Identification of a cryptic type III polyketide synthase (1,3,6,8-tetrahydroxynaphthalene synthase) from Streptomyces peucetius ATCC 27952

Molecules and Cells

Volumn 26, Issue 4, 2008, Pages 362-367

  Ghimire, Gopal Prasad ^a   Oh, Tae Jin ^a   Liou, Kwangkyoung ^a   Sohng, Jae Kyung ^a  

^a SunMoon University   (South Korea)

Author keywords

1,3,6,8 tetrahydroxynaphthalene synthase; Chalcone synthase; Heterologous expression; Streptomyces peucetius

Indexed keywords

1,3,6,8 TETRAHYDROXYNAPHTHALENE SYNTHASE; FLAVIOLIN; MALONYL COENZYME A; NAPHTHOQUINONE; POLYKETIDE SYNTHASE; UNCLASSIFIED DRUG;

AROMATIZATION; ARTICLE; BACTERIAL STRAIN; CATALYSIS; CYCLIZATION; ENZYME ACTIVITY; GENE EXPRESSION; GENE IDENTIFICATION; GENE SEQUENCE; GENETIC TRANSFORMATION; HETEROLOGOUS EXPRESSION; IN VITRO STUDY; IN VIVO STUDY; METABOLITE; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATION; SECONDARY METABOLITE; SEQUENCE ANALYSIS; STREPTOMYCES; STREPTOMYCES PEUCETIUS;

ACYLTRANSFERASES; AMINO ACID SEQUENCE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ELECTROPHORESIS, POLYACRYLAMIDE GEL; MOLECULAR SEQUENCE DATA; NAPHTHOLS; NAPHTHOQUINONES; PHENOTYPE; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS, PROTEIN; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STREPTOMYCES;

STREPTOMYCES PEUCETIUS; STREPTOMYCES PEUCETIUS ATCC 27952;

EID: 58049213484     PISSN: 10168478     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Austin, M.B., and Noel, J.P. (2003). The chalcone synthase superfamily of type III polyketide synthase. Nat. Prod. Rep. 20, 79-110.
2. Bangera, M.G., and Thomashow, L.S. (1999). Identification and characterization of a gene cluster for synthesis of the polyketide antibiotic 2,4-diacetylphloroglucinol from Pseudomonas flourescens Q2-87. J. Bacteriol. 181, 3155-3163.
3. Basnet, D.B., Oh, T.J., Vu, T.T., Sthapit, B., Liou, K., Lee, H.C., Yoo, J.C., and Sohng, J.K. (2006). Angucyclines Sch 47554 and Sch 47555 from Streptomyces sp. SCC-2136: cloning, sequencing, and characterization. Mol. Cells 22, 154-162.
4. Challis, G.L., and Hopwood, D.A. (2003). Synergy and contingency as driving forces for the evolution of multiple secondary metabolite production by Streptomyces species. Proc. Natl. Acad. Sci. USA 100, 14555-14561.
5. Cortes, J., Velasco, J., Foster, G., Blackaby, A.P., Rudd, B.A., and Wilkinson, B. (2002). Identification and cloning of a type III polyketide synthase required for diffusible pigment biosynthesis in Saccharopolyspora erythraea. Mol. Microbiol. 44, 1213-1224.
6. Funa, N., Ohnishi, Y., Fujii, I., Shibuya, M., Ebizuka, Y., and Horinouchi, S. (1999). A new pathway for polyketide synthesis in microorganisms. Nature 400, 897-899.
7. Funa, N., Ohnishi, Y., Ebizuka, Y., and Horinouchi, S. (2002). Alteration of reaction and substrate specificity of a bacterial type III polyketide synthase by site-directed mutagenesis. Biochem. J. 367, 781-789.
8. Funa, N., Funabashi, M., Yoshimura, E., and Horinouchi, S. (2005). A novel quinone-forming monooxygenase family involved in the modification of aromatic polyketides. J. Biol. Chem. 280, 14514-14523.
9. Gross, F., Luniak, N., Perlova, O., Gaitatzis, N., Kodama, H.J., Gerth, K., Gottschalk, D., Dittmann, E., and Muller, R. (2006). Bacterial type III polyketide synthases: phylogenetic analysis and potential for the production of novel secondary metabolites by heterologous expression in Pseudomonas. Arch. Microbiol. 185, 28-38.
10. Gruschow, S., Buchholz, T.J., Seufert, W., Dordick, J.S., and Sherman, D.H. (2007). Substrate profile analysis and ACPmediated acyl transfer in Streptomyces coelicolor type III polyketide synthases. Chembiochem. 8, 863-868.
11. Haapalaininen, A.M., Merilainen, G., and Wierenga, R.K. (2006). The thiolase: condensing enzymes with diverse reaction specificities. Trends Biochem. Sci. 31, 64-71.
12. Izumikawa, M., Shipley, P.R., Hopke, J.N., Hare, T.O., Xiang, L., Noel, J.P., and Moore, B.S. (2003). Expression and characterization of the type III polyketise synthase 1,3,6,8-tetrahydroxynaphthalene synthase from Streptomyces coelicolor A3(2). J. Ind. Microbiol. Biotechnol. 30, 510-515.
13. Jez, J.M., Ferrer, J.L., Bowman, M.E., Dixon, R.A., and Noel, J.P. (2000). Dissection of malonyl-coenzyme A decarboxylation from polyketide formation in the reaction mechanism of a plant polyketide synthase. Biochemistry 39, 890-902.
14. Khosla, C., and Harbury, P.B. (2001). Modular enzymes. Nature 409, 247-252.
15. Kieser, T., Bibb, M.J., Buttner, M.J., Chater, K.F., and Hopwood, D.A. (2000). Practical Streptomyces genetics. The John Innes Foundation, Norwich, England.
16. Moore, B.S., and Hopke, J.N. (2001). Discovery of a new bacterial polyketide biosynthetic pathway. Chembiochem. 2, 35-38.
17. Parajuli, N., Basnet, D.B., Lee, H.C., Sohng, J.K., and Liou, K. (2004). Genome analyses of Streptomyces peucetius ATCC 27952 for the identification and comparison of cytochrome P450 complement with other Streptomyces. Arch. Biochem. Biophys. 425, 233-241.
18. Shen, B. (2003). Polyketide biosynthesis beyond the type I, II and III polyketide synthase paradigms. Curr. Opin. Chem. Biol. 7, 285-295.
19. Sthapit, B., Oh, T.J., Lamichhane, R., Liou, K., Lee, H.C., Kim, C.G., and Sohng, J.K. (2004). Neocarzinostatin naphthoate synthase: an unique iterative type I PKS from neocarzinostatin producer Streptomyces carzinostaticus. FEBS Lett. 155, 201-206.
20. Ueda, K., Kim, K.M., Beppu, T., and Horinouchi, S. (1995). Overexpression of a gene cluster encoding a chalcone synthase like protein confers redbrown pigment production in Streptomyces griseus. J. Antibiot. 48, 638-646.