Treatment and prevention of herpes labialis

Canadian Family Physician

Volumn 54, Issue 12, 2008, Pages 1683-1687

  Opstelten, Wim ^a   Neven, Arie Knuistingh ^b   Eekhof, Just ^b  

^a DUTCH COLLEGE OF GENERAL PRACTITIONERS   (Netherlands)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ACICLOVIR; FAMCICLOVIR; GLYCINE; LIDOCAINE; PENCICLOVIR; PLACEBO; PRILOCAINE; SUNSCREEN; VALACICLOVIR; ZINC OXIDE; ZINC SULFATE;

ABSENCE OF SIDE EFFECTS; ANTIVIRAL THERAPY; BURNING SENSATION; CLINICAL TRIAL; CREAM; DISEASE DURATION; DRUG DOSE REGIMEN; DRUG INDUCED HEADACHE; HERPES LABIALIS; HUMAN; HYPERTHERMIC THERAPY; INFECTION PREVENTION; LONG TERM CARE; NAUSEA; PRURITUS; RELAPSE; REVIEW; SHORT COURSE THERAPY; SINGLE DRUG DOSE; SKIN TIGHTNESS; SUN EXPOSURE; SYMPTOM; UNSPECIFIED SIDE EFFECT; XEROSIS;

ANTIVIRAL AGENTS; DRUG ADMINISTRATION ROUTES; HERPES LABIALIS; HUMANS; TREATMENT OUTCOME;

EID: 58049209591     PISSN: 0008350X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (42)

1. Van der Linden MW, Westert GP, De Bakker DH, Schellevis FG. [Second national study into diseases and actions in general practice.] Utrecht, Bilthoven: Netherlands Institute for Health Services Research (NIVEL), National Institute of Public Health and the Environment (RIVM); 2004. [Dutch]
2. Embil JA, Stephens RG, Manuel FR. Prevalence of recurrent herpes labialis and aphthous ulcers among young adults on six continents. Can Med Assoc J 1975;113(7):627-30.
3. Sparano JA, Sarta C. Infection prophylaxis and antiretroviral therapy in patients with HIV infection and malignancy. Curr Opin Oncol 1996;8(5):392-9.
4. Scoular A, Norrie J, Gillespie G, Mir N, Carman WF. Longitudinal study of genital infection by herpes simplex virus type 1 in Western Scotland over 15 years. BMJ 2002;324(7350):1366-7.
5. Lafferty WE, Coombs RW, Benedetti J, Critchlow C, Corey L. Recurrences after oral and genital herpes simplex virus infection. Influence of site of infection and viral type. N Engl J Med 1987;316(23):1444-9.
6. Corey L, Handsfield HH. Genital herpes and public health: addressing a global problem. JAMA 2000;283(6):791-4.
7. Ross JD, Smith IW, Elton RA. The epidemiology of herpes simplex types 1 and 2 infection of the genital tract in Edinburgh 1978-1991. Genitourin Med 1993;69(5):381-3.
8. Wheeler CE Jr. The herpes simplex problem. J Am Acad Dermatol 1988;18(1 Pt 2):163-8.
9. Esmann J. The many challenges of facial herpes simplex virus infection. J Antimicrob Chemother 2001;47(Suppl T1):17-27.
10. Straus SE, Rooney JF, Sever JL, Seidlin M, Nusinoff-Lehrman S, Cremer K. NIH Conference. Herpes simplex virus infection: biology, treatment, and prevention. Ann Intern Med 1985;103(3):404-19.
11. Opstelten W. Stomatitis herpetica. In: Eekhof JAH, Knuistingh Neven A, Verheij TJM, editors. [Minor ailments in children.] Maarssen, The Netherlands: Elsevier; 2005. p. 273-5. [Dutch]
12. Godfrey HR, Godfrey NJ, Godfrey JC, Riley D. A randomized clinical trial on the treatment of oral herpes with topical zinc oxide/glycine. Altern Ther Health Med 2001;7(3):49-56.
13. Kneist W, Hempel B, Borelli S. [Clinical double-blind trial of topical zinc sulfate for herpes labialis recidivans.] Arzneimittelforschung 1995;45(5):624-6. [German]
14. Cassuto J. Topical local anaesthetics and herpes simplex. Lancet 1989;1(8629):100-1.
15. Van Vloten WA, Swart RN, Pot F. Topical acyclovir therapy in patients with recurrent orofacial herpes simplex infections. J Antimicrob Chemother 1983;12(Suppl B):89-93.
16. Spruance SL, Nett R, Marbury T, Wolff R, Johnson J, Spaulding T. Acyclovir cream for treatment of herpes simplex labialis: results of two randomized, double-blind, vehicle-controlled, multicenter clinical trials. Antimicrob Agents Chemother 2002;46(7):2238-43.
17. Spruance SL, Schnipper LE, Overall JC Jr, Kern ER, Wester B, Modlin J, et al. Treatment of herpes simplex labialis with topical acyclovir in polyethylene glycol. J Infect Dis 1982;146(1):85-90.
18. Fiddian AP, Yeo JM, Stubbings R, Dean D. Successful treatment of herpes labialis with topical acyclovir. Br Med J (Clin Res Ed) 1983;286(6379):1699-701.
19. Fiddian AP, Ivanyi L. Topical acyclovir in the management of recurrent herpes labialis. Br J Dermatol 1983;109(3):321-6.
20. Shaw M, King M, Best JM, Banatvala JE, Gibson JR, Klaber MR. Failure of acyclovir cream in treatment of recurrent herpes labialis. Br Med J (Clin Res Ed) 1985;291(6487):7-9.
21. Raborn GW, McGaw WT, Grace M, Percy J, Samuels S. Herpes labialis treatment with acyclovir 5% modified aqueous cream: a double-blind randomized trial. Oral Surg Oral Med Oral Pathol 1989;67(6):676-9.
22. Raborn GW, McGaw WT, Grace M, Houle L. Herpes labialis treatment with acyclovir 5 per cent ointment. J Can Dent Assoc 1989;55(2):135-7.
23. Evans TG, Bernstein DI, Raborn GW, Harmenberg J, Kowalski J, Spruance SL. Double-blind, randomized, placebo-controlled study of topical 5% acyclovir-1% hydrocortisone cream (ME-609) for treatment of UV radiation-induced herpes labialis. Antimicrob Agents Chemother 2002;46(6):1870-4.
24. Horwitz E, Pisanty S, Czerninski R, Helser M, Eliav E, Touitou E. A clinical evaluation of a novel liposomal carrier for acyclovir in the topical treatment of recurrent herpes labialis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1999;87(6):700-5.
25. Boon R, Goodman JJ, Martinez J, Marks GL, Gamble M, Welch C. Penciclovir cream for the treatment of sunlight-induced herpes simplex labialis: a randomized, double-blind, placebo-controlled trial. Penciclovir Cream Herpes Labialis Study Group. Clin Ther 2000;22(1):76-90.
26. Spruance SL, Rea TL, Thoming C, Tucker R, Saltzman R, Boon R. Penciclovir cream for the treatment of herpes simplex labialis. A randomized, multicenter, double-blind, placebo-controlled trial. Topical Penciclovir Collaborative Study Group. JAMA 1997;277(17):1374-9.
27. Raborn GW, McGaw WT, Grace M, Tyrrell LD, Samuels SM. Oral acyclovir and herpes labialis: a randomized, double-blind, placebo-controlled study. J Am Dent Assoc 1987;115(1):38-42.
28. Spruance SL, Stewart JC, Rowe NH, McKeough MB, Wenerstrom G, Freeman DJ. Treatment of recurrent herpes simplex labialis with oral acyclovir. J Infect Dis 1990;161(2):185-90.
29. Spruance SL, Jones TM, Blatter MM, Vargas-Cortes M, Barber J, Hill J, et al. High-dose, short-duration, early valacyclovir therapy for episodic treatment of cold sores: results of two randomized, placebo-controlled, multicenter studies. Antimicrob Agents Chemother 2003;47(3):1072-80.
30. Spruance SL, Bodsworth N, Resnick H, Conant M, Oeuvray C, Gao J, et al. Single-dose, patient-initiated famciclovir: a randomized, double-blind, placebo-controlled trial for episodic treatment of herpes labialis. J Am Acad Dermatol 2006;55(1):47-53.
31. Rooney JF, Bryson Y, Mannix ML, Dillon M, Wohlenberg CR, Banks S, et al. Prevention of ultraviolet-light-induced herpes labialis by sunscreen. Lancet 1991;338(8780):1419-22.
32. Mills J, Hauer L, Gottlieb A, Dromgoole S, Spruance S. Recurrent herpes labialis in skiers. Clinical observations and effect of sunscreen. Am J Sports Med 1987;15(1):76-8.
33. Spruance SL, Freeman DJ, Stewart JC, McKeough MB, Wenerstrom LG, Krueger GG, et al. The natural history of ultraviolet radiation-induced herpes simplex labialis and response to therapy with peroral and topical formulations of acyclovir. J Infect Dis 1991;163(4):728-34.
34. Raborn GW, Martel AY, Grace MG, McGaw WT. Herpes labialis in skiers: randomized clinical trial of acyclovir cream versus placebo. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1997;84(6):641-5.
35. Spruance SL, Kriesel JD. Treatment of herpes simplex labialis. Herpes 2002;9(3):64-9.
36. Spruance SL, Hamill ML, Hoge WS, Davis LG, Mills J. Acyclovir prevents reactivation of herpes simplex labialis in skiers. JAMA 1988;260(11):1597-9.
37. Raborn GW, Martel AY, Grace MG, McGaw WT. Oral acyclovir in prevention of herpes labialis. A randomized, double-blind, multi-centered clinical trial. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1998;85(1):55-9.
38. Fawcett HA, Wansbrough-Jones MH, Clark AE, Leigh IM. Prophylactic topical acyclovir for frequent recurrent herpes simplex infection with and without erythema multiforme. Br Med J (Clin Res Ed) 1983;287(6395):798-9.
39. Gibson JR, Klaber MR, Harvey SG, Tosti A, Jones D, Yeo JM. Prophylaxis against herpes labialis with acyclovir cream-a placebo-controlled study. Dermatologica 1986;172(2):104-7.
40. Meyrick Thomas RH, Dodd HJ, Yeo JM, Kirby JD. Oral acyclovir in the suppression of recurrent non-genital herpes simplex virus infection. Br J Dermatol 1985;113(6):731-5.
41. Rooney JF, Straus SE, Mannix ML, Wohlenberg CR, Alling DW, Dumois JA, et al. Oral acyclovir to suppress frequently recurrent herpes labialis. A double-blind, placebo-controlled trial. Ann Intern Med 1993;118(4):268-72.
42. Baker D, Eisen D. Valacyclovir for prevention of recurrent herpes labialis: 2 double-blind, placebo-controlled studies. Cutis 2003;71(3):239-42.