Ezrin - A useful factor in the prognosis of nephrotic syndrome in children: An immunohistochemical approach

Journal of Clinical Pathology

Volumn 59, Issue 9, 2006, Pages 916-920

  Ostalska Nowicka, D ^a   Zachwieja, J ^a   Nowicki, M ^a   Kaczmarek, E ^a   Siwinska, A ^a   Witt, M ^b  

^a POZNAN UNIVERSITY OF MEDICAL SCIENCES   (Poland)

^b UNIVERSITY OF DRESDEN MEDICAL SCHOOL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

EZRIN; MONOCLONAL ANTIBODY; STEROID;

ARTICLE; CHILD; CONTROLLED STUDY; FOCAL GLOMERULOSCLEROSIS; GLOMERULOPATHY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KIDNEY BIOPSY; KIDNEY TUMOR; MAJOR CLINICAL STUDY; MICROSCOPY; NEPHRECTOMY; NEPHROSIS; PODOCYTE; PRIORITY JOURNAL; PROGNOSIS; PROLIFERATIVE GLOMERULONEPHRITIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RISK FACTOR;

ADOLESCENT; BIOLOGICAL MARKERS; BIOPSY; CYTOSKELETAL PROTEINS; DRUG RESISTANCE; FEMALE; GLOMERULOSCLEROSIS, FOCAL SEGMENTAL; HUMANS; IMMUNOENZYME TECHNIQUES; KIDNEY GLOMERULUS; MALE; MESANGIAL CELLS; NEPHROSIS, LIPOID; NEPHROTIC SYNDROME; PODOCYTES; PROGNOSIS; SIALOGLYCOPROTEINS; STEROIDS;

EID: 33748857020     PISSN: 00219746     EISSN: None     Source Type: Journal    
DOI: 10.1136/jcp.2005.031732     Document Type: Article

References (31)

1. Churg J, Habib R, White RHR. Pathology of the nephrotic syndrome in children. Lancet 1970;760:1299-302.
2. Glassock R. The nephrotic syndrome. Hosp Pract 1979;14:105-9, 115-18, 123-9.
3. White RHR, Glasgow EF, Mills RJ. Clinicopathological study of nephrotic syndrome in childhood. Lancet 1970;1:1353-8.
4. Waldherr R, Gubler MC, Levy M, et al. The significance of pure diffuse mesangial proliferation in idiopathic nephrotic syndrome. Clin Nephrol 1978;10:171-9.
5. Brown E. The nephrotic syndrome. Postgrad Med J 1985;61:1057-62.
6. Abeyagunawardena A, Brogan PA, Trompeter RS. Immunosuppressive therapy of childhood idiopathic nephrotic syndrome. Expert Opin Pharmacother 2002;3:513-19.
7. Daniels BS. The role of glomerular epithelial cells in the maintenance of the glomerular filtration barrier. Am J Nephrol 1993;13:318-23.
8. Vasmant D, Maurice M, Feldmann G. Cytoskeleton ultrastructure of podocytes and glomerular endothelial cells in man and in the rat. Anat Rec 1984;210:17-24.
9. Drenckhahn D, Franke RP. Ultrastructural organization of contractile and cytoskeletal proteins in glomerular podocytes of chicken, rat, and man. Lab Invest 1988;59:673-82.
10. Moll R, Franke W, Shiller D, et al. The catalog of human cytokeratin polypeptides: patterns of expression of specific cytokeratins in normal epithelia, tumors and cultured cells. Cell 1982;31:11-24.
11. Kerjaschki D, Sharkey DJ, Farquhar MG. Identification and characterization of podocalyxin-the major sialoprotein of the renal glomerular epithelial cell. J Cell Biol 1984;98:1591-6.
12. Mundel P, Held HW, Mundel TM, et al. Synaptopodin: An actin associated protein in telencephalic dendrites and renal podocytes. J Cell Biol 1997;139:193-204.
13. Tekada T. Podocyte cytoskeleton is connected to the integral membrane protein podocalyxin through Na+/H+-exchanger regulatory factor 2 and ezrin. Clin Exp Nephrol 2003;7:260-9.
14. Horvat R, Hovorka A, Dekan G, et al. Endothelial cell membranes contain podocalyxin: the major sialoprotein of visceral glomerular epithelial cells. J Cell Biol 1986;102:486-91.
15. Orlando R, Takeda T, Zak B, et al. The glomerular epithelial cell anti-adhesin, podocalyxin, associates with the actin cytoskeleton through interactions with ezrin. J Am Soc Nephrol 2001;12:1589-98.
16. Turunen O, Wahlstrom T, Vaheri A. Ezrin has a COOH-terminal actin-binding site that is conserved in the ezrin protein family. J Cell Biol 1994;126:1445-53.
17. Arpin M, Algrain M, Louvard D. Membrane-actin microfilament connections: an increasing diversity of players related to band 4.1. Curr Opin Cell Biol 1994;16:136-41.
18. Hugo C, Nangaku M, Shankland SJ, et al. The plasma membrane-actin linking protein, ezrin, is a glomerular epithelial cell marker in glomerulogenesis, in the adult kidney and in glomerular injury. Kidney Int 1998;54:1934-44.
19. Report of the International Study of Kidney Disease in Children. The primary nephrotic syndrome in children. Identification of patients with minimal change nephrotic syndrome from initial response to prednisone. J Pediatr 1981;98:561-4.
20. Gulati S, Sharma A, Sharma R, et al. Do current recommendations for kidney biopsy in nephrotic syndrome need modifications? Pediatr Nephrol 2002;17:404-8.
21. Hsu S, Raine L, Fanger H. Use of avidin-biotin peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. J Histochem Cytochem 1981;29:577-80.
22. Armitage P. Statistical methods in medical investigations [in Polish], 1st edn. Warszawa: PZWL, 1978:97-103.
23. Andrews P. Morphological alterations of the glomelular (visceral) epithelium in response to pathological and experimental situations. J Electron Microsc Tech 1988;9:115-44.
24. Kriz W, Lemley KV. The role of the podocyte in glomerulosclerosis. Curr Opin Nephrol Hypertens 1999;8:489-97.
25. Koop K, Eikmans M, Baelde H, et al. Expression of podocyte-associated molecules in acquired human kidney diseases. J Am Soc Nephrol 2003;14:2063-71.
26. Horinouchi I, Nakazato H, Kawano T, et al. In situ evaluation of podocin in normal and glomerular diseases. Kidney Int 2003;64:2092-9.
27. Srivastava T, Garola RE, Whiting JM, et al. Synaptopodin expression in idiopathic nephrotic syndrome of childhood. Kidney Int 2001;59:118-25.
28. Ostalska-Nowicka D, Zachwieja J, Nowicki M, et al. Expression of intermediate filaments of podocytes within nephrotic syndrome glomerulopathies in children. Histochem Cell Biol 2004;121:109-13.
29. Ostalska-Nowicka D, Zachwieja J, Nowicki M, et al. Vascular endothelial growth factor (VEGF-C1)-dependent inflammatory response of podocytes in nephrotic syndrome glomerulopathies in children: an imunohistochemical approach. Histopathology 2005;46:176-83.
30. Mundel P, Shankland S. Podocyte biology and response to injury. J Am Soc Nephrol 2002;13:3005-15.
31. Kuusniemi AM, Lapatto R, Holmberg C. Kidneys with heavy proteinuria show fibrosis, inflammation, and oxidative stress, but no tubular phenotyping change. Kidney Int 2005;68:121-32.