Immunohistochemical profiling of benign, low malignant potential and low grade serous epithelial ovarian tumors

BMC Cancer

Volumn 8, Issue , 2008, Pages

  Ouellet, Véronique ^a   Ling, Tak Hay ^a,b   Normandin, Karine ^a   Madore, Jason ^a   Lussier, Christian ^a   Barrès, Véronique ^a   Bachvarov, Dimcho ^c,d   Rancourt, Claudine ^e   Tonin, Patricia N ^f,g   Provencher, Diane M ^a,h   Mes Masson, Anne Marie ^a,h  

^a CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^c UNIVERSITÉ LAVAL   (Canada)

^d LAVAL UNIVERSITY   (Canada)

^e UNIVERSITÉ DE SHERBROOKE   (Canada)

^f MCGILL UNIVERSITY   (Canada)

^g RESEARCH INSTITUTE OF THE MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

^h UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; PROTEIN APE1; PROTEIN CCNB1; PROTEIN CCNE1; PROTEIN CKD1; PROTEIN P21; PROTEIN SET; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; UNCLASSIFIED DRUG; TUMOR MARKER;

ADULT; ARTICLE; BENIGN TUMOR; CANCER GRADING; CANCER INHIBITION; CONTROLLED STUDY; DIFFERENTIAL DIAGNOSIS; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; OVARY TUMOR; PROTEIN ANALYSIS; PROTEIN EXPRESSION; SEROUS EPITHELIAL OVARY TUMOR; TISSUE MICROARRAY; TUMOR CLASSIFICATION; TUMOR DIFFERENTIATION; CYSTADENOMA; METABOLISM; PATHOLOGY;

CYSTADENOMA, SEROUS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; OVARIAN NEOPLASMS; TISSUE ARRAY ANALYSIS; TUMOR MARKERS, BIOLOGICAL;

EID: 58149088152     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-8-346     Document Type: Article

References (67)

1. Crum CP Drapkin R Kindelberger D Medeiros F Miron A Lee Y Lessons from BRCA: The tubal fimbria emerges as an origin for pelvic serous cancer Clin Med Res 2007, 5(1):35-44 1855333 17456833 10.3121/cmr.2007.702
2. Crum CP Drapkin R Miron A Ince TA Muto M Kindelberger DW Lee Y The distal fallopian tube: A new model for pelvic serous carcinogenesis Curr Opin Obstet Gynecol 2007, 19(1):3-9 17218844
3. Chen VW Ruiz B Killeen JL Cote TR Wu XC Correa CN Pathology and classification of ovarian tumors Cancer 2003, 97(10 Suppl):2631-2642 10.1002/cncr.11345 12733128
4. Auersperg N Wong AS Choi KC Kang SK Leung PC Ovarian surface epithelium: biology, endocrinology, and pathology Endocr Rev 2001, 22(2):255-288 10.1210/er.22.2.255 11294827
5. Scully RE Common epithelial tumors of borderline malignancy (carcinomas of low malignant potential) Bull Cancer 1982, 69(3):228-238 6289947
6. Dietel M Hauptmann S Serous tumors of low malignant potential of the ovary. 1. Diagnostic pathology Virchows Arch 2000, 436(5):403-412 10.1007/s004280050467 10881733
7. Hart WR Borderline epithelial tumors of the ovary Mod Pathol 2005, 18(Suppl 2):S33-50 10.1038/modpathol.3800307 15761465
8. Burger CW Prinssen HM Baak JP Wagenaar N Kenemans P The management of borderline epithelial tumors of the ovary Int J Gynecol Cancer 2000, 10(3):181-197 10.1046/j.1525-1438.2000.010003181.x 11240673
9. Tavassoli FA Serous tumor of low malignant potential with early stromal invasion (serous LMP with microinvasion) Mod Pathol 1988, 1(6):407-414 2464824
10. Silverberg SG Histopathologic grading of ovarian carcinoma: A review and proposal Int J Gynecol Pathol 2000, 19(1):7-15 10.1097/ 00004347-200001000-00003 10638449
11. Heintz AP Odicino F Maisonneuve P Beller U Benedet JL Creasman WT Ngan HY Pecorelli S Carcinoma of the ovary Int J Gynaecol Obstet 2003, 83(Suppl 1):135-166 10.1016/S0020-7292(03)90118-4 14763172
12. Malpica A Grading of ovarian cancer: A histotype-specific approach Int J Gynecol Pathol 2008, 27(2):175-181 18317226
13. Shih Ie M Kurman RJ Ovarian tumorigenesis: A proposed model based on morphological and molecular genetic analysis Am J Pathol 2004, 164(5):1511-1518 1615664 15111296
14. Shih Ie M Kurman RJ Molecular pathogenesis of ovarian borderline tumors: new insights and old challenges Clin Cancer Res 2005, 11(20):7273-7279 10.1158/1078-0432.CCR-05-0755 16243797
15. de Souza PL Friedlander ML Prognostic factors in ovarian cancer Hematol Oncol Clin North Am 1992, 6(4):761-782 1500385
16. Bell DA Scully RE Ovarian serous borderline tumors with stromal microinvasion: A report of 21 cases Hum Pathol 1990, 21(4):397-403 10.1016/0046-8177(90)90201-F 2318481
17. Hanselaar AG Vooijs GP Mayall B Ras-Zeijlmans GJ Chadha-Ajwani S Epithelial markers to detect occult microinvasion in serous ovarian tumors Int J Gynecol Pathol 1993, 12(1):20-27 7678103
18. Jones MB Borderline ovarian tumors: Current concepts for prognostic factors and clinical management Clin Obstet Gynecol 2006, 49(3):517-525 10.1097/00003081-200609000-00011 16885658
19. Bell DA Longacre TA Prat J Kohn EC Soslow RA Ellenson LH Malpica A Stoler MH Kurman RJ Serous borderline (low malignant potential, atypical proliferative) ovarian tumors: Workshop perspectives Hum Pathol 2004, 35(8):934-948 10.1016/j.humpath.2004.03.005 15297961
20. Longacre TA McKenney JK Tazelaar HD Kempson RL Hendrickson MR Ovarian serous tumors of low malignant potential (borderline tumors): outcome-based study of 276 patients with long-term (> or = 5-year) follow-up Am J Surg Pathol 2005, 29(6):707-723 10.1097/ 01.pas.0000164030.82810.db 15897738
21. Kennedy AW Hart WR Ovarian papillary serous tumors of low malignant potential (serous borderline tumors). A long-term follow-up study, including patients with microinvasion, lymph node metastasis, and transformation to invasive serous carcinoma Cancer 1996, 78(2):278-286 10.1002/(SICI)1097-0142(19960715)78:2<278::AID-CNCR14>3.0.CO;2-T 8674004
22. Young RH Scully RE Pathology of epithelial tumors Hematol Oncol Clin North Am 1992, 6(4):739-760 1500384
23. Seidman JD Soslow RA Vang R Berman JJ Stoler MH Sherman ME Oliva E Kajdacsy-Balla A Berman DM Copeland LJ Borderline ovarian tumors: diverse contemporary viewpoints on terminology and diagnostic criteria with illustrative images Hum Pathol 2004, 35(8):918-933 10.1016/ j.humpath.2004.03.004 15297960
24. Hoskins WJ Young RC Markman M Perez AP Barakat RR Randall M Principles and Practice of Gynecologic Oncology Philadelphie: Lippincott Williams & Wilkins 4 2005
25. Nayar R Siriaunkgul S Robbins KM McGowan L Ginzan S Silverberg SG Microinvasion in low malignant potential tumors of the ovary Hum Pathol 1996, 27(6):521-527 10.1016/S0046-8177(96)90156-2 8666359
26. Burks RT Sherman ME Kurman RJ Micropapillary serous carcinoma of the ovary. A distinctive low-grade carcinoma related to serous borderline tumors Am J Surg Pathol 1996, 20(11):1319-1330 10.1097/ 00000478-199611000-00003 8898836
27. Prat J De Nictolis M Serous borderline tumors of the ovary: A long-term follow-up study of 137 cases, including 18 with a micropapillary pattern and 20 with microinvasion Am J Surg Pathol 2002, 26(9):1111-1128 10.1097/ 00000478-200209000-00002 12218568
28. Eichhorn JH Bell DA Young RH Scully RE Ovarian serous borderline tumors with micropapillary and cribriform patterns: A study of 40 cases and comparison with 44 cases without these patterns Am J Surg Pathol 1999, 23(4):397-409 10.1097/00000478-199904000-00004 10199469
29. Seidman JD Ronnett BM Kurman RJ Pathology of borderline (low malignant potential) ovarian tumours Best Pract Res Clin Obstet Gynaecol 2002, 16(4):499-512 10.1053/beog.2002.0300 12413931
30. Ouellet V Guyot MC Le Page C Filali-Mouhim A Lussier C Tonin PN Provencher DM Mes-Masson AM Tissue array analysis of expression microarray candidates identifies markers associated with tumor grade and outcome in serous epithelial ovarian cancer Int J Cancer 2006, 119(3):599-607 10.1002/ijc.21902 16572426
31. Ouellet V Le Page C Guyot MC Lussier C Tonin PN Provencher DM Mes-Masson AM SET complex in serous epithelial ovarian cancer Int J Cancer 2006, 119(9):2119-2126 10.1002/ijc.22054 16823850
32. Ouellet V Le Page C Madore J Guyot MC Barres V Lussier C Tonin PN Provencher DM Mes-Masson AM An apoptotic molecular network identified by microarray: On the TRAIL to new insights in epithelial ovarian cancer Cancer 2007 17569106
33. Warrenfeltz S Pavlik S Datta S Kraemer ET Benigno B McDonald JF Gene expression profiling of epithelial ovarian tumours correlated with malignant potential Mol Cancer 2004, 3(1):27 524500 15471544 10.1186/ 1476-4598-3-27
34. Meinhold-Heerlein I Bauerschlag D Hilpert F Dimitrov P Sapinoso LM Orlowska-Volk M Bauknecht T Park TW Jonat W Jacobsen A et al. Molecular and prognostic distinction between serous ovarian carcinomas of varying grade and malignant potential Oncogene 2005, 24(6):1053-1065 10.1038/ sj.onc.1208298 15558012
35. Ouellet V Provencher DM Maugard CM Le Page C Ren F Lussier C Novak J Ge B Hudson TJ Tonin PN et al. Discrimination between serous low malignant potential and invasive epithelial ovarian tumors using molecular profiling Oncogene 2005, 24(29):4672-4687 10.1038/sj.onc.1208214 15940270
36. Bonome T Lee JY Park DC Radonovich M Pise-Masison C Brady J Gardner GJ Hao K Wong WH Barrett JC et al. Expression profiling of serous low malignant potential, low-grade, and high-grade tumors of the ovary Cancer Res 2005, 65(22):10602-10612 10.1158/0008-5472.CAN-05-2240 16288054
37. el-Deiry WS Tokino T Velculescu VE Levy DB Parsons R Trent JM Lin D Mercer WE Kinzler KW Vogelstein B WAF1, a potential mediator of p53 tumor suppression Cell 1993, 75(4):817-825 10.1016/0092-8674(93)90500-P 8242752
38. Kim TK In vitro transcriptional activation of p21 promoter by p53 Biochem Biophys Res Commun 1997, 234(2):300-302 10.1006/bbrc.1997.6637 9177263
39. Xiong Y Hannon GJ Zhang H Casso D Kobayashi R Beach D p21 is a universal inhibitor of cyclin kinases Nature 1993, 366(6456):701-704 10.1038/ 366701a0 8259214
40. Harper JW Adami GR Wei N Keyomarsi K Elledge SJ The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases Cell 1993, 75(4):805-816 10.1016/0092-8674(93)90499-G 8242751
41. Boulaire J Fotedar A Fotedar R The functions of the cdk-cyclin kinase inhibitor p21WAF1 Pathol Biol (Paris) 2000, 48(3):190-202 10858953
42. Macaluso M Montanari M Cinti C Giordano A Modulation of cell cycle components by epigenetic and genetic events Semin Oncol 2005, 32(5):452-457 10.1053/j.seminoncol.2005.07.009 16210085
43. Buchynska LG Nesina IP Yurchenko NP Bilyk OO Grinkevych VN Svintitsky VS Expression of p53, p21WAF1/CIP1, p16INK4A and Ki-67 proteins in serous ovarian tumors Exp Oncol 2007, 29(1):49-53 17431389
44. Terauchi F Okamoto A Nagashima T Kobayashi Y Moritake T Yamamoto Y Takakura S Iwaki S Ogura H Clinical significance of p21(WAF1/CIP1) and p53 expression in serous cystadenocarcinoma of the ovary Oncol Rep 2005, 14(2):363-368 16012716
45. Plisiecka-Halasa J Karpinska G Szymanska T Ziolkowska I Madry R Timorek A Debniak J Ulanska M Jedryka M Chudecka-Glaz A et al. P21WAF1, P27KIP1, TP53 and C-MYC analysis in 204 ovarian carcinomas treated with platinum-based regimens Ann Oncol 2003, 14(7):1078-1085 10.1093/annonc/ mdg299 12853350
46. Vassilopoulos I Korkolopoulou P Konstantinidou AE Patsouris E Eftichiadis C Thymara I Perdiki M Pavlakis K Agapitos E Davaris PS Evaluation of the cyclin-dependent kinase inhibitor p21Cip1 in epithelial ovarian tumors of low malignant potential and adenocarcinomas Histol Histopathol 2003, 18(3):761-770 12792888
47. Palazzo JP Monzon F Burke M Hyslop T Dunton C Barusevicius A Capuzzi D Kovatich AJ Overexpression of p21WAF1/CIP1 and MDM2 characterizes serous borderline ovarian tumors Hum Pathol 2000, 31(6):698-704 10.1053/ hupa.2000.7641 10872663
48. Bukholm IK Nesland JM Protein expression of p53, p21 (WAF1/CIP1), bcl-2, Bax, cyclin D1 and pRb in human colon carcinomas Virchows Arch 2000, 436(3):224-228 10.1007/s004280050034 10782880
49. Shoji T Tanaka F Takata T Yanagihara K Otake Y Hanaoka N Miyahara R Nakagawa T Kawano Y Ishikawa S et al. Clinical significance of p21 expression in non-small-cell lung cancer J Clin Oncol 2002, 20(18):3865-3871 10.1200/JCO.2002.09.147 12228206
50. Tamura M Sawabata N Kobayashi S Umezu H Seki N Yoshii N Karube Y Araki O Ishihama H Nagai S et al. Prognostic significance of p21 protein expression in patients with pulmonary squamous cell carcinoma following induction chemotherapy Ann Thorac Cardiovasc Surg 2007, 13(1):9-14 17392664
51. Kapranos N Stathopoulos GP Manolopoulos L Kokka E Papadimitriou C Bibas A Yiotakis J Adamopoulos G p53, p21 and p27 protein expression in head and neck cancer and their prognostic value Anticancer Res 2001, 21(1B):521-528 11299798
52. Migaldi M Sgambato A Garagnani L Ardito R Ferrari P De Gaetani C Cittadini A Trentini GP Loss of p21Waf1 expression is a strong predictor of reduced survival in primary superficial bladder cancers Clin Cancer Res 2000, 6(8):3131-3138 10955794
53. Mattioli E Vogiatzi P Sun A Abbadessa G Angeloni G D'Ugo D Trani D Gaughan JP Vecchio FM et al. Cevenini G Immunohistochemical analysis of pRb2/p130, VEGF, EZH2, p53, p16(INK4A), p27(KIP1), p21(WAF1), Ki-67 expression patterns in gastric cancer J Cell Physiol 2007, 210(1):183-191 10.1002/jcp.20833 16998811
54. Fauvet R Poncelet C Hugol D Lavaur A Feldmann G Darai E Expression of apoptosis-related proteins in endometriomas and benign and malignant ovarian tumours Virchows Arch 2003, 443(1):38-43 10.1007/ s00428-003-0813-3 12756564
55. Goto M Tsukamoto T Inada K Mizoshita T Ogawa T Terada A Hyodo I Shimozato K Hasegawa Y Tatematsu M Loss of p21WAF1/CIP1 expression in invasive fronts of oral tongue squamous cell carcinomas is correlated with tumor progression and poor prognosis Oncol Rep 2005, 14(4):837-846 16142340
56. Edmonston TB Cuesta KH Burkholder S Barusevicius A Rose D Kovatich AJ Boman B Fry R Fishel R Palazzo JP Colorectal carcinomas with high microsatellite instability: Defining a distinct immunologic and molecular entity with respect to prognostic markers Hum Pathol 2000, 31(12):1506-1514 10.1053/hupa.2000.20383 11150376
57. Ogino S Kawasaki T Kirkner GJ Ogawa A Dorfman I Loda M Fuchs CS Down-regulation of p21 (CDKN1A/CIP1) is inversely associated with microsatellite instability and CpG island methylator phenotype (CIMP) in colorectal cancer J Pathol 2006, 210(2):147-154 10.1002/path.2030 16850502
58. Lee H Park G Jung JH Ahn WS Lee JM Kim BK Kang CS Diagnostic approach using the expression profiling of the P53 tumor suppressor gene and its related proteins in ovarian epithelial tumors Int J Gynecol Cancer 2005, 15(3):453-461 10.1111/j.1525-1438.2005.15308.x 15882169
59. Rhodes DR Yu J Shanker K Deshpande N Varambally R Ghosh D Barrette T Pandey A Chinnaiyan AM Large-scale meta-analysis of cancer microarray data identifies common transcriptional profiles of neoplastic transformation and progression Proc Natl Acad Sci USA 2004, 101(25):9309-9314 438973 15184677 10.1073/pnas.0401994101
60. Kettunen E Anttila S Seppanen JK Karjalainen A Edgren H Lindstrom I Salovaara R Nissen AM Salo J Mattson K et al. Differentially expressed genes in nonsmall cell lung cancer: Expression profiling of cancer-related genes in squamous cell lung cancer Cancer Genet Cytogenet 2004, 149(2):98-106 10.1016/S0165-4608(03)00300-5 15036884
61. Wikman H Kettunen E Seppanen JK Karjalainen A Hollmen J Anttila S Knuutila S Identification of differentially expressed genes in pulmonary adenocarcinoma by using cDNA array Oncogene 2002, 21(37):5804-5813 10.1038/sj.onc.1205726 12173052
62. Koon N Schneider-Stock R Sarlomo-Rikala M Lasota J Smolkin M Petroni G Zaika A Boltze C Meyer F Andersson L et al. Molecular targets for tumour progression in gastrointestinal stromal tumours Gut 2004, 53(2):235-240 1774925 14724156 10.1136/gut.2003.021238
63. Singer G Kurman RJ Chang HW Cho SK Shih Ie M Diverse tumorigenic pathways in ovarian serous carcinoma Am J Pathol 2002, 160(4):1223-1228 1867233 11943707
64. Singer G Stohr R Cope L Dehari R Hartmann A Cao DF Wang TL Kurman RJ Shih Ie M Patterns of p53 mutations separate ovarian serous borderline tumors and low- and high-grade carcinomas and provide support for a new model of ovarian carcinogenesis: A mutational analysis with immunohistochemical correlation Am J Surg Pathol 2005, 29(2):218-224 10.1097/01.pas.0000146025.91953.8d 15644779
65. Scott M McCluggage WG Current concepts in ovarian epithelial tumorigenesis: Correlation between morphological and molecular data Histol Histopathol 2006, 21(1):81-92 16267789
66. Kurman RJ Seidman JD Shih IM Serous borderline tumours of the ovary Histopathology 2005, 47(3):310-315 10.1111/j.1365-2559.2005.02186.x 16115232
67. Koornstra JJ Kleibeuker JH van Geelen CM Rijcken FE Hollema H de Vries EG de Jong S Expression of TRAIL (TNF-related apoptosis-inducing ligand) and its receptors in normal colonic mucosa, adenomas, and carcinomas J Pathol 2003, 200(3):327-335 10.1002/path.1364 12845629