 and IgG3 monoclonal antibodies can eliminate recognition by human cells expressing Fc gamma R1 and/or Fc gamma RII receptors. Biochemical Journal, 259, 347 353.
93. Weitkamp, L.A., Johnson, S.T., Larson, L.B., Hackbarth, S.A., Pierce, K.L. Oesterling, K.F. (1993) Severe, symptomatic haemolytic transfusion reactions secondary to strong HLA antibody directed toward A2 public and private epitopes. Transfusion, 33, 55S (abstract).
94. Wentworth, A.D., Jones, L.H., Wenworth, P. Jr., Janda, K.D. Lerner, R.A. (2000) Antibodies have the intrinsic capacity to destroy antigens. Proceedings of the National Academy of Science of the United States of America, 97, 10930 10935.
95. Wentworth, P. Jr., Jones, L.H., Wentworth, A., Zhu, X., Larsen, N.A., Wilson, I.A., Xu, X., Goddard, W.A., Janda, K.D., Eschenmoser, A. Lerner, R.A 2001) Antibody catalysis of the oxidation of water. Science, 293, 1806 1811.
96. Wentworth, P. Jr., McDunn, J.E., Wentworth, A.D., Takeuchi, C., Nieva, J., Jones, T., Baut, ista, C., Ruedi, J.M., Gutierrez, A., Janda, K.D., Babior, B.M., Eschenmoser, A. Lerner, R.A 2002) Evidence for antibody-catalzyed ozone formation in bacterial killing and inflammation. Science, 298, 2195 2199.
97. Win, N., New, H., Lee, E. de la Fuente, J. (2008) Hyperhemolysis syndrome in sickle cell disease: case report (recurrent episode) and literature review. Transfusion, 48, 1231 1238.
98. Worlledge, S.M. Blajchman, M.A. (1972) The autoimmune haemolytic anaemias. British Journal of Haematology, 23, 61 69.