Borderline epithelial tumors of the ovary

Modern Pathology

Volumn 18, Issue , 2005, Pages 33-50

  Hart, William R ^a,b  

^a LERNER RESEARCH INSTITUTE   (United States)

^b CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE   (United States)

Author keywords

Borderline tumors; Mucinous; Neoplasms; Ovary; Serous

Indexed keywords

ANTINEOPLASTIC AGENT;

BORDERLINE TUMOR; CANCER ADJUVANT THERAPY; CANCER GRAFT; CANCER INVASION; CANCER STAGING; CELL NUCLEUS; CELL TYPE; CONFERENCE PAPER; EPITHELIUM CELL; EPITHELIUM TUMOR; HISTOPATHOLOGY; HUMAN; INTESTINE CELL; MICROSCOPY; MITOSIS RATE; MUCINOUS BORDERLINE TUMOR; NOMENCLATURE; OVARY TUMOR; PERITONEUM PSEUDOMYXOMA; PERITONEUM TUMOR; PRIORITY JOURNAL; PROGNOSIS; SALPINGOOOPHORECTOMY; SEROUS BORDERLINE TUMOR; TUMOR CLASSIFICATION;

ADENOCARCINOMA, MUCINOUS; CYSTADENOCARCINOMA, PAPILLARY; CYSTADENOCARCINOMA, SEROUS; FEMALE; HUMANS; LYMPHATIC METASTASIS; OVARIAN NEOPLASMS; PROGNOSIS;

EID: 13244252264     PISSN: 08933952     EISSN: 15300285     Source Type: Journal    
DOI: 10.1038/modpathol.3800307     Document Type: Article

References (93)

1. Pickel H, Tamussino K. History of gynecological pathology. XIV. Hermann Joannes Pfannenstiel. Int J Gynecol Pathol 2003;22:310-314.
2. Abel C, Bandler SW. Gynecological Pathology. A Manual of Microscopic Technique and Diagnosis in Gynecological Practice For Students and Physicians. William Wood & Company: New York, 1901.
3. Taylor Jr HC. Malignant and semi-malignant tumors of the ovary. Surg Gynecol Obstet 1929;48:204-230.
4. Munnell EW, Taylor HC. Ovarian carcinoma: a review of 200 primary and 51 secondary cases. Am J Obstet Gynecol 1949;58:943-959.
5. Fisher ER, Krieger JS, Skirpan PJ. Ovarian cystoma. Clinicopathological observations. Cancer 1955;8: 437-445.
6. Tamakoshi K, Kikkawa F, Nakashima N, et al. Clinical behavior of borderline ovarian tumors: a study of 150 cases. J Surg Oncol 1997;64:147-152.
7. FIGO. International Federation of Gynecology and Obstetrics. Classification and staging of malignant tumours in the female pelvis. Acta Obstet Gynecol Scand 1971;50:1-7.
8. Aure JC, Hoeg K, Kolstad P. Clinical and histologic studies of ovarian carcinoma: long-term follow-up of 990 cases. Obstet Gynecol 1971;37:1-9.
9. Hart WR, Norris HJ. Borderline and malignant mucinous tumors of the ovary. Histologic criteria and clinical behavior. Cancer 1973;31:1031-1045.
10. Kottmeier HL. Problems relating to classification and stage-grouping of malignant tumors in the female pelvis. In: Eleventh Annual Clinical Conference on Cancer, 1996. University of Texas MD Anderson Hospital and Tumor Institute, Yearbook Medical Publishers, Inc.: Chicago, 1966, pp 17-32.
11. Nieminen U, Purola E. Stage and prognosis of ovarian cystadenocarcinomas. Acta Obstet Gynec Scand 1970; 49:49-55.
12. Serov SF, Scully RE, Sobin LH. International Histologic Classification of Tumours. No. 9. Histological Typing of Ovarian Tumours. World Health Organization: Geneva, 1973.
13. Scully RE, Sobin LH. Histologic Typing of Ovarian Tumors, 2nd edn. In: World Health Organization International Histological Classification of Tumors. Springer-Verlag: Berlin, Heidelberg, 1999.
14. Santesson L, Kottmeier HL. General classification of ovarian tumors. In: Gentil F, Junqueira AC (eds). Ovarian Cancer (UICC Monograph Series). Springer-Verlag: New York, 1968, pp 1-8.
15. Hart WR. Ovarian epithelial tumors of borderline malignancy (carcinomas of low malignant potential). Hum Pathol 1977;8:541-549.
16. Katzenstein AA, Mazur MT, Morgan TE, et al. Proliferative serous tumors of the ovary: histologic features and prognosis. Am J Surg Pathol 1978;2: 339-355.
17. Nikrui N. Survey of clinical behavior of patients with borderline epithelial tumors of the ovary. Gynecol Oncol 1981;12:107-119.
18. Scully RE. Ovarian tumors: a review. Am J Pathol 1977;87:686-720.
19. Scully RE. Common epithelial tumors of borderline malignancy (carcinomas of low malignant potential). Bull Cancer (Paris) 1982;69:228-238.
20. Russell P. The pathological assessment of ovarian neoplasms. I. Introduction to the common ‘epithelial’ tumours and analysis of benign ‘epithelial’ tumours. Pathol 1979;11:5-26.
21. Russell P, Merkur H. Proliferating ovarian ‘epithelial’ tumours: a clinico-pathological analysis of 144 cases. Aust NZJ Obstet Gynaecol 1979;19:45-51.
22. Leitao Jr MM, Boyd J, Hummer A, et al. Clinicopathologic analysis of early-stage sporadic ovarian carcinoma. Am J Surg Pathol 2004;28:147-159.
23. Russell P. Surface epithelial-stromal tumors of the ovary. In: Kurman RJ (ed). Blaustein’s Pathology of the Female Genital Tract, 4th edn. Springer-Verlag: New York, 1994, pp 705-782.
24. Tavassoli FA, Devilee P (eds). World Health Organization Classification of Tumours. Pathology and Genetics. Tumours of the Breast and Female Genital Organs. IARC Press: Lyon, 2003.
25. Lee KR, Scully RE. Mucinous tumors of the ovary: a clinicopathologic study of 196 borderline tumors (of intestinal type) and carcinomas, including an evaluation of 11 cases with ‘pseudomyxoma peritonei’. Am J Surg Pathol 2000;24:1447-1464.
26. Rodriguez IM, Prat J. Mucinous tumors of the ovary: a clinicopathologic analysis of 75 borderline tumors (of intestinal type) and carcinomas. Am J Surg Pathol 2002;26:139-152.
27. Scully RE, Young RH, Clement PB. Tumors of the ovary, maldeveloped gonads, fallopian tube, and broad ligament. In: Rosai J (ed). Atlas of Tumor Pathology, Third Series, Fascicle 23. Armed Forces Institute of Pathology: Washington, DC, 1998.
28. Riopel MA, Ronnett BM, Kurman RJ. Evaluation of diagnostic criteria and behavior of ovarian intestinaltype mucinous tumors: atypical proliferative (borderline) tumors and intraepithelial, microinvasive, invasive, and metastatic carcinomas. Am J Surg Pathol 1999;23:617-635.
29. Hoerl HD, Hart WR. Primary ovarian mucinous cystadenocarcinomas: a clinicopathologic study of 49 cases with long-term follow-up. Am J Surg Pathol 1998;22:1449-1462.
30. Kennedy AW, Hart WR. Ovarian papillary serous tumors of low malignant potential (serous borderline tumors): a long term follow-up study, including patients with microinvasion, lymph node metastasis, and transformation to invasive serous carcinoma. Cancer 1996;78:278-286.
31. Segal GH, Hart WR. Ovarian serous tumors of low malignant potential (serous borderline tumors): the relationship of exophytic surface tumor to peritoneal ‘implants’. Am J Surg Pathol 1992;16: 577-583.
32. Goldblum JR, Hart WR. Localized and diffuse mesotheliomas of the genital tract and peritoneum in women: a clinicopathologic study of nineteen true mesothelial neoplasms, other than adenomatoid tumors, multicystic mesotheliomas and localized fibrous tumors. Am J Surg Pathol 1995;19:1124-1137.
33. Kao GF, Norris HJ. Cystadenofibromas of the ovary with epithelial atypia. Am J Surg Pathol 1978;2: 357-363.
34. Bostwick DG, Tazelaar HD, Ballon SC, et al. Ovarian epithelial tumors of borderline malignancy: a clinical and pathologic study of 109 cases. Cancer 1986;58: 2052-2065.
35. Lage JM, Weinberg DS, Huettner PC, et al. Flow cytometric analysis of nuclear DNA content in ovarian tumors. Association of ploidy with tumor type, histologic grade, and clinical stage. Cancer 1992; 69:2668-2675.
36. Burks RT, Sherman ME, Kurman RJ. Micropapillary serous carcinoma of the ovary: a distinctive low-grade carcinoma related to serous borderline tumors. Am J Surg Pathol 1996;20:1319-1330.
37. Seidman JD, Kurman RJ. Subclassification of serous borderline tumors of the ovary into benign and malignant types: a clinicopathologic study of 65 advanced stage cases. Am J Surg Pathol 1996;20: 1331-1345.
38. Prat J, de Nictolis M. Serous borderline tumors of the ovary: a long-term follow-up study of 137 cases, including 18 with a micropapillary pattern and 20 with microinvasion. Am J Surg Pathol 2002;26: 1111-1128.
39. Deavers MT, Gershenson DM, Tortolero-Luna G, et al. Micropapillary and cribriform patterns in ovarian serous tumors of low malignant potential: a study of 99 advanced stage cases. Am J Surg Pathol 2002; 26:1129-1141.
40. Eichhorn JH, Bell DA, Young RH, et al. Ovarian serous borderline tumors with micropapillary and cribriform patterns: a study of 40 cases and comparison with 44 cases without these patterns. Am J Surg Pathol 1999; 23:397-409.
41. Hart WR. Pathology of malignant and borderline (low malignant potential) epithelial tumors of ovary. In: Coppleson M, Monaghan JM, Morrow CP, Tattersall MHN (eds). Gynecologic Oncology, 2nd edn, Chapter 55. Churchill-Livingstone: Edinburgh, 1992, pp 863-887.
42. Bell DA, Scully RE. Ovarian serous borderline tumors with stromal microinvasion: a report of 21 cases. Hum Pathol 1990;21:397-403.
43. Tavassoli FA. Serous tumor of low malignant potential with early stromal invasion (serous LMP with microinvasion). Mod Pathol 1988;1:407-414.
44. Hanselaar AGJM, Vooijs GP, Mayall B, et al. Epithelial markers to detect occult microinvasion in serous ovarian tumors. Int J Gynecol Pathol 1993;12:20-27.
45. Mooney J, Silva E, Tornos C, et al. Unusual features of serous neoplasms of low malignant potential during pregnancy. Gynecol Oncol 1997;65:30-35.
46. Buttin BM, Herzog TJ, Powell MA, et al. Epithelial ovarian tumors of low malignant potential: the role of microinvasion. Obstet Gynecol 2002;99: 11-17.
47. McKenney JK, Balzer BL, Longacre TA. Ovarian serous tumors of low malignant potential with stromal microinvasion: a clinicopathologic study of 36 cases. Mod Pathol 2004;17:205A-206A.
48. Bell DA, Weinstock MA, Scully RE. Peritoneal implants of ovarian serous borderline tumors: histologic features and prognosis. Cancer 1988;62:2212-2222.
49. Rollins SE, Young RH, Bell DA. Autoimplants involving serous borderline tumors of the ovary: a clinico-pathologic study of 30 cases. Mod Pathol 2004; 17:213A.
50. Gilks CB, Alkushi A, Yue JJW, et al. Advanced-stage serous borderline tumors of the ovary: a clinicopathological study of 49 cases. Int J Gynecol Pathol 2002; 22:29-36.
51. Bell KA, Smith Sehdev AE, Kurman RJ. Refined diagnostic criteria for implants associated with ovarian atypical proliferative serous tumors (borderline) and micropapillary serous carcinomas. Am J Surg Pathol 2001;25:419-432.
52. Silva EG, Kurman RJ, Russell P, et al. Symposium: ovarian tumors of borderline malignancy. Int J Gynecol Pathol 1996;15:281-302.
53. Malpica A, Deavers MT, Gershenson D, et al. Serous tumors involving extra-abdominal/extra-pelvic sites after the diagnosis of an ovarian serous neoplasm of low malignant potential. Am J Surg Pathol 2001;25: 988-996.
54. Silva EG, Tornos C, Zhuang Z, et al. Tumor recurrence in stage I ovarian serous neoplasms of low malignant potential. Int J Gynecol Pathol 1998;17:1-6.
55. Moore WF, Bentley RC, Berchuck A, et al. Some mullerian inclusion cysts in lymph nodes may sometimes be metastases from serous borderline tumors of the ovary. Am J Surg Pathol 2000;24:710-718.
56. Bell DA, Scully RE. Serous borderline tumors of the peritoneum. Am J Surg Pathol 1990;14:230-239.
57. Biscotti CV, Hart WR. Peritoneal serous micropapillomatosis of low malignant potential (serous borderline tumors of the peritoneum): a clinicopathologic study of 17 cases. Am J Surg Pathol 1992;16:467-475.
58. Zanotti KM, Hart WR, Kennedy AW, et al. Allelic imbalance on chromosome 17p13 in borderline (low malignant potential) epithelial ovarian tumors. Int J Gynecol Pathol 1999;18:247-253.
59. Sieben NLG, Kolkman-Uljee SM, Flanagan AM, et al. Molecular genetic evidence for monoclonal origin of bilateral ovarian serous borderline tumors. Am J Pathol 2003;162:1095-1101.
60. Diebold J, Seemuller F, Lohrs U. K-RAS mutations in ovarian and extraovarian lesions of serous tumors of borderline malignancy. Lab Invest 2003;83:251-258.
61. Tan LK, Flynn SD, Carcangiu ML. Ovarian serous borderline tumors with lymph node involvement. Am J Surg Pathol 1994;18:904-912.
62. Shiraki M, Otis CN, Donovan JT, et al. Ovarian serous borderline epithelial tumors with multiple retroperitoneal nodal involvement: metastasis or malignant transformation of epithelial glandular inclusions? Gynecol Oncol 1992;46:255-258.
63. Leake JF, Rader JS, Woodruff JD, et al. Retroperitoneal lymphatic involvement with epithelial ovarian tumors of low malignant potential. Gynecol Oncol 1991; 42:124-130.
64. Rice LW, Berkowitz RS, Mark SD, et al. Epithelial ovarian tumors of borderline malignancy. Gynecol Oncol 1990;39:195-198.
65. Rota SM, Zanetta G, Ieda N, et al. Clinical relevance of retroperitoneal involvement from epithelial ovarian tumors of borderline malignancy. Int J Gynecol Cancer 1999;9:477-480.
66. Clement PB, Young RH, Oliva E, et al. Hyperplastic mesothelial cells within abdominal lymph nodes: mimic of metastatic ovarian carcinoma and serous borderline tumor—a report of two cases associated with ovarian neoplasms. Mod Pathol 1996;9:879-886.
67. Koern J, Trope CG, Abeler VM. A retrospective study of 370 borderline tumors of the ovary treated at the Norwegian Radium Hospital from 1970 to 1982: a review of clinicopathologic features and treatment modalities. Cancer 1993;71:1810-1820.
68. Lee KR, Castrillon DH, Nucci MR. Pathologic findings in eight cases of ovarian serous borderline tumors, three with foci of serous carcinoma, that preceded death or morbidity from invasive carcinoma. Int J Gynecol Pathol 2001;20:329-334.
69. Seidman JD, Kurman RJ. Ovarian serous borderline tumors: a critical review of the literature with emphasis on prognostic indicators. Hum Pathol 2000; 31:539-557.
70. Sehdev AES, Sehdev PS, Kurman RJ. Noninvasive and invasive micropapillary (low-grade) serous carcinoma of the ovary: a clinicopathologic analysis of 135 cases. Am J Surg Pathol 2003;27:725-736.
71. Staebler A, Heselmeyer-Haddad K, Bell K, et al. Micropapillary serous carcinoma of the ovary has distinct patterns of chromosomal imbalances by comparative genomic hybridization compared with atypical proliferative serous tumors and serous carcinomas. Hum Pathol 2002;33:47-59.
72. Katabuchi H, Tashiro H, Cho KR, et al. Micropapillary serous carcinoma of the ovary: an immunohistochemical and mutational analysis of p53. Int J Gynecol Pathol 1998;17:54-60.
73. Slomovitz BM, Caputo TA, Gretz III HF, et al. A comparative analysis of 57 serous borderline tumors with and without a noninvasive micropapillary component. Am J Surg Pathol 2002;26:592-600.
74. Kempson RL, Hendrickson MR. Ovarian serous borderline tumors: the citadel defended (Editorial). Hum Pathol 2000;31:525-526.
75. Barnhill DA, Kurman RJ, Brady MF, et al. Preliminary analysis of the behavior of stage I ovarian serous tumors of low malignant potential: a Gynecologic Oncology Group study. J Clin Oncol 1995;13: 2752-2756.
76. Rutgers JL, Scully RE. Ovarian mu¨ llerian mucinous papillary cystadenomas of borderline malignancy: a clinicopathologic analysis. Cancer 1988;61:340-348.
77. Guerrieri C, Hogberg T, Wingren S, et al. Mucinous borderline and malignant tumors of the ovary. A clinicopathologic and DNA ploidy study of 92 cases. Cancer 1994;74:2329-2340.
78. Nayar R, Siriaunkgul S, Robbins KM, et al. Microinvasion in low malignant potential tumors of the ovary. Hum Pathol 1996;27:521-527.
79. Khunamornpong S, Russell P, Dalrymple JC. Proliferating (LMP) mucinous tumors of the ovaries with microinvasion: morphologic assessment of 13 cases. Int J Gynecol Pathol 1999;18:238-246.
80. Lee HI, Jun S-Y, Ro JY, et al. Evaluation of diagnostic criteria in primary ovarian mucinous tumors with an emphasis on the significance of microinvasion. Mod Pathol 2004;17:201A.
81. Young R, Gilks B, Scully R. Mucinous tumors of the appendix associated with mucinous tumors of the ovary and pseudomyxoma peritonei: a clinicopathologic analysis of 22 cases supporting an origin in the appendix. Am J Surg Pathol 1991;15:415-429.
82. Prayson RA, Hart WR, Petras RE. Pseudomyxoma peritonei: a clinicopathologic study of 19 cases with emphasis on site of origin and nature of associated ovarian tumors. Am J Surg Pathol 1994;18:591-603.
83. Ronnett BM, Kurman RJ, Zahn CM, et al. Pseudomyxoma peritonei in women: a clinicopathologic analysis of 30 cases with emphasis on site of origin, prognosis, and relationship to ovarian mucinous tumors of low malignant potential. Hum Pathol 1995;26:509-524.
84. Misdraji J, Yantiss RK, Graeme-Cook FM, et al. Appendiceal mucinous neoplasms: a clinicopathologic analysis of 107 cases. Am J Surg Pathol 2003;27:1089-1103.
85. O’Connell JT, Hacker CM, Barsky SH. MUC2 is a molecular marker for pseudomyxoma peritonei. Mod Pathol 2002;15:958-972.
86. Ronnett BM, Seidman JD. Mucinous tumors arising in ovarian mature cystic teratomas: relationship to the clinical syndrome of pseudomyxoma peritonei. Am J Surg Pathol 2003;27:650-657.
87. McKenney JK, Soslow RA, Longacre TA. Mucinous neoplasms arising in mature teratomas: a clinicopathologic study of ovarian and sacrococcygeal tumors. Mod Pathol 2004;17:206A.
88. Chaitin BA, Gershenson DM, Evans HL. Mucinous tumors of the ovary: a clinicopathologic study of 70 cases. Cancer 1985;55:1958-1962.
89. Kikkawa F, Kawai M, Tamakoshi K, et al. Mucinous carcinoma of the ovary: clinicopathologic analysis. Oncology 1996;53:303-307.
90. Sumithran E, Susil BJ, Looi LM. The prognostic significance of grading in borderline mucinous tumors of the ovary. Hum Pathol 1988;19:15-18.
91. Watkin W, Silva EG, Gershenson DM. Mucinous carcinoma of the ovary: pathologic prognostic factors. Cancer 1992;69:208-212.
92. Ludwick CL, Gilks CB, Yaziji H, et al. Aggressive behavior of stage 1 ovarian mucinous tumors without destructive stromal invasion. Mod Pathol 2004;17: 205A.
93. Kliman L, Rome RM, Fortune DW. Low malignant potential tumors of the ovary: a study of 76 cases. Obstet Gynecol 1986;68:338-344.