Penciclovir cream for the treatment of sunlight-induced herpes simplex labialis: A randomized, double-blind, placebo-controlled trial

Clinical Therapeutics

Volumn 22, Issue 1, 2000, Pages 76-90

  Boon, Ron ^a   Goodman, J John ^b   Martinez, Juan ^b   Marks, G Lynn ^a   Gamble, Michael ^c   Welch, Christine ^d  

^a GLAXOSMITHKLINE   (United Kingdom)

^b Hill Top Research Inc   (United States)

^c SmithKline Beecham Consumer Healthcare   (United States)

^d Fast Trak Consultancy Services   (United Kingdom)

Author keywords

Attributes; Herpes labialis; Penciclovir; Sunlight; Symptoms

Indexed keywords

PENCICLOVIR; PLACEBO;

ADULT; AGED; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CREAM; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SCREENING; DRUG TOLERABILITY; FEMALE; HERPES LABIALIS; HUMAN; MAJOR CLINICAL STUDY; MALE; RANDOMIZED CONTROLLED TRIAL; SUN EXPOSURE; TREATMENT OUTCOME;

EID: 0033975527     PISSN: 01492918     EISSN: 1879114X     Source Type: Journal    
DOI: 10.1016/S0149-2918(00)87979-5     Document Type: Article

References (17)

1. 1. Whitley RJ. Herpes simplex viruses. In: BN Fields, DM Knipe, et al, eds. Virology. 2nd ed. New York: Raven Press Ltd.; 1990:1843-1887.
2. 2. Spruance SL. Herpes simplex labialis. In: Sacks SL, Straus SE, Whitley RJ, Griffiths PD, eds. Clinical Management of Herpes Viruses. Amsterdam: IOS Press; 1995:8-42.
3. 3. Spruance SL, Rea TL, Thoming C, et al. Penciclovir cream for the treatment of herpes simplex labialis: A randomized, multicenter, double-blind, placebo-controlled trial. JAMA. 1997;277:1374-1379.
4. 4. Wheeler CE. Pathogenesis of recurrent herpes simplex infections. J Invest Dermatol. 1975;65:341-346.
5. 5. Spruance SL. The pathogenesis of herpes simplex labialis: Experimental induction of lesions with UV light. J Clin Microbiol. 1985;22:366-368.
6. 6. Spruance SL, Freeman DJ, Stewart JCB, et al. The natural history of ultraviolet radiation-induced herpes simplex labialis and response to therapy with perioral and topical formulations of acyclovir. J Infect Dis. 1991;163:728-734.
7. 7. Spruance SL. The natural history of recurrent oral-facial herpes simplex virus infection. Semin Dermatol. 1992;11:200-206.
8. 8. Raborn GW, for the Penciclovir Topical Collaborative Study Group. Penciclovir cream for recurrent herpes simplex labialis: An effective new treatment. In: Programs and abstracts of the 36th Annual Meeting of the Interscience Conference on Antimicrobial Agents and Chemotherapy; September 15-18, 1996; New Orleans, La; Abstract H81.
9. 9. Wolff K, Gschnait F, Honigsman H, et al. Phototesting and dosimetry for photochemotherapy. Br J Dermatol. 1977; 96:1-10.
10. 10. Sayer RM, Desrochers DL, Wilson CJ, Marlowe E. Skin type, minimal erythema dose (MED) and sunlight acclimatization. J Am Acad Dermatol. 1981;5:439-443.
11. 11. Remtulla A, Renskers KJ, Goodman JJ. Measurement of natural sunlight exposure required to produce minimal erythema dose on human skin. J Derm Clin Eval Soc. 1992;3:28-29.
12. 12. Rooney JF, Bryson Y, Mannix ML, et al. Prevention of ultraviolet light-induced herpes labialis by sunscreen. Lancet. 1991; 388:1419-1422.
13. 13. Cox DR. Regression models and life tables (with discussion). J R Stat Soc. 1972; 34:187-220.
14. 14. Fiddian AP, Yeo JM, Stubbings R, Dean D. Successful treatment of herpes labialis with topical acyclovir. Br Med J. 1983; 286:1699-1701.
15. 15. Van Vloten WA, Swart RNJ, Pot F. Topical acyclovir therapy in patients with recurrent orofacial herpes simplex infections. J Antimicrob Chemother. 1983;12 (Suppl B):89-93.
16. 16. Raborn GW, McGaw WT, Grace M. Herpes labialis treatment with acyclovir 5% modified aqueous cream: A double-blind, randomized trial. Oral Surg Oral Med Oral Pathol. 1989;67:676-679.
17. 17. Shaw M, King M, Best JM, et al. Failure of acyclovir cream in treatment of recurrent herpes labialis. Br Med J. 1985;291:7-9.