Evaluation of dichloroacetic acid for carcinogenicity in genetically modified Tg.AC hemizygous and p53 haploinsufficient mice

Toxicological Sciences

Volumn 107, Issue 1, 2009, Pages 19-26

  Kissling, Grace E ^a   Malarkey, David E ^a   Vallant, Molly K ^a   Johnson, Jerry D ^b   Hejtmancik, Milton R ^b   Herbert, Ronald A ^a   Boorman, Gary A ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b BATTELLE MEMORIAL INSTITUTE   (United States)

Author keywords

Bioassays; Dichloroacetic acid; Drinking water; Mice; p53; Tg.AC

Indexed keywords

CARCINOGEN; DICHLOROACETIC ACID; DISINFECTANT AGENT; DRINKING WATER; PROTEIN P53;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARCINOGEN TESTING; CELL VACUOLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOPLASM; DISEASE SEVERITY; EXPERIMENTAL MODEL; FEMALE; HEMIZYGOSITY; INCIDENCE; LIVER CARCINOGENESIS; LIVER CELL; LIVER TUMOR; LONG TERM EXPOSURE; LUNG ADENOMA; MALE; MOUSE; NONHUMAN; RAT; SKIN PAPILLOMA; TRANSGENIC ANIMAL;

ADENOCARCINOMA, BRONCHIOLO-ALVEOLAR; ANIMALS; CARCINOGENICITY TESTS; CARCINOMA, HEPATOCELLULAR; DICHLOROACETATE; DISEASE MODELS, ANIMAL; FEMALE; LIVER NEOPLASMS; MALE; MICE; MICE, TRANSGENIC; NEOPLASMS; PAPILLOMA; SKIN NEOPLASMS; VACUOLES; WATER; WATER SUPPLY;

MUS; RATTUS; RODENTIA;

EID: 58049200680     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfn228     Document Type: Article

References (27)

1. Barton, H. A., Bull, R., Schultz, I., and Anderson, M. E. (1999). Dichloroacetate (DCA) dosimetry: Interpreting DCA-induced liver cancer dose response and the potential for DCA to contribute to trichloroethylene-induced liver cancer. Toxicol. Lett. 106, 9-21.
2. Boorman, G. A., Dellarco, V., Dunnick, J. K., Chapin, R. E., Hunter, S., Hauchman, F., Gardner, H., Cox, C., and Sills, R. C. (1999). Drinking water disinfection byproducts: Review and approach to toxicity evaluation. Environ. Health Perspect. 107, 207-217.
3. Boorman, G. A., and Eustis, S. L. (1986). The pathology working group as a means for assuring pathology quality in toxicological studies. In Managing Conduct and Data Quality of Toxicological Studies (B. K. Hoover, J. K. Baldwin, A. F. Uelner, C. E. Whitmire, C. L. Davies, and D. W. Bristol, Eds.), Vol. 1, pp. 271-275. Princeton Scientific Publishing Co., Inc., Princeton, NJ.
4. Bull, R. J., Orner, G. A., Cheng, R. S., Stillwell, L., Stauber, A. J., Sasser, L. B., Lingohr, M. K., and Thrall, B. D. (2002). Contribution of dichloroacetate and trichloroacetate to liver tumor induction in mice by trichloroethylene. Toxicol. Appl. Pharmacol. 182, 55-65.
5. Bull, R. J., Sanchez, I. M., Nelson, M. A., Larson, J. L., and Lansing, A. J. (1990). Liver tumor induction in B6C3F1 mice by dichloroacetate and trichloroacetate. Toxicology 63, 341-359.
6. Bull, R. J., Sasser, L. B., and Lei, X. C. (2004). Interactions in the tumor-promoting activity of carbon tetrachloride, trichloroacetate, and dichloroacetate in the liver of male B6C3F1 mice. Toxicology 199, 169-183.
7. Cannon, R. E., Spalding, J. W., Trempus, C. S., Szczesniak, C. J., Virgil, K. M., Humble, M. C., and Tennant, R. W. (1997). Kinetics of wound-induced (v-Ha-ras transgene expression and papilloma development in transgenic Tg.AC mice. Mol. Carcinogenesis 20 108-114.
8. Carter, J. H., Carter, H. W., Deddens, J. A., Hurst, B. M., George, M. H., and DeAngelo, A. B. (2003). A 2-year dose-response study of lesion sequences during hepatocellular carcinogenesis in the male B6C3F1 mouse given the drinking water chemical dichloroacetic acid. Environ. Health Perspect. 111, 53-64.
9. Daniel, F. B., DeAngelo, A. B., Stober, J. A., Olson, G. R., and Page, N. P. (1992). Hepatocarcinogenicity of chloral hydrate, 2-chloroacetaldehyde, and dichloroacetic acid in the male B6C3F1 mouse. Fundam. Appl. Toxicol. 19, 159-168.
10. DeAngelo, A. B., Daniel, F. B., Most, B. M., and Olson, G. R. (1996). The carcinogenicity of dichloroacetic acid in the male Fischer 344 rat. Toxicology 114, 207-221.
11. DeAngelo, A. B., Daniel, F. B., Stober, J. A., and Olson, G. R. (1991). The carcinogenicity of dichloroacetic acid in the male B6C3F1 mouse. Fundam. Appl. Toxicol. 16, 337-347.
12. DeAngelo, A. B., George, M. H., and House, D. E. (1999). Hepatocarcinogenicity in the male B6C3F1 mouse following a lifetime exposure to dichloroacetic acid in the drinking water: Dose-response determination and modes of action. J. Toxicol. Environ. Health A 58, 485-507.
13. Eastin, W. C., Haseman, J. K., Mahler, J. F., and Bucher, J. R. (1998). The National Toxicology Program evaluation of genetically altered mice as predictive models for identifying carcinogens. Toxicol. Pathol. 26, 461-473.
14. Gart, J. J., Chu, K. C., and Tarone, R. E. (1979). Statistical issues in interpretation of chronic bioassay tests for carcinogenicity. J. Natl. Cancer Inst. 62, 957-974.
15. Haseman, J. K. (2000). Using the NTP database to assess the value of rodent carcinogenicity studies for determining human cancer risk. Drug Metab. Rev. 32, 169-186.
16. Herren-Freund, S. L., Pereira, M. A., Khoury, M. D., and Olson, G. (1987). The carcinogenicity of trichloroethylene and its metabolites, trichloroacetic acid and dichloroacetic acid, in mouse liver. Toxicol. Appl. Pharmacol. 15, 193-189.
17. IARC. (1995). Dichloroacetic acid. In IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Dry Cleaning, Some Chlorinated Solvents and other Industrial Chemicals, Vol. 63, pp. 271-291. IARC Press, Lyon, France.
18. IARC. (2004). Dichloroacetic acid. In IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Some Drinking-Water Disinfectants and Contaminants, Including Arsenic, Vol. 84, pp. 359-402. IARC Press, Lyon, France.
19. MacDonald, J., French, J. E., Gerson, R. J., Goodman, J., Inoue, T., Jacobs, A., Kasper, P., Keller, D., Lavin, A., Long, G., et al. (2004). The utility of genetically modified mouse assays for identifying human carcinogens: A basic understanding and path forward. Toxicol. Sci. 77, 199-194.
20. NRC. (1996). Guide for the Care and Use of Laboratory Animals. National Academy Press, Washington, DC.
21. NTP. (2006). Toxicology study of dichloroacetic acid (CAS No. 79-43-6) in genetically modified (FVB Tg.AC hemizygous) mice (dermal and drinking water studies) and carcinogenicity studies of dichloroacetic acid in genetically modified [B6.129-Trp53tm1Brd (N5) haploinsufficient] mice (drinking water studies). Research Triangle Park, NC 27709, U. S. Dept. of Health and Human Services, Public Health Service, NIH: 1-212
22. Pereira, M. A. (1996). Carcinogenic activity of dichloroacetic acid and trichloroacetic acid in the liver of female B6C3F1 mice. Fundam. Appl. Toxicol. 31, 192-199.
23. Pereira, M. A., Kramer, P. M., Conran, P. B., and Tao, L. (2001). Effect of chloroform on dichloroacetic acid and trichloroacetic acid-induced hypomethylation and expression of the c-myc gene and on their promotion of liver and kidney tumors in mice. Carcinogenesis 22, 1511-1519.
24. Pritchard, J. B., French, J. E., Davis, B. J., and Haseman, J. K. (2003). The role of transgenic mouse models in carcinogen identification. Environ. Health Perspect. 111, 444-454.
25. Spalding, J. W., French, J. E., Stasiewicz, S., Furedit-Machacek, M., Conner, F., Tice, R. R., and Tennant, R. W. (2000). Response of transgenic mouse lines p53(+/-) and Tg.AC to agents tested in conventional carcinogenicity bioassays. Toxicol. Sci. 53, 213-223.
26. Tennant, R. W., French, J. E., and Spalding, J. W. (1995). Identifying chemical carcinogens and assessing potential risk in short-term bioassays using transgenic mouse models. Environ. Health Perspect. 103, 942-949.
27. Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. (1992). Salmonella mutagenicity tests: V. Results from the testing of 311 chemicals. Environ. Mol. Mutagen. 19, 2-141.