Synthesis and use of 4-peptidylhydrazido-N-hexyl-1,8-naphthalimides as fluorogenic histochemical substrates for dipeptidyl peptidase IV and tripeptidyl peptidase I

European Journal of Medicinal Chemistry

Volumn 44, Issue 1, 2009, Pages 384-392

  Ivanov, Ivaylo ^a   Tasheva, Donka ^a   Todorova, Ralitza ^b   Dimitrova, Mashenka ^b  

^a UNIVERSITY OF SOFIA   (Bulgaria)

^b BULGARIAN ACADEMY OF SCIENCES   (Bulgaria)

Author keywords

Dipeptidyl peptidase IV; Enzyme histochemistry; Fluorogenic substrates; Naphthalimide derivatives; Tripeptidyl peptidase I

Indexed keywords

2 HEXYL 6 HYDRAZINO 1H BENZO[DE]ISOQUINOLINE 1,3[2H] DIONE; 4 PEPTIDYLHYDRAZIDO N HEXYL 1,8 NAPHTHALIMIDE; ALANYLALANYLPHENYLALANINE N' (2 HEXYL 1,3 DIOXO 2,3 DIHYDRO 1H BENZO[DE]ISOQUINOLIN 6 YL)HYDRAZIDE DERIVATIVE; DIPEPTIDYL PEPTIDASE IV; FLUORESCENT DYE; GLYCYLPROLINE N' (2 HEXYL 1,3 DIOXO 2,3 DIHYDRO 1H BENZO[DE]ISOQUINOLIN 6 YL)HYDRAZIDE DERIVATIVE; GLYCYLPROLYLMETHIONINE N' (2 HEXYL 1,3 DIOXO 2,3 DIHYDRO 1H BENZO[DE]ISOQUINOLIN 6 YL)HYDRAZIDE DERIVATIVE; NAPHTHALIMIDE DERIVATIVE; PEPTIDASE; TRIPEPTIDYL PEPTIDASE I; UNCLASSIFIED DRUG;

ARTICLE; DRUG SYNTHESIS; ENZYME LOCALIZATION; ENZYME SUBSTRATE COMPLEX; FLUORESCENCE; HISTOCHEMISTRY; MOLECULAR MODEL; REACTION ANALYSIS;

ANIMALS; ANTIGENS, CD26; ENDOPEPTIDASES; FLUORESCENT DYES; HISTOCYTOCHEMISTRY; HUMANS; NAPHTHALIMIDES; PEPTIDES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 57949084030     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2008.02.036     Document Type: Article

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